|
US6924128B2
(en)
|
1994-12-06 |
2005-08-02 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant AAV vectors
|
|
WO1998011244A2
(en)
|
1996-09-11 |
1998-03-19 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Aav4 vector and uses thereof
|
|
US6989264B2
(en)
|
1997-09-05 |
2006-01-24 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
US6346415B1
(en)
|
1997-10-21 |
2002-02-12 |
Targeted Genetics Corporation |
Transcriptionally-activated AAV inverted terminal repeats (ITRS) for use with recombinant AAV vectors
|
|
WO1999061601A2
(en)
|
1998-05-28 |
1999-12-02 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Aav5 vector and uses thereof
|
|
US6759237B1
(en)
|
1998-11-05 |
2004-07-06 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
|
|
AU780231B2
(en)
|
1998-11-10 |
2005-03-10 |
University Of North Carolina At Chapel Hill, The |
Virus vectors and methods of making and administering the same
|
|
US6893865B1
(en)
|
1999-04-28 |
2005-05-17 |
Targeted Genetics Corporation |
Methods, compositions, and cells for encapsidating recombinant vectors in AAV particles
|
|
AU7739000A
(en)
|
1999-10-01 |
2001-05-10 |
University Of Florida |
Temperature-sensitive regulation of viral vector production
|
|
DE10120265A1
(de)
*
|
2001-04-25 |
2002-11-14 |
Deutsches Krebsforsch |
AAV-Helferplasmide zur Helfervirus-freien Verpackung und Pseudotypisierung von AAV-Vektoren
|
|
MX359371B
(es)
|
2001-11-13 |
2018-09-25 |
Univ Pennsylvania |
Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo.
|
|
AU2008202344B2
(en)
*
|
2001-11-13 |
2011-08-25 |
The Trustees Of The University Of Pennsylvania |
A method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby
|
|
CN112029800A
(zh)
*
|
2001-11-13 |
2020-12-04 |
宾夕法尼亚大学托管会 |
检测和/或鉴定腺伴随病毒(aav)序列以及分离所鉴定的新型序列的方法
|
|
PT1453547T
(pt)
|
2001-12-17 |
2016-12-28 |
Univ Pennsylvania |
Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas
|
|
DK2573170T3
(en)
*
|
2001-12-17 |
2018-04-09 |
Univ Pennsylvania |
Sequences of adeno-associated virus (AAV) serotype 9, vectors containing them, and their use
|
|
AU2003218162B2
(en)
|
2002-03-15 |
2009-10-29 |
The Curators Of The University Of Missouri |
Mutants of the P4 protein of nontypable haemophilus influenzae with reduced enzymatic activity
|
|
US7419817B2
(en)
|
2002-05-17 |
2008-09-02 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. |
Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
|
|
US8927269B2
(en)
|
2003-05-19 |
2015-01-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Avian adenoassociated virus and uses thereof
|
|
EP2345731B1
(de)
|
2003-09-30 |
2015-10-21 |
The Trustees of the University of Pennsylvania |
Adenoassoziierte Virus-Claden, Sequenzen, diese enthaltende Vektoren und ihre Verwendungen
|
|
US8137960B2
(en)
|
2003-12-04 |
2012-03-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Bovine adeno-associated viral (BAAV) vector and uses thereof
|
|
ES2361000T3
(es)
|
2004-04-28 |
2011-06-13 |
The Trustees Of The University Of Pennsylvania |
Suministro secuencial de moléculas inmunogénicas mediante administraciones de un adenovirus y de un virus adeno-asociado.
|
|
CA2563500C
(en)
|
2004-04-28 |
2016-06-28 |
The Trustees Of The University Of Pennsylvania |
Immunization regimen with e4-deleted adenovirus prime and e1-deleted adenovirus boost
|
|
JP5136766B2
(ja)
|
2004-12-15 |
2013-02-06 |
ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
キメラベクター
|
|
ES2525067T3
(es)
|
2005-04-07 |
2014-12-17 |
The Trustees Of The University Of Pennsylvania |
Método de incremento de la función de un vector de AAV
|
|
WO2006119432A2
(en)
|
2005-04-29 |
2006-11-09 |
The Government Of The U.S.A., As Rep. By The Sec., Dept. Of Health & Human Services |
Isolation, cloning and characterization of new adeno-associated virus (aav) serotypes
|
|
WO2008016391A2
(en)
*
|
2006-01-31 |
2008-02-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Self-complementary parvoviral vectors, and methods for making and using the same
|
|
EP2018421B1
(de)
|
2006-04-28 |
2012-12-19 |
The Trustees of the University of Pennsylvania |
Skalierbares herstellungsverfahren für aav
|
|
WO2009105135A1
(en)
|
2008-02-19 |
2009-08-27 |
Celladon Corporation |
Compositions for enhanced uptake of viral vectors in the myocardium
|
|
WO2010093784A2
(en)
|
2009-02-11 |
2010-08-19 |
The University Of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
US20120093775A1
(en)
|
2009-03-27 |
2012-04-19 |
Proyecto De Biomedicina Cima, S.L. |
Methods and compositions for the treatment of cirrhosis and liver fibrosis
|
|
BR112012010755A2
(pt)
|
2009-11-05 |
2015-09-22 |
Proyecto Biomedicina Cima Sl |
constructo de gene que permite a expressão hepato-específica induzível de um polinucleotídeo de interesse em resposta a um agente indutor, vetor, genoma viral recombinante, vírion, método in vitro para a expressão de um polinucleotídeo de interesse em uma célula de origem hepática, composição farmacêutica e operador-promotor bi-direcional induzível adequado para a expressão hepato-específica induzível de dois polinucleotídeos de interesse por um agente indutor
|
|
EP2524037B1
(de)
|
2010-01-12 |
2018-05-16 |
The University Of North Carolina At Chapel Hill |
Restriktive umgekehrte endverstärkungen für virusvektoren
|
|
EP2605798A1
(de)
|
2010-07-12 |
2013-06-26 |
Universidad Autònoma de Barcelona |
Gentherapiezusammensetzung für die behandlung von diabetes
|
|
WO2012057363A1
(ja)
|
2010-10-27 |
2012-05-03 |
学校法人自治医科大学 |
神経系細胞への遺伝子導入のためのアデノ随伴ウイルスビリオン
|
|
WO2012109570A1
(en)
|
2011-02-10 |
2012-08-16 |
The University Of North Carolina At Chapel Hill |
Viral vectors with modified transduction profiles and methods of making and using the same
|
|
CN105755044A
(zh)
|
2011-04-22 |
2016-07-13 |
加利福尼亚大学董事会 |
具有变异衣壳的腺相关病毒病毒体及其使用方法
|
|
EP2692868A1
(de)
|
2012-08-02 |
2014-02-05 |
Universitat Autònoma De Barcelona |
Adenoassoziierte virale (AAV) Vektoren für die Transduktion von Fettgewebe
|
|
EP2900686B1
(de)
|
2012-09-28 |
2020-06-10 |
The University of North Carolina At Chapel Hill |
Gegen oligodendrozyten gerichtete aav-vektoren
|
|
ES2926774T3
(es)
|
2013-03-15 |
2022-10-28 |
Univ North Carolina Chapel Hill |
Métodos y composiciones para vectores AAV de doble unión de glicano
|
|
WO2014143932A1
(en)
|
2013-03-15 |
2014-09-18 |
The University Of North Carolina At Chapel Hill |
Synthetic adeno-associated virus inverted terminal repeats
|
|
US20160122727A1
(en)
|
2013-06-13 |
2016-05-05 |
Shire Human Genetic Therapies, Inc. |
Messenger rna based viral production
|
|
HK1222673A1
(zh)
*
|
2013-07-12 |
2017-07-07 |
The Children's Hospital Of Philadelphia |
Aav载体和用於抗aav(腺相关病毒)中和抗体的检测
|
|
WO2015044292A1
(en)
|
2013-09-26 |
2015-04-02 |
Universitat Autonoma De Barcelona |
Gene therapy compositions for use in the prevention and/or treatment of non-alcoholic fatty liver disease
|
|
GB201403684D0
(en)
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
SMT202000531T1
(it)
|
2014-03-09 |
2020-11-10 |
Univ Pennsylvania |
Composizioni utili in trattamento di deficit di ornitina transcarbamilasi(otc)
|
|
US9458464B2
(en)
|
2014-06-23 |
2016-10-04 |
The Johns Hopkins University |
Treatment of neuropathic pain
|
|
EP3194430A1
(de)
|
2014-09-16 |
2017-07-26 |
Universitat Autònoma De Barcelona |
Adeno-assoziierte virusvektoren zur gentheraüie von stoffwechselkrankheiten
|
|
EP4344741A3
(de)
|
2014-11-21 |
2024-08-28 |
The University of North Carolina at Chapel Hill |
Auf das zentrale nervensystem gerichtete aav-vektoren
|
|
US11033638B2
(en)
|
2015-01-07 |
2021-06-15 |
Universität Autonoma De Barcelona |
Single-vector gene construct comprising insulin and glucokinase genes
|
|
US10907176B2
(en)
|
2015-01-14 |
2021-02-02 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for targeted gene transfer
|
|
MX388739B
(es)
|
2015-02-06 |
2025-03-20 |
Univ North Carolina Chapel Hill |
Casetes optimizados de expresión del gen humano del factor viii de coagulación y su uso.
|
|
ES2865487T3
(es)
|
2015-09-28 |
2021-10-15 |
Univ North Carolina Chapel Hill |
Métodos y composiciones para vectores virales que evaden los anticuerpos
|
|
SG11201802408RA
(en)
|
2015-11-05 |
2018-05-30 |
Bamboo Therapeutics Inc |
Modified friedreich ataxia genes and vectors for gene therapy
|
|
WO2017100674A1
(en)
|
2015-12-11 |
2017-06-15 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aav1
|
|
ES2934848T3
(es)
|
2015-12-11 |
2023-02-27 |
Univ Pennsylvania |
Método de purificación escalable para AAV8
|
|
EP3387138B1
(de)
|
2015-12-11 |
2022-01-26 |
The Trustees Of The University Of Pennsylvania |
Skalierbares reinigungsverfahren für aav9
|
|
US11028372B2
(en)
|
2015-12-11 |
2021-06-08 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for AAVRH10
|
|
JP7406783B2
(ja)
|
2015-12-14 |
2023-12-28 |
ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
パルボウイルスベクターの高められた送達のための改変キャプシドタンパク質
|
|
EP3411484B1
(de)
|
2016-02-05 |
2023-10-04 |
Emory University |
Injektion von einzelsträngigem oder selbstkomplementärem adeno-assoziiertem virus 9 in den liquor
|
|
CA3011943A1
(en)
|
2016-02-22 |
2017-08-31 |
The University Of North Carolina At Chapel Hill |
Aav-idua vector for treatment of mps i-associated blindness
|
|
EP3449250B1
(de)
|
2016-04-28 |
2020-11-04 |
Indiana University Research & Technology Corporation |
Verfahren und zusammensetzungen zur auflösung von komponenten einer viruspräparation
|
|
US11299751B2
(en)
|
2016-04-29 |
2022-04-12 |
Voyager Therapeutics, Inc. |
Compositions for the treatment of disease
|
|
AU2017257169B2
(en)
|
2016-04-29 |
2021-07-08 |
Adverum Biotechnologies, Inc. |
Evasion of neutralizing antibodies by a recombinant adeno-associated virus
|
|
EP3448874A4
(de)
|
2016-04-29 |
2020-04-22 |
Voyager Therapeutics, Inc. |
Zusammensetzungen zur behandlung einer erkrankung
|
|
US20190224339A1
(en)
*
|
2016-04-29 |
2019-07-25 |
Voyager Therapeutics, Inc. |
Compositions for the treatment of disease
|
|
US11866462B2
(en)
*
|
2016-05-04 |
2024-01-09 |
Oregon Health & Science University |
Recombinant adeno-associated viral vectors
|
|
US11364308B2
(en)
|
2016-05-13 |
2022-06-21 |
4D Molecular Therapeutics Inc. |
Adeno-associated virus variant capsids and methods of use thereof
|
|
CN109415730A
(zh)
|
2016-06-13 |
2019-03-01 |
北卡罗来纳大学教堂山分校 |
优化的cln1基因和表达盒以及它们的应用
|
|
CA2971303C
(en)
|
2016-06-21 |
2026-03-03 |
Bamboo Therapeutics, Inc. |
Optimized mini-dystrophin genes and expression cassettes and their use
|
|
BR112019001344A2
(pt)
|
2016-07-26 |
2019-04-30 |
The University Of North Carolina At Chapel Hill |
tolerância imunológica mediada por vetor no olho
|
|
CA3040179A1
(en)
|
2016-10-19 |
2018-04-26 |
Adverum Biotechnologies, Inc. |
Modified aav capsids and uses thereof
|
|
EP3535396A1
(de)
|
2016-11-01 |
2019-09-11 |
Novartis AG |
Verfahren und zusammensetzungen zur verbesserung der genbearbeitung
|
|
WO2018134168A1
(en)
|
2017-01-17 |
2018-07-26 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of expressing a polynucleotide of interest in the cone photoreceptors
|
|
JP2020510424A
(ja)
*
|
2017-02-28 |
2020-04-09 |
アドヴェラム バイオテクノロジーズ, インコーポレイテッド |
改変aavカプシドおよびその使用
|
|
NZ756587A
(en)
|
2017-03-15 |
2025-12-19 |
Univ North Carolina Chapel Hill |
Polyploid adeno-associated virus vectors and methods of making and using the same
|
|
EP3388520A1
(de)
|
2017-04-11 |
2018-10-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Verfahren und pharmazeutische zusammensetzung zur reduzierung der expression von nkcc1 in einer darauf angewiesenen person
|
|
IL270882B2
(en)
|
2017-05-24 |
2024-02-01 |
Univ Barcelona Autonoma |
Viral expression vectors containing the coding sequence for FIBROBLAST GROWTH FACTOR 21 (FGF21
|
|
CN118252954A
(zh)
|
2017-07-13 |
2024-06-28 |
迈阿密大学 |
用于管理疼痛的方法
|
|
BR112020001060A2
(pt)
|
2017-07-27 |
2020-07-14 |
Novartis Ag |
variantes de trem2 resistentes a shedase
|
|
RU2770922C2
(ru)
|
2017-09-20 |
2022-04-25 |
4Д Молекьюлар Терапьютикс Инк. |
Капсиды вариантов аденоассоциированных вирусов и методы их применения
|
|
WO2019060538A1
(en)
|
2017-09-20 |
2019-03-28 |
The Trustees Of Indiana University |
METHODS FOR LIPOPROTEIN RESOLUTION BY MASS SPECTROMETRY
|
|
CN111867635A
(zh)
|
2017-10-20 |
2020-10-30 |
法国国家卫生及研究医学协会 |
包括视网膜下递送治疗有效量的重组aav9衍生载体的在对象的视锥细胞光感受器中表达目的多核苷酸的方法
|
|
RU2020118342A
(ru)
|
2017-11-07 |
2021-12-08 |
Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл |
Оптимизированные гены aga и экспрессионные кластеры и их применение
|
|
CN111770999A
(zh)
|
2017-11-27 |
2020-10-13 |
4D分子治疗有限公司 |
腺相关病毒变体衣壳和用于抑制血管生成的应用
|
|
EP3738137A1
(de)
|
2018-01-12 |
2020-11-18 |
The Trustees of Indiana University |
Konstruktion einer elektrostatischen linearen ionenfalle für massenspektrometrie mit ladungsdetektion
|
|
CN111954548A
(zh)
|
2018-02-21 |
2020-11-17 |
亚克安娜生命科学有限公司 |
流体递送系统和方法
|
|
EP3759218A4
(de)
|
2018-02-28 |
2021-12-08 |
The University of North Carolina at Chapel Hill |
Verfahren und zusammensetzungen für antikörperausweichende virusvektoren
|
|
EP3774852A1
(de)
|
2018-04-03 |
2021-02-17 |
Stridebio, Inc. |
Antikörpermeidende virale vektoren
|
|
AU2019247748A1
(en)
|
2018-04-03 |
2020-10-08 |
Ginkgo Bioworks, Inc. |
Antibody-evading virus vectors
|
|
MX2020010465A
(es)
|
2018-04-03 |
2021-01-08 |
|
Vectores de virus para direccionamiento a tejidos oftalmicos.
|
|
TWI869346B
(zh)
|
2018-05-30 |
2025-01-11 |
瑞士商諾華公司 |
Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法
|
|
WO2019236143A1
(en)
|
2018-06-04 |
2019-12-12 |
The Trustees Of Indiana University |
Apparatus and method for calibrating or resetting a charge detector
|
|
WO2019236139A1
(en)
|
2018-06-04 |
2019-12-12 |
The Trustees Of Indiana University |
Interface for transporting ions from an atmospheric pressure environment to a low pressure environment
|
|
EP4391015A3
(de)
|
2018-06-04 |
2024-10-09 |
The Trustees of Indiana University |
Ionenfallenanordnung für hochdurchsatz-ladungserkennungsmassenspektrometrie
|
|
JP7398810B2
(ja)
|
2018-06-04 |
2023-12-15 |
ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー |
静電線形イオン・トラップにイオンを捕獲する装置および方法
|
|
CA3100838A1
(en)
|
2018-06-04 |
2019-12-12 |
The Trustees Of Indiana University |
Charge detection mass spectrometry with real time analysis and signal optimization
|
|
AU2019287468B2
(en)
|
2018-06-12 |
2024-10-10 |
The University Of North Carolina At Chapel Hill |
Synthetic liver-tropic adeno-associated virus capsids and uses thereof
|
|
WO2019241486A1
(en)
|
2018-06-13 |
2019-12-19 |
Voyager Therapeutics, Inc. |
Engineered 5' untranslated regions (5' utr) for aav production
|
|
BR112020025268A2
(pt)
|
2018-06-28 |
2021-03-09 |
The University Of North Carolina At Chapel Hill |
Cassetes de expressão e genes cln5 otimizados e seu uso
|
|
CN112770812A
(zh)
|
2018-07-24 |
2021-05-07 |
沃雅戈治疗公司 |
产生基因治疗制剂的系统和方法
|
|
IL280300B2
(en)
|
2018-08-10 |
2025-06-01 |
Univ North Carolina Chapel Hill |
Optimized cln7 genes and expression cassettes and their use
|
|
WO2020046791A1
(en)
|
2018-08-27 |
2020-03-05 |
Alcyone Lifesciences, Inc. |
Fluid delivery systems and methods
|
|
WO2020072849A1
(en)
|
2018-10-04 |
2020-04-09 |
Voyager Therapeutics, Inc. |
Methods for measuring the titer and potency of viral vector particles
|
|
WO2020072844A1
(en)
|
2018-10-05 |
2020-04-09 |
Voyager Therapeutics, Inc. |
Engineered nucleic acid constructs encoding aav production proteins
|
|
UY38407A
(es)
|
2018-10-15 |
2020-05-29 |
Novartis Ag |
Anticuerpos estabilizadores de trem2
|
|
CN113166781A
(zh)
|
2018-10-15 |
2021-07-23 |
沃雅戈治疗公司 |
在杆状病毒/Sf9系统中大规模生产rAAV的表达载体
|
|
JP2022506066A
(ja)
|
2018-11-05 |
2022-01-17 |
ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
最適化されたfig4遺伝子および発現カセットならびにそれらの使用
|
|
CN113574632B
(zh)
|
2018-11-20 |
2024-07-30 |
印地安纳大学理事会 |
用于单粒子质谱分析的轨道阱
|
|
EP4443473A3
(de)
|
2018-12-03 |
2025-01-01 |
The Trustees of Indiana University |
Vorrichtung zur gleichzeitigen analyse mehrerer ionen mit einer elektrostatischen linearen ionenfalle
|
|
WO2020132385A1
(en)
|
2018-12-21 |
2020-06-25 |
The University Of North Carolina At Chapel Hill |
Optimized galc genes and expression cassettes and their use
|
|
BR112021015817A2
(pt)
|
2019-02-22 |
2021-10-13 |
The Trustees Of The University Of Pennsylvania |
Vírus adeno-associado recombinante para tratamento de neurodegeneração com início na idade adulta associado a grn
|
|
SG11202108044YA
(en)
|
2019-02-25 |
2021-09-29 |
Novartis Ag |
Compositions and methods to treat bietti crystalline dystrophy
|
|
US20220154211A1
(en)
|
2019-02-25 |
2022-05-19 |
Novartis Ag |
Compositions and methods to treat bietti crystalline dystrophy
|
|
AR118465A1
(es)
|
2019-03-21 |
2021-10-06 |
Stridebio Inc |
Vectores de virus adenoasociados recombinantes
|
|
EP3947700A4
(de)
|
2019-04-01 |
2023-01-04 |
Tenaya Therapeutics, Inc. |
Adeno-assoziiertes virus mit manipuliertem kapsid
|
|
EP3959741A1
(de)
|
2019-04-23 |
2022-03-02 |
The Trustees of Indiana University |
Identifizierung von probensubspezies basierend auf partikelladungsverhalten unter strukturveränderungen induzierenden probenbedingungen
|
|
CN114127088B
(zh)
|
2019-04-23 |
2024-05-14 |
国家医疗保健研究所 |
变体衣壳蛋白和腺相关病毒aav变体及其药物组合物
|
|
JP2022530457A
(ja)
|
2019-04-26 |
2022-06-29 |
サンガモ セラピューティクス, インコーポレイテッド |
遺伝子操作aav
|
|
EP4169535A1
(de)
|
2019-04-26 |
2023-04-26 |
The University of North Carolina at Chapel Hill |
Verfahren und zusammensetzungen für dualen glycanbindenden aav2,5-vektor
|
|
WO2020223215A1
(en)
|
2019-04-29 |
2020-11-05 |
The University Of North Carolina At Chapel Hill |
Optimized sumf1 genes and expression cassettes and their use
|
|
US12465655B2
(en)
|
2019-05-22 |
2025-11-11 |
The University Of North Carolina At Chapel Hill |
UBE3A genes and expression cassettes and their use
|
|
JP2022533438A
(ja)
|
2019-05-24 |
2022-07-22 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
改変ウイルス粒子およびその使用
|
|
EP3990030A1
(de)
|
2019-06-27 |
2022-05-04 |
Pfizer Inc. |
Verfahren zur behandlung von duchenne-muskeldystrophie mittels aav-mini-dystrophin-gentherapie
|
|
ES2948620T3
(es)
|
2019-07-10 |
2023-09-14 |
Masonic Medical Res Laboratory |
Vgll4 con elemento regulador CIS de UCP-1 y método de uso del mismo
|
|
CN114502590A
(zh)
|
2019-09-18 |
2022-05-13 |
诺华股份有限公司 |
Entpd2抗体、组合疗法、以及使用这些抗体和组合疗法的方法
|
|
TW202124446A
(zh)
|
2019-09-18 |
2021-07-01 |
瑞士商諾華公司 |
與entpd2抗體之組合療法
|
|
WO2021061650A1
(en)
|
2019-09-25 |
2021-04-01 |
The Trustees Of Indiana University |
Apparatus and method for pulsed mode charge detection mass spectrometry
|
|
GB201913974D0
(en)
|
2019-09-27 |
2019-11-13 |
King S College London |
Vector
|
|
CN114728237B
(zh)
|
2019-10-10 |
2026-02-24 |
印地安纳大学理事会 |
用于识别、选择和纯化粒子的系统和方法
|
|
JP2022551739A
(ja)
|
2019-10-17 |
2022-12-13 |
ストライドバイオ,インコーポレイテッド |
ニーマン・ピック病c型の治療のためのアデノ随伴ウイルスベクター
|
|
JP7690209B2
(ja)
|
2019-12-18 |
2025-06-10 |
ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー |
電荷測定装置を有する質量分析計
|
|
EP4100991B1
(de)
|
2020-02-03 |
2025-01-29 |
The Trustees of Indiana University |
Ein massenspektrometer zur ladungsdetektion und entsprechende methode
|
|
JP2023515820A
(ja)
|
2020-02-28 |
2023-04-14 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
メープルシロップ尿症の遺伝子治療
|
|
EP4121168A1
(de)
|
2020-03-20 |
2023-01-25 |
University of Florida Research Foundation, Inc. |
Gentherapie für das schabyne-syndrom
|
|
US12605465B2
(en)
|
2020-03-23 |
2026-04-21 |
The University Of North Carolina At Chapel Hill |
AAV-NAGLU vectors for treatment of mucopolysaccharidosis IIIB
|
|
AU2021265768B2
(en)
|
2020-04-27 |
2023-03-30 |
4D Molecular Therapeutics Inc. |
Adeno-associated variants, formulations and methods for pulmonary delivery
|
|
JP2023524577A
(ja)
|
2020-05-05 |
2023-06-12 |
ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル |
改変アデノ随伴ウイルス5カプシドおよびその使用
|
|
CA3186207A1
(en)
|
2020-07-23 |
2022-01-27 |
Rachel BAILEY |
Optimized slc13a5 genes and expression cassettes and their use
|
|
WO2022032140A2
(en)
|
2020-08-07 |
2022-02-10 |
Amicus Therapeutics, Inc. |
Vesicle targeting proteins and uses of same
|
|
AU2021328475A1
(en)
|
2020-08-19 |
2023-03-16 |
Sarepta Therapeutics, Inc. |
Adeno-associated virus vectors for treatment of Rett syndrome
|
|
BR112023006305A2
(pt)
|
2020-10-09 |
2023-05-09 |
Tenaya Therapeutics Inc |
Métodos e composições de terapia gênica com placofilina-2
|
|
CN116490514A
(zh)
|
2020-10-28 |
2023-07-25 |
北卡罗来纳-查佩尔山大学 |
用于双重聚糖结合aav2.5载体的方法和组合物
|
|
WO2022093769A1
(en)
|
2020-10-28 |
2022-05-05 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for dual glycan binding aav2.5 vector
|
|
AU2021375404A1
(en)
|
2020-11-03 |
2023-06-08 |
Pfizer Inc. |
Methods for purification of aav vectors by anion exchange chromatography
|
|
US20240052322A1
(en)
|
2020-12-15 |
2024-02-15 |
Pfizer Inc. |
HILIC UPLC-MS Method For Separating and Analyzing Intact Adeno-Associated Virus Capsid Proteins
|
|
IL303959A
(en)
|
2020-12-23 |
2023-08-01 |
Pfizer |
Methods for purification of aav vectors by affinity chromatography
|
|
TW202242124A
(zh)
|
2021-01-14 |
2022-11-01 |
美商史崔德生物公司 |
靶向t細胞之aav載體
|
|
WO2022165313A1
(en)
|
2021-02-01 |
2022-08-04 |
Regenxbio Inc. |
Gene therapy for neuronal ceroid lipofuscinoses
|
|
US20240307553A1
(en)
|
2021-04-01 |
2024-09-19 |
Pfizer Inc. |
Pharmaceutical compositions containing adeno-associated viral vector
|
|
WO2022221529A1
(en)
|
2021-04-16 |
2022-10-20 |
Asklepios Biopharmaceutical, Inc. |
Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response
|
|
US20250188126A1
(en)
|
2021-04-26 |
2025-06-12 |
Alexion Pharma International Operations Limited |
Adeno-associated viral vector capsids with improved tissue tropism
|
|
US20240252679A1
(en)
|
2021-05-28 |
2024-08-01 |
Shanghai Regenelead Therapies Co., Ltd. |
Recombinant adeno-associated virus having variant capsid, and application thereof
|
|
WO2022269466A1
(en)
|
2021-06-22 |
2022-12-29 |
Pfizer Inc. |
Production of adeno-associated virus vector in insect cells
|
|
EP4363437A1
(de)
|
2021-07-01 |
2024-05-08 |
Amicus Therapeutics, Inc. |
Neurotensinvarianten und markierte proteine mit neurotensin oder sortilin-propeptid
|
|
KR20240032971A
(ko)
|
2021-07-08 |
2024-03-12 |
테나야 테라퓨틱스, 인코포레이티드 |
유전자 요법을 위한 최적화된 발현 카세트
|
|
CA3228916A1
(en)
|
2021-08-11 |
2023-02-16 |
King's College London |
Compositions and methods for improved treatment of disorders affecting the central nervous system
|
|
CA3234809A1
(en)
|
2021-10-20 |
2023-04-27 |
Steven Goldman |
Isolated glial progenitor cells for use in the competition treatment of age-related white matter loss
|
|
EP4426331A1
(de)
|
2021-11-02 |
2024-09-11 |
University of Rochester |
Tcf7l2-vermittelte remyelinisierung im gehirn
|
|
JP2024540181A
(ja)
|
2021-11-04 |
2024-10-31 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
骨格筋に再標的化されたウイルス粒子
|
|
WO2023114816A1
(en)
|
2021-12-14 |
2023-06-22 |
Neurogene, Inc. |
Recombinant optimized galc constructs and methods for treating galc-associated disorders
|
|
GB202201242D0
(en)
|
2022-01-31 |
2022-03-16 |
Univ Edinburgh |
Recombinant optimized mecp2 cassettes and methods for treating rett syndrome and related disorders
|
|
TW202342759A
(zh)
|
2022-02-04 |
2023-11-01 |
美商史崔德生物公司 |
重組腺相關病毒載體及其使用方法
|
|
WO2023201207A1
(en)
|
2022-04-11 |
2023-10-19 |
Tenaya Therapeutics, Inc. |
Adeno-associated virus with engineered capsid
|
|
GB202206336D0
(en)
|
2022-04-29 |
2022-06-15 |
Univ Edinburgh |
Recombinant therapeutic FMR1 constructs and methods of treating fragile X syndrome and related disorders
|
|
US20250353883A1
(en)
|
2022-05-06 |
2025-11-20 |
Novartis Ag |
Novel recombinant aav vp2 fusion polypeptides
|
|
US20250302998A1
(en)
|
2022-05-09 |
2025-10-02 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
|
WO2024003687A1
(en)
|
2022-06-28 |
2024-01-04 |
Pfizer Inc. |
Nucleic acids encoding acid alpha-glucosidase (gaa) and vectors for gene therapy
|
|
CA3263388A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
VIRAL PARTICLES RETRIBUTED TO TRANSFERRIN RECEPTOR 1
|
|
WO2024038365A1
(en)
|
2022-08-16 |
2024-02-22 |
Pfizer Inc. |
Methods for purification of aav vectors by anion exchange chromatography
|
|
KR20250116795A
(ko)
|
2022-11-14 |
2025-08-01 |
리제너론 파마슈티칼스 인코포레이티드 |
별아교세포로의 섬유아세포 성장 인자 수용체 3-매개된 전달을 위한 조성물 및 방법
|
|
WO2024124019A2
(en)
|
2022-12-07 |
2024-06-13 |
Ginkgo Bioworks, Inc. |
Aav vectors targeting hematopoietic stem cells
|
|
EP4634220A2
(de)
|
2022-12-16 |
2025-10-22 |
Regeneron Pharmaceuticals, Inc. |
An aav-partikel bindende antigenbindende moleküle und verwendungen
|
|
WO2024147114A1
(en)
|
2023-01-06 |
2024-07-11 |
Bloomsbury Genetic Therapies Limited |
Compositions and methods for treating parkinson's disease
|
|
EP4658294A2
(de)
|
2023-02-02 |
2025-12-10 |
University of Rochester |
Kompetitiver ersatz von gliazellen
|
|
EP4665764A1
(de)
|
2023-02-13 |
2025-12-24 |
Regeneron Pharmaceuticals, Inc. |
Behandlung von muskelerkrankungen mit anti-humanen cacng1-antikörpern
|
|
WO2024215653A1
(en)
|
2023-04-10 |
2024-10-17 |
Tenaya Therapeutics, Inc. |
Guide rnas, vectors, and virions for targeting mutations in the pln gene
|
|
WO2024215655A1
(en)
|
2023-04-10 |
2024-10-17 |
Tenaya Therapeutics, Inc. |
Cardioprotective bag3 therapies
|
|
WO2024229105A1
(en)
|
2023-05-02 |
2024-11-07 |
Regeneron Pharmaceuticals, Inc. |
Anti-human m-cadherin (cdh15) antibodies, conjugates, and uses thereof for delivery of genetic payloads to muscle cells
|
|
EP4630457A1
(de)
|
2023-08-18 |
2025-10-15 |
Regeneron Pharmaceuticals, Inc. |
Bispezifische antigenbindende moleküle und verwendungen davon
|
|
TW202508610A
(zh)
|
2023-08-23 |
2025-03-01 |
大陸商上海瑞宏迪醫藥有限公司 |
醫藥組成物及其用途
|
|
WO2025082618A1
(en)
|
2023-10-20 |
2025-04-24 |
Fuse Vectors Aps |
In vitro parvovirus capsid manufacturing
|
|
WO2025090427A1
(en)
|
2023-10-23 |
2025-05-01 |
University Of Rochester |
Glial-targeted relief of hyperexcitability in neurodegenerative diseases
|
|
WO2025151796A1
(en)
|
2024-01-11 |
2025-07-17 |
Regeneron Pharmaceuticals, Inc. |
Viral particles retargeted to nervous system tissues
|
|
US20250242018A1
(en)
|
2024-01-26 |
2025-07-31 |
Regeneron Pharmaceuticals, Inc. |
Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration
|
|
WO2025184603A2
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
The use of cd40 inhibitors for inhibiting an immune response and enabling immunogen administration and re-administration
|
|
WO2025250454A1
(en)
|
2024-05-28 |
2025-12-04 |
University Of Rochester |
Adeno-associated viruses evolved to specifically target human glial progenitor cells in vivo
|
|
WO2025255452A2
(en)
|
2024-06-07 |
2025-12-11 |
Regeneron Pharmaceuticals, Inc. |
Antigen-binding molecules that bind to aav particles and uses thereof
|
|
WO2026017965A1
(en)
|
2024-07-19 |
2026-01-22 |
The University Court Of The University Of Edinburgh |
Recombinant therapeutic fxn constructs and methods of treating friedreich ataxia and related conditions
|
|
WO2026025058A1
(en)
|
2024-07-25 |
2026-01-29 |
Regeneron Pharmaceuticals, Inc. |
Aav viral particles retargeted to egfr-expressing cancer cells
|
|
WO2026039325A2
(en)
|
2024-08-12 |
2026-02-19 |
Regeneron Pharmaceuticals, Inc. |
Modified mtm1 genes and uses thereof
|