ATE361975T1 - Tiermodell für hepatitis-virus infektion - Google Patents

Tiermodell für hepatitis-virus infektion

Info

Publication number
ATE361975T1
ATE361975T1 AT94917988T AT94917988T ATE361975T1 AT E361975 T1 ATE361975 T1 AT E361975T1 AT 94917988 T AT94917988 T AT 94917988T AT 94917988 T AT94917988 T AT 94917988T AT E361975 T1 ATE361975 T1 AT E361975T1
Authority
AT
Austria
Prior art keywords
mammal
liver tissue
transplanted
preparation
human
Prior art date
Application number
AT94917988T
Other languages
English (en)
Inventor
Yair Reisner
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/061,706 external-priority patent/US5652373A/en
Priority claimed from IL10695193A external-priority patent/IL106951A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE361975T1 publication Critical patent/ATE361975T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • C07K16/118—Hepatitis C virus; GB virus C [GBV-C]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physiology (AREA)
  • Environmental Sciences (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Animal Husbandry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT94917988T 1993-05-17 1994-05-13 Tiermodell für hepatitis-virus infektion ATE361975T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/061,706 US5652373A (en) 1990-01-15 1993-05-17 Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
IL10695193A IL106951A0 (en) 1993-05-17 1993-09-08 Engraftment of xenogeneic non-hematopoietic cells and tissue in normal mammals

Publications (1)

Publication Number Publication Date
ATE361975T1 true ATE361975T1 (de) 2007-06-15

Family

ID=26322684

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94917988T ATE361975T1 (de) 1993-05-17 1994-05-13 Tiermodell für hepatitis-virus infektion

Country Status (8)

Country Link
EP (1) EP0699235B1 (de)
JP (1) JP3064421B2 (de)
AT (1) ATE361975T1 (de)
AU (1) AU6949994A (de)
CA (1) CA2161798C (de)
DE (1) DE69434968T2 (de)
ES (1) ES2287929T3 (de)
WO (1) WO1994027556A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980886A (en) * 1994-12-14 1999-11-09 University Of Washington Recombinant vectors for reconstitution of liver
US6107027A (en) * 1994-12-14 2000-08-22 University Of Washington Ribozymes for treating hepatitis C
US6296844B1 (en) 1995-09-27 2001-10-02 The General Hospital Corporation Asialocytokines and treatment of liver disease
AU7377296A (en) * 1995-09-27 1997-04-17 General Hospital Corporation, The Method for treating hepatitis virus infection
US6034297A (en) * 1997-09-26 2000-03-07 Cedars-Sinai Medical Center In vivo, animal model for expression of hepatitis C virus
US6995299B2 (en) 1999-11-02 2006-02-07 University Of Connecticut Propagation of human hepatocytes in non-human animals
US6525242B1 (en) 1999-11-02 2003-02-25 The University Of Connecticut Propagation of human hepatocytes in non-human mammals
US6509514B1 (en) 2000-03-17 2003-01-21 Kmt Hepatech, Inc. Chimeric animal model susceptible to human hepatitis C virus infection
WO2004006664A1 (ja) * 2002-07-16 2004-01-22 Japan Science And Technology Agency 非癌部肝臓組織が移植されたモデル動物およびその作製方法
US7273963B2 (en) 2004-08-20 2007-09-25 Kmt Hepatech, Inc. Malarial animal model having a chimeric human liver
WO2017035375A1 (en) * 2015-08-25 2017-03-02 The Uab Research Foundation Methods for stem cell transplantation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0438053B1 (de) * 1990-01-15 1999-06-16 Yeda Research And Development Company Limited Dauerhafte Verpflanzung und Entwicklung menschlicher hämatopoietischer Zellinien bei normalen Säugetieren
JPH04252128A (ja) * 1990-08-03 1992-09-08 Systemix Inc 免疫化された宿主における変性された異種移植器官系
EP0517199A1 (de) * 1991-06-04 1992-12-09 Yeda Research And Development Company, Ltd. Dauerhafte Transplantation von menschlichen Zellen und Geweben in normalen Säugetieren

Also Published As

Publication number Publication date
AU6949994A (en) 1994-12-20
EP0699235B1 (de) 2007-05-09
DE69434968D1 (de) 2007-06-21
ES2287929T3 (es) 2007-12-16
EP0699235A1 (de) 1996-03-06
DE69434968T2 (de) 2008-01-10
JP3064421B2 (ja) 2000-07-12
CA2161798C (en) 2005-04-05
JPH08511937A (ja) 1996-12-17
WO1994027556A3 (en) 1995-06-08
WO1994027556A2 (en) 1994-12-08
CA2161798A1 (en) 1994-12-08

Similar Documents

Publication Publication Date Title
DK720488A (da) Immunokompromitterede kimaerepattedyr og anvendelse heraf til fremstilling af celler og stoffer
Forbes et al. Intercalated discs of mammalian heart: a review of structure and function
DK1044262T3 (da) Könsspecifik inseminering af pattedyr med et lavt antal sædceller
NO20022180D0 (no) Hematopoietisk differensiering av humane embryoniske stamceller
MXPA02007137A (es) Fuente de tejido hepatico.
BR9506652A (pt) Materiais e métodos para gerenciamento de rejeição hiperaguda em xenotransplante em ser humano
DE69434968D1 (de) Tiermodell für hepatitis-virus infektion
EP0562877A3 (en) Cell fixative and method of staining cells without destroying the cell surface
ATE161041T1 (de) Verfahren zur hcv-züchtung in zell-linien aus b- oder t-lymphozyten
ATE252825T1 (de) Verlängerte lagerung roter blutzellen
DE69624937D1 (de) Verfahren zur verminderung der strahlentherapie oder der radiomimetischen chemotherapie bei der transplantation von hematopoietischen, pluripotenten zellen
WO1999061589A3 (en) Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof
FI913266A0 (fi) Foerfarande foer infoerande av exogen dna i djurets somatiska och groddceller.
ATE191501T1 (de) Verwendung von hepatocyten-wachstumsfaktoren zur herstellung eines vermehrungssystems für hematopoietische stammzellen
PT765398E (pt) Populacao de celulas enriquecedoras em progenitores mieloides e linfoides e metodos de as fazer e utilizar
ATE225183T1 (de) Verwendung von hepatozyten-wachstumsfaktor zur induzierung der proliferation und differenzierung von hämatopoietischen zellen
Krishan et al. Chromosome studies of cell lines and tumors derived from a single specimen of human leukemic blood by cell culture and heterotransplantation
Tocci et al. Comparison of fresh, cryopreserved and cultured haematopoietic stem cells from fetal liver
ATE8108T1 (de) Verfahren zur kultivierung in vitro des hepatitis b-virus.
YU46029B (sh) Postopek za pripravo živega cepiva proti mumpsu
DK1238057T3 (da) Fremgangsmåde til produktion af vedhæftende dyreceller
DE69916302D1 (de) Verwendung von dendritischen zellen-depletierten zusammensetzungen zur verbesserung der transplantation von allogenen hämatopoietischen zellen
SU1533329A1 (ru) Штамм гибридных культивируемых клеток животных mus musculus, используемый для получения моноклональных антител к белку е оболочки вирусов комплекса клещевого энцефалита
DE69030214D1 (de) Methode zur Transplantation von befruchteten Eiern
GB1457277A (en) Transplant enhancing antisera

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties