ATE365026T1 - Mikroporation von gewebe zur verabreichung von bioaktiven substanzen - Google Patents

Mikroporation von gewebe zur verabreichung von bioaktiven substanzen

Info

Publication number
ATE365026T1
ATE365026T1 AT03002035T AT03002035T ATE365026T1 AT E365026 T1 ATE365026 T1 AT E365026T1 AT 03002035 T AT03002035 T AT 03002035T AT 03002035 T AT03002035 T AT 03002035T AT E365026 T1 ATE365026 T1 AT E365026T1
Authority
AT
Austria
Prior art keywords
microporation
permeant
administration
tissue
organism
Prior art date
Application number
AT03002035T
Other languages
English (en)
Inventor
Jonathan A Eppstein
Original Assignee
Altea Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1997/011670 external-priority patent/WO1998000193A1/en
Application filed by Altea Therapeutics Corp filed Critical Altea Therapeutics Corp
Application granted granted Critical
Publication of ATE365026T1 publication Critical patent/ATE365026T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Electrotherapy Devices (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
  • Laser Surgery Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
AT03002035T 1996-12-31 1997-12-30 Mikroporation von gewebe zur verabreichung von bioaktiven substanzen ATE365026T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77841596A 1996-12-31 1996-12-31
PCT/US1997/011670 WO1998000193A1 (en) 1996-07-03 1997-07-03 Multiple mechanical microporation of skin or mucosa

Publications (1)

Publication Number Publication Date
ATE365026T1 true ATE365026T1 (de) 2007-07-15

Family

ID=25113276

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03002035T ATE365026T1 (de) 1996-12-31 1997-12-30 Mikroporation von gewebe zur verabreichung von bioaktiven substanzen

Country Status (9)

Country Link
EP (2) EP0952850A2 (de)
JP (5) JP2001512329A (de)
AT (1) ATE365026T1 (de)
AU (1) AU5623298A (de)
CA (2) CA2276312C (de)
DE (1) DE69737836T2 (de)
DK (1) DK1314400T3 (de)
ES (1) ES2289192T3 (de)
WO (1) WO1998029134A2 (de)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE241405T1 (de) * 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6517532B1 (en) 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
CA2330211A1 (en) * 1998-06-08 1999-12-16 Karel Petrak Formulations for electroporation
DE69939906D1 (de) 1998-07-14 2008-12-24 Altea Therapeutics Corp Transdermale transportvorrichtung zum kontrollierten entfernen von biologischen membranen durch pyrotechnische ladung
EP1148902A1 (de) * 1999-01-22 2001-10-31 PowderJect Research Limited Methode zur steigerung von nadelloser transdermaler medikamentenverabreichung in pulverform
DK1189660T3 (da) 1999-06-08 2006-08-21 Altea Therapeutics Corp Apparat til mikroperforering af biologiske membraner ved hjælp af tyndfilms-vævsgrænseflade-anordninger samt fremgangsmåde til fremstilling deraf
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7113821B1 (en) * 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
JP4868679B2 (ja) * 1999-10-14 2012-02-01 ポーラ化成工業株式会社 エレクトロポーレーション用の組成物
AU2001251349A1 (en) * 2000-04-06 2001-10-23 Sontra Medical, Inc. Method and device for enhanced transdermal drug delivery
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US7141034B2 (en) 2000-06-08 2006-11-28 Altea Therapeutics Corporation Transdermal drug delivery device, method of making same and method of using same
IL137689A0 (en) * 2000-08-03 2001-10-31 L R Res & Dev Ltd System for enhanced chemical debridement
JP5507030B2 (ja) * 2000-09-08 2014-05-28 アルザ・コーポレーシヨン 経路閉鎖を阻害することによる経皮的薬物流動の減少の抑制方法
US7632522B2 (en) 2000-09-28 2009-12-15 Nanocyte Inc. Use of stinging cells/capsules for the delivery of active agents to keratinous substances
EP1379127B1 (de) 2000-09-28 2013-04-17 Nanocyte Inc. Methoden, zusammensetzungen und vorrichtungen unter verwendung von stechzellen/kapseln zur abgabe eines therapeutischen mittels oder eines kosmetischen mittels in ein gewebe
US6882884B1 (en) 2000-10-13 2005-04-19 Soundskin, L.L.C. Process for the stimulation of production of extracellular dermal proteins in human tissue
US6794376B2 (en) * 2000-12-06 2004-09-21 William Beaumont Hospital Methods and compositions for enhancing diffusion of therapeutic agents through tissue
DK1372708T3 (da) 2001-02-13 2008-10-20 Us Gov Sec Army Vaccine til transkutan immunisering mod rejsediarre
JP2004529906A (ja) 2001-03-19 2004-09-30 イオマイ コーポレイシヨン 経皮的免疫賦活
AU2003219805B2 (en) * 2002-02-15 2009-06-04 Eisai Inc. Electroporation methods for introducing bioactive agents into cells
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
EP1519755B1 (de) 2002-03-26 2008-05-07 Nanocyte Inc. Nesselzellen mit expression eines exogenen polynucleotids, das ein therapeutisches, diagnostisches oder kosmetisches mittel kodiert, und diese nesselzellen verwendende verfahren, zusammensetzungen und vorrichtungen oder daraus gewonnene kapseln zur abgabe des therapeutischen, diagnostischen oder kosmetischen mittels in ein gewebe
AU2003226605A1 (en) 2002-04-19 2003-11-03 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
AU2003245573A1 (en) 2002-06-19 2004-01-06 Palomar Medical Technologies, Inc. Method and apparatus for treatment of cutaneous and subcutaneous conditions
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
WO2006111201A1 (en) 2005-04-18 2006-10-26 Pantec Biosolutions Ag Laser microporator
US8834862B2 (en) 2005-04-19 2014-09-16 Nanocyte Inc. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
EP2258441A3 (de) 2005-09-02 2011-09-21 Intercell USA, Inc. Vorrichtungen für die transkutane Abgabe von Vakzinen und transdermale Abgabe von Arzneimitteln
US8346347B2 (en) 2005-09-15 2013-01-01 Palomar Medical Technologies, Inc. Skin optical characterization device
JP4921795B2 (ja) 2006-01-06 2012-04-25 株式会社東芝 超音波薬剤導入装置及び医用画像診断装置
KR101039758B1 (ko) 2006-04-28 2011-06-09 젤티크 애스세틱스, 인코포레이티드. 피하 지질 과다 세포의 개선된 냉각을 위한 치료 장치와함께 사용하기 위한 동결 방지제
US7586957B2 (en) 2006-08-02 2009-09-08 Cynosure, Inc Picosecond laser apparatus and methods for its operation and use
US8192474B2 (en) 2006-09-26 2012-06-05 Zeltiq Aesthetics, Inc. Tissue treatment methods
US20080077201A1 (en) 2006-09-26 2008-03-27 Juniper Medical, Inc. Cooling devices with flexible sensors
US9132031B2 (en) 2006-09-26 2015-09-15 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US20100004582A1 (en) 2006-10-25 2010-01-07 Pantec Biosolutions Ag Wide-Area Parasystemic Treatment of Skin Related Conditions
AU2008208009B2 (en) 2007-01-22 2013-08-15 Passport Technologies, Inc. Transdermal porator and patch system and method for using same
US20080287839A1 (en) 2007-05-18 2008-11-20 Juniper Medical, Inc. Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
EP3488833B1 (de) 2007-08-21 2025-10-22 Zeltiq Aesthetics, Inc. Überwachung der kühlung von subkutanen lipidreichen zellen, z.b. kühlung von fettgewebe
US9037229B2 (en) 2007-10-09 2015-05-19 Syneron Medical Ltd Magnetic patch coupling
US8281675B2 (en) 2007-10-17 2012-10-09 Syneron Medical Ltd Dissolution rate verification
KR101287351B1 (ko) 2007-12-05 2013-07-23 시네론 메디컬 리미티드 피부 치료장치용 캐리어
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
JP5519000B2 (ja) 2009-04-30 2014-06-11 ゼルティック エステティックス インコーポレイテッド 脂肪が豊富な皮下細胞から熱を除去するためのデバイス、システム、及び方法
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
EP2459268B1 (de) 2009-07-30 2013-05-29 Alma Lasers Ltd Sonotrode
US9014799B2 (en) * 2009-10-08 2015-04-21 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including electrically-actuated permeation enhancement
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
CA2787374A1 (en) 2010-01-25 2011-07-28 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associated devices, systems and methods
RU2013105790A (ru) * 2010-07-13 2014-08-20 Скотт МАКНАЛТИ Система, способ и установка для снятия биометрических данных
US8676338B2 (en) 2010-07-20 2014-03-18 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
PL2753352T5 (pl) 2010-09-03 2022-10-17 Valneva Austria Gmbh Izolowany polipeptyd białek toksyny a i toksyny b z c. difficile i jego zastosowania
US10722395B2 (en) 2011-01-25 2020-07-28 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
WO2013158299A1 (en) 2012-04-18 2013-10-24 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
WO2013166162A1 (en) * 2012-05-01 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
EP2973894A2 (de) 2013-03-15 2016-01-20 Cynosure, Inc. Optische picosekunden-strahlungssysteme und verfahren zur verwendung
US10517892B2 (en) * 2013-10-22 2019-12-31 Medtronic Minimed, Inc. Methods and systems for inhibiting foreign-body responses in diabetic patients
ES2974899T3 (es) 2014-01-31 2024-07-02 Zeltiq Aesthetics Inc Composiciones y sistemas de tratamiento para el enfriamiento mejorado de tejido rico en lípidos
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
US11178823B2 (en) 2014-04-07 2021-11-23 Premier Citrus Apz, Llc Systems and methods for using light energy to facilitate penetration of substances in plants
US9265260B1 (en) 2014-04-07 2016-02-23 Gpd Technologies Llc Systems and methods for using light energy to facilitate penetration of substances in plants
US10278334B2 (en) 2014-04-07 2019-05-07 Premier Citrus Apz, Llc Systems and methods for delivering nucleic acids to a plant
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
WO2016054079A1 (en) 2014-09-29 2016-04-07 Zyomed Corp. Systems and methods for blood glucose and other analyte detection and measurement using collision computing
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
US11154418B2 (en) 2015-10-19 2021-10-26 Zeltiq Aesthetics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
AU2015417085B2 (en) * 2015-12-10 2019-07-18 Premier Citrus Apz, Llc Systems and methods for using light energy to facilitate penetration of substances in plants
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
AU2017206118B2 (en) 2016-01-07 2021-09-30 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
US10765552B2 (en) 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
US11191278B2 (en) 2016-03-25 2021-12-07 Premier Citrus Apz, Llc Systems and methods for delivering nucleic acids to a plant
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US10682297B2 (en) 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US10555831B2 (en) 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
KR101929761B1 (ko) * 2017-01-03 2018-12-17 (주)엠큐어 약물주입홀이 형성된 니들모듈
KR101938187B1 (ko) * 2017-01-03 2019-01-14 (주)엠큐어 약물주입홀의 개폐가 가능한 니들모듈
US11439455B2 (en) 2017-03-27 2022-09-13 Novoxel Ltd. System, device and method for intradermal solution delivery
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
CN112042066A (zh) 2018-02-26 2020-12-04 赛诺秀股份有限公司 调q倾腔亚纳秒激光器
CN110604867B (zh) * 2018-06-15 2024-08-02 海创医疗科技(深圳)有限公司 一种超声中频导药仪
CN112789013A (zh) 2018-07-31 2021-05-11 斯尔替克美学股份有限公司 改善肤质的方法、装置和系统
US11622943B2 (en) * 2019-05-10 2023-04-11 Chamkurkishtiah Panduranga Rao System and method for allergen-specific epicutaneous immunotherapy
US12588862B2 (en) * 2019-05-10 2026-03-31 Tepit, Llc System and method for allergen-specific epicutaneous immunotherapy
AU2020275934B2 (en) 2019-05-16 2025-09-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
CN112490602B (zh) * 2020-10-19 2021-09-24 电子科技大学 一种基于多层结构的THz导波调控装置
WO2023161966A1 (en) * 2022-02-24 2023-08-31 Teoresi S.P.A. Device for inducing cell permeability in a portion of tissue by opto-poration
KR102892381B1 (ko) * 2024-08-20 2025-12-02 엘지전자 주식회사 미용장치

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5850905Y2 (ja) * 1981-05-27 1983-11-19 桜アルミ株式会社 温熱治療器
JPS58121943A (ja) * 1982-01-16 1983-07-20 小林　敏男 高周波脱毛装置用脱毛針
JPS6268466A (ja) * 1985-09-24 1987-03-28 大盛商事株式会社 つぼ当て治療器
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US5749847A (en) * 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
DE68925030T2 (de) * 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
JPH04150871A (ja) * 1990-10-12 1992-05-25 Azusa Eng:Kk 流動磁場応用健康用具
IT1244667B (it) * 1991-03-28 1994-08-08 Enea Procedimento di microperforazione laser di cellule.
CA2066963A1 (en) * 1991-05-15 1992-11-16 Norio Daikuzono Laser light irradiation apparatus
US5225282A (en) * 1991-12-13 1993-07-06 Molecular Bioquest, Inc. Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer
JP3368603B2 (ja) * 1992-02-28 2003-01-20 オリンパス光学工業株式会社 遺伝子治療用処置具
EP0637942B1 (de) * 1992-04-24 1999-05-06 Surgical Laser Technologies, Inc. Medizinische vorrichtung
US5342355A (en) * 1992-10-19 1994-08-30 Laser Centers Of America Energy delivering cap element for end of optic fiber conveying laser energy
US5643252A (en) * 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
CA2187023A1 (en) * 1994-04-13 1995-10-26 Steven Andrew Giannos Temporally controlled drug delivery systems
JPH10511008A (ja) * 1994-06-24 1998-10-27 シグナス， インコーポレイテッド 膜透過性制御のための電子電圧パルスを用いた生物学的活性因子のパルス使用送達システム
US5586981A (en) * 1994-08-25 1996-12-24 Xin-Hua Hu Treatment of cutaneous vascular and pigmented lesions
AU5869796A (en) * 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
AU725269B2 (en) * 1995-07-25 2000-10-12 Massachusetts Institute Of Technology Enhanced transdermal transport using ultrasound
ES2536459T3 (es) * 1995-08-29 2015-05-25 Nitto Denko Corporation Microporación de piel humana para administración de fármacos y aplicaciones de supervisión
ATE241405T1 (de) * 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten

Also Published As

Publication number Publication date
JP5657040B2 (ja) 2015-01-21
EP1314400B1 (de) 2007-06-20
EP0952850A2 (de) 1999-11-03
ES2289192T3 (es) 2008-02-01
WO1998029134A3 (en) 1998-10-15
CA2789115C (en) 2014-04-29
JP2013165967A (ja) 2013-08-29
JP2010005425A (ja) 2010-01-14
JP5680685B2 (ja) 2015-03-04
EP1314400A3 (de) 2003-10-15
JP2001512329A (ja) 2001-08-21
DE69737836D1 (de) 2007-08-02
CA2789115A1 (en) 1998-07-09
EP1314400A2 (de) 2003-05-28
JP2008307391A (ja) 2008-12-25
DE69737836T2 (de) 2008-03-06
DK1314400T3 (da) 2007-10-15
WO1998029134A2 (en) 1998-07-09
AU5623298A (en) 1998-07-31
JP2013099586A (ja) 2013-05-23
CA2276312C (en) 2012-11-27
CA2276312A1 (en) 1998-07-09

Similar Documents

Publication Publication Date Title
ATE365026T1 (de) Mikroporation von gewebe zur verabreichung von bioaktiven substanzen
AU3880697A (en) Multiple mechanical microporation of skin or mucosa
DE60126637D1 (de) Mikrostrukturen zur behandlung und aufbereitung der haut
US5445611A (en) Enhancement of transdermal delivery with ultrasound and chemical enhancers
DE60003580D1 (de) MEDIZINISCHE VORRICHTUNG mit nukleinsäurehaltiger synthetischer Oberfläche zur in-vivo Induktion seiner Endothelialisierung
GB2307414A (en) Microporation of human skin for drug delivery and monitoring applications
BR9807816A (pt) Permeação anestésica tópica assistida a laser
ATE449841T1 (de) Mikronadel-einrichtungen und verfahren zur deren herstellung
DE60021403D1 (de) Isoalloxazinderivate zur neutralisierung von biologischen schmutzstoffen
PT994705E (pt) Composicoes terapeuticas e dieteticas contendo acidos gordos essenciais e dissulfuretos bioactivos
WO2004073786A3 (en) Laser ionization therapy system and method
ATE396657T1 (de) Vorrichtung zur myokardialen revaskularisation
ATE254884T1 (de) Biologisch abbaubare vorrichtung
EP1563788A3 (de) Mikroperforation von menschlicher Haut zur Medikamentenverabreichung und Überwachungsanwendungen
FI832672A0 (fi) Medicinskt foerfarande och preparat
DE60033633D1 (de) Kit aus polyakrylamidgel zur herstellung einer kapsel im gewebe eines säugetierorganismus und tierischen allogenen oder xenogenen zellen , zur behandlung von onkologischen krankheiten und der diabetes mellitus
US20050123595A1 (en) Composition for removing tattoos
RU2164404C1 (ru) Способ приготовления состава для талассотерапии
ATE399551T1 (de) Hilfsmittel und methoden zur transdermalen applikation von felodipin
RU2000118745A (ru) Способ лазерной терапии
UA30501A (uk) Спосіб лікування склеродермії у дітей з утягненням в патологічний процес органів шлунково-кишкового тракту

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1314400

Country of ref document: EP