ATE362934T1 - Verbrückte bicyclische (1,4) benzodiazepine als vasopressinrezeptorantagonisten - Google Patents

Verbrückte bicyclische (1,4) benzodiazepine als vasopressinrezeptorantagonisten

Info

Publication number
ATE362934T1
ATE362934T1 AT02778547T AT02778547T ATE362934T1 AT E362934 T1 ATE362934 T1 AT E362934T1 AT 02778547 T AT02778547 T AT 02778547T AT 02778547 T AT02778547 T AT 02778547T AT E362934 T1 ATE362934 T1 AT E362934T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
bridged bicyclic
benzodiazepines
vasopressin receptor
vasopressin
Prior art date
Application number
AT02778547T
Other languages
English (en)
Inventor
Alexey Dyatkin
William Hoekstra
Bruce Maryanoff
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of ATE362934T1 publication Critical patent/ATE362934T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02778547T 2001-10-29 2002-10-11 Verbrückte bicyclische (1,4) benzodiazepine als vasopressinrezeptorantagonisten ATE362934T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34104901P 2001-10-29 2001-10-29

Publications (1)

Publication Number Publication Date
ATE362934T1 true ATE362934T1 (de) 2007-06-15

Family

ID=23336043

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02778547T ATE362934T1 (de) 2001-10-29 2002-10-11 Verbrückte bicyclische (1,4) benzodiazepine als vasopressinrezeptorantagonisten

Country Status (12)

Country Link
US (1) US6936604B2 (de)
EP (1) EP1442040B1 (de)
JP (1) JP2005507939A (de)
KR (1) KR20050035173A (de)
CN (1) CN1608068A (de)
AT (1) ATE362934T1 (de)
CA (1) CA2465497A1 (de)
DE (1) DE60220305T2 (de)
ES (1) ES2287326T3 (de)
HU (1) HUP0401722A3 (de)
PL (1) PL370114A1 (de)
WO (1) WO2003037901A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008518915A (ja) * 2004-10-28 2008-06-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ バソプレシンｖ２受容体アンタゴニストとしての新規な［１，４］ベンゾジアゼピン

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860600A (en) * 1972-07-10 1975-01-14 Sterling Drug Inc Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
US5985869A (en) * 1989-10-20 1999-11-16 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
US5700796A (en) * 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
AU732214C (en) * 1997-03-31 2001-10-25 Wakamoto Pharmaceutical Co., Ltd. Biphenyl derivatives and drug composition
EP1147115B3 (de) 1999-01-19 2008-12-24 Ortho-McNeil Pharmaceutical, Inc. Tricyclische benzodiazepine als vasopressin antagonisten

Also Published As

Publication number Publication date
PL370114A1 (en) 2005-05-16
WO2003037901A1 (en) 2003-05-08
EP1442040B1 (de) 2007-05-23
KR20050035173A (ko) 2005-04-15
CN1608068A (zh) 2005-04-20
DE60220305T2 (de) 2008-01-17
HUP0401722A3 (en) 2008-07-28
CA2465497A1 (en) 2003-05-08
DE60220305D1 (de) 2007-07-05
EP1442040A1 (de) 2004-08-04
US20030119822A1 (en) 2003-06-26
ES2287326T3 (es) 2007-12-16
HUP0401722A2 (hu) 2005-01-28
JP2005507939A (ja) 2005-03-24
US6936604B2 (en) 2005-08-30

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties