ATE362362T1 - Zusammensetzung von einem ppar-alpha agonisten und metformin zur behandlung von obesitas - Google Patents

Zusammensetzung von einem ppar-alpha agonisten und metformin zur behandlung von obesitas

Info

Publication number
ATE362362T1
ATE362362T1 AT03780062T AT03780062T ATE362362T1 AT E362362 T1 ATE362362 T1 AT E362362T1 AT 03780062 T AT03780062 T AT 03780062T AT 03780062 T AT03780062 T AT 03780062T AT E362362 T1 ATE362362 T1 AT E362362T1
Authority
AT
Austria
Prior art keywords
metformin
ppar
obesitas
treatment
composition
Prior art date
Application number
AT03780062T
Other languages
English (en)
Inventor
Jean-Louis Junien
Alan Edgar
Original Assignee
Fournier Lab Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Lab Ireland Ltd filed Critical Fournier Lab Ireland Ltd
Application granted granted Critical
Publication of ATE362362T1 publication Critical patent/ATE362362T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03780062T 2002-11-28 2003-11-26 Zusammensetzung von einem ppar-alpha agonisten und metformin zur behandlung von obesitas ATE362362T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02292940A EP1424070A1 (de) 2002-11-28 2002-11-28 Zusammensetzung von einem PPAR-alpha Agonisten und Metformin zur Senkung des Serumtriglyceridspiegels

Publications (1)

Publication Number Publication Date
ATE362362T1 true ATE362362T1 (de) 2007-06-15

Family

ID=32241358

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03780062T ATE362362T1 (de) 2002-11-28 2003-11-26 Zusammensetzung von einem ppar-alpha agonisten und metformin zur behandlung von obesitas

Country Status (21)

Country Link
US (2) US20060142397A1 (de)
EP (2) EP1424070A1 (de)
JP (1) JP2006508995A (de)
CN (1) CN1777417B (de)
AT (1) ATE362362T1 (de)
AU (1) AU2003288175B2 (de)
BR (1) BR0316810A (de)
CA (1) CA2507894C (de)
CY (1) CY1106749T1 (de)
DE (1) DE60313886T2 (de)
DK (1) DK1569634T3 (de)
EA (1) EA009772B1 (de)
ES (1) ES2287546T3 (de)
MA (1) MA27553A1 (de)
MX (1) MXPA05005707A (de)
NO (1) NO20052549L (de)
PT (1) PT1569634E (de)
SI (1) SI1569634T1 (de)
TN (1) TNSN05148A1 (de)
WO (1) WO2004047831A2 (de)
ZA (1) ZA200504345B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
EP1457206A1 (de) * 2003-03-13 2004-09-15 Fournier Laboratories Ireland Limited Kombinierte Verwendung von einem Fibrat und von Orlistat zur Behandlung von Obesitas
EP1559419A1 (de) * 2004-01-23 2005-08-03 Fournier Laboratories Ireland Limited Pharmazeutische Darreichungsformen enthaltend Metformin und ein Fibrat, sowie deren Herstellungsprozesse
FR2896160B1 (fr) * 2006-01-13 2008-04-25 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agonistes du ppar alpha.
US8883721B2 (en) * 2009-05-12 2014-11-11 Mcgill University Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US9724381B2 (en) 2009-05-12 2017-08-08 The Administrators Of The Tulane Educational Fund Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
WO2011159917A2 (en) 2010-06-16 2011-12-22 The Administrators Of The Tulane Educational Fund Growth hormone secretatogue receptor antagonists and uses thereof
FR3050112B1 (fr) * 2016-04-15 2020-09-04 Soc Civ Immobiliere Gecinq Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques
CN107496397A (zh) * 2016-06-14 2017-12-22 重庆安格龙翔医药科技有限公司 一种二甲双胍与非诺贝酸的复合物及其制剂
FR3056908B1 (fr) * 2016-09-30 2019-04-19 Nashpharm Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie
CN111374093A (zh) * 2018-12-28 2020-07-07 高倩 超级肥胖小鼠的构建与鉴定方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT323195B (de) * 1973-03-16 1975-06-25 Hurka Wilhelm Verfahren zur herstellung neuer salze von biguaniden
FR2275199A1 (fr) * 1974-06-19 1976-01-16 Cerpha (chloro-4 phenoxy) isobutyrate de dimethylbiguanide, son procede de preparation et medicaments contenant ce produit comme principe actif
US5190970A (en) * 1990-10-19 1993-03-02 E. R. Squibb & Sons, Inc. Method for preventing onset of or treating Type II diabetes employing a cholesterol lowering drug alone or in combination with an ace inhibitor
US5739106A (en) * 1995-06-07 1998-04-14 Rink; Timothy J. Appetite regulating compositions
EP1011651B1 (de) * 1996-02-02 2005-04-27 Merck & Co., Inc. Verfahren zur behandlung von diabetes und verwandter krankheitszustände.
AU4050797A (en) * 1996-08-02 1998-02-25 Ligand Pharmaceuticals Incorporated Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators
FR2774591B1 (fr) * 1998-02-12 2000-05-05 Lipha Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie
US5942500A (en) * 1998-04-27 1999-08-24 Perry; Stephen C. Dietary composition to reduce dietary fats
FR2796940B1 (fr) * 1999-07-26 2005-04-08 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
US6498193B2 (en) * 1999-12-22 2002-12-24 Trustees Of Dartmouth College Treatment for complications of type 2 diabetes
US6569879B2 (en) * 2000-02-18 2003-05-27 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
US20030092736A1 (en) * 2001-05-30 2003-05-15 Cheng Peter T. Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
US20050101542A1 (en) * 2002-08-20 2005-05-12 Regents Of The University Of California Combination therapy for controlling appetites

Also Published As

Publication number Publication date
WO2004047831A3 (en) 2005-02-24
EA200500691A1 (ru) 2005-12-29
BR0316810A (pt) 2005-10-18
EP1569634A2 (de) 2005-09-07
CN1777417B (zh) 2010-10-06
WO2004047831A2 (en) 2004-06-10
TNSN05148A1 (fr) 2007-05-14
ZA200504345B (en) 2006-08-30
CY1106749T1 (el) 2012-05-23
US20060142397A1 (en) 2006-06-29
EP1569634B1 (de) 2007-05-16
AU2003288175B2 (en) 2008-11-13
AU2003288175A1 (en) 2004-06-18
PT1569634E (pt) 2007-08-22
SI1569634T1 (sl) 2007-10-31
NO20052549L (no) 2005-06-10
EP1569634B8 (de) 2007-08-29
DK1569634T3 (da) 2007-09-10
DE60313886T2 (de) 2008-01-17
CA2507894C (en) 2011-01-04
EP1424070A1 (de) 2004-06-02
MA27553A1 (fr) 2005-10-03
CN1777417A (zh) 2006-05-24
EA009772B1 (ru) 2008-04-28
HK1077755A1 (en) 2006-02-24
JP2006508995A (ja) 2006-03-16
DE60313886D1 (de) 2007-06-28
ES2287546T3 (es) 2007-12-16
US20100144874A1 (en) 2010-06-10
MXPA05005707A (es) 2005-07-26
CA2507894A1 (en) 2004-06-10

Similar Documents

Publication Publication Date Title
ATE345136T1 (de) Cysteinprotease-hemmer mit 2-cyano-4-amino- pyrimidinstruktur und cathepsin-k-hemmender wirkung zur behandlung von entzündungen und anderen erkrankungen
DE60238576D1 (de) Zusammensetzung zur Herstellung von Elektroden und Elektroden
DE602004017037D1 (de) 2,3-dihydro-6-nitroimidazoä2,1-büoxazolverbindungen zur behandlung von tuberkulose
DE60320007D1 (de) Phenethanolamin-derivate zur behandlung von atemwegserkrankungen
DE50306850D1 (de) Benzodiazepin-substituierte piperdine zur verwendung in der behandlung von cardiovaskulären erkrankungen
DE602004020072D1 (de) 1,2,3,4-tetrasubstituiertes indol zur behandlung von atemwegserkrankungen
DE60319865D1 (de) Substituierte amin-derivate und deren verwendung zur behandlung von angionese-bedingten erkrankungen
ATE405840T1 (de) Zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur hemmung von transthyretin-fehlfaltung
ATE417606T1 (de) Phenethanolamin-derivate zur behandlung von erkrankungen der atemwege
DE60328517D1 (de) Neue verwendung von lycopin zur behandlung von erkrankungen im zusammenhang mit androgenwirkung
ATE346082T1 (de) Glucocorticoidrezeptorliganden zur behandlung von stoffwechselstörungen
DE60216495D1 (de) Vaginale zusammensetzung enthaltend lidocaine zur behandlung von gebärmutterrhythmusstörung
DE602004025463D1 (de) Verwendung von ciclesonide zur erhaltung des feinen teilchengrössenanteils von formoterol
DE60313886D1 (de) Zusammensetzung von einem ppar-alpha agonisten und metformin zur behandlung von obesitas
ATE279386T1 (de) Retinoide zur behandlung von emphysem
DE60304695D1 (de) 7-ARYLSULFONAMID-2,3,4,5-TETRAHYDRO-1H-BENZOiDöAZEPINE MIT 5-HT6 REZEPTOR AFFINITÄT ZUR BEHANDLUNG VON ZENTRALNERVENSYSTEMERKRANKUNGEN
DE60130661D1 (de) Verwendung der 13-cis retinsäure zur behandlung von emphysemen
DE60333205D1 (de) Histaminika zur behandlung von allergischer rhinitis
DE50305507D1 (de) Zusammensetzungen zur herstellung von aminoplasterzeugnissen
DE60206289D1 (de) Verwendung von bibn4096 in kombination mit anderen migränemitteln zur behandlung von migräne
ATE271861T1 (de) Verwendung von nmda-antagonisten und/oder natriumkanalantagonisten zur behandlung von entzündlichen erkrankungen
DE69931487D1 (de) Verwendung von apomorphin zur behandlung der vorzeitigen ejakulation
DE60325496D1 (de) Verwendung von dihydroimidazolonen zur behandlung von epilepsie bei hunden
DE602005016141D1 (de) S-mirtazapin zur behandlung von hitzewallungen
DE60208701D1 (de) Verwendung von cetrorelix zur behandlung vom jakob-creutzfeldt-syndrom

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1569634

Country of ref document: EP