DK1501507T3 - Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet - Google Patents

Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet

Info

Publication number
DK1501507T3
DK1501507T3 DK03724241T DK03724241T DK1501507T3 DK 1501507 T3 DK1501507 T3 DK 1501507T3 DK 03724241 T DK03724241 T DK 03724241T DK 03724241 T DK03724241 T DK 03724241T DK 1501507 T3 DK1501507 T3 DK 1501507T3
Authority
DK
Denmark
Prior art keywords
modulators
chemokine receptor
tertrahydropyridopyridine
tetrahydropyranyl
cyclopentyl
Prior art date
Application number
DK03724241T
Other languages
English (en)
Inventor
Gregori Morriello
Shankaran Kothandaraman
Deodialsingh Guiadeen
Christopher Moyes
Richard Jiao
Lihu Yang
Stephen D Goble
Sander G Mills
Alexander Pasternak
Changyou Zhou
Gabor Butora
Cheng Tang
Original Assignee
Merck & Co Inc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Sharp & Dohme filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK1501507T3 publication Critical patent/DK1501507T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK03724241T 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet DK1501507T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37618002P 2002-04-29 2002-04-29
PCT/US2003/012929 WO2003092586A2 (en) 2002-04-29 2003-04-25 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
DK1501507T3 true DK1501507T3 (da) 2008-09-29

Family

ID=29401316

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03724241T DK1501507T3 (da) 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet

Country Status (15)

Country Link
US (1) US6812234B2 (da)
EP (1) EP1501507B1 (da)
JP (1) JP3780291B2 (da)
AT (1) ATE396993T1 (da)
AU (1) AU2003231114B8 (da)
CA (1) CA2483752C (da)
CY (1) CY1110399T1 (da)
DE (1) DE60321333D1 (da)
DK (1) DK1501507T3 (da)
ES (1) ES2306867T3 (da)
NZ (1) NZ536477A (da)
PT (1) PT1501507E (da)
SI (1) SI1501507T1 (da)
WO (1) WO2003092586A2 (da)
ZA (1) ZA200407940B (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
WO2004050024A2 (en) 2002-11-27 2004-06-17 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
WO2004082616A2 (en) * 2003-03-18 2004-09-30 Merck & Co. Inc. Tetrahydropyranyl cyclopentyl heterocylic amide modulators of chemokine receptor activity
AU2004231087B2 (en) * 2003-04-15 2007-01-04 Merck Sharp & Dohme Corp. Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
CA2521625A1 (en) * 2003-04-17 2004-11-04 Merck & Co., Inc. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
WO2004110376A2 (en) * 2003-06-06 2004-12-23 Merck & Co., Inc. Ccr-2 antagonists for treatment of neuropathic pain
RU2317295C1 (ru) * 2003-10-27 2008-02-20 Мерк Энд Ко., Инк. Соль антагониста ccr-2
AR045875A1 (es) * 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2
CA2550596C (en) 2003-12-18 2011-03-15 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
JP2007519633A (ja) * 2004-01-02 2007-07-19 メルク　エンド　カムパニー　インコーポレーテッド アルキルアミノ、アリールアミノおよびスルホンアミドシクロペンチルアミド系のケモカイン受容体活性調節剤
CN1913778A (zh) * 2004-01-28 2007-02-14 默克公司 趋化因子受体活性的氨基环戊基吡啶并吡嗪酮调节剂
EP1742919A4 (en) * 2004-04-26 2010-04-28 Merck Sharp & Dohme TETRAHYDROPYRANYL-CYCLOPENTYL-1-SUBSTITUTED AND 1,1-DISUBSTITUTED TETRAHYDROISOCHINOLINE MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY
US7557124B2 (en) 2004-04-26 2009-07-07 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
WO2005105092A2 (en) * 2004-04-28 2005-11-10 Merck & Co., Inc. 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
CN1950085A (zh) * 2004-05-11 2007-04-18 因赛特公司 作为趋化因子受体调节剂的3－(4－杂芳基环己基氨基)环戊烷羧酰胺
AP2006003849A0 (en) 2004-06-28 2006-12-31 Incyte Corp 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
AU2005259983B2 (en) * 2004-06-28 2011-07-28 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
CA2593545A1 (en) * 2005-01-06 2006-07-13 Merck & Co., Inc. Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders
JP2008536484A (ja) * 2005-03-11 2008-09-11 メルク エンド カムパニー インコーポレーテッド （ｒ）−４，４−ジメトキシ−ピラン−３−オールなどの（ｒ）−４，４−ジアルコキシ−ピラン−３−オールの調製方法
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
PL2370442T3 (pl) * 2008-11-26 2013-08-30 Pfizer 3-Aminocyklopentanokarboksamidy jako modulatory receptora chemokiny
ES2551557T3 (es) 2008-12-19 2015-11-19 Boehringer Ingelheim International Gmbh Pirimidin-4-carboxamidas cíclicas como antagonistas del receptor CCR2 para el tratamiento de inflamaciones, asma y EPOC
PL2513093T3 (pl) 2009-12-17 2015-03-31 Centrexion Therapeutics Corp Nowi antagoniści receptora CCR2 i ich zastosowanie
MX2012007253A (es) 2009-12-22 2012-07-17 Cephalon Inc Derivados triciclicos y sus usos y composiciones farmaceuticas.
US9040526B2 (en) 2010-02-09 2015-05-26 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
US9018212B2 (en) * 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
WO2012125663A2 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
EP2962691A4 (en) 2013-02-28 2016-08-31 Santen Pharmaceutical Co Ltd AGENT FOR THE PREVENTION OR TREATMENT OF DISEASES OF THE POSTERIOR PART OF THE IL CONTAINING A TETRAHYDROPYRANYLAMINOCYCLOPENTYLCARBONYLTETRAHYDROPYRIDOPYRIDINE DERIVATIVE AS ACTIVE INGREDIENT
RU2726206C2 (ru) 2015-05-21 2020-07-09 Кемосентрикс, Инк. Модуляторы ccr2
MX383744B (es) 2015-07-02 2025-03-14 Centrexion Therapeutics Corp Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona.
WO2018134731A1 (en) 2017-01-17 2018-07-26 Glaxosmithkline Intellectual Property Development Limited Non peptidic heterobivalent molecules for treating inflammatory diseases
EP3687525B1 (en) 2017-09-25 2025-10-29 ChemoCentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
CN112105353B (zh) 2018-01-08 2024-04-19 凯莫森特里克斯股份有限公司 Ccr2拮抗剂治疗实体瘤的方法
CN119925562B (zh) * 2023-11-03 2025-11-28 中国科学院上海药物研究所 趋化因子受体2拮抗剂在制备治疗糖尿病并发焦虑症的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002A (en) * 1841-03-12 Tor and planter for plowing
US3647804A (en) 1970-02-27 1972-03-07 Upjohn Co Cycloalkanecarboxamides
US3772308A (en) 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
JPH09291034A (ja) * 1996-02-27 1997-11-11 Yoshitomi Pharmaceut Ind Ltd 縮合ピリジン化合物およびその医薬としての用途
GB9812037D0 (en) 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US6500844B1 (en) * 1999-06-11 2002-12-31 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
WO2002013824A1 (en) * 2000-08-17 2002-02-21 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
WO2002070523A1 (en) 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
MY129850A (en) * 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Also Published As

Publication number Publication date
ATE396993T1 (de) 2008-06-15
AU2003231114B8 (en) 2008-08-14
PT1501507E (pt) 2008-08-12
WO2003092586A3 (en) 2004-09-16
JP2005523929A (ja) 2005-08-11
CY1110399T1 (el) 2014-04-09
SI1501507T1 (sl) 2008-12-31
EP1501507A4 (en) 2006-05-17
US6812234B2 (en) 2004-11-02
DE60321333D1 (de) 2008-07-10
EP1501507B1 (en) 2008-05-28
CA2483752C (en) 2011-03-29
CA2483752A1 (en) 2003-11-13
WO2003092586A2 (en) 2003-11-13
US20040167156A1 (en) 2004-08-26
NZ536477A (en) 2005-05-27
JP3780291B2 (ja) 2006-05-31
AU2003231114A1 (en) 2003-11-17
ZA200407940B (en) 2006-06-28
EP1501507A2 (en) 2005-02-02
ES2306867T3 (es) 2008-11-16
AU2003231114B2 (en) 2008-07-24

Similar Documents

Publication Publication Date Title
ATE396993T1 (de) Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität
ATE404538T1 (de) Tetrahydropyranylcyclopentyltetrahydroisochino- linmodulatoren der chemokinrezeptoraktivität
ES2271063T3 (es) Moduladores ciclopentilos de la actividad del receptor de la quimioquina.
WO2004042351A3 (en) Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity
EA200601007A1 (ru) 7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы
JO2479B1 (en) Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
ATE338461T1 (de) Pyrazolpyrimidinfungizide
EA200700192A1 (ru) Производные фталазина в качестве ингибиторов parp
WO2004041777A3 (en) Heteroarylpiperidine modulators of chemokine receptor activity
DK1313721T3 (da) Ikke-imidazol-aryloxyalkylaminer som H3-receptorligander
SE9702773D0 (sv) Novel compounds
ATE345349T1 (de) Purinderivate
ATE354622T1 (de) Flüssigkristallines medium
ATE411287T1 (de) Neue metallproteinaseinhibitoren
DE602004031115D1 (de) Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
SE9903290D0 (sv) Novel compounds
CO5680420A2 (es) Compuestos de 6-amino-1h-indazol y 4-aminobenzenofurano como inhibidores de la fosfodiesterasa 4
DE60041001D1 (de) Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
ATE344242T1 (de) N-cyclopentylmodulatoren der chemokine rezeptoraktivität
SE9904128D0 (sv) Novel compounds
EA200400661A1 (ru) Фенилалкины
DE59803066D1 (de) Substituierte benzyloxyimino-verbindungen
ATE374751T1 (de) 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern
SE0004244D0 (sv) Novel compounds and their use