ATE365715T1 - Benzo(f)isoindolderivate mit affinität zum ep4- rezeptor - Google Patents

Benzo(f)isoindolderivate mit affinität zum ep4- rezeptor

Info

Publication number: ATE365715T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; benzo; och; cyclopropyl
Prior art date: 2001-02-09

Application number

AT02712040T

Other languages

English (en)

Inventor

M S Congreve

Gerard Giblin

Andrew Mason

Neil Miller

Susan Roomans

Ann Walker

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-09

Filing date

2002-02-07

Publication date

2007-07-15

2002-02-07 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE365715T1 publication Critical patent/ATE365715T1/de

Links

HDWLTFIPCUUUDU-UHFFFAOYSA-N 2h-benzo[f]isoindole Chemical class C1=CC=CC2=CC3=CNC=C3C=C21 HDWLTFIPCUUUDU-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
-1 2 -cyclopropyl Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
ARFPOOKHKRZHNI-UHFFFAOYSA-N 2-[4-(4,9-diethoxy-3-oxo-1h-benzo[f]isoindol-2-yl)phenyl]acetic acid Chemical compound O=C1C2=C(OCC)C3=CC=CC=C3C(OCC)=C2CN1C1=CC=C(CC(O)=O)C=C1 ARFPOOKHKRZHNI-UHFFFAOYSA-N 0.000 abstract 1
101100274581 Caenorhabditis elegans chc-1 gene Proteins 0.000 abstract 1
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
PQIOSYKVBBWRRI-UHFFFAOYSA-N methylphosphonyl difluoride Chemical group CP(F)(F)=O PQIOSYKVBBWRRI-UHFFFAOYSA-N 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02712040T 2001-02-09 2002-02-07 Benzo(f)isoindolderivate mit affinität zum ep4- rezeptor ATE365715T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0103269.7A GB0103269D0 (en)	2001-02-09	2001-02-09	Napthalene derivatives

Publications (1)

Publication Number	Publication Date
ATE365715T1 true ATE365715T1 (de)	2007-07-15

Family

ID=9908451

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02712040T ATE365715T1 (de)	2001-02-09	2002-02-07	Benzo(f)isoindolderivate mit affinität zum ep4- rezeptor

Country Status (8)

Country	Link
US (3)	US7166631B2 (de)
EP (2)	EP1886993B1 (de)
JP (1)	JP4355495B2 (de)
AT (1)	ATE365715T1 (de)
DE (1)	DE60220890T2 (de)
ES (2)	ES2435778T3 (de)
GB (1)	GB0103269D0 (de)
WO (1)	WO2002064564A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0103269D0 (en) *	2001-02-09	2001-03-28	Glaxo Group Ltd	Napthalene derivatives
ES2584606T3 (es)	2002-10-10	2016-09-28	Ono Pharmaceutical Co., Ltd.	Microesferas que comprenden ONO-1301
WO2006122403A1 (en) *	2005-05-19	2006-11-23	Merck Frosst Canada Ltd.	Quinoline derivatives as ep4 antagonists
UY30121A1 (es)	2006-02-03	2007-08-31	Glaxo Group Ltd	Nuevos compuestos
EA014428B1 (ru) *	2006-02-03	2010-12-30	Глэксо Груп Лимитед	Производные бензоизоиндола для лечения боли
GB0602900D0 (en) *	2006-02-13	2006-03-22	Glaxo Group Ltd	Novel Compounds
US8110681B2 (en) *	2006-03-17	2012-02-07	The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Compounds for the treatment of spinal muscular atrophy and other uses
GB0615111D0 (en) *	2006-07-28	2006-09-06	Glaxo Group Ltd	Novel compounds
GB0615105D0 (en) *	2006-07-28	2006-09-06	Glaxo Group Ltd	Novel compounds
GB0620619D0 (en) *	2006-10-17	2006-11-29	Glaxo Group Ltd	Novel compounds
GB0623203D0 (en) *	2006-11-21	2007-01-03	Glaxo Group Ltd	Novel compounds
AU2007331471C1 (en)	2006-12-15	2013-07-25	Glaxo Group Limited	Benzamide derivatives as EP4 receptor agonists
GB0715463D0 (en) *	2007-08-08	2007-09-19	Glaxo Group Ltd	Novel compounds
GB0721611D0 (en)	2007-11-02	2007-12-12	Glaxo Group Ltd	Novel compounds
EP2913047B1 (de)	2012-10-29	2019-05-08	Cardio Incorporated	Spezifisches therapeutikum für pulmonale erkrankungen
US9968716B2 (en)	2013-10-15	2018-05-15	Ono Pharmaceutical Co., Ltd.	Drug-eluting stent graft
CR20180323A (es)	2015-11-20	2018-08-06	Idorsia Pharmaceuticals Ltd	Derivados de indol n-sustituídos como moduladores de los receptores de pge2
TWI768043B (zh)	2017-05-18	2022-06-21	瑞士商愛杜西亞製藥有限公司	N-取代吲哚衍生物
US11839613B2 (en)	2017-05-18	2023-12-12	Idorsia Pharmaceuticals Ltd	Pyrimidine derivatives as PGE2 receptor modulators
PE20191814A1 (es)	2017-05-18	2019-12-27	Idorsia Pharmaceuticals Ltd	Derivados de pirimidina como moduladores del receptor de pge2
TW201900179A (zh)	2017-05-18	2019-01-01	瑞士商愛杜西亞製藥有限公司	作為pge2受體調節劑之苯并呋喃及苯并噻吩衍生物
KR102612140B1 (ko)	2017-05-18	2023-12-08	이도르시아 파마슈티컬스 리미티드	피리미딘 유도체
CN118388331B (zh) *	2024-05-07	2025-05-16	山东极地医药科技有限公司	一种羟基丙酮的生产工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10265454A (ja)	1997-01-27	1998-10-06	Ono Pharmaceut Co Ltd	３，７−ジチアプロスタン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤
US6043275A (en)	1998-04-16	2000-03-28	Ono Pharmaceutical Co., Ltd.	3,7-dithiaprostanoic acid derivative
TWI249520B (en)	1998-07-15	2006-02-21	Ono Pharmaceutical Co	5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient
US6437146B1 (en)	1998-09-25	2002-08-20	Fujisawa Pharmaceutical Co., Ltd.	Oxazole compounds as prostaglandin e2 agonists or antagonists
JP2002527393A (ja)	1998-10-15	2002-08-27	メルクエンドカムパニーインコーポレーテッド	骨吸収阻害方法
AU6836200A (en)	1999-08-10	2001-03-05	Glaxo Group Limited	Use of ep4 receptor ligands in the treatment of, inter alia, neuropathic pain and colon cancer
GB0031295D0 (en) *	2000-12-21	2001-01-31	Glaxo Group Ltd	Naphthalene derivatives
GB0103269D0 (en) *	2001-02-09	2001-03-28	Glaxo Group Ltd	Napthalene derivatives

2001
- 2001-02-09 GB GBGB0103269.7A patent/GB0103269D0/en not_active Ceased
2002
- 2002-02-07 DE DE60220890T patent/DE60220890T2/de not_active Expired - Lifetime
- 2002-02-07 ES ES07111018T patent/ES2435778T3/es not_active Expired - Lifetime
- 2002-02-07 AT AT02712040T patent/ATE365715T1/de not_active IP Right Cessation
- 2002-02-07 EP EP07111018.3A patent/EP1886993B1/de not_active Expired - Lifetime
- 2002-02-07 WO PCT/GB2002/000522 patent/WO2002064564A1/en not_active Ceased
- 2002-02-07 US US10/467,487 patent/US7166631B2/en not_active Expired - Fee Related
- 2002-02-07 EP EP02712040A patent/EP1368312B1/de not_active Expired - Lifetime
- 2002-02-07 ES ES02712040T patent/ES2288547T3/es not_active Expired - Lifetime
- 2002-02-07 JP JP2002564497A patent/JP4355495B2/ja not_active Expired - Fee Related
2006
- 2006-11-08 US US11/557,511 patent/US20070088068A1/en not_active Abandoned
2008
- 2008-04-30 US US12/111,989 patent/US7732622B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE60220890D1 (de)	2007-08-09
US7166631B2 (en)	2007-01-23
EP1886993B1 (de)	2013-09-18
EP1886993A1 (de)	2008-02-13
EP1368312A1 (de)	2003-12-10
DE60220890T2 (de)	2008-02-28
WO2002064564A1 (en)	2002-08-22
EP1368312B1 (de)	2007-06-27
JP4355495B2 (ja)	2009-11-04
US20050080257A1 (en)	2005-04-14
US20080234358A1 (en)	2008-09-25
US20070088068A1 (en)	2007-04-19
JP2004520400A (ja)	2004-07-08
ES2288547T3 (es)	2008-01-16
GB0103269D0 (en)	2001-03-28
US7732622B2 (en)	2010-06-08
ES2435778T3 (es)	2013-12-23

Legal Events

Date	Code	Title	Description
2007-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE365715T1 (de)	2007-07-15	Benzo(f)isoindolderivate mit affinität zum ep4- rezeptor
FI894066A0 (fi)	1989-08-30	Depressionshaemmande n-substituerade nikotinamidfoereningar.
DK0771794T3 (da)	2006-09-11	Oxygenholdige heterocykliske forbindelser
DE60033964D1 (de)	2007-04-26	Phenoxypropanolamin-derivate, ihre herstellung und therapeutische verwendung
ATE380818T1 (de)	2007-12-15	Piperazine-substituierte aryl-benzodiazepinen und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychose
MXPA01004854A (es)	2005-07-25	Nuevos compuestos de piperazina y piperidina.
FI913614A0 (fi)	1991-07-29	Menetelmä terapeuttisesti käyttökelpoisten N-sulfonyyli-indoliinijohdannaisten valmistamiseksi
DE69230442D1 (de)	2000-01-20	Pyrimidozykloalkanen als angiotensin ii antagonisten.
NO159794C (no)	1989-02-08	Analogifremgangsm te ved fremstilling av terapeutisk virksomme 7-substituerte theofyllinderivater.
ATE95816T1 (de)	1993-10-15	2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung.
CA2589438C (en)	2014-07-22	Treatment of inflammatory bowel disease
WO2001029049A3 (de)	2001-11-01	Imidazolderivate als phosphodiesterase vii-hemmer
DE69201184D1 (de)	1995-02-23	5- Piperazinylalkyl-1,5-Benzothiazepinone verwendbar als Calciumantagonisten.
DE60102106D1 (de)	2004-04-01	Diazacyclooctanverbindungen und ihre therapeutische Verwendung
NO306021B1 (no)	1999-09-06	3-(indol-3-yl)propensyrederivater som NMDA-antagonister
ES2140552T3 (es)	2000-03-01	Derivados indol como inhibidores de la 5-alfa-reductasa-1.
ES2162731B1 (es)	2003-02-16	Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.
AR017500A1 (es)	2001-09-12	Derivados de naftilpiperacin-ftalacinonas
PT1214312E (pt)	2004-08-31	Indoles 5-aminoalquilo e 5-aminocarbonilo substituidos