ATE430146T1 - Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten - Google Patents
Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituentenInfo
- Publication number
- ATE430146T1 ATE430146T1 AT05755566T AT05755566T ATE430146T1 AT E430146 T1 ATE430146 T1 AT E430146T1 AT 05755566 T AT05755566 T AT 05755566T AT 05755566 T AT05755566 T AT 05755566T AT E430146 T1 ATE430146 T1 AT E430146T1
- Authority
- AT
- Austria
- Prior art keywords
- polyhydroxylated
- mri
- substituents
- magnetic resonance
- contrast agent
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title abstract 2
- 238000002595 magnetic resonance imaging Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000005298 paramagnetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Radiology & Medical Imaging (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58518104P | 2004-07-02 | 2004-07-02 | |
| PCT/EP2005/006958 WO2006002875A1 (en) | 2004-07-02 | 2005-06-28 | Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE430146T1 true ATE430146T1 (de) | 2009-05-15 |
Family
ID=34971296
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05755566T ATE430146T1 (de) | 2004-07-02 | 2005-06-28 | Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten |
| AT05772650T ATE429933T1 (de) | 2004-07-02 | 2005-06-28 | 1,4-bis(carboxymethyl)-6- |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05772650T ATE429933T1 (de) | 2004-07-02 | 2005-06-28 | 1,4-bis(carboxymethyl)-6- |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7988950B2 (de) |
| EP (2) | EP1765812B1 (de) |
| JP (2) | JP5106107B2 (de) |
| CN (2) | CN1993357B (de) |
| AT (2) | ATE430146T1 (de) |
| DE (2) | DE602005014248D1 (de) |
| WO (3) | WO2006002873A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004038134B4 (de) | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| US8926945B2 (en) | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
| FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| JP5064761B2 (ja) | 2005-12-21 | 2012-10-31 | 富士フイルム株式会社 | ジエチレントリアミン型金属キレート構造を有する高級脂肪酸トリエステル及びアミド誘導体 |
| EP1964846A1 (de) * | 2007-02-27 | 2008-09-03 | Bracco Imaging, S.P.A. | Herstellungsverfahren für Kontrastmittel |
| US8320647B2 (en) | 2007-11-20 | 2012-11-27 | Olea Medical | Method and system for processing multiple series of biological images obtained from a patient |
| EP2147684A1 (de) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Selektiv gegen Metallproteasen wirkende Diagnosemittel |
| EP2393472B1 (de) | 2008-12-05 | 2019-06-05 | NanoMed Holdings Pty Ltd | Amphiphile prodrugs |
| KR101142730B1 (ko) * | 2009-03-16 | 2012-05-04 | 가천의과학대학교 산학협력단 | 상자성-이노시톨 포스페이트 복합체를 이용한 자기공명영상용 조영제 |
| KR101253100B1 (ko) * | 2010-02-16 | 2013-04-10 | 경북대학교 산학협력단 | 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용 |
| US8722020B2 (en) | 2010-03-31 | 2014-05-13 | General Electric Company | Hydroxylated contrast enhancement agents |
| US8765977B2 (en) | 2010-03-31 | 2014-07-01 | General Electric Company | Hydroxylated contrast enhancement agents and imaging method |
| US8362281B2 (en) | 2010-03-31 | 2013-01-29 | General Electric Company | Intermediates for hydroxylated contrast enhancement agents |
| EP2639227A1 (de) * | 2012-03-14 | 2013-09-18 | Bracco Imaging S.p.A | Neue Klasse von Diazepinderivatchelatbildnern und Komplexe mit paramagnetischen Metallen als MRI-Kontrastmittel |
| JP6251744B2 (ja) * | 2012-09-07 | 2017-12-20 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | ＭＲＩ用の両親媒性錯体を含む常磁性固体脂質ナノ粒子（ｐＳＬＮ） |
| EP3101012A1 (de) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung |
| JP6491747B2 (ja) | 2015-09-30 | 2019-03-27 | デューク・ユニヴァーシティ | 磁気共鳴画像法用の造影剤 |
| DK3386954T3 (da) * | 2015-12-10 | 2021-02-15 | Bracco Imaging Spa | Dimere kontrastmidler |
| US11353533B2 (en) | 2016-02-24 | 2022-06-07 | Ohio State Innovation Foundation | Methods and devices for contrast agent magnetic resonance imaging |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| ES2814555T3 (es) | 2016-11-28 | 2021-03-29 | Bayer Pharma AG | Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética |
| CA3037803A1 (en) | 2016-12-12 | 2018-06-21 | Bracco Imaging Spa | Dimeric contrast agents |
| KR102550339B1 (ko) | 2016-12-21 | 2023-07-04 | 지이 헬스케어 에이에스 | Mri 영상화제로서 적합한 테트라아자비시클로-매크로사이클 기재의 망가니즈 킬레이트 화합물 |
| FR3069245B1 (fr) * | 2017-07-21 | 2019-07-26 | Guerbet | Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales |
| DE102017129405A1 (de) | 2017-12-11 | 2019-06-13 | Universitätsklinikum Jena | Neue DAZA-Chelatoren als Liganden in der Leberbildgebung |
| EP3728168B1 (de) * | 2017-12-20 | 2022-03-30 | General Electric Company | Anionische chelatverbindungen |
| US11684682B2 (en) | 2018-11-12 | 2023-06-27 | Bracco Imaging S.P.A. | Chelating AAZTA conjugates and complexes thereof |
| EP3883613A1 (de) | 2018-11-23 | 2021-09-29 | Bayer Aktiengesellschaft | Formulierung für kontrastmittel und verfahren zur herstellung davon |
| JPWO2024018761A1 (de) * | 2022-07-19 | 2024-01-25 | ||
| CN119775160B (zh) * | 2025-03-10 | 2025-06-06 | 西安三维科技发展有限责任公司 | 耐温稠化剂及其制备方法、清洁压裂液 |
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| DE3129906C3 (de) | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
| IT1213029B (it) | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
| HU208947B (en) | 1987-07-16 | 1994-02-28 | Nycomed As | Diagnostical compositions and process for producing aminopolycarboxylic acids, their derivatives and metal-kelates |
| GB9320277D0 (en) * | 1993-10-01 | 1993-11-17 | Nycomed Salutar Inc | Chelants |
| DE4009119A1 (de) * | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| IT1245853B (it) * | 1990-11-16 | 1994-10-25 | Bracco Spa | 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono |
| IT1252180B (it) | 1991-12-10 | 1995-06-05 | Bracco Ind Chimica Spa | 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono |
| US5324503A (en) | 1992-02-06 | 1994-06-28 | Mallinckrodt Medical, Inc. | Iodo-phenylated chelates for x-ray contrast |
| FR2694559B1 (fr) | 1992-08-06 | 1994-10-28 | Atta | Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical. |
| US5330743A (en) * | 1992-11-12 | 1994-07-19 | Magnetic Research, Inc. | Aminosaccharide contrast agents for magnetic resonance images |
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| DE69426811T2 (de) * | 1993-12-30 | 2001-09-13 | Guerbet, Villepinte | Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen |
| IT1274038B (it) | 1994-07-29 | 1997-07-14 | Bracco Spa | Chelanti macrociclici loro chelati e relativi usi in campo diagnostico |
| DE19508058A1 (de) | 1995-02-21 | 1996-08-22 | Schering Ag | Verfahren zur Herstellung von DTPA-Tetraestern der terminalen Carbonsäuren und deren Verwendung zur Herstellung pharmazeutischer Mittel |
| DE19646762B4 (de) * | 1996-11-04 | 2004-05-13 | Schering Ag | Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren |
| IT1291624B1 (it) | 1997-04-18 | 1999-01-11 | Bracco Spa | Chelati complessi di metalli paramagnetici a bassa tossicita' |
| DE19719033C1 (de) * | 1997-04-29 | 1999-01-28 | Schering Ag | Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel |
| AU752812B2 (en) * | 1997-11-17 | 2002-10-03 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| US6353025B1 (en) | 1997-12-18 | 2002-03-05 | Kissei Pharmaceutical Co., Ltd. | Phenylaminoalkylcarboxylic acid derivatives and pharmaceutical compositions comprising the same |
| DE19849465A1 (de) * | 1998-10-21 | 2000-04-27 | Schering Ag | Dimere Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel |
| US6342598B1 (en) * | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
| FR2793795B1 (fr) | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
| FR2794744B1 (fr) | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| DE19959084B4 (de) | 1999-12-08 | 2005-05-12 | Schott Ag | Organisches LED-Display und Verfahren zu seiner Herstellung |
| IT1315263B1 (it) | 1999-12-21 | 2003-02-03 | Bracco Spa | Composti chelanti,loro chelati con ioni metallici paramagnetici, loropreparazione ed uso |
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| EP2286843A3 (de) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Arzneimitteln zur Zielgerichtung von Endothelzellen |
| DE10064467C2 (de) * | 2000-12-15 | 2002-10-31 | Schering Ag | Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung |
| ITMI20011518A1 (it) | 2001-07-17 | 2003-01-17 | Bracco Imaging Spa | Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia |
| ITMI20011708A1 (it) | 2001-08-03 | 2003-02-03 | Bracco Imaging Spa | Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m |
| FR2836916B1 (fr) | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
-
2005
- 2005-06-28 AT AT05755566T patent/ATE430146T1/de not_active IP Right Cessation
- 2005-06-28 US US11/630,605 patent/US7988950B2/en not_active Expired - Fee Related
- 2005-06-28 DE DE602005014248T patent/DE602005014248D1/de not_active Expired - Lifetime
- 2005-06-28 CN CN2005800266748A patent/CN1993357B/zh not_active Expired - Fee Related
- 2005-06-28 JP JP2007519678A patent/JP5106107B2/ja not_active Expired - Fee Related
- 2005-06-28 DE DE602005014234T patent/DE602005014234D1/de not_active Expired - Lifetime
- 2005-06-28 JP JP2007519677A patent/JP4956426B2/ja not_active Expired - Fee Related
- 2005-06-28 AT AT05772650T patent/ATE429933T1/de not_active IP Right Cessation
- 2005-06-28 WO PCT/EP2005/006956 patent/WO2006002873A2/en not_active Ceased
- 2005-06-28 EP EP05755566A patent/EP1765812B1/de not_active Expired - Lifetime
- 2005-06-28 US US11/630,600 patent/US8540966B2/en not_active Expired - Fee Related
- 2005-06-28 WO PCT/EP2005/006958 patent/WO2006002875A1/en not_active Ceased
- 2005-06-28 WO PCT/EP2005/006957 patent/WO2006002874A1/en not_active Ceased
- 2005-06-28 EP EP05772650A patent/EP1786475B1/de not_active Expired - Lifetime
- 2005-06-28 CN CN2005800266752A patent/CN101090739B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1765812A1 (de) | 2007-03-28 |
| US20110256067A1 (en) | 2011-10-20 |
| DE602005014234D1 (de) | 2009-06-10 |
| WO2006002873A2 (en) | 2006-01-12 |
| EP1786475B1 (de) | 2009-04-29 |
| JP5106107B2 (ja) | 2012-12-26 |
| WO2006002875A1 (en) | 2006-01-12 |
| EP1765812B1 (de) | 2009-04-29 |
| US8540966B2 (en) | 2013-09-24 |
| EP1786475A2 (de) | 2007-05-23 |
| ATE429933T1 (de) | 2009-05-15 |
| CN1993357A (zh) | 2007-07-04 |
| JP4956426B2 (ja) | 2012-06-20 |
| CN101090739B (zh) | 2012-10-10 |
| DE602005014248D1 (de) | 2009-06-10 |
| CN101090739A (zh) | 2007-12-19 |
| WO2006002874A1 (en) | 2006-01-12 |
| US20070258905A1 (en) | 2007-11-08 |
| WO2006002873A3 (en) | 2007-05-10 |
| JP2008505142A (ja) | 2008-02-21 |
| US7988950B2 (en) | 2011-08-02 |
| JP2008505141A (ja) | 2008-02-21 |
| CN1993357B (zh) | 2011-10-19 |
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