ATE361286T1 - Borrelidin-derivate und ihre medizinische anwendung - Google Patents

Borrelidin-derivate und ihre medizinische anwendung

Info

Publication number
ATE361286T1
ATE361286T1 AT03786170T AT03786170T ATE361286T1 AT E361286 T1 ATE361286 T1 AT E361286T1 AT 03786170 T AT03786170 T AT 03786170T AT 03786170 T AT03786170 T AT 03786170T AT E361286 T1 ATE361286 T1 AT E361286T1
Authority
AT
Austria
Prior art keywords
borrelidin
medical applications
polyketide
derivatives
polyketides
Prior art date
Application number
AT03786170T
Other languages
English (en)
Inventor
Jose A Salas
Carmen Mendez
Carlos Olano
Cesar Sanchez
Alfredo F Brana
Barrie Wilkinson
Christine J Martin
Steven Moss
Peter F Leadlay
Marko Oliynyk
Original Assignee
Biotica Tech Ltd
Univ Oviedo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Tech Ltd, Univ Oviedo filed Critical Biotica Tech Ltd
Application granted granted Critical
Publication of ATE361286T1 publication Critical patent/ATE361286T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03786170T 2002-12-27 2003-12-24 Borrelidin-derivate und ihre medizinische anwendung ATE361286T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0230217.2A GB0230217D0 (en) 2002-12-27 2002-12-27 Borrelidin-producing polyketide synthase and its uses

Publications (1)

Publication Number Publication Date
ATE361286T1 true ATE361286T1 (de) 2007-05-15

Family

ID=9950463

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03786170T ATE361286T1 (de) 2002-12-27 2003-12-24 Borrelidin-derivate und ihre medizinische anwendung

Country Status (13)

Country Link
US (2) US7560252B2 (de)
EP (3) EP1576160B8 (de)
JP (1) JP2006514548A (de)
CN (1) CN1732264A (de)
AT (1) ATE361286T1 (de)
AU (1) AU2003295169B2 (de)
BR (1) BR0317118A (de)
CA (1) CA2506669A1 (de)
DE (1) DE60313659T2 (de)
ES (1) ES2287552T3 (de)
GB (1) GB0230217D0 (de)
MX (1) MXPA05005323A (de)
WO (1) WO2004058976A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0609981D0 (en) * 2006-05-19 2006-06-28 Biotica Tech Ltd Novel compounds
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
DE102008014077A1 (de) 2008-03-13 2009-09-17 Discovery Partner International Gmbh Borrelidin-Derivate
CN101583152B (zh) 2008-05-15 2011-08-24 华为技术有限公司 一种信息传递方法、装置和系统
CN102224242B (zh) 2008-09-24 2014-09-24 中国科学院上海有机化学研究所 新基因簇
AU2010279325B2 (en) 2009-08-05 2016-10-20 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
US9394313B2 (en) 2010-09-14 2016-07-19 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
CN102181390B (zh) * 2011-03-21 2012-11-14 北京市农林科学院 一株小链霉菌及其应用
BR112013024367A2 (pt) * 2011-03-25 2016-07-19 Zhejiang Hisun Pharm Co Ltd métodos para prevenir e controlar a deterioração da raiz da soja pela phytophthora e para a preparação de agente de revestimento de semente e usos da borrelidina
EP2607374A1 (de) * 2011-12-21 2013-06-26 Sanofi Verfahren zur rekombinanten Herstellung von Labyrinthopeptinen und funktionalen Derivaten davon
WO2014018620A1 (en) 2012-07-25 2014-01-30 University Of Vermont And State Agricultural College Methods and compounds for reducing threonyl-trna synthetase activity
US10125358B2 (en) 2012-07-25 2018-11-13 University Of Vermont And State Agricultural College Methods and compounds for increasing threonyl-tRNA synthetase activity
WO2014018618A1 (en) 2012-07-25 2014-01-30 University Of Vermont And State Agricultural College Methods and compounds for diagnosing threonyl-trna synthetase-associated diseases and conditions
WO2014085419A1 (en) * 2012-11-29 2014-06-05 The Texas A&M University System Engineering the production of a conformational variant of occidiofungin that has enhanced inhibitory activity against fungal species
PL3302428T3 (pl) 2015-06-04 2026-04-13 Sol-Gel Technologies Ltd. Preparaty do zastosowania miejscowego do dostarczania związków inhibitora hedgehog i ich zastosowanie
WO2017011407A2 (en) 2015-07-10 2017-01-19 The Regents Of The University Of California Producing adipic acid and related compounds using hybrid polyketide synthases
CN106916836B (zh) * 2015-12-24 2022-08-12 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN106434406B (zh) * 2016-04-13 2019-10-22 塔里木大学 一种产生疏螺旋体素的放线菌及其应用
GB201808663D0 (en) * 2018-05-25 2018-07-11 Innes John Centre Method
CN109266594B (zh) * 2018-09-25 2021-10-26 天津科技大学 一种恩拉霉素高产菌株及其构建方法
CA3148992A1 (en) * 2019-08-06 2021-02-11 The Regents Of The University Of California Scaleable preparation of polyketides
WO2021041932A2 (en) * 2019-08-28 2021-03-04 The Regents Of The University Of California Genetically engineered microbes and biosynthetic methods
WO2021226415A1 (en) * 2020-05-07 2021-11-11 The Regents Of The University Of California Delta lactones through engineered polyketide synthases
CN111979148B (zh) * 2020-08-13 2021-06-25 江南大学 糖多孢菌组合物及其在食品中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4759928A (en) * 1986-01-31 1988-07-26 Washington State University Research Foundation Antibiotic: Treponemycin
DE3607287A1 (de) 1986-03-06 1988-01-07 Bayer Ag Verfahren zur herstellung von borrelidin und seine verwendung zur schaedlingsbekaempfung
JPH08173176A (ja) 1994-12-22 1996-07-09 Mercian Corp 血管新生阻害剤
JP3786461B2 (ja) 1996-02-22 2006-06-14 メルシャン株式会社 新生理活性物質
ES2244001T3 (es) * 1996-07-05 2005-12-01 Biotica Technology Limited Eritromicinas y procedimiento para su preparacion.
TW515841B (en) * 1998-01-16 2003-01-01 Dev Center Biotechnology Novel strain of Streptomyces candidus, and relevant uses thereof
GB9912563D0 (en) 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
HUP9902628A3 (en) * 1999-08-02 2001-07-30 Ivax Gyogyszerki Kft Angiogenesis inhibiting borrelidin derivatives, their use and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CN1732264A (zh) 2006-02-08
WO2004058976A2 (en) 2004-07-15
DE60313659D1 (de) 2007-06-14
EP1576160A2 (de) 2005-09-21
DE60313659T2 (de) 2008-04-03
EP1840216A2 (de) 2007-10-03
EP1961747A2 (de) 2008-08-27
AU2003295169B2 (en) 2009-12-10
MXPA05005323A (es) 2006-03-10
US20090286291A1 (en) 2009-11-19
EP1576160B8 (de) 2007-06-27
AU2003295169A1 (en) 2004-07-22
JP2006514548A (ja) 2006-05-11
ES2287552T3 (es) 2007-12-16
EP1840216A3 (de) 2007-10-17
US7560252B2 (en) 2009-07-14
AU2003295169A8 (en) 2004-07-22
BR0317118A (pt) 2005-10-25
EP1576160B1 (de) 2007-05-02
GB0230217D0 (en) 2003-02-05
WO2004058976A3 (en) 2005-02-17
US20070065920A1 (en) 2007-03-22
CA2506669A1 (en) 2004-07-15

Similar Documents

Publication Publication Date Title
ATE361286T1 (de) Borrelidin-derivate und ihre medizinische anwendung
DE69934242D1 (de) Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen
ATE370161T1 (de) Herstellung von polyketiden und anderen natürlichen produkten
WO2004099231A3 (en) Glycopegylation methods and proteins/peptides produced by the methods
DK1831362T3 (da) Syreaktive svampeproteaser
WO2005028443A3 (en) Protein tyrosine kinase enzyme inhibitors
WO2002014485A3 (en) Kallikrein gene
WO2004013312A3 (en) Tocopherol biosynthesis related genes and uses thereof
NO20030495D0 (no) Peptider som presenteres av celler
ATE450544T1 (de) Streptavidin-bindungspeptid
WO2002097062A3 (en) Recombinant narbonolide polyketide synthase
DE69928395D1 (de) Cyclin-e2 proteine und dafür kodierende gene
BR0313083A (pt) moléculas de adamts4 modificadas,polinucleotìdeo, vetor, processos para produção, composição farmacêutica, bem como uso das mesmas
WO2004081033A3 (en) Synthesis of proteins by cell-free protein expression
ZA200610470B (en) Novel sequence for improving expression of nucleic acid
EP1383783A4 (de) Gencluster für die biosynthese von leinamycin, dessen komponenten und deren verwendung
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
ATE513906T1 (de) Galactosyltransferase
EP1760152A4 (de) Verfahren zur dipeptidherstellung
WO2008002548A3 (en) Novel human acidic mammalian chitinase and use thereof
DE60206151D1 (de) Gene und proteine für polyketide biosynthese
WO2003031642A3 (en) lovE VARIANT REGULATOR MOLECULES
WO2002074048A8 (en) P-glycoproteins and uses thereof
ATE520775T1 (de) Raygraspollen-spezifische promotoren und expressionskonstrukte
WO2004087883A3 (en) lovE VARIANT REGULATOR MOLECULES

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1576160

Country of ref document: EP