ATE361280T1 - Verfahren zur herstellung von hochreinem nicotinamid - Google Patents
Verfahren zur herstellung von hochreinem nicotinamidInfo
- Publication number
- ATE361280T1 ATE361280T1 AT99935809T AT99935809T ATE361280T1 AT E361280 T1 ATE361280 T1 AT E361280T1 AT 99935809 T AT99935809 T AT 99935809T AT 99935809 T AT99935809 T AT 99935809T AT E361280 T1 ATE361280 T1 AT E361280T1
- Authority
- AT
- Austria
- Prior art keywords
- nicotinamide
- usp grade
- high purity
- producing high
- strategies
- Prior art date
Links
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003966 nicotinamide Drugs 0.000 title abstract 3
- 235000005152 nicotinamide Nutrition 0.000 title abstract 3
- 239000011570 nicotinamide Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 abstract 1
- 238000005341 cation exchange Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9355398P | 1998-07-21 | 1998-07-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE361280T1 true ATE361280T1 (de) | 2007-05-15 |
Family
ID=22239561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99935809T ATE361280T1 (de) | 1998-07-21 | 1999-07-21 | Verfahren zur herstellung von hochreinem nicotinamid |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6218543B1 (de) |
| EP (1) | EP1098879B1 (de) |
| JP (1) | JP4901002B2 (de) |
| KR (1) | KR20010072009A (de) |
| CN (1) | CN1310710A (de) |
| AT (1) | ATE361280T1 (de) |
| AU (1) | AU5121199A (de) |
| DE (1) | DE69935985T2 (de) |
| TW (1) | TW539670B (de) |
| WO (1) | WO2000005211A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102249994B (zh) * | 2011-05-10 | 2014-05-07 | 浙江爱迪亚营养科技开发有限公司 | 一种烟酸的制备方法 |
| CN102219734B (zh) * | 2011-05-10 | 2013-08-07 | 浙江爱迪亚营养科技开发有限公司 | 一种烟酰胺的制备方法 |
| EP3469913A1 (de) * | 2017-10-12 | 2019-04-17 | Wolfgang Zwickenpflug | Verfahren zur herstellung von nicotinsäure |
| JP7126437B2 (ja) | 2018-12-11 | 2022-08-26 | 川崎重工業株式会社 | 蓋部材取付装置 |
| JP7530750B2 (ja) * | 2020-06-10 | 2024-08-08 | 花王株式会社 | 歯肉退縮抑制剤 |
| CN114634269B (zh) * | 2020-12-15 | 2022-12-02 | 山东潍坊润丰化工股份有限公司 | 一种从废水中回收烟酰胺的方法 |
| CN118925271B (zh) * | 2024-10-12 | 2024-12-17 | 安徽瑞邦生物科技有限公司 | 一种烟酰胺水合液提纯设备及其提纯工艺 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB879551A (en) * | 1957-10-28 | 1961-10-11 | Merck & Co Inc | Ion-exchange purification of nicotinamide |
| FR1335502A (fr) * | 1960-06-02 | 1963-08-23 | Merck & Co Inc | Nouveaux composés d'adsorption de la nicotinamide |
| US3143465A (en) | 1961-06-19 | 1964-08-04 | Wallace & Tiernan Inc | Pharmaceutical preparations comprising phosphorus containing cation exchange resins having a basic drug adsorbed thereon; and treatment therewith |
| DE2517053A1 (de) * | 1975-04-17 | 1976-10-28 | Degussa | Verfahren zur gewinnung von nicotinsaeureamid |
| DE2517054C2 (de) | 1975-04-17 | 1985-04-25 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von Nicotinsäureamid |
| NL7706612A (en) | 1977-06-16 | 1978-12-19 | Stamicarbon | Nicotinamide prepn. from aq. 3-cyano-pyridine soln. - by hydrolysis with anion exchanger and extraction with organic solvent |
| DE3028904A1 (de) | 1980-07-30 | 1982-02-25 | Degussa Ag, 6000 Frankfurt | Verfahren zur reinigung von nicotinsaeureamid i. |
| DE3028791A1 (de) * | 1980-07-30 | 1982-02-25 | Degussa Ag, 6000 Frankfurt | Verfahren zur reinigung von nicotinsaeureamid ii. |
| US4764276A (en) | 1984-07-30 | 1988-08-16 | Advanced Separation Technologies Incorporated | Device for continuous contacting of fluids and solids |
| US4522726A (en) | 1984-07-30 | 1985-06-11 | Progress Equities Incorporated | Advanced separation device and method |
| SU1288183A1 (ru) | 1985-03-11 | 1987-02-07 | Институт химических наук АН КазССР | Способ получени изоникотиновой кислоты |
| US4808317A (en) | 1985-03-19 | 1989-02-28 | Advanced Separation Technologies Incorporated | Process for continuous contacting of fluids and solids |
| SU1553530A1 (ru) | 1988-02-10 | 1990-03-30 | Институт химических наук АН КазССР | Способ получени пиридин-2-карбоксамида |
| JPH057000A (ja) | 1991-06-28 | 1993-01-14 | Nippon Sheet Glass Co Ltd | ａ−Ｓｉを用いた薄膜トランジスタ |
| JP3409353B2 (ja) | 1992-04-30 | 2003-05-26 | 住友化学工業株式会社 | アミド化合物の製造方法および使用される微生物 |
| JP3483156B2 (ja) | 1994-02-08 | 2004-01-06 | 株式会社マルマンプロダクツ | 眼鏡用蝶番 |
| JP2836473B2 (ja) | 1994-02-23 | 1998-12-14 | 株式会社セガ・エンタープライゼス | プライズゲームマシン |
| EP1021408A1 (de) | 1996-02-09 | 2000-07-26 | Reilly Industries, Inc. | Kontinuierliches verfahren zur hydrolyse von cyanopyridinen unter im wesentlichen adiabatischen bedingungen |
-
1999
- 1999-07-20 TW TW088112320A patent/TW539670B/zh not_active IP Right Cessation
- 1999-07-21 KR KR1020017000877A patent/KR20010072009A/ko not_active Withdrawn
- 1999-07-21 AT AT99935809T patent/ATE361280T1/de active
- 1999-07-21 CN CN99808993A patent/CN1310710A/zh active Pending
- 1999-07-21 DE DE69935985T patent/DE69935985T2/de not_active Expired - Lifetime
- 1999-07-21 EP EP99935809A patent/EP1098879B1/de not_active Expired - Lifetime
- 1999-07-21 WO PCT/US1999/016536 patent/WO2000005211A1/en not_active Ceased
- 1999-07-21 JP JP2000561167A patent/JP4901002B2/ja not_active Expired - Lifetime
- 1999-07-21 AU AU51211/99A patent/AU5121199A/en not_active Abandoned
- 1999-07-21 US US09/358,201 patent/US6218543B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1098879A4 (de) | 2003-01-02 |
| WO2000005211A1 (en) | 2000-02-03 |
| US6218543B1 (en) | 2001-04-17 |
| CN1310710A (zh) | 2001-08-29 |
| JP2002521365A (ja) | 2002-07-16 |
| EP1098879B1 (de) | 2007-05-02 |
| KR20010072009A (ko) | 2001-07-31 |
| DE69935985T2 (de) | 2008-01-10 |
| EP1098879A1 (de) | 2001-05-16 |
| DE69935985D1 (de) | 2007-06-14 |
| JP4901002B2 (ja) | 2012-03-21 |
| AU5121199A (en) | 2000-02-14 |
| TW539670B (en) | 2003-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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