ATE363901T1 - C-2'-methylierte paclitaxel-derivate zur verwendung als antitumorale mittel - Google Patents

C-2'-methylierte paclitaxel-derivate zur verwendung als antitumorale mittel

Info

Publication number: ATE363901T1
Authority: AT; Austria
Prior art keywords: sub; methylated; paclitaxel derivatives; antitumoral agents; formula
Prior art date: 2001-08-07

Application number

AT02764753T

Other languages

English (en)

Inventor

Ezio Bombardelli

Gabriele Fontana

Arturo Battaglia

Samanta Cimitan

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-07

Filing date

2002-07-23

Publication date

2007-06-15

2002-07-23 Application filed by Indena Spa filed Critical Indena Spa

2007-06-15 Application granted granted Critical

2007-06-15 Publication of ATE363901T1 publication Critical patent/ATE363901T1/de

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
150000004579 taxol derivatives Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000005676 cyclic carbonates Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 t-butoxycarbonyl Chemical group 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Epoxy Compounds (AREA)

AT02764753T 2001-08-07 2002-07-23 C-2'-methylierte paclitaxel-derivate zur verwendung als antitumorale mittel ATE363901T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2001MI001734A ITMI20011734A1 (it)	2001-08-07	2001-08-07	Derivanti tassanici e procedimenti per la loro preparazione

Publications (1)

Publication Number	Publication Date
ATE363901T1 true ATE363901T1 (de)	2007-06-15

Family

ID=11448252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02764753T ATE363901T1 (de)	2001-08-07	2002-07-23	C-2'-methylierte paclitaxel-derivate zur verwendung als antitumorale mittel

Country Status (20)

Country	Link
US (1)	US7153884B2 (de)
EP (1)	EP1423108B1 (de)
KR (1)	KR100894580B1 (de)
CN (1)	CN100370980C (de)
AT (1)	ATE363901T1 (de)
AU (1)	AU2002328942B2 (de)
BR (1)	BR0211770A (de)
CA (1)	CA2456523A1 (de)
DE (1)	DE60220524T2 (de)
DK (1)	DK1423108T3 (de)
ES (1)	ES2287310T3 (de)
HU (1)	HUP0401275A3 (de)
IL (1)	IL160233A0 (de)
IT (1)	ITMI20011734A1 (de)
MX (1)	MXPA04001234A (de)
NO (1)	NO20040535L (de)
PL (1)	PL194975B1 (de)
PT (1)	PT1423108E (de)
RU (1)	RU2287528C2 (de)
WO (1)	WO2003013503A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101932938B (zh) *	2007-11-30	2014-08-27	克雷特诊疗服务公司	作为标记物用于化学疗法的tle3
CN101851231A (zh) *	2010-05-27	2010-10-06	东北林业大学	一种多西紫杉醇新衍生物的合成方法及其在制备抗肿瘤药物中的应用
CN104650012A (zh) *	2013-11-22	2015-05-27	天士力控股集团有限公司	一种紫杉烷类化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2059631C1 (ru) *	1991-11-29	1996-05-10	Дзе Юниверсити оф Канзас	Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
FR2721024B1 (fr) *	1994-06-09	1996-07-12	Rhone Poulenc Rorer Sa	Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

2001
- 2001-08-07 IT IT2001MI001734A patent/ITMI20011734A1/it unknown
2002
- 2002-07-23 US US10/485,982 patent/US7153884B2/en not_active Expired - Fee Related
- 2002-07-23 BR BR0211770-3A patent/BR0211770A/pt not_active IP Right Cessation
- 2002-07-23 KR KR1020047001736A patent/KR100894580B1/ko not_active Expired - Fee Related
- 2002-07-23 CN CNB028153529A patent/CN100370980C/zh not_active Expired - Fee Related
- 2002-07-23 DK DK02764753T patent/DK1423108T3/da active
- 2002-07-23 MX MXPA04001234A patent/MXPA04001234A/es active IP Right Grant
- 2002-07-23 WO PCT/EP2002/008185 patent/WO2003013503A1/en not_active Ceased
- 2002-07-23 EP EP02764753A patent/EP1423108B1/de not_active Expired - Lifetime
- 2002-07-23 IL IL16023302A patent/IL160233A0/xx unknown
- 2002-07-23 PL PL367868A patent/PL194975B1/pl not_active IP Right Cessation
- 2002-07-23 HU HU0401275A patent/HUP0401275A3/hu unknown
- 2002-07-23 CA CA002456523A patent/CA2456523A1/en not_active Abandoned
- 2002-07-23 PT PT02764753T patent/PT1423108E/pt unknown
- 2002-07-23 RU RU2004103481/04A patent/RU2287528C2/ru not_active IP Right Cessation
- 2002-07-23 DE DE60220524T patent/DE60220524T2/de not_active Expired - Fee Related
- 2002-07-23 ES ES02764753T patent/ES2287310T3/es not_active Expired - Lifetime
- 2002-07-23 AU AU2002328942A patent/AU2002328942B2/en not_active Ceased
- 2002-07-23 AT AT02764753T patent/ATE363901T1/de not_active IP Right Cessation
2004
- 2004-02-05 NO NO20040535A patent/NO20040535L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20040030926A (ko)	2004-04-09
US20040242674A1 (en)	2004-12-02
NO20040535L (no)	2004-04-26
CA2456523A1 (en)	2003-02-20
WO2003013503A1 (en)	2003-02-20
ITMI20011734A1 (it)	2003-02-07
EP1423108A1 (de)	2004-06-02
PL194975B1 (pl)	2007-07-31
AU2002328942B2 (en)	2007-08-30
IL160233A0 (en)	2004-07-25
CN1538841A (zh)	2004-10-20
MXPA04001234A (es)	2004-05-27
RU2004103481A (ru)	2005-06-10
BR0211770A (pt)	2004-07-27
ITMI20011734A0 (it)	2001-08-07
KR100894580B1 (ko)	2009-04-24
HUP0401275A2 (hu)	2004-10-28
DE60220524T2 (de)	2008-02-07
HK1066483A1 (en)	2005-03-24
US7153884B2 (en)	2006-12-26
EP1423108B1 (de)	2007-06-06
RU2287528C2 (ru)	2006-11-20
PL367868A1 (en)	2005-03-07
PT1423108E (pt)	2007-08-28
ES2287310T3 (es)	2007-12-16
CN100370980C (zh)	2008-02-27
DE60220524D1 (de)	2007-07-19
HUP0401275A3 (en)	2007-05-29
DK1423108T3 (da)	2007-10-01

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2007-11-15

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