ATE360696T1 - Interferon-ähnliches protein zcyto21 - Google Patents
Interferon-ähnliches protein zcyto21Info
- Publication number
- ATE360696T1 ATE360696T1 AT01950827T AT01950827T ATE360696T1 AT E360696 T1 ATE360696 T1 AT E360696T1 AT 01950827 T AT01950827 T AT 01950827T AT 01950827 T AT01950827 T AT 01950827T AT E360696 T1 ATE360696 T1 AT E360696T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- zcyto21
- interferon
- acid sequence
- genetically engineered
- Prior art date
Links
- 101100232735 Homo sapiens IFNL1 gene Proteins 0.000 title 1
- 102100020990 Interferon lambda-1 Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 238000011813 knockout mouse model Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000011830 transgenic mouse model Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21544600P | 2000-06-30 | 2000-06-30 | |
| US28542401P | 2001-04-20 | 2001-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360696T1 true ATE360696T1 (de) | 2007-05-15 |
Family
ID=26910034
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01950827T ATE360696T1 (de) | 2000-06-30 | 2001-06-29 | Interferon-ähnliches protein zcyto21 |
| AT06012489T ATE404670T1 (de) | 2000-06-30 | 2001-06-29 | Allelische variante des interferon-ähnlichen proteins zcyto21 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06012489T ATE404670T1 (de) | 2000-06-30 | 2001-06-29 | Allelische variante des interferon-ähnlichen proteins zcyto21 |
Country Status (13)
| Country | Link |
|---|---|
| US (18) | US6927040B2 (de) |
| EP (4) | EP1717316B1 (de) |
| JP (1) | JP4377126B2 (de) |
| CN (1) | CN100448993C (de) |
| AT (2) | ATE360696T1 (de) |
| AU (1) | AU2001271786A1 (de) |
| BR (1) | BR0112119A (de) |
| CA (1) | CA2413258C (de) |
| DE (2) | DE60135393D1 (de) |
| DK (2) | DK1717316T3 (de) |
| ES (2) | ES2286128T3 (de) |
| RU (1) | RU2292394C2 (de) |
| WO (1) | WO2002002627A2 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE360696T1 (de) | 2000-06-30 | 2007-05-15 | Zymogenetics Inc | Interferon-ähnliches protein zcyto21 |
| US7910313B2 (en) * | 2001-04-20 | 2011-03-22 | Zymogenetics, Inc. | Cytokine protein family |
| US7038032B2 (en) * | 2001-04-20 | 2006-05-02 | Zymogenetics, Inc. | Cytokine protein family |
| US20030104579A1 (en) * | 2001-05-10 | 2003-06-05 | Baum Peter R. | Cytokine polypeptides |
| US6902930B2 (en) * | 2001-08-29 | 2005-06-07 | Vanderbilt University | Human Mob-5 (IL-24) receptors and uses thereof |
| WO2003066002A2 (en) | 2002-02-08 | 2003-08-14 | University Of Medicine And Dentistry Of New Jersey | IFN-a/b-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION |
| EP1497415B1 (de) | 2002-04-19 | 2010-12-29 | ZymoGenetics, L.L.C. | Verfahren zum nachweis oder zur modulierung der wechselwirkung eines cytokinrezeptors mit seinem ligand |
| WO2004015113A2 (en) * | 2002-08-07 | 2004-02-19 | Delta Biotechnology Ltd. | Albumin-fused ciliary neurotrophic factor |
| JP2006509041A (ja) * | 2002-10-23 | 2006-03-16 | ザイモジェネティクス,インコーポレイティド | Il−28およびil−29を用いるウイルス感染を治療するための方法 |
| PT2251353E (pt) * | 2003-08-07 | 2013-05-07 | Zymogenetics Inc | Preparações homogéneas de il-28 e il-29 |
| JP4896005B2 (ja) * | 2004-04-02 | 2012-03-14 | ザイモジェネティクス リミテッド ライアビリティ カンパニー | Il−28およびil−29システイン変異体を用いるウイルス感染を治療するための方法 |
| WO2006012644A2 (en) * | 2004-07-29 | 2006-02-02 | Zymogenetics, Inc. | Use of il-28 and il-29 to treat cancer |
| RU2389502C2 (ru) * | 2004-07-29 | 2010-05-20 | Займодженетикс, Инк. | Применение il-28 и il-29 для лечения карциномы и аутоиммунных нарушений |
| US20060178301A1 (en) * | 2005-02-04 | 2006-08-10 | Mathias Jurs | Albumin-fused ciliary neurotrophic factor |
| AU2006272937A1 (en) * | 2005-07-20 | 2007-02-01 | Bristol-Myers Squibb Company | Use of truncated cysteine IL28 and IL29 mutants to treat cancers and autoimmune disorders |
| AU2006269908A1 (en) * | 2005-07-20 | 2007-01-25 | Bristol-Myers Squibb Company | IL28 and IL29 truncated cysteine mutants and antiviral methods of using same |
| DK1931704T3 (da) * | 2005-10-04 | 2011-03-14 | Zymogenetics L L C | Frembringelse og rensning af IL-29 |
| TW200744634A (en) * | 2006-02-21 | 2007-12-16 | Wyeth Corp | Methods of using antibodies against human IL-22 |
| EP3103813A1 (de) | 2007-12-07 | 2016-12-14 | ZymoGenetics, Inc. | Anti-humane il-21 monoklonale antikörper |
| WO2009124309A2 (en) | 2008-04-04 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same |
| AU2009255994B2 (en) * | 2008-06-05 | 2014-07-17 | Bristol-Myers Squibb Company | Use of pegylated Type III Interferons for the treatment of hepatitis C |
| EP2344546A1 (de) * | 2008-10-13 | 2011-07-20 | Zymogenetics, Inc. | Einzelketten-fc-typ-iii-interferone und verfahren zuen zu deren anwendung |
| EP2563720A1 (de) | 2010-04-28 | 2013-03-06 | Murata Manufacturing Co., Ltd. | Perowskitmaterial mit anionengesteuerten dielektrischen eigenschaften, dünnschichtkondensatorvorrichtung und herstellungsverfahren dafür |
| FR2975185A1 (fr) * | 2011-05-12 | 2012-11-16 | Univ Claude Bernard Lyon | Procede de determination in vitro de la presence d'une sclerose en plaques |
| RU2549710C2 (ru) * | 2012-06-29 | 2015-04-27 | Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) | Способ очистки рекомбинантного белка интерфероноподобного фактора iii типа |
| CN102998450B (zh) * | 2012-11-22 | 2014-10-15 | 北京正旦国际科技有限责任公司 | 一种食管癌免疫质谱检测试剂盒的制备方法 |
| CN109293782A (zh) | 2014-01-08 | 2019-02-01 | 德益阳光生物技术(北京)有限责任公司 | 融合多肽及使用方法 |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US10835496B2 (en) | 2015-04-21 | 2020-11-17 | Eiger Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising lonafarnib and ritonavir |
| LT3416675T (lt) | 2016-02-19 | 2021-06-25 | Eiger Biopharmaceuticals, Inc. | Hepatito delta viruso infekcijos gydymas interferonu lambda |
| AU2017336078B2 (en) * | 2016-09-30 | 2022-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Variant type III interferons and synthekines |
Family Cites Families (62)
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|---|---|---|---|---|
| DE3000213A1 (de) | 1980-01-04 | 1981-07-09 | Zahnfabrik Wienand Söhne & Co GmbH, 6072 Dreieich | Verfahren zur herstellung eines vernetzten polymerisatz fuer dentalzwecke |
| CY1346A (en) | 1980-01-08 | 1987-01-16 | Biogen Nv | Dna sequences,recombinant dna molecules and processes for producing human interferon-like polypeptides |
| AU560472B2 (en) | 1981-08-25 | 1987-04-09 | Celltech Limited | Yeast expression vectors |
| US4579821A (en) | 1981-11-23 | 1986-04-01 | University Patents, Inc. | Control of DNA sequence transcription |
| US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
| US4486533A (en) | 1982-09-02 | 1984-12-04 | St. Louis University | Filamentous fungi functional replicating extrachromosomal element |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
| US4977092A (en) | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| US5139936A (en) | 1983-02-28 | 1992-08-18 | Collaborative Research, Inc. | Use of the GAL1 yeast promoter |
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| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
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| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
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| GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
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| US5063154A (en) | 1987-06-24 | 1991-11-05 | Whitehead Institute For Biomedical Research | Pheromone - inducible yeast promoter |
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| US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
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| NZ271230A (en) | 1994-02-14 | 1998-03-25 | Zymogenetics Inc | Hematopoietic proteins, production and use |
| US6451578B1 (en) * | 1994-02-14 | 2002-09-17 | Abbott Laboratories | Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use |
| US5641655A (en) | 1994-11-30 | 1997-06-24 | Zymogenetics, Inc. | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
| US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
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| US5716808A (en) | 1995-11-09 | 1998-02-10 | Zymogenetics, Inc. | Genetic engineering of pichia methanolica |
| US6025539A (en) * | 1996-04-09 | 2000-02-15 | Mayo Foundation For Medical Education And Research | IL-5 transgenic mouse |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| AU3721397A (en) * | 1996-07-09 | 1998-02-02 | Genetics Institute Inc. | Secreted proteins and polynucleotides encoding them |
| US5854039A (en) | 1996-07-17 | 1998-12-29 | Zymogenetics, Inc. | Transformation of pichia methanolica |
| US5736383A (en) | 1996-08-26 | 1998-04-07 | Zymogenetics, Inc. | Preparation of Pichia methanolica auxotrophic mutants |
| US5985614A (en) | 1996-08-30 | 1999-11-16 | Human Genome Sciences, Inc. | Polynucleotides encoding interleukin-19 |
| ATE549918T1 (de) | 1996-12-03 | 2012-04-15 | Amgen Fremont Inc | Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden |
| GB9702944D0 (en) * | 1997-02-13 | 1997-04-02 | Univ Manchester | Reducing fibrosis |
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| US5965704A (en) | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
| JP2002505879A (ja) | 1998-03-09 | 2002-02-26 | シェーリング コーポレイション | ヒトレセプタータンパク質;関連する試薬および方法 |
| EP1073730A1 (de) * | 1998-04-17 | 2001-02-07 | Whitehead For Biomedical Research | Verwendung von ribozym zum verbinden von nukleinsäuren mit polypeptiden |
| AR021876A1 (es) * | 1998-12-18 | 2002-08-07 | Schering Corp | Terapia de combinacion para vhc por induccion de ribavirina - interferon alfa pegilado |
| US6685931B1 (en) * | 1998-12-22 | 2004-02-03 | Schering Corporation | Treatment of hepatitis C virus infections with interleukin-10 |
| ATE360696T1 (de) * | 2000-06-30 | 2007-05-15 | Zymogenetics Inc | Interferon-ähnliches protein zcyto21 |
| AU2002255478A1 (en) * | 2001-01-10 | 2002-09-12 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| US7038032B2 (en) | 2001-04-20 | 2006-05-02 | Zymogenetics, Inc. | Cytokine protein family |
| US20030104579A1 (en) | 2001-05-10 | 2003-06-05 | Baum Peter R. | Cytokine polypeptides |
| JP3939160B2 (ja) * | 2001-05-25 | 2007-07-04 | 独立行政法人科学技術振興機構 | 腎臓における外来遺伝子発現方法 |
| WO2003066002A2 (en) | 2002-02-08 | 2003-08-14 | University Of Medicine And Dentistry Of New Jersey | IFN-a/b-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION |
| JP2006509041A (ja) * | 2002-10-23 | 2006-03-16 | ザイモジェネティクス,インコーポレイティド | Il−28およびil−29を用いるウイルス感染を治療するための方法 |
| PT2251353E (pt) | 2003-08-07 | 2013-05-07 | Zymogenetics Inc | Preparações homogéneas de il-28 e il-29 |
| JP4896005B2 (ja) | 2004-04-02 | 2012-03-14 | ザイモジェネティクス リミテッド ライアビリティ カンパニー | Il−28およびil−29システイン変異体を用いるウイルス感染を治療するための方法 |
| AU2006272937A1 (en) * | 2005-07-20 | 2007-02-01 | Bristol-Myers Squibb Company | Use of truncated cysteine IL28 and IL29 mutants to treat cancers and autoimmune disorders |
| AU2009255994B2 (en) | 2008-06-05 | 2014-07-17 | Bristol-Myers Squibb Company | Use of pegylated Type III Interferons for the treatment of hepatitis C |
| EP2344546A1 (de) | 2008-10-13 | 2011-07-20 | Zymogenetics, Inc. | Einzelketten-fc-typ-iii-interferone und verfahren zuen zu deren anwendung |
-
2001
- 2001-06-29 AT AT01950827T patent/ATE360696T1/de active
- 2001-06-29 AT AT06012489T patent/ATE404670T1/de active
- 2001-06-29 ES ES01950827T patent/ES2286128T3/es not_active Expired - Lifetime
- 2001-06-29 AU AU2001271786A patent/AU2001271786A1/en not_active Abandoned
- 2001-06-29 RU RU2003103099/13A patent/RU2292394C2/ru active
- 2001-06-29 DE DE60135393T patent/DE60135393D1/de not_active Expired - Lifetime
- 2001-06-29 EP EP06012489A patent/EP1717316B1/de not_active Expired - Lifetime
- 2001-06-29 DK DK06012489T patent/DK1717316T3/da active
- 2001-06-29 EP EP01950827A patent/EP1294888B1/de not_active Expired - Lifetime
- 2001-06-29 CN CNB018131530A patent/CN100448993C/zh not_active Ceased
- 2001-06-29 US US09/895,834 patent/US6927040B2/en not_active Expired - Lifetime
- 2001-06-29 JP JP2002507878A patent/JP4377126B2/ja not_active Expired - Lifetime
- 2001-06-29 WO PCT/US2001/021087 patent/WO2002002627A2/en not_active Ceased
- 2001-06-29 ES ES06012489T patent/ES2311253T3/es not_active Expired - Lifetime
- 2001-06-29 CA CA2413258A patent/CA2413258C/en not_active Expired - Lifetime
- 2001-06-29 DK DK01950827T patent/DK1294888T3/da active
- 2001-06-29 DE DE60128093T patent/DE60128093T2/de not_active Expired - Lifetime
- 2001-06-29 EP EP08100616A patent/EP1939293A3/de not_active Withdrawn
- 2001-06-29 EP EP09172071A patent/EP2132984A3/de not_active Withdrawn
- 2001-06-29 BR BR0112119-7A patent/BR0112119A/pt active Search and Examination
-
2004
- 2004-03-02 US US10/790,996 patent/US20040146988A1/en not_active Abandoned
- 2004-08-27 US US10/927,891 patent/US7252969B2/en not_active Expired - Lifetime
- 2004-08-27 US US10/927,815 patent/US7253261B2/en not_active Expired - Lifetime
- 2004-08-27 US US10/928,539 patent/US7241870B2/en not_active Expired - Lifetime
-
2006
- 2006-10-10 US US11/548,108 patent/US20070043209A1/en not_active Abandoned
- 2006-10-10 US US11/548,023 patent/US7445913B2/en not_active Expired - Lifetime
- 2006-10-10 US US11/548,056 patent/US7485700B2/en not_active Expired - Lifetime
- 2006-10-10 US US11/548,138 patent/US20070049736A1/en not_active Abandoned
-
2007
- 2007-10-16 US US11/873,272 patent/US7655223B2/en not_active Expired - Lifetime
- 2007-10-26 US US11/925,097 patent/US7498154B2/en not_active Expired - Lifetime
-
2008
- 2008-01-09 US US11/971,624 patent/US20080214788A1/en not_active Abandoned
- 2008-12-22 US US12/341,273 patent/US20090326204A1/en not_active Abandoned
-
2009
- 2009-11-30 US US12/628,078 patent/US7833520B2/en not_active Expired - Fee Related
-
2010
- 2010-09-30 US US12/895,139 patent/US7919595B2/en not_active Expired - Fee Related
-
2011
- 2011-03-02 US US13/039,223 patent/US20110172170A1/en not_active Abandoned
- 2011-09-08 US US13/227,548 patent/US20120036590A1/en not_active Abandoned
-
2012
- 2012-05-03 US US13/463,046 patent/US20120258458A1/en not_active Abandoned
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