ATE361060T1 - Ionenstärkenunabhängige pharmazeutische formulierung mit verzögerter freisetzung - Google Patents

Ionenstärkenunabhängige pharmazeutische formulierung mit verzögerter freisetzung

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Publication number
ATE361060T1
ATE361060T1 AT01985673T AT01985673T ATE361060T1 AT E361060 T1 ATE361060 T1 AT E361060T1 AT 01985673 T AT01985673 T AT 01985673T AT 01985673 T AT01985673 T AT 01985673T AT E361060 T1 ATE361060 T1 AT E361060T1
Authority
AT
Austria
Prior art keywords
pharmaceutical formulation
ionic strength
delayed release
release pharmaceutical
strength independent
Prior art date
Application number
AT01985673T
Other languages
English (en)
Inventor
Henricus R M Gorissen
Henderik W Frijlink
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Application granted granted Critical
Publication of ATE361060T1 publication Critical patent/ATE361060T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physiology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
AT01985673T 2000-09-29 2001-09-28 Ionenstärkenunabhängige pharmazeutische formulierung mit verzögerter freisetzung ATE361060T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1016295 2000-09-29
EP00203381 2000-09-29

Publications (1)

Publication Number Publication Date
ATE361060T1 true ATE361060T1 (de) 2007-05-15

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ID=26072736

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01985673T ATE361060T1 (de) 2000-09-29 2001-09-28 Ionenstärkenunabhängige pharmazeutische formulierung mit verzögerter freisetzung

Country Status (25)

Country Link
US (1) US8034379B2 (de)
EP (1) EP1345595B1 (de)
JP (1) JP5049450B2 (de)
KR (1) KR100833469B1 (de)
CN (1) CN1466451B (de)
AT (1) ATE361060T1 (de)
AU (2) AU2002223572B2 (de)
BR (1) BR0114272A (de)
CA (1) CA2426666A1 (de)
CZ (1) CZ299411B6 (de)
DE (1) DE60128263T2 (de)
DK (1) DK1345595T3 (de)
DZ (1) DZ3473A1 (de)
ES (1) ES2284709T3 (de)
HU (1) HUP0301177A3 (de)
IL (2) IL154731A0 (de)
MX (1) MXPA03002769A (de)
NO (1) NO20031409D0 (de)
NZ (1) NZ524641A (de)
PL (1) PL203217B1 (de)
PT (1) PT1345595E (de)
RU (1) RU2285519C2 (de)
SI (1) SI1345595T1 (de)
SK (1) SK287066B6 (de)
WO (1) WO2002026214A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070099931A1 (en) * 2004-03-19 2007-05-03 Wyeth Pharmaceutical dosage forms and compositions
CN101027061B (zh) 2004-05-11 2014-03-12 情感智能有限责任公司 药物制剂及其在治疗女性性功能障碍中的应用
US20060003003A1 (en) * 2004-06-28 2006-01-05 Bakker Johan A Oral sustained release formulation of tedisamil with gastric retention properties
AR049936A1 (es) * 2004-06-28 2006-09-13 Solvay Pharm Bv Formulacion oral de liberacion sostenida de tedisamil con propiedades de retencion gastrica
RU2385724C2 (ru) * 2004-06-28 2010-04-10 Солвей Фармасьютикалс Б.В. Пероральная композиция тедисамила с замедленным высвобождением, обладающая свойством задержки в желудке
JP2006143598A (ja) * 2004-11-16 2006-06-08 Nichi-Iko Pharmaceutical Co Ltd 経時的な変色を抑制した医薬組成物
BRPI0615771A2 (pt) * 2005-09-09 2011-05-24 Wyeth Corp método que compreende administrar a um paciente uma forma de dosagem oral; método para minimizar um efeito colateral adverso associado com a administração de lecozotan a um paciente; método para administrar lecozotan a um paciente; método de tratar doença de alzheimer em um paciente; uso de lecozotan na preparação de um medicamento na forma de dosagem oral; e uso de lecozotan na preparação de um medicamento na forma de dosagem oral para minimizar um efeito colateral adverso associado com a administração de lecozotan a um paciente
EP1790343A1 (de) 2005-11-11 2007-05-30 Emotional Brain B.V. Pharmazeutische Zusammensetzungen und deren Verwendung zur Behandlung sexueller Störungen der Frau
US8669258B2 (en) 2006-10-30 2014-03-11 The Board Of Regents Of The University Of Texas System Treatment for gastroparesis using sepiapterin
US7863275B2 (en) * 2006-10-30 2011-01-04 The Board Of Regents Of The University Of Texas System Uses of tetrahydrobiopterin and derivatives thereof
EP1925307A1 (de) 2006-11-03 2008-05-28 Emotional Brain B.V. Verwendung von 3-alpha-androstanediol zur Behandlung sexueller Dysfunktion
US7965077B2 (en) * 2008-05-08 2011-06-21 Everspin Technologies, Inc. Two-axis magnetic field sensor with multiple pinning directions
MX381895B (es) 2009-02-13 2025-03-13 Romark Laboratories Lc Formulaciones farmaceuticas de liberacion controlada de nitazoxanida.
WO2013157833A1 (ko) * 2012-04-18 2013-10-24 서울대학교산학협력단 베타-차단제를 유효성분으로 포함하는 비만, 비만으로 인한 대사성 질환 및 골감소증 예방, 개선 또는 치료용 조성물
KR102116495B1 (ko) * 2013-08-28 2020-06-03 삼성디스플레이 주식회사 축합환 화합물을 포함하는 유기 전계 발광 소자
WO2016020901A1 (en) 2014-08-07 2016-02-11 Acerta Pharma B.V. Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate
CN104352471A (zh) * 2014-11-21 2015-02-18 哈尔滨圣吉药业股份有限公司 一种马来酸氟伏沙明缓释片及其制备方法
JP2020525436A (ja) 2017-06-21 2020-08-27 ミネルバ・ニューロサイエンシズ・インコーポレイテッド 胃耐性制御放出経口剤形
TWI841545B (zh) * 2018-12-12 2024-05-11 日商田邊三菱製藥股份有限公司 耐胃性控制釋放經口劑型
US12016851B2 (en) * 2022-04-11 2024-06-25 Chiesi Farmaceutici S.P.A. Modified release pharmaceutical formulations comprising deferiprone

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
FR2588188B1 (fr) 1985-10-04 1988-01-08 Delalande Sa Comprime de sel(s) hydrosoluble(s) de cinepazide a liberation programmee et son procede de preparation
US4786503A (en) 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
US5009895A (en) * 1990-02-02 1991-04-23 Merck & Co., Inc. Sustained release with high and low viscosity HPMC
DE4139763A1 (de) * 1991-12-03 1993-06-09 Kali-Chemie Pharma Gmbh, 3000 Hannover, De Kristalline fumarsaure salze von 9,9-alkylen-3,7-diazabicyclononan-verbindungen und diese verbindungen enthaltende arzneimittel
DE4329794C2 (de) * 1993-09-03 1997-09-18 Gruenenthal Gmbh Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung
ZA959221B (en) 1994-11-02 1997-04-30 Janssen Pharmaceutica Nv Cisapride extended release
CN1162263A (zh) * 1994-11-02 1997-10-15 詹森药业有限公司 西沙必利的缓释口服组合物
WO1997004752A1 (en) * 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
CA2216215A1 (en) * 1997-04-05 1998-10-05 Isa Odidi Controlled release formulations using intelligent polymers having opposing wettability characteristics of hydrophobicity and hydrophilicity
ATE302597T1 (de) * 1997-06-06 2005-09-15 Depomed Inc Im magen verweilende orale dosierungsformen von wasserlöslichen arzneistoffen mit kontrollierter freisetzung
US5948440A (en) 1997-12-17 1999-09-07 Ranbaxy Laboratories Limited Modified release matrix formulation of cefaclor and cephalexin
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
JP2002517466A (ja) * 1998-06-08 2002-06-18 アドバンスド メディスン インコーポレーテッド 新規カリウムチャンネル薬剤およびそれらの用途
IL141762A0 (en) * 1998-10-01 2002-03-10 Novartis Ag New oral formulations
CO5140079A1 (es) 1998-10-14 2002-03-22 Novartis Ag Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo
AU2002231175A1 (en) 2000-12-27 2002-07-08 Focal, Inc. Controlled release of anti-arrhythmic agents from a biodegradable polyethylene oxide hydrogel for local application to the heart

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CA2426666A1 (en) 2002-04-04
KR20030036861A (ko) 2003-05-09
AU2002223572B2 (en) 2005-09-08
CZ299411B6 (cs) 2008-07-16
RU2285519C2 (ru) 2006-10-20
NO20031409L (no) 2003-03-27
US8034379B2 (en) 2011-10-11
HUP0301177A2 (hu) 2003-10-28
MXPA03002769A (es) 2003-07-28
SI1345595T1 (sl) 2007-08-31
DE60128263T2 (de) 2008-01-10
PL360670A1 (en) 2004-09-20
CN1466451A (zh) 2004-01-07
SK3552003A3 (en) 2003-10-07
EP1345595B1 (de) 2007-05-02
JP2004509915A (ja) 2004-04-02
ES2284709T3 (es) 2007-11-16
NZ524641A (en) 2004-09-24
DK1345595T3 (da) 2007-09-10
IL154731A0 (en) 2003-10-31
WO2002026214A1 (en) 2002-04-04
US20040013727A1 (en) 2004-01-22
BR0114272A (pt) 2003-08-26
SK287066B6 (sk) 2009-11-05
HK1060691A1 (en) 2004-08-20
PT1345595E (pt) 2007-08-13
CN1466451B (zh) 2010-05-12
IL154731A (en) 2008-11-26
HUP0301177A3 (en) 2006-07-28
KR100833469B1 (ko) 2008-05-29
EP1345595A1 (de) 2003-09-24
DE60128263D1 (de) 2007-06-14
NO20031409D0 (no) 2003-03-27
CZ2003898A3 (cs) 2003-06-18
AU2357202A (en) 2002-04-08
PL203217B1 (pl) 2009-09-30
DZ3473A1 (fr) 2002-04-04

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