ATE365709T1 - Verfahren zur herstellung von pyrazinverbindungen - Google Patents
Verfahren zur herstellung von pyrazinverbindungenInfo
- Publication number
- ATE365709T1 ATE365709T1 AT01925711T AT01925711T ATE365709T1 AT E365709 T1 ATE365709 T1 AT E365709T1 AT 01925711 T AT01925711 T AT 01925711T AT 01925711 T AT01925711 T AT 01925711T AT E365709 T1 ATE365709 T1 AT E365709T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrazine compounds
- trichlorophenyl
- pyrazine
- producing
- producing pyrazine
- Prior art date
Links
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- NNXUYJFHOVCRSM-UHFFFAOYSA-N 3-(2,3,5-trichlorophenyl)pyrazine-2,6-diamine Chemical compound NC1=NC(N)=CN=C1C1=CC(Cl)=CC(Cl)=C1Cl NNXUYJFHOVCRSM-UHFFFAOYSA-N 0.000 abstract 2
- WQHQDSQKLXQGIM-UHFFFAOYSA-N 2-[[cyano-(2,3,5-trichlorophenyl)methyl]amino]ethanimidamide Chemical compound NC(=N)CNC(C#N)C1=CC(Cl)=CC(Cl)=C1Cl WQHQDSQKLXQGIM-UHFFFAOYSA-N 0.000 abstract 1
- LNJZJDLDXQQJSG-UHFFFAOYSA-N 2-phenylpyrazine Chemical class C1=CC=CC=C1C1=CN=CC=N1 LNJZJDLDXQQJSG-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0010971.0A GB0010971D0 (en) | 2000-05-05 | 2000-05-05 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE365709T1 true ATE365709T1 (de) | 2007-07-15 |
Family
ID=9891108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01925711T ATE365709T1 (de) | 2000-05-05 | 2001-05-02 | Verfahren zur herstellung von pyrazinverbindungen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6803464B2 (de) |
| EP (1) | EP1278721B1 (de) |
| JP (1) | JP2003532702A (de) |
| AT (1) | ATE365709T1 (de) |
| AU (1) | AU2001252395A1 (de) |
| CY (1) | CY1109090T1 (de) |
| DE (1) | DE60129122T2 (de) |
| DK (1) | DK1278721T3 (de) |
| ES (1) | ES2284640T3 (de) |
| GB (1) | GB0010971D0 (de) |
| PT (1) | PT1278721E (de) |
| WO (1) | WO2001085674A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006214454B2 (en) * | 2005-02-15 | 2011-05-19 | Jazz Pharmaceuticals, Inc. | Dosage form and method for sustained release of a substituted pyrazine compound |
| WO2009146112A1 (en) * | 2008-04-02 | 2009-12-03 | University Of Virginia Patent Foundation | Compositions and methods for inhibiting sphingosine kinase |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| JP7553453B2 (ja) | 2019-03-01 | 2024-09-18 | フラメル アイルランド リミテッド | 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物 |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA26473A1 (fr) * | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
| GB9818881D0 (en) * | 1998-08-28 | 1998-10-21 | Glaxo Group Ltd | Compounds |
-
2000
- 2000-05-05 GB GBGB0010971.0A patent/GB0010971D0/en not_active Ceased
-
2001
- 2001-05-02 JP JP2001582275A patent/JP2003532702A/ja active Pending
- 2001-05-02 AU AU2001252395A patent/AU2001252395A1/en not_active Abandoned
- 2001-05-02 DK DK01925711T patent/DK1278721T3/da active
- 2001-05-02 DE DE60129122T patent/DE60129122T2/de not_active Expired - Lifetime
- 2001-05-02 US US10/275,457 patent/US6803464B2/en not_active Expired - Fee Related
- 2001-05-02 ES ES01925711T patent/ES2284640T3/es not_active Expired - Lifetime
- 2001-05-02 AT AT01925711T patent/ATE365709T1/de active
- 2001-05-02 EP EP01925711A patent/EP1278721B1/de not_active Expired - Lifetime
- 2001-05-02 WO PCT/GB2001/001929 patent/WO2001085674A1/en not_active Ceased
- 2001-05-02 PT PT01925711T patent/PT1278721E/pt unknown
-
2007
- 2007-09-25 CY CY20071101230T patent/CY1109090T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60129122T2 (de) | 2007-10-11 |
| DE60129122D1 (de) | 2007-08-09 |
| PT1278721E (pt) | 2007-07-13 |
| ES2284640T3 (es) | 2007-11-16 |
| WO2001085674A1 (en) | 2001-11-15 |
| GB0010971D0 (en) | 2000-06-28 |
| US20030149053A1 (en) | 2003-08-07 |
| AU2001252395A1 (en) | 2001-11-20 |
| US6803464B2 (en) | 2004-10-12 |
| EP1278721A1 (de) | 2003-01-29 |
| CY1109090T1 (el) | 2014-07-02 |
| DK1278721T3 (da) | 2007-10-01 |
| EP1278721B1 (de) | 2007-06-27 |
| JP2003532702A (ja) | 2003-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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