ATE363478T1 - Renin inhibitoren - Google Patents

Renin inhibitoren

Info

Publication number
ATE363478T1
ATE363478T1 AT00929401T AT00929401T ATE363478T1 AT E363478 T1 ATE363478 T1 AT E363478T1 AT 00929401 T AT00929401 T AT 00929401T AT 00929401 T AT00929401 T AT 00929401T AT E363478 T1 ATE363478 T1 AT E363478T1
Authority
AT
Austria
Prior art keywords
renin inhibitors
renin
inhibitors
Prior art date
Application number
AT00929401T
Other languages
English (en)
Inventor
Volker Breu
Daniel Bur
Hans-Peter Maerki
Eric Vieira
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE363478T1 publication Critical patent/ATE363478T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00929401T 1999-04-27 2000-04-20 Renin inhibitoren ATE363478T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99108200 1999-04-27

Publications (1)

Publication Number Publication Date
ATE363478T1 true ATE363478T1 (de) 2007-06-15

Family

ID=8238051

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00929401T ATE363478T1 (de) 1999-04-27 2000-04-20 Renin inhibitoren

Country Status (22)

Country Link
US (1) US6197959B1 (de)
EP (1) EP1180103B1 (de)
JP (1) JP3602449B2 (de)
KR (1) KR100476916B1 (de)
CN (1) CN1323079C (de)
AR (1) AR018717A1 (de)
AT (1) ATE363478T1 (de)
AU (1) AU761392B2 (de)
BR (1) BR0010076A (de)
CA (1) CA2370244C (de)
CO (1) CO5170512A1 (de)
CZ (1) CZ20013737A3 (de)
DE (1) DE60035039T2 (de)
ES (1) ES2286021T3 (de)
HU (1) HUP0200881A3 (de)
MX (1) MXPA01010855A (de)
PE (1) PE20010068A1 (de)
PL (1) PL362903A1 (de)
SK (1) SK15172001A3 (de)
TR (1) TR200103067T2 (de)
WO (1) WO2000064887A1 (de)
ZA (1) ZA200108739B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214832A1 (en) * 2003-04-10 2004-10-28 Cuiman Cai Piperazine derivative renin inhibitors
TW200513461A (en) 2003-10-01 2005-04-16 Speedel Experimenta Ag Organische verbindungen
AR045950A1 (es) * 2003-10-09 2005-11-16 Speedel Experimenta Ag Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos.
DE602004022704D1 (de) * 2003-11-26 2009-10-01 Novartis Ag 4-phenylpiperidinderivate als renininhibitoren
TW200613274A (en) * 2004-07-09 2006-05-01 Speedel Experimenta Ag Organic compounds
RU2407523C2 (ru) 2004-10-08 2010-12-27 Новартис Аг Применение ингибиторов ренина для профилактики или лечения диастолической дисфункции или диастолической сердечной недостаточности
GB0428526D0 (en) * 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
EP1707202A1 (de) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organische Verbindungen
WO2006103275A1 (en) * 2005-03-31 2006-10-05 Speedel Experimenta Ag 3,4,5-substituted piperidines as renin inhibitors
ES2352564T3 (es) * 2005-03-31 2011-02-21 Novartis Ag Piperidinas sustituidas.
EP1897879A3 (de) * 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-Substituierte Piperidine als Renin-Inhibitoren
TW200833687A (en) * 2005-03-31 2008-08-16 Speedel Experimenta Ag Substituted piperidines
GB0508992D0 (en) * 2005-05-03 2005-06-08 Novartis Ag Organic compounds
EP1885718B1 (de) * 2005-05-11 2017-03-15 Life Technologies Corporation Chemische fluoreszente verbindungen mit hoher selektivität für doppelstrang-dna sowie verfahren zu ihrer verwendung
AU2006253805A1 (en) 2005-05-27 2006-12-07 Actelion Pharmaceuticals Ltd. Novel piperidine carboxylic acid amide derivatives
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
JP5306821B2 (ja) * 2005-12-30 2013-10-02 ノバルティス アーゲー レニン阻害剤としての３，５−置換ピペリジン化合物
TW200804359A (en) * 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines
EP1908761A1 (de) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organische Verbindungen
NZ582098A (en) 2007-06-25 2012-03-30 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
TW200934499A (en) * 2007-11-02 2009-08-16 Speedel Experimenta Ag 4,4-disubstituted piperidines
SG175877A1 (en) * 2009-05-04 2011-12-29 Plexxikon Inc Compounds and methods for inhibition of renin, and indications therefor
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
EP2810644A1 (de) 2013-06-06 2014-12-10 Ferrer Internacional, S.A. Orale Formulierung zur Behandlung von Herz-Kreislauf-Erkrankungen
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL193686B1 (pl) * 1995-09-07 2007-03-30 Hoffmann La Roche Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych

Also Published As

Publication number Publication date
CN1349524A (zh) 2002-05-15
CO5170512A1 (es) 2002-06-27
KR20020005017A (ko) 2002-01-16
DE60035039T2 (de) 2008-02-07
KR100476916B1 (ko) 2005-03-17
WO2000064887A1 (en) 2000-11-02
MXPA01010855A (es) 2002-05-06
DE60035039D1 (de) 2007-07-12
AU4750100A (en) 2000-11-10
CA2370244C (en) 2007-03-27
CZ20013737A3 (cs) 2002-04-17
US6197959B1 (en) 2001-03-06
TR200103067T2 (tr) 2002-05-21
AR018717A1 (es) 2001-11-28
JP3602449B2 (ja) 2004-12-15
ES2286021T3 (es) 2007-12-01
CN1323079C (zh) 2007-06-27
SK15172001A3 (sk) 2002-06-04
BR0010076A (pt) 2002-01-15
EP1180103B1 (de) 2007-05-30
PE20010068A1 (es) 2001-01-29
HUP0200881A2 (en) 2002-08-28
ZA200108739B (en) 2003-01-23
PL362903A1 (en) 2004-11-02
JP2002543072A (ja) 2002-12-17
EP1180103A1 (de) 2002-02-20
HUP0200881A3 (en) 2003-05-28
AU761392B2 (en) 2003-06-05
CA2370244A1 (en) 2000-11-02

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Legal Events

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