ATE362993T1 - Verfahren zur entwicklung von pdk1-modulatoren - Google Patents

Verfahren zur entwicklung von pdk1-modulatoren

Info

Publication number
ATE362993T1
ATE362993T1 AT03730356T AT03730356T ATE362993T1 AT E362993 T1 ATE362993 T1 AT E362993T1 AT 03730356 T AT03730356 T AT 03730356T AT 03730356 T AT03730356 T AT 03730356T AT E362993 T1 ATE362993 T1 AT E362993T1
Authority
AT
Austria
Prior art keywords
pdk1
protein kinase
selecting
compound
modulators
Prior art date
Application number
AT03730356T
Other languages
English (en)
Inventor
Dario Alessi
Ricardo Biondi
David Komander
Aalten Van
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of ATE362993T1 publication Critical patent/ATE362993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C43/00—Alloys containing radioactive materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Metallurgy (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Materials For Photolithography (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Liquid Crystal Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacture And Refinement Of Metals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03730356T 2002-06-08 2003-06-09 Verfahren zur entwicklung von pdk1-modulatoren ATE362993T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0213186.0A GB0213186D0 (en) 2002-06-08 2002-06-08 Methods

Publications (1)

Publication Number Publication Date
ATE362993T1 true ATE362993T1 (de) 2007-06-15

Family

ID=9938208

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03730356T ATE362993T1 (de) 2002-06-08 2003-06-09 Verfahren zur entwicklung von pdk1-modulatoren

Country Status (7)

Country Link
US (1) US7792665B2 (de)
EP (1) EP1513947B1 (de)
AT (1) ATE362993T1 (de)
AU (1) AU2003241038A1 (de)
DE (1) DE60313967T2 (de)
GB (1) GB0213186D0 (de)
WO (1) WO2003104481A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006020755A2 (en) * 2004-08-10 2006-02-23 Beth Israel Deaconess Medical Center, Inc. Methods for identifying inhibitors of the mtor pathway as diabetes therapeutics
WO2008019890A2 (en) * 2006-08-18 2008-02-21 Biondi Ricardo M Method of modulation of protein phosphorylation-dependent conformational transitions with low molecular weight compounds
EP2182058A1 (de) 2008-10-17 2010-05-05 Universität des Saarlandes Hochauflösende Struktur der Proteinkinase-PDK1 und allosterische Effekte niedermolekularer Aktivatoren
US9556426B2 (en) 2009-09-16 2017-01-31 Celgene Avilomics Research, Inc. Protein kinase conjugates and inhibitors
AU2010339456A1 (en) * 2009-12-30 2012-07-05 Celgene Avilomics Research, Inc. Ligand-directed covalent modification of protein
EP2627650A2 (de) 2010-05-26 2013-08-21 Merck Sharp & Dohme Corp. N-phenyl-imidazol-carboxamid-hemmer von 3-phosphoinositidabhängiger proteinkinase-1
EP2865757A1 (de) 2013-10-22 2015-04-29 Sylentis, S.A.U. siRNA und deren Verwendung in Verfahren und Zusammensetzungen zur Hemmung der Expression des PDK1-Gens
JP6709273B2 (ja) * 2018-03-28 2020-06-10 公益財団法人福岡県産業・科学技術振興財団 蒸着装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854992A (en) * 1996-09-26 1998-12-29 President And Fellows Of Harvard College System and method for structure-based drug design that includes accurate prediction of binding free energy
ATE310825T1 (de) 1997-03-17 2005-12-15 Medical Res Council Phosphatidyl-3,4,5-triphosphat abhängige proteinkinase
EP1141001A2 (de) 1998-12-14 2001-10-10 Medical Research Council Auf der verwendung von proteinkinasen basierende screeningverfahren
WO2000035946A1 (en) 1998-12-14 2000-06-22 The University Of Dundee Methods
AU3114600A (en) 1998-12-16 2000-07-03 Vertex Pharmaceuticals Incorporated Crystallized p38 complexes
GB9906245D0 (en) 1999-03-19 1999-05-12 Medical Res Council Enzyme
WO2000070030A1 (en) 1999-05-19 2000-11-23 Amgen Inc. Crystal of a lymphocyte kinase-ligand complex and methods of use
US6670167B1 (en) * 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
AU1760001A (en) 1999-11-10 2001-06-06 Quest Diagnostics Investments Incorporated Use of computationally derived protein structures of genetic polymorphisms in pharmacogenomics and clinical applications
WO2001044497A2 (en) 1999-12-02 2001-06-21 University Of Dundee Protein kinase regulation
WO2001071347A1 (en) 2000-03-23 2001-09-27 California Institute Of Technology Method and apparatus for predicting ligand binding interactions
US6484103B1 (en) 2000-09-11 2002-11-19 Astex Technology Limited Crystal structure
US20040137518A1 (en) * 2002-01-31 2004-07-15 Lambert Millard Hurst CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME

Also Published As

Publication number Publication date
US7792665B2 (en) 2010-09-07
DE60313967T2 (de) 2008-01-17
EP1513947B1 (de) 2007-05-23
WO2003104481A2 (en) 2003-12-18
DE60313967D1 (de) 2007-07-05
AU2003241038A1 (en) 2003-12-22
EP1513947A2 (de) 2005-03-16
US20050232804A1 (en) 2005-10-20
WO2003104481A3 (en) 2004-09-23
AU2003241038A8 (en) 2003-12-22
GB0213186D0 (en) 2002-07-17

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