ATE364402T1 - Stabile injizierbare diclofenac- zubereitungen - Google Patents

Stabile injizierbare diclofenac- zubereitungen

Info

Publication number: ATE364402T1
Authority: AT; Austria
Prior art keywords: diclofenac; cyclodextrin; salt; stable injectable; pharmaceutically acceptable
Prior art date: 2004-03-10

Application number

AT04257437T

Other languages

English (en)

Inventor

Lawrence John Penkler

Original Assignee

Shimoda Biotech Pty Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-10

Filing date

2004-11-30

Publication date

2007-07-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34826259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE364402(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-11-30 Application filed by Shimoda Biotech Pty Ltd filed Critical Shimoda Biotech Pty Ltd

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE364402T1 publication Critical patent/ATE364402T1/de

Links

DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 title abstract 7
229960001259 diclofenac Drugs 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title 1
229920000858 Cyclodextrin Polymers 0.000 abstract 3
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 3
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
229960004308 acetylcysteine Drugs 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
229960001484 edetic acid Drugs 0.000 abstract 1
238000007918 intramuscular administration Methods 0.000 abstract 1
238000001990 intravenous administration Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

AT04257437T 2004-03-10 2004-11-30 Stabile injizierbare diclofenac- zubereitungen ATE364402T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US55135104P	2004-03-10	2004-03-10

Publications (1)

Publication Number	Publication Date
ATE364402T1 true ATE364402T1 (de)	2007-07-15

Family

ID=34826259

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04257437T ATE364402T1 (de)	2004-03-10	2004-11-30	Stabile injizierbare diclofenac- zubereitungen
AT07075004T ATE454905T1 (de)	2004-03-10	2004-11-30	Stabile injizierbare diclofenac- zubereitungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT07075004T ATE454905T1 (de)	2004-03-10	2004-11-30	Stabile injizierbare diclofenac- zubereitungen

Country Status (19)

Country	Link
US (2)	US20050238674A1 (de)
EP (2)	EP1574221B1 (de)
JP (1)	JP2007528384A (de)
KR (1)	KR20070028331A (de)
AT (2)	ATE364402T1 (de)
AU (1)	AU2004317520B2 (de)
BR (1)	BRPI0418474A (de)
CA (1)	CA2555429C (de)
CY (1)	CY1106824T1 (de)
DE (2)	DE602004025151D1 (de)
DK (2)	DK1767219T3 (de)
ES (2)	ES2287658T3 (de)
IL (1)	IL177529A (de)
MX (1)	MXPA06010336A (de)
PL (2)	PL1574221T3 (de)
PT (2)	PT1767219E (de)
SI (2)	SI1767219T1 (de)
WO (2)	WO2005092387A1 (de)
ZA (2)	ZA200607631B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA013616B1 (ru)	2005-02-01	2010-06-30	Троикаа Фармасьютикалз Лтд.	Инъекционные препараты диклофенака и его фармацевтически приемлемых солей
US20060205080A1 (en) *	2005-03-01	2006-09-14	David Frey	Formulations for therapeutic viruses having enhanced storage stability
EP2522343A1 (de) *	2006-03-28	2012-11-14	Javelin Pharmaceuticals, Inc.	Formulierungen aus niedrigdosiertem Diclofenac und Beta-Cyclodextrin
MX2008012496A (es) *	2006-03-28	2009-01-07	Javelin Pharmaceuticals Inc	Formulaciones de farmacos anti-inflamatorios no esteroidales de baja dosis y beta-ciclodextrina.
AU2012209035B9 (en) *	2006-03-28	2014-05-22	Javelin Pharmaceuticals, Inc.	Formulations of low dose diclofenac and beta-cyclodextrin
CL2007003877A1 (es)	2007-12-28	2008-06-27	Univ De Concepcion Lab Androma	Composicion farmaceutica que comprende un complejo de inclusion formado por disulfiram y una ciclodextrina; y su uso para el tratamiento de la dependencia de alcohol y cocaina.
US20100022652A1 (en) *	2008-07-28	2010-01-28	Tyco Healthcare Group Lp	Antimicrobial and Anticoagulant Compositions and Methods
JP2012520342A (ja)	2009-03-16	2012-09-06	ジェンメディカ・セラピューティックス・ソシエダッド・リミターダ	代謝障害を処置するのに有用な抗炎症剤および抗酸化剤のコンジュゲート
US8466197B2 (en)	2010-12-14	2013-06-18	Genmedica Therapeutics Sl	Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
GB201021267D0 (en)	2010-12-15	2011-01-26	Reckitt Benckiser Healthcare Int Ltd	Novel pharmaceutical formulation
MY166036A (en) *	2011-07-20	2018-05-21	Hospira Inc	Methods of treating pain
EP2741742A1 (de) *	2011-08-11	2014-06-18	Cross SA	Pharmazeutische zusammensetzung mit einem wirkstoff mit mindestens einer toxophoren funktion und n-acetyl-l-cystein
KR101260636B1 (ko)	2012-11-29	2013-05-13	씨제이제일제당 (주)	안정화된 페메트렉시드 제제
US20140187635A1 (en)	2012-12-28	2014-07-03	Themis Medicare Limited	Diclofenac compositions
US20140275261A1 (en)	2013-03-15	2014-09-18	Dr. Reddy's Laboratories, Inc.	Diclofenac parenteral compositions
KR101485243B1 (ko)	2013-05-08	2015-01-21	씨제이헬스케어 주식회사	안정화된 페메트렉시드 제제
US11110073B2 (en)	2017-03-24	2021-09-07	Cadila Healthcare Limited	Storage stable aqueous injectable solution comprising diclofenac
US20190142789A1 (en) *	2017-08-09	2019-05-16	Piedmont Animal Health, Llc	Therapeutic formulations and uses thereof
US20220280463A1 (en)	2019-09-09	2022-09-08	Ftf Pharma Private Limited	Pharmaceutical formulations comprising diclofenac
US11707443B2 (en)	2019-09-26	2023-07-25	Rk Pharma Inc.	Storage stable aqueous parenteral solutions comprising diclofenac
CN110872942B (zh) *	2019-10-24	2021-09-28	中国石油化工股份有限公司	油藏注采耦合方式下不同作用力对采收率贡献的研究方法

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Publication number	Priority date	Publication date	Assignee	Title
DE3446873A1 (de) *	1984-12-21	1986-07-10	Merckle Gmbh	Fluessige diclofenac-zubereitungen
US5690954A (en) *	1987-05-22	1997-11-25	Danbiosyst Uk Limited	Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
US5389681A (en) *	1992-10-22	1995-02-14	Ciba-Geigy Corporation	Parenteral solutions for diclofenac salts
IL111184A (en) *	1993-10-08	2000-08-13	Farmarc Nederland B V Of Cito	Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin
ZA949182B (en) *	1993-12-02	1995-07-26	South African Druggists Ltd	Pharmaceutical composition
AU3609795A (en) *	1994-10-10	1996-05-02	Novartis Ag	Ophthalmic and aural compositions containing diclofenac potassium
US5821237A (en) *	1995-06-07	1998-10-13	The Procter & Gamble Company	Compositions for visually improving skin
AU5774796A (en) *	1995-06-13	1997-01-09	Dyer, Alison Margaret	Pharmaceutical compositions containing lornoxicam and cyclod extrin
TW434023B (en) *	1995-09-18	2001-05-16	Novartis Ag	Preserved ophthalmic composition
FR2751875B1 (fr) *	1996-08-05	1998-12-24	Scr Newpharm	Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
MXPA01011283A (es) *	1999-05-03	2002-11-04	Battelle Memorial Institute	Composiciones par aerosolizacion e inhalacion.
EP1219304B1 (de) *	2000-12-28	2004-10-20	Fresenius Kabi Austria GmbH	Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung
WO2003063824A2 (en) *	2002-02-01	2003-08-07	Shimoda Biotech (Pty) Ltd	Pharmaceutical composition
JP2005521690A (ja) *	2002-02-22	2005-07-21	ファルマシア・コーポレーション	ゴム系を含む眼科用製剤

2004
- 2004-11-30 DE DE602004025151T patent/DE602004025151D1/de not_active Expired - Lifetime
- 2004-11-30 PL PL04257437T patent/PL1574221T3/pl unknown
- 2004-11-30 ZA ZA200607631A patent/ZA200607631B/xx unknown
- 2004-11-30 US US10/999,155 patent/US20050238674A1/en not_active Abandoned
- 2004-11-30 PT PT07075004T patent/PT1767219E/pt unknown
- 2004-11-30 EP EP04257437A patent/EP1574221B1/de not_active Expired - Lifetime
- 2004-11-30 DK DK07075004.7T patent/DK1767219T3/da active
- 2004-11-30 MX MXPA06010336A patent/MXPA06010336A/es active IP Right Grant
- 2004-11-30 PT PT04257437T patent/PT1574221E/pt unknown
- 2004-11-30 AT AT04257437T patent/ATE364402T1/de active
- 2004-11-30 AT AT07075004T patent/ATE454905T1/de active
- 2004-11-30 PL PL07075004T patent/PL1767219T3/pl unknown
- 2004-11-30 DE DE602004006952T patent/DE602004006952T2/de not_active Expired - Lifetime
- 2004-11-30 DK DK04257437T patent/DK1574221T3/da active
- 2004-11-30 SI SI200431321T patent/SI1767219T1/sl unknown
- 2004-11-30 CA CA2555429A patent/CA2555429C/en not_active Expired - Fee Related
- 2004-11-30 AU AU2004317520A patent/AU2004317520B2/en not_active Ceased
- 2004-11-30 ES ES04257437T patent/ES2287658T3/es not_active Expired - Lifetime
- 2004-11-30 ES ES07075004T patent/ES2336034T3/es not_active Expired - Lifetime
- 2004-11-30 JP JP2007502421A patent/JP2007528384A/ja active Pending
- 2004-11-30 SI SI200430347T patent/SI1574221T1/sl unknown
- 2004-11-30 EP EP07075004A patent/EP1767219B1/de not_active Expired - Lifetime
- 2004-11-30 KR KR1020067018393A patent/KR20070028331A/ko not_active Ceased
- 2004-11-30 WO PCT/IB2004/003918 patent/WO2005092387A1/en not_active Ceased
- 2004-11-30 BR BRPI0418474-2A patent/BRPI0418474A/pt not_active Application Discontinuation
2005
- 2005-03-04 WO PCT/US2005/007354 patent/WO2005086763A2/en not_active Ceased
2006
- 2006-08-16 IL IL177529A patent/IL177529A/en not_active IP Right Cessation
2007
- 2007-08-23 CY CY20071101108T patent/CY1106824T1/el unknown
2008
- 2008-07-04 ZA ZA200805860A patent/ZA200805860B/en unknown
2011
- 2011-06-03 US US13/153,283 patent/US20120142779A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL177529A0 (en)	2006-12-10
US20050238674A1 (en)	2005-10-27
AU2004317520A1 (en)	2005-10-06
ATE454905T1 (de)	2010-01-15
CA2555429C (en)	2010-05-18
ZA200607631B (en)	2008-10-29
EP1767219A3 (de)	2007-04-25
DK1574221T3 (da)	2007-07-16
WO2005092387A1 (en)	2005-10-06
EP1767219B1 (de)	2010-01-13
HK1079118A1 (en)	2006-03-31
JP2007528384A (ja)	2007-10-11
DE602004025151D1 (de)	2010-03-04
AU2004317520B2 (en)	2011-06-09
MXPA06010336A (es)	2007-02-16
US20120142779A1 (en)	2012-06-07
DK1767219T3 (da)	2010-05-10
CA2555429A1 (en)	2005-10-06
ES2336034T3 (es)	2010-04-07
PL1574221T3 (pl)	2007-10-31
DE602004006952D1 (de)	2007-07-26
SI1574221T1 (sl)	2007-10-31
WO2005086763A3 (en)	2006-03-02
EP1767219A2 (de)	2007-03-28
BRPI0418474A (pt)	2007-06-19
PT1574221E (pt)	2007-07-09
SI1767219T1 (sl)	2010-03-31
KR20070028331A (ko)	2007-03-12
EP1574221A1 (de)	2005-09-14
DE602004006952T2 (de)	2008-02-14
PL1767219T3 (pl)	2010-06-30
PT1767219E (pt)	2010-02-15
ES2287658T3 (es)	2007-12-16
CY1106824T1 (el)	2012-05-23
ZA200805860B (en)	2009-05-27
IL177529A (en)	2013-08-29
EP1574221B1 (de)	2007-06-13
WO2005086763A2 (en)	2005-09-22

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2007-10-15

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