ATE36466T1 - Verfahren zum erzeugen von koernigem mannitol, geeignet fuer direkte komprimierung. - Google Patents

Verfahren zum erzeugen von koernigem mannitol, geeignet fuer direkte komprimierung.

Info

Publication number
ATE36466T1
ATE36466T1 AT85401933T AT85401933T ATE36466T1 AT E36466 T1 ATE36466 T1 AT E36466T1 AT 85401933 T AT85401933 T AT 85401933T AT 85401933 T AT85401933 T AT 85401933T AT E36466 T1 ATE36466 T1 AT E36466T1
Authority
AT
Austria
Prior art keywords
mannitol
raw material
heating zone
direct compression
extrusion
Prior art date
Application number
AT85401933T
Other languages
English (en)
Inventor
Michel Serpelloni
Patrick Lemay
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roquette Freres filed Critical Roquette Freres
Application granted granted Critical
Publication of ATE36466T1 publication Critical patent/ATE36466T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/26—Hexahydroxylic alcohols
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT85401933T 1984-10-03 1985-10-03 Verfahren zum erzeugen von koernigem mannitol, geeignet fuer direkte komprimierung. ATE36466T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8415212A FR2571046B1 (fr) 1984-10-03 1984-10-03 Procede de preparation de mannitol granulaire directement compressible
EP19850401933 EP0177428B1 (de) 1984-10-03 1985-10-03 Verfahren zum Erzeugen von körnigem Mannitol, geeignet für direkte Komprimierung

Publications (1)

Publication Number Publication Date
ATE36466T1 true ATE36466T1 (de) 1988-09-15

Family

ID=9308323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85401933T ATE36466T1 (de) 1984-10-03 1985-10-03 Verfahren zum erzeugen von koernigem mannitol, geeignet fuer direkte komprimierung.

Country Status (16)

Country Link
US (1) US5160680A (de)
EP (1) EP0177428B1 (de)
JP (1) JPH0643352B2 (de)
KR (1) KR930007408B1 (de)
CN (1) CN1005963B (de)
AT (1) ATE36466T1 (de)
CA (1) CA1272216A (de)
DE (1) DE3564380D1 (de)
DK (1) DK173282B1 (de)
ES (1) ES8700219A1 (de)
FI (1) FI85367C (de)
FR (1) FR2571046B1 (de)
GR (1) GR852391B (de)
IE (1) IE58890B1 (de)
NO (1) NO166707C (de)
PT (1) PT81251B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3522359A1 (de) * 1985-06-22 1987-01-02 Basf Ag Verfahren zum konfektionieren von kristallinen, organischen materialien
BE1002635A6 (nl) * 1988-12-09 1991-04-16 Amylum Nv Werkwijze voor het vervaardigen van een mengsel van zetmeel en polyvinylalcohol en aldus vervaardigd mengsel.
US5811547A (en) * 1992-10-14 1998-09-22 Nippon Shinyaju Co., Ltd. Method for inducing crystalline state transition in medicinal substance
ATE189770T1 (de) * 1992-10-14 2000-03-15 Nippon Shinyaku Co Ltd Verfahren zur verschiebung eines kristallzustandes
FR2710637B1 (fr) * 1993-09-28 1995-12-08 Roquette Freres Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
DE19541242A1 (de) 1995-11-06 1997-05-07 Hoechst Ag Lagerstabile Kunststoffadditive
US6235947B1 (en) * 1997-04-14 2001-05-22 Takeda Chemical Industries, Ltd. D-mannitol and its preparation
CZ333698A3 (cs) 1996-04-16 1999-01-13 Bayer Ag D-mannitol a způsob jeho přípravy
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
EP1128817A1 (de) * 1998-10-27 2001-09-05 Biovail Technologies Ltd Mikropartikel enthaltend peg und/oder peg glycerylestern
US7815937B2 (en) * 1998-10-27 2010-10-19 Biovail Laboratories International Srl Quick dissolve compositions and tablets based thereon
CA2342121C (fr) * 2000-03-29 2010-05-25 Roquette Freres Mannitol pulverulent et son procede de preparation
AU2001273496A1 (en) * 2000-07-24 2002-02-05 Boehringer Ingelheim Pharmaceuticals Inc. Apparatus and method for predicting the suitability of a substance for dry granulation by roller compaction using small sample sizes
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
DE10161402A1 (de) * 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
US8545881B2 (en) * 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
CA2568717C (en) * 2004-06-17 2013-12-10 Cargill Incorporated Steam agglomeration of polyols
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ589750A (en) 2004-10-21 2012-07-27 Aptalis Pharmatech Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
CN101166517B (zh) * 2005-05-10 2012-01-04 诺瓦提斯公司 制备含有可压性差的治疗性化合物的组合物的挤压方法
WO2006122021A1 (en) * 2005-05-10 2006-11-16 Novartis Ag Extrusion process for making compositions with poorly compressible therapeutic compounds
CN100413834C (zh) * 2006-07-11 2008-08-27 广西南宁化学制药有限责任公司 一种可压缩颗粒甘露醇的制备方法
EP2183262A1 (de) * 2007-07-27 2010-05-12 Cargill, Incorporated Mikronisierung von polyolen
SG10201407965XA (en) 2009-12-02 2015-02-27 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them
CN103196284A (zh) * 2013-04-08 2013-07-10 马锡林 制粒式单锥干燥器
FR3038836B1 (fr) 2015-07-17 2017-07-14 Roquette Freres Granules de mannitol pour compression directe
CN110787722A (zh) * 2019-12-01 2020-02-14 浙江华康药业股份有限公司 一种结晶甘露醇干法造粒装置及工艺

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951263A (en) * 1957-10-30 1960-09-06 Heyden Newport Chemical Corp Treatment of polyhydric alcohols
US3341415A (en) * 1964-02-12 1967-09-12 Warner Lambert Pharmaceutical Pharmaceutical tablet excipients of solid particles of a binary solid solution of mannitol with a sugar
US3966857A (en) * 1969-12-31 1976-06-29 Congoleum Industries, Inc. Lubrication of extruded materials
US4133857A (en) * 1975-09-16 1979-01-09 Chisso Corporation Method for producing a granular sorbic acid
JPS5220444A (en) * 1976-06-16 1977-02-16 Matsushita Electric Ind Co Ltd Extinguisher of liquid fuel combustor
JPS5365806A (en) * 1976-11-19 1978-06-12 Nippon Shiryo Kogyo Kk Method of making granular powder of crystalline sugar alcohol
US4302413A (en) * 1978-11-16 1981-11-24 Rogers Corporation Process for preparing extrudable polyimide granules
FR2451357A1 (fr) * 1979-03-16 1980-10-10 Roquette Freres Procede pour la mise sous forme comprimee du sorbitol et produit resultant
GB2054599B (en) * 1979-06-08 1983-03-16 Nat Res Dev Tableting of powder mixtures
DE3049196A1 (de) * 1980-12-24 1982-07-29 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von granulaten aus organischen in form einer schmelze vorliegenden stoffen
DE3245170A1 (de) * 1982-12-07 1984-06-07 Merck Patent Gmbh, 6100 Darmstadt Verbesserter sorbit, verfahren zur herstellung und verwendung
FR2588005B1 (fr) * 1985-10-02 1987-12-11 Roquette Freres Maltitol poudre directement compressible et son procede de preparation

Also Published As

Publication number Publication date
FR2571046A1 (fr) 1986-04-04
FR2571046B1 (fr) 1987-10-16
JPH0643352B2 (ja) 1994-06-08
PT81251A (fr) 1985-11-01
PT81251B (pt) 1987-10-20
CN1005963B (zh) 1989-12-06
ES547529A0 (es) 1986-10-01
GR852391B (de) 1985-12-23
FI85367B (fi) 1991-12-31
FI853843L (fi) 1986-04-04
NO166707C (no) 1991-08-28
EP0177428A1 (de) 1986-04-09
US5160680A (en) 1992-11-03
IE852425L (en) 1986-04-03
CN85108629A (zh) 1986-07-23
FI853843A0 (fi) 1985-10-03
KR930007408B1 (ko) 1993-08-10
JPS61178943A (ja) 1986-08-11
EP0177428B1 (de) 1988-08-17
NO853918L (no) 1986-04-04
DK450585D0 (da) 1985-10-03
FI85367C (fi) 1992-04-10
DE3564380D1 (en) 1988-09-22
CA1272216A (en) 1990-07-31
DK450585A (da) 1986-04-04
NO166707B (no) 1991-05-21
KR860002979A (ko) 1986-05-19
IE58890B1 (en) 1993-12-01
ES8700219A1 (es) 1986-10-01
DK173282B1 (da) 2000-06-05

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time