NO20071914L - Kontrollert avleveringssystem - Google Patents

Kontrollert avleveringssystem

Info

Publication number
NO20071914L
NO20071914L NO20071914A NO20071914A NO20071914L NO 20071914 L NO20071914 L NO 20071914L NO 20071914 A NO20071914 A NO 20071914A NO 20071914 A NO20071914 A NO 20071914A NO 20071914 L NO20071914 L NO 20071914L
Authority
NO
Norway
Prior art keywords
delivery system
controlled delivery
carrier
anesthetic
administration
Prior art date
Application number
NO20071914A
Other languages
English (en)
Other versions
NO342596B1 (no
Inventor
Adrian Neil Verity
Original Assignee
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corp filed Critical Durect Corp
Publication of NO20071914L publication Critical patent/NO20071914L/no
Publication of NO342596B1 publication Critical patent/NO342596B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Anesthesiology (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Optical Communication System (AREA)
  • Amplifiers (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Detergent Compositions (AREA)
  • Selective Calling Equipment (AREA)

Abstract

Den foreliggende oppfinnelse vedrører hittil ukjente bedøvende sammensetninger inneholdende et ikke-polymerisk bærermateriale og et bedøvelsesmiddel, hvor sammensetningene er passende for å tilveiebringe en vedvarende lokalbedøvelse uten en initiell stor opptreden og som har en varighet i omtrent 24 timer eller lengre. Enkelte sammensetninger tilveiebringes også som innbefatter et første bedøvelsesmiddel og et andre bedøvelsesmiddel. I slike sammensetninger er det andre bedøvelsesmiddelet et løsningsmiddel for det første bedøvelsesmiddelet og tilveiebringer en begynnende bedøvelseseffekt ved administrering til et individ. Den ikke-polymeriske bæreren kan valgfritt være et høyviskositets flytende bærermateriale slik som en passende sukkerester. Sammensetningene kan videre innbefatte en eller flere ytterligere ingredienser inklusive aktive og inaktive materialer. Fremgangsmåter for anvendelse av sammensetningene i henhold til oppfinnelsen for å produsere en vedvarende bedøvelseseffekt ved et sete i et individ tilveiebringes også.
NO20071914A 2004-09-17 2007-04-16 Sammensetninger for vedvarende lokal bedøvelse omfattende bupivacain som et bedøvingsmiddel og sukroseacetatisobutyrat som en bærer NO342596B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61079704P 2004-09-17 2004-09-17
US69139505P 2005-06-17 2005-06-17
PCT/US2005/032863 WO2006033948A2 (en) 2004-09-17 2005-09-15 Sustained local anesthetic composition containing preferably a sugar ester such as saib

Publications (2)

Publication Number Publication Date
NO20071914L true NO20071914L (no) 2007-06-15
NO342596B1 NO342596B1 (no) 2018-06-18

Family

ID=35949130

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071914A NO342596B1 (no) 2004-09-17 2007-04-16 Sammensetninger for vedvarende lokal bedøvelse omfattende bupivacain som et bedøvingsmiddel og sukroseacetatisobutyrat som en bærer

Country Status (25)

Country Link
US (9) US8753665B2 (no)
EP (4) EP1809329B1 (no)
JP (2) JP5285275B2 (no)
KR (2) KR101492361B1 (no)
AT (1) ATE537844T1 (no)
AU (1) AU2005287175B2 (no)
BR (1) BRPI0515372B8 (no)
CA (1) CA2581287C (no)
CY (2) CY1112625T1 (no)
DK (3) DK2767292T3 (no)
EA (2) EA014852B1 (no)
ES (3) ES2602273T3 (no)
GE (1) GEP20094831B (no)
HR (1) HRP20120254T1 (no)
HU (1) HUE032040T2 (no)
IL (1) IL181474A (no)
LT (1) LT2767292T (no)
MX (1) MX2007002962A (no)
NO (1) NO342596B1 (no)
NZ (1) NZ553369A (no)
PL (2) PL1809329T3 (no)
PT (3) PT2767292T (no)
RS (1) RS52198B (no)
SI (2) SI2767292T1 (no)
WO (1) WO2006033948A2 (no)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
DK2767292T3 (en) * 2004-09-17 2016-12-19 Durect Corp RENEWABLE local anesthetic COMPOSITION CONTAINING SAIB
MX2007003968A (es) * 2004-10-01 2008-03-04 Ramscor Inc Composiciones de farmaco de liberacion sostenida convenientemente implantables.
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
AU2007325918B2 (en) 2006-11-03 2013-10-17 Durect Corporation Transdermal delivery systems comprising bupivacaine
SI2139457T1 (sl) * 2007-03-28 2016-09-30 Innocoll Pharmaceutical Limited Naprava za dajanje zdravila za zagotavljanje lokalne analgezije, lokalne anestezije ali živčne blokade
WO2009100222A1 (en) * 2008-02-08 2009-08-13 Qps Llc Non-polymeric compositions for controlled drug delivery
WO2010077732A2 (en) * 2008-12-09 2010-07-08 Aether Medical Llc Implantable analgesic
US9045600B2 (en) 2009-05-13 2015-06-02 Keraplast Technologies, Ltd. Biopolymer materials
CN105748402B (zh) * 2010-11-24 2022-06-03 杜雷科特公司 生物可降解的药物递送组合物
PL3409271T3 (pl) * 2012-05-16 2024-11-18 Orexa B.V. Środki znieczulające miejscowo dla ułatwienia przyjmowania i retencji pokarmu
US9592227B2 (en) 2013-03-15 2017-03-14 Heron Therapeutics, Inc. Compositions of a polyorthoester and an aprotic solvent
CA2913100C (en) * 2013-05-24 2021-10-26 Danmarks Tekniske Universitet Gel formulations for guiding radiotherapy
WO2015088990A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
WO2015123734A1 (en) * 2014-02-21 2015-08-27 The University Of Sydney Liquid carrier materials
CN106535886A (zh) 2014-04-21 2017-03-22 赫伦治疗有限公司 长效聚合物输送系统
EP3509601A1 (en) 2014-04-21 2019-07-17 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
KR20170025011A (ko) 2015-08-27 2017-03-08 고려대학교 산학협력단 통증완화약물의 지속성 방출을 위한 약학적 조성물 및 그 투여를 위한 투여 장치
WO2017193066A1 (en) * 2016-05-05 2017-11-09 Liquidia Technologies, Inc. Precision controlled load and release particles for post-operative pain
CN109310680B (zh) * 2016-06-30 2022-11-01 度瑞公司 长效配制物
US10682340B2 (en) 2016-06-30 2020-06-16 Durect Corporation Depot formulations
CA3048485C (en) * 2016-12-26 2022-07-19 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
KR102248445B1 (ko) * 2017-03-27 2021-05-04 프루티 홀딩스 리미티드 불용성 착물 또는 이의 용매화물, 약제학적 조성물 및 이의 용도
EP3691618A1 (en) 2017-10-06 2020-08-12 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents
RU2674025C1 (ru) * 2017-10-25 2018-12-04 Общество с ограниченной ответственностью "Научно-производственная фирма "ЭЛЕСТ" (ООО "НПФ "ЭЛЕСТ") Лекарственное средство на основе порфиринового фотосенсибилизатора копропорфирина для лечения рака кожи методом фотодинамической терапии
CN116650732A (zh) 2018-01-08 2023-08-29 铸造疗法股份有限公司 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法
US12458589B2 (en) 2018-05-12 2025-11-04 Foundry Therapeutics, Inc. Implantable polymer depots for the controlled release of therapeutic agents
EP3843710A1 (en) 2018-08-28 2021-07-07 Foundry Therapeutics, Inc. Polymer implants
WO2021141956A1 (en) * 2020-01-06 2021-07-15 Pacira Pharmaceuticals, Inc, Treatment of pain associated with cesarean section surgery with sustained-release liposomal anesthetic compositions
WO2021141963A1 (en) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions
WO2021141959A1 (en) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Treatment of pain by administration of sustained-release liposomal anesthetic compositions
WO2021146215A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
US20230190650A1 (en) * 2020-02-25 2023-06-22 The University Of North Carolina At Chapel Hill Eutectic based anesthetic compositions and applications thereof
EP4274573A4 (en) 2021-01-11 2024-12-11 Pacira Pharmaceuticals, Inc. TREATMENT OF HIP PAIN WITH LIPOSOMAL SUSTAINED-RELEASE ANESTHESIA COMPOSITIONS
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods
CN115068414B (zh) * 2021-03-16 2023-07-21 湖南慧泽生物医药科技有限公司 供注射用罗哌卡因长效溶液制剂及其制备方法
EP4308084A4 (en) 2021-03-19 2025-04-23 Pacira Pharmaceuticals, Inc. TREATMENT OF PAIN IN PEDIATRIC PATIENTS BY ADMINISTRATION OF SUSTAINED-RELEASE LIPOSOMAL ANESTHETIC COMPOSITIONS
CN115414324A (zh) * 2021-05-31 2022-12-02 中国科学院过程工程研究所 一种载局部麻醉药的乳剂及其制备方法
CA3249951A1 (en) 2022-01-28 2023-08-03 Rebel Medicine Inc Injectable pharmaceutical compositions for treating pain
US11918565B1 (en) 2022-11-03 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions
US12226610B2 (en) 2022-11-03 2025-02-18 Pacira Pharmaceuticals, Inc. Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions

Family Cites Families (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US556450A (en) * 1896-03-17 Antifriction-bearing
US2931802A (en) * 1958-04-30 1960-04-05 Eastman Kodak Co Mixed esters of glucose and sucrose
GB1088992A (en) 1963-09-19 1967-10-25 Squibb & Sons Inc Protective dressings
US4411890A (en) 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US3743398A (en) * 1971-03-22 1973-07-03 Eastman Kodak Co Motion picture projector
NO139560C (no) 1972-04-29 1979-04-04 Takeda Chemical Industries Ltd Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater
SE7413710L (no) 1973-11-01 1975-05-02 Wellcome Found
DE2438350C3 (de) * 1974-08-09 1979-06-13 Hoechst Ag, 6000 Frankfurt Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2438352A1 (de) 1974-08-09 1976-02-26 Hoechst Ag Peptidcyclopropylamide mit lh-rh/fshrh-wirkung
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
JPS55154991A (en) * 1979-05-23 1980-12-02 Hisamitsu Pharmaceut Co Inc Beta-d-fructopyranoside derivative
NZ194405A (en) * 1979-08-02 1982-05-25 Dut Pty Ltd Producing liquid hydrocarbon streams by hydrogenation of fossil-based feedstock
US4692147A (en) * 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
DE3716302C2 (de) 1987-05-15 1996-02-01 Henkel Kgaa Verbesserte resorbierbare Knochenwachse und ihre Verwendung
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
JPS59210024A (ja) 1983-05-13 1984-11-28 Taiyo Kagaku Kk トコフエロ−ル乳化物
US4622219A (en) 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
US4725442A (en) 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
JPS607418U (ja) 1983-06-28 1985-01-19 株式会社デンソー 歯付スラストワツシヤをもつ軸受装置
US4891225A (en) 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4630019A (en) 1984-09-28 1986-12-16 Westinghouse Electric Corp. Molded case circuit breaker with calibration adjusting means for a bimetal
US4725852A (en) * 1985-05-09 1988-02-16 Burlington Industries, Inc. Random artificially perturbed liquid apparatus and method
US4780320A (en) 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
ES2058111T3 (es) * 1986-06-10 1994-11-01 Euro Celtique Sa Composicion de liberacion controlada de dihidrocodeina.
US4970075A (en) 1986-07-18 1990-11-13 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4861598A (en) * 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
GB8626098D0 (en) * 1986-10-31 1986-12-03 Euro Celtique Sa Controlled release hydromorphone composition
US5234520A (en) 1987-03-20 1993-08-10 Morgan Adhesives Co. Method of making an adhesive construction
US5391381A (en) * 1987-06-25 1995-02-21 Alza Corporation Dispenser capable of delivering plurality of drug units
US4795641A (en) * 1987-08-20 1989-01-03 Eastman Kodak Company Polymer blends having reverse phase morphology for controlled delivery of bioactive agents
US5350741A (en) * 1988-07-30 1994-09-27 Kanji Takada Enteric formulations of physiologically active peptides and proteins
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US4987893A (en) 1988-10-12 1991-01-29 Rochal Industries, Inc. Conformable bandage and coating material
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
GB8926612D0 (en) 1989-11-24 1990-01-17 Erba Farmitalia Pharmaceutical compositions
IT1240643B (it) 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
US5110685A (en) 1990-05-18 1992-05-05 Exxon Chemical Patents, Inc. Low friction, abrasion resistant polymer coating
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
EP0539559A1 (en) 1991-04-03 1993-05-05 Eastman Kodak Company HIGH DURABILITY MASK FOR DRY ETCHING OF GaAs
JP3313124B2 (ja) * 1991-07-31 2002-08-12 森下仁丹株式会社 親水性物質を内容物とするシームレスカプセルおよびその製法
US5487898A (en) * 1991-08-26 1996-01-30 Abbott Laboratories Compositions and method for the sublingual or buccal administration therapeutic agents
IL102857A (en) 1991-08-26 1997-02-18 Abbott Lab Compositions for the sublingual or buccal administration of therapeutic agents which are degraded upon oral administration
IL103275A0 (en) 1991-10-01 1993-02-21 Lilly Co Eli Injectable extended release formulations and methods
YU87892A (sh) 1991-10-01 1995-12-04 Eli Lilly And Company Lilly Corporate Center Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu
AU2605592A (en) 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
DE69230040T2 (de) * 1991-10-21 2000-01-05 Peptech Ltd Biokompatibles implantat für die zeitliche abstimmung der ovulation von stuten
US5266331A (en) 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5656295A (en) * 1991-11-27 1997-08-12 Euro-Celtique, S.A. Controlled release oxycodone compositions
EP0615438B1 (en) 1991-12-05 1996-07-24 Mallinckrodt Veterinary, Inc. A carbohydrate glass matrix for the sustained release of a therapeutic agent
WO1993011754A1 (en) * 1991-12-11 1993-06-24 The Procter & Gamble Company Cetylpyridinium chloride and domiphen bromide in organic solvent
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
ZA932272B (en) * 1992-03-30 1993-10-19 Alza Corp Viscous suspensions of controlled-release drug particles
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
DE69331387T2 (de) 1992-09-10 2002-08-22 Childrens Medical Center Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika
PL174772B1 (pl) 1993-01-06 1998-09-30 Kinerton Ltd Kompozycja farmaceutyczna zawierająca jonowy konjugat cząsteczkowy
US5340572A (en) * 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
DE69405719T2 (de) * 1993-03-17 1998-01-15 Minnesota Mining & Mfg Aerosolzubereitung, enthaltend ein aus einem diol-disäure-derivat abgeleitetes dispergiermittel
KR100321649B1 (ko) * 1993-03-17 2002-07-22 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 에스테르,아미드또는머캅토에스테르로부터유도된분산보조제를함유하는에어로졸제제
DK44193D0 (da) 1993-04-20 1993-04-20 Euromed I S Saarforbinding og klaebemiddel til en saarforbinding eller lignende
IL110014A (en) 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
JP3257750B2 (ja) 1993-07-20 2002-02-18 エチコン・インコーポレーテツド ε−カプロラクトンおよびラクチドの液状コポリマー
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
TW282403B (no) 1993-08-26 1996-08-01 Takeda Pharm Industry Co Ltd
WO1995009613A1 (en) 1993-10-04 1995-04-13 Mark Chasin Controlled release microspheres
DE69431071T2 (de) 1993-12-29 2003-03-20 Matrix Pharma Zusammensetzung für lokale freigabe von zytostatika
EP1125577B1 (en) * 1994-04-08 2006-02-15 QLT USA, Inc. Liquid drug delivery compositions
US5633000A (en) * 1994-06-23 1997-05-27 Axxia Technologies Subcutaneous implant
WO1996009290A1 (en) * 1994-09-23 1996-03-28 Chiroscience Limited Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof
US5599852A (en) 1994-10-18 1997-02-04 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
MX9703025A (es) 1994-10-25 1997-10-31 Chiroscience Ltd Proceso para preparar levobupivacaina y sus analogos.
WO1996012699A1 (en) 1994-10-25 1996-05-02 Chiroscience Limited Crystallisation of levobupivacaine and analogues thereof
US6384227B2 (en) * 1995-01-18 2002-05-07 Darwin Discovery Ltd. Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents
GB9501071D0 (en) 1995-01-18 1995-03-08 Chiroscience Ltd Racemisation
US5968542A (en) * 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US5747058A (en) * 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
EP1525858A1 (en) 1995-06-07 2005-04-27 Durect Corporation High viscosity liquid controlled delivery system
US6413536B1 (en) * 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US5942241A (en) 1995-06-09 1999-08-24 Euro-Celtique, S.A. Formulations and methods for providing prolonged local anesthesia
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
DE69720190T2 (de) 1996-02-02 2003-12-11 Alza Corp Implantierbares system mit verzögerter freisetzung von leuprolid
US6245351B1 (en) * 1996-03-07 2001-06-12 Takeda Chemical Industries, Ltd. Controlled-release composition
AU733867B2 (en) * 1996-06-24 2001-05-31 Euro-Celtique S.A. Methods for providing safe local anesthesia
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US6046187A (en) * 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US5747051A (en) * 1996-09-27 1998-05-05 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing an amide of a hydroxy fatty acid and a retinoid
US6572880B2 (en) 1996-10-24 2003-06-03 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
US6479074B2 (en) 1996-10-24 2002-11-12 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
ATE318580T1 (de) 1996-12-20 2006-03-15 Alza Corp Gelzusammensetzungen und verfahren
US6203813B1 (en) * 1997-01-13 2001-03-20 Lance L. Gooberman Pharmaceutical delivery device and method of preparation therefor
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
DE19714765A1 (de) 1997-04-10 1998-10-15 Merck Patent Gmbh Verwendung von niedermolekularen, oligomeren Estern von alpha-Hydroxysäuren und/oder aromatischen o-Hydroxysäuren in kosmetischen Formulierungen
US5919473A (en) * 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
US5840329A (en) 1997-05-15 1998-11-24 Bioadvances Llc Pulsatile drug delivery system
US6051558A (en) 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
DE69818675T2 (de) 1997-07-29 2004-07-29 Alcon Laboratories, Inc., Fort Worth Galaktomannanpolymere und borat enthaltende augenarzneimittel
BR9814883A (pt) 1997-11-19 2000-10-03 Darwin Discovery Ltd Formulação anestésica
RU2180557C2 (ru) * 1998-06-26 2002-03-20 Казахский Государственный национальный университет им. Аль-Фараби Анестезирующий состав пролонгированного действия
CA2335837A1 (en) 1998-06-29 2000-01-06 Pharmaceuticals Applications Associates, Llc Methods and transdermal compositions for pain relief
US6312717B1 (en) 1998-07-07 2001-11-06 Bristol-Myers Squibb Company Method for treatment of anxiety and depression
DE19858891A1 (de) 1998-12-19 2000-06-21 Merck Patent Gmbh Verbesserte Knochensiegel
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
AU763945B2 (en) * 1999-06-04 2003-08-07 Skyepharma Inc. Oil-core compositions for the sustained release of hydrophobic drugs
AU5025300A (en) 1999-06-18 2001-01-09 Southern Biosystems, Inc. Compositions for controlled release of the hormone gnrh and its analogs
YU43702A (sh) * 1999-12-23 2004-11-25 Pfizer Products Inc. Farmaceutske kompozicije koje obezbeđuju povećanje koncentracije leka
DE50112157D1 (de) 2000-01-11 2007-04-19 Roland Bodmeier Kit zur implantation enthaltend eine trägerphase und ein lösungsmittel
BR0002246A (pt) * 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
JP4361710B2 (ja) * 2000-04-19 2009-11-11 ジェネンテック・インコーポレーテッド 徐放製剤
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
WO2002010436A2 (en) 2000-07-28 2002-02-07 The Brigham And Women's Hospital, Inc. Prognostic classification of breast cancer
FR2814308B1 (fr) * 2000-09-15 2003-03-14 France Telecom Procede de gestion de l'usage d'une ligne de telecommunication et systeme de mise en oeuvre
AU2002227383B2 (en) * 2000-10-30 2004-07-08 Euro-Celtique S.A. Controlled release hydrocodone formulations
US20030152637A1 (en) * 2001-01-25 2003-08-14 Mark Chasin Local anesthetic, and method of use
PT1397155E (pt) * 2001-06-21 2015-12-07 Genentech Inc Formulação de libertação sustentada
ATE507816T1 (de) * 2001-11-14 2011-05-15 Durect Corp Injizierbare depotzusammensetzungen und deren verwendung
FR2838349B1 (fr) 2002-04-15 2004-06-25 Laurence Paris Compositions liquides pour capsules molle a liberation prolongee et leur procede de fabrication
PT2561860T (pt) 2002-05-31 2018-05-08 Titan Pharmaceuticals Inc Dispositivo polimérico implantável para a libertação prolongada de buprenorfina
US20040109893A1 (en) * 2002-06-25 2004-06-10 Guohua Chen Sustained release dosage forms of anesthetics for pain management
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
JP4417039B2 (ja) * 2002-06-28 2010-02-17 太陽化学株式会社 水中油滴型乳化組成物
JP4712380B2 (ja) 2002-07-26 2011-06-29 三笠製薬株式会社 外用剤
EP1575616A2 (en) * 2002-10-25 2005-09-21 Pfizer Products Inc. Novel injectable depot formulations
JP2006505579A (ja) * 2002-10-25 2006-02-16 ファイザー・プロダクツ・インク 懸濁形態でのアリール複素環活性薬物の蓄積製剤
EP2218448B1 (en) * 2002-12-13 2015-09-23 Durect Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
KR20050088196A (ko) 2002-12-19 2005-09-02 알자 코포레이션 안정한 비수성 단일 상 겔 및 이식가능한 장치로부터전달하기 위한 이의 제형
DE10312346A1 (de) 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10322469A1 (de) 2003-05-19 2004-12-16 Bayer Healthcare Ag Heterocyclische Verbindungen
WO2005048742A1 (en) * 2003-11-14 2005-06-02 Eastman Chemical Company Sucrose acetate isobutyrate formulation
US20050106304A1 (en) 2003-11-14 2005-05-19 Cook Phillip M. Sucrose acetate isobutyrate formulation
US20050232876A1 (en) 2004-04-19 2005-10-20 Robin Lynn Minga Skin care compositions
WO2005111993A1 (ja) * 2004-05-14 2005-11-24 Yanmar Co., Ltd. キャビンの制音構造
US20050266087A1 (en) 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
DK2767292T3 (en) * 2004-09-17 2016-12-19 Durect Corp RENEWABLE local anesthetic COMPOSITION CONTAINING SAIB
EP1877077A2 (en) 2005-02-03 2008-01-16 Intarcia Therapeutics, Inc. An implantable interferon-containing device
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
JP5194273B2 (ja) 2007-09-20 2013-05-08 三菱電機株式会社 半導体装置
SE531980C2 (sv) 2008-01-17 2009-09-22 Avtech Sweden Ab Flygstyrningsförfarande samt datorprogram och datorprogramprodukt för att genomföra förfarandet

Also Published As

Publication number Publication date
EA014852B1 (ru) 2011-02-28
IL181474A0 (en) 2007-07-04
SI2767292T1 (sl) 2017-01-31
US20090036490A1 (en) 2009-02-05
EA200700653A1 (ru) 2007-10-26
NZ553369A (en) 2010-11-26
ES2496765T3 (es) 2014-09-19
US20130289069A1 (en) 2013-10-31
MX2007002962A (es) 2008-03-05
HRP20120254T1 (hr) 2012-04-30
SI2415484T1 (sl) 2014-10-30
EP3103477A1 (en) 2016-12-14
BRPI0515372A (pt) 2008-07-22
PL2415484T3 (pl) 2014-11-28
HUE032040T2 (en) 2017-09-28
BRPI0515372B8 (pt) 2021-05-25
US20110009451A1 (en) 2011-01-13
US8153661B2 (en) 2012-04-10
PT2415484E (pt) 2014-09-19
US20160235726A1 (en) 2016-08-18
KR20070059148A (ko) 2007-06-11
JP5285275B2 (ja) 2013-09-11
WO2006033948A2 (en) 2006-03-30
WO2006033948A3 (en) 2006-06-08
EP2767292B1 (en) 2016-08-24
US20080167630A1 (en) 2008-07-10
ES2378671T3 (es) 2012-04-16
US20190231762A1 (en) 2019-08-01
US20180256553A1 (en) 2018-09-13
PT2767292T (pt) 2016-11-23
RS52198B (sr) 2012-10-31
NO342596B1 (no) 2018-06-18
ES2602273T3 (es) 2017-02-20
JP2009073839A (ja) 2009-04-09
EP2767292A1 (en) 2014-08-20
PL1809329T3 (pl) 2012-08-31
ATE537844T1 (de) 2012-01-15
AU2005287175B2 (en) 2011-12-01
US8753665B2 (en) 2014-06-17
EP2415484B1 (en) 2014-06-18
IL181474A (en) 2014-05-28
PT1809329E (pt) 2012-03-29
DK2415484T3 (da) 2014-09-22
US20170216267A1 (en) 2017-08-03
US20150111924A1 (en) 2015-04-23
US8846072B2 (en) 2014-09-30
HK1201437A1 (en) 2015-09-04
JP5285374B2 (ja) 2013-09-11
US8153149B2 (en) 2012-04-10
EP1809329B1 (en) 2011-12-21
KR101492361B1 (ko) 2015-02-11
DK1809329T3 (da) 2012-04-02
CY1118360T1 (el) 2017-06-28
EP1809329A2 (en) 2007-07-25
BRPI0515372B1 (pt) 2020-10-06
KR20130136595A (ko) 2013-12-12
GEP20094831B (en) 2009-11-25
AU2005287175A1 (en) 2006-03-30
CY1112625T1 (el) 2016-02-10
LT2767292T (lt) 2016-12-12
DK2767292T3 (en) 2016-12-19
CA2581287A1 (en) 2006-03-30
EA201001885A1 (ru) 2011-12-30
CA2581287C (en) 2015-08-25
KR101351771B1 (ko) 2014-02-17
JP2008513467A (ja) 2008-05-01
EP2415484A1 (en) 2012-02-08

Similar Documents

Publication Publication Date Title
EA200700653A1 (ru) Система контролируемой доставки
WO2008120207A3 (en) Compositions for nasal delivery
NO20053297D0 (no) Inhaleringsinnretning for transpulmonaer administrering.
EP1909772A4 (en) TRANSDERMAL DRUG FORMULATION
EG24701A (en) Cap for drug delivery devices
WO2007130491A3 (en) Patient customized therapeutic regimens
UA99431C2 (uk) Спосіб збирання пристрою для доставки ліків та пристрій для доставки ліків
EP1611880A3 (en) Pharmaceutical formulations for the safe administration of drugs used in the treatment of drug addiction
EP2219725A4 (en) CUFFS FOR ACTIVE INJECTION
DK1432402T3 (da) Sammensætning til tilförsel af lægemiddelkombinationer
EP1922025A4 (en) MEDICAMENT-FREE IMPLANT
TW200806291A (en) Pharmaceutical formulations
EP1898849A4 (en) NEW PROGRAMS FOR CONTRAZEPTIVE DEVICES WITH CONTROLLED DRUG DELIVERY
EA200501697A1 (ru) Дозируемая форма, содержащая пантопразол в качестве активного ингредиента
ATE526012T1 (de) Pharmazeutische formulierungen von meloxicam
ITMI20041245A1 (it) Composizioni farmaceutiche iniettabnili comprendenti diclofenac sodico e b-ciclodestrina
ZA200802187B (en) Drug delivery system for topical administration
NO20064808L (no) Orale matrixformuleringer med licarbazepin
EA200501565A1 (ru) Предназначенная для перорального приёма лекарственная форма для антагонистов протонного насоса
CY1110717T1 (el) Ενα πρωτοτυπο συστημα χορηγησης φαρμακου για τους αναστολεις αντλιας πρωτονιων και τις διαδικασιες τους
BRPI0509014A (pt) comprimidos desintegráveis que compreendem licarbazepina
IS7383A (is) Skammtaform með stýrða lyflosun til inngjafar
EP4340885A4 (en) BIOMICROBUR PLATFORM FOR THERAPEUTIC DELIVERY
EP1947938A4 (en) MACROCYCLIC FORMULATIONS FOR TRANSMEMBRANAL DRUG DISPERSION
PA8623301A1 (es) Utilizacion de un derivado del pirazol para la preparacion de medicamentos utiles en la prevencion y el tratamiento de las dislipidemias y de enfermedades asociadas con las dislipidemias y/o la obesidad

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees