ATE361299T1 - Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungen - Google Patents
Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungenInfo
- Publication number
- ATE361299T1 ATE361299T1 AT03727569T AT03727569T ATE361299T1 AT E361299 T1 ATE361299 T1 AT E361299T1 AT 03727569 T AT03727569 T AT 03727569T AT 03727569 T AT03727569 T AT 03727569T AT E361299 T1 ATE361299 T1 AT E361299T1
- Authority
- AT
- Austria
- Prior art keywords
- oligomers
- contrast agents
- intermediate compounds
- line
- formulae
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/65812—Cyclic phosphazenes [P=N-]n, n>=3
- C07F9/65815—Cyclic phosphazenes [P=N-]n, n>=3 n = 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0202791A FR2836916B1 (fr) | 2002-03-05 | 2002-03-05 | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE361299T1 true ATE361299T1 (de) | 2007-05-15 |
Family
ID=27763565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03727569T ATE361299T1 (de) | 2002-03-05 | 2003-03-05 | Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070098643A1 (de) |
| EP (1) | EP1480979B1 (de) |
| AT (1) | ATE361299T1 (de) |
| AU (1) | AU2003233361A1 (de) |
| DE (1) | DE60313585T2 (de) |
| FR (1) | FR2836916B1 (de) |
| WO (1) | WO2003074523A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004307356A (ja) * | 2003-04-02 | 2004-11-04 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | 新規なデンドリマーおよび造影剤 |
| FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| FR2857967B1 (fr) * | 2003-07-25 | 2015-04-24 | Centre Nat Rech Scient | Complexes de lanthanide, leur preparation et leurs utilisations |
| FR2867473B1 (fr) | 2004-03-12 | 2006-06-23 | Guerbet Sa | Compose de porphyrines et utilisation a haut champ en irm |
| WO2006002873A2 (en) * | 2004-07-02 | 2006-01-12 | Bracco Imaging Spa | 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri ) |
| FR2883562B1 (fr) * | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
| US20060275217A1 (en) * | 2005-05-06 | 2006-12-07 | Caravan Peter D | Chemical exchange saturation transfer contrast agents |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| US8926945B2 (en) | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| RU2425831C2 (ru) * | 2005-12-02 | 2011-08-10 | Джи-И Хелткер АС | Мультимерные контрастные агенты для магнитного резонанса |
| CA2629143A1 (en) * | 2005-12-02 | 2007-06-07 | Ge Healthcare As | Multimeric magentic resonance contrast agents |
| EP2279190A1 (de) * | 2008-04-18 | 2011-02-02 | Ge Healthcare As | Paramagnetische, um einen zentralen kern angeordnete chelate enthaltende verbindungen und ihre verwendung in der magnetresonanzbilddarstellung und spektroskopie |
| NO331773B1 (no) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| EP3101012A1 (de) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| ES2814555T3 (es) | 2016-11-28 | 2021-03-29 | Bayer Pharma AG | Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética |
| FR3069245B1 (fr) | 2017-07-21 | 2019-07-26 | Guerbet | Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales |
| PT4151637T (pt) | 2018-08-06 | 2025-03-26 | Bracco Imaging Spa | Agentes de contraste à base de pcta que suportam gadolínio |
| KR102934987B1 (ko) | 2018-11-23 | 2026-03-09 | 바이엘 악티엔게젤샤프트 | 조영 매체의 제형 및 그의 제조 방법 |
| CN111875667B (zh) * | 2020-07-16 | 2021-12-21 | 南方科技大学 | 有机金属螯合物及其制备方法与应用、探针 |
| WO2022165424A1 (en) * | 2021-02-01 | 2022-08-04 | Inventure, LLC | Synthesis methods and compositions of low intermediate and low dichelate intermediate contrast agents |
| TW202510874A (zh) | 2023-09-01 | 2025-03-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種大環化合物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567411A (en) * | 1986-11-10 | 1996-10-22 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group |
| FR2736051B3 (fr) * | 1995-06-29 | 1997-09-26 | Guerbet Sa | Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique |
| FR2772025B1 (fr) * | 1997-12-10 | 2000-03-03 | Guerbet Sa | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
-
2002
- 2002-03-05 FR FR0202791A patent/FR2836916B1/fr not_active Expired - Fee Related
-
2003
- 2003-03-05 EP EP03727569A patent/EP1480979B1/de not_active Expired - Lifetime
- 2003-03-05 AU AU2003233361A patent/AU2003233361A1/en not_active Abandoned
- 2003-03-05 US US10/505,875 patent/US20070098643A1/en not_active Abandoned
- 2003-03-05 WO PCT/FR2003/000712 patent/WO2003074523A2/fr not_active Ceased
- 2003-03-05 DE DE60313585T patent/DE60313585T2/de not_active Expired - Fee Related
- 2003-03-05 AT AT03727569T patent/ATE361299T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1480979A2 (de) | 2004-12-01 |
| WO2003074523A2 (fr) | 2003-09-12 |
| FR2836916B1 (fr) | 2004-06-11 |
| WO2003074523A3 (fr) | 2004-03-25 |
| EP1480979B1 (de) | 2007-05-02 |
| US20070098643A1 (en) | 2007-05-03 |
| DE60313585T2 (de) | 2007-12-27 |
| AU2003233361A8 (en) | 2003-09-16 |
| DE60313585D1 (de) | 2007-06-14 |
| AU2003233361A1 (en) | 2003-09-16 |
| FR2836916A1 (fr) | 2003-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE361299T1 (de) | Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungen | |
| CY1105385T1 (el) | Παραγωγα αλφα-αμινο-οξεων, μεθοδος για την παρασκευη αυτων και χρηση αυτων σαν αναστολεις διπεπτιδυλ-πεπτιδασης iv (dpp iv) | |
| CY1106969T1 (el) | Αναστολεις dpp-iv | |
| CY1111616T1 (el) | Ετεροαρυλ ενωσεις που περιεχουν αζωτο και χρηση αυτων στην αυξηση ενδογενους ερυθροποιητινης | |
| ATE270817T1 (de) | Fungizide | |
| DE60106022D1 (de) | Thiophenverbindungen zur verwendung als antikrebsmittel | |
| ATE430146T1 (de) | Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten | |
| DE50002836D1 (de) | Substituierte anilinverbindungen | |
| DE60218213D1 (de) | Pyridyloxyalkancarbonsäureamid-derivate verwendbar als fungizide | |
| ATE399168T1 (de) | Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren | |
| ITMI20011708A0 (it) | Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m | |
| BG66117B1 (bg) | Литиеви комплекси на n-(1-хидроксиметил-2,3- дихидроксипропил)-1,4,7-трискарбоксиметил-1,4,7,10-тетраазациклододекан, тяхното получаване и приложение | |
| NO20050738L (no) | Ny fremgangsmate for syntesen av (7-metoksy-3,4-dihydro-1-naftalanyl)acetonitril og dens anvendelse i syntesen av agomelatin | |
| DE60110914D1 (de) | Verbindungen und ihre verwendung als hemmer des glycintransports | |
| ATE439350T1 (de) | Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex | |
| MXPA05010650A (es) | Pirazoles sustituidos. | |
| ATE399169T1 (de) | Imidazopyridinderivate als inhibitoren der induzierbaren no-synthase | |
| MX2008001778A (es) | Combinacion de un agente hipnotico y un compuesto de bis arilo y heteroarilo sustituido y aplicacion terapeutica de la misma. | |
| ATE403655T1 (de) | Imidazopyridinderivate als induzierbare no- synthaseinhibitoren | |
| DK1178985T3 (da) | Substituerede thienocycloalk(en)ylamino-1,3,5-triaziner | |
| DE602004014523D1 (de) | Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase | |
| ATE340175T1 (de) | Imidazo(4,5-böchinolinderivate und ihre verwendung als inhibitoren der induzierbaren no- synthase | |
| ATE468319T1 (de) | M-diaminobenzole und deren säureaddukte sowie deren verwendung in färbemitteln | |
| EA200700098A1 (ru) | Производные 4-арилморфолин-3-она, их получение и их применение в терапии | |
| ATE388710T1 (de) | Phthalazinderivate als phosphodiesterase-4-hemmer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |