DK0438053T3 - Varig transplantation og udvikling af humane hæmopoietiske cellelinjer i normale pattedyr - Google Patents

Varig transplantation og udvikling af humane hæmopoietiske cellelinjer i normale pattedyr

Info

Publication number
DK0438053T3
DK0438053T3 DK91100047T DK91100047T DK0438053T3 DK 0438053 T3 DK0438053 T3 DK 0438053T3 DK 91100047 T DK91100047 T DK 91100047T DK 91100047 T DK91100047 T DK 91100047T DK 0438053 T3 DK0438053 T3 DK 0438053T3
Authority
DK
Denmark
Prior art keywords
transplantation
sustained
development
cell lines
hemopoietic cell
Prior art date
Application number
DK91100047T
Other languages
English (en)
Inventor
Yair Reisner
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL9306790A external-priority patent/IL93067A/en
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of DK0438053T3 publication Critical patent/DK0438053T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biochemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK91100047T 1990-01-15 1991-01-02 Varig transplantation og udvikling af humane hæmopoietiske cellelinjer i normale pattedyr DK0438053T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL9306790A IL93067A (en) 1990-01-15 1990-01-15 Chimeric non-human mammal
US61830390A 1990-11-26 1990-11-26

Publications (1)

Publication Number Publication Date
DK0438053T3 true DK0438053T3 (da) 1999-11-22

Family

ID=26322038

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91100047T DK0438053T3 (da) 1990-01-15 1991-01-02 Varig transplantation og udvikling af humane hæmopoietiske cellelinjer i normale pattedyr

Country Status (4)

Country Link
EP (1) EP0438053B1 (da)
DE (1) DE69131331T2 (da)
DK (1) DK0438053T3 (da)
IL (1) IL97128A (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0481058T3 (da) * 1990-05-03 1996-12-02 Systemix Inc Humant, lymfatisk væv i en immunokompromitteret vært
US5804160A (en) * 1991-06-04 1998-09-08 Yeda Research And Development Co. Ltd Animal model for hepatitis virus infection
US5858328A (en) * 1991-06-04 1999-01-12 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5849987A (en) * 1992-06-02 1998-12-15 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
EP0517199A1 (en) * 1991-06-04 1992-12-09 Yeda Research And Development Company, Ltd. Durable engraftment of human tissue and cells in normal mammals
DE69229254T2 (de) * 1991-10-30 1999-09-23 Idemitsu Kosan Co. Ltd., Tokio/Tokyo Verfahren zur Herstellung von menschlichen Lymphozyten und menschlichen Antikörpern; und so hergestellte Antikörper
US6353150B1 (en) * 1991-11-22 2002-03-05 Hsc Research And Development Limited Partnership Chimeric mammals with human hematopoietic cells
US5866757A (en) * 1992-06-02 1999-02-02 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
WO1994005779A1 (en) * 1992-09-09 1994-03-17 O'brien, Caroline, Jane Testing individual immune response to an antibody with scid mouse
US6018096A (en) * 1993-05-03 2000-01-25 Surrogen, Inc. Animal model for engraftment, proliferation and differentiation of human hematopoietic stem cells
ES2287929T3 (es) * 1993-05-17 2007-12-16 Yeda Research And Development Co., Ltd. Modelo animal para la infeccion por el virus de la hepatitis.
US5663481A (en) * 1993-08-06 1997-09-02 Mount Sinai Hospital Corporation Animal model of the human immune system
US5849990A (en) * 1994-12-19 1998-12-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Animal model for a non-hodgkin's lymphoma
IL112109A0 (en) * 1994-12-22 1995-03-15 Yeda Res & Dev Engraftment of hematopoietic cells from a primate donor to a primate recipient
EP0873399A4 (en) * 1995-09-05 2000-07-19 Gen Hospital Corp MONOCLONAL LYMPHOCYTES AND METHODS OF USE
IL118625A0 (en) * 1996-06-11 1996-10-16 Xtl Biopharmaceuticals Limited Anti HBV antibodies
US6509514B1 (en) 2000-03-17 2003-01-21 Kmt Hepatech, Inc. Chimeric animal model susceptible to human hepatitis C virus infection
US7273963B2 (en) 2004-08-20 2007-09-25 Kmt Hepatech, Inc. Malarial animal model having a chimeric human liver
US8541646B2 (en) 2009-10-06 2013-09-24 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
PT4233537T (pt) 2011-02-15 2025-09-08 Regeneron Pharma Ratinhos humanizados para m-csf e utilizações dos mesmos
IN2015DN02032A (da) 2012-09-07 2015-08-14 Univ Yale
ES2884598T3 (es) 2012-11-05 2021-12-10 Regeneron Pharma Animales no humanos modificados genéticamente y métodos de uso de los mismos
PT3482629T (pt) 2014-05-19 2021-02-18 Univ Yale Animais não humanos geneticamente modificados que expressam epo humana
PT3282835T (pt) 2015-04-13 2023-07-25 Univ Yale Ratinhos knockin de sirpa-il15 humanizadas e métodos de utilização dos mesmos

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3853201T2 (de) * 1987-12-23 1995-09-14 Univ Leland Stanford Junior Schimäre immunkompromittierende Säugetiere und ihre Verwendung.

Also Published As

Publication number Publication date
EP0438053A1 (en) 1991-07-24
IL97128A (en) 2000-12-06
DE69131331D1 (de) 1999-07-22
IL97128A0 (en) 1992-05-25
EP0438053B1 (en) 1999-06-16
DE69131331T2 (de) 2000-03-02

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