ATE366259T1 - Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren - Google Patents

Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren

Info

Publication number: ATE366259T1
Authority: AT; Austria
Prior art keywords: peptide; amyloid peptide; group; compounds; amino
Prior art date: 1999-03-04

Application number

AT00916028T

Other languages

English (en)

Inventor

Mark A Findeis

Kathryn Phillips

Gary L Olson

Christopher Self

Original Assignee

Praecis Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-04

Filing date

2000-03-03

Publication date

2007-07-15

2000-03-03 Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE366259T1 publication Critical patent/ATE366259T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
150000008574 D-amino acids Chemical class 0.000 title abstract 4
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title abstract 4
230000006919 peptide aggregation Effects 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title 1
230000001105 regulatory effect Effects 0.000 title 1
125000003368 amide group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 1
229930182819 D-leucine Natural products 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
229930182832 D-phenylalanine Natural products 0.000 abstract 1
KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 abstract 1
229930182831 D-valine Natural products 0.000 abstract 1
230000003942 amyloidogenic effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT00916028T 1999-03-04 2000-03-03 Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren ATE366259T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12273699P	1999-03-04	1999-03-04

Publications (1)

Publication Number	Publication Date
ATE366259T1 true ATE366259T1 (de)	2007-07-15

Family

ID=22404455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00916028T ATE366259T1 (de)	1999-03-04	2000-03-03	Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren

Country Status (19)

Country	Link
US (3)	US6610658B1 (de)
EP (1)	EP1161449B1 (de)
JP (2)	JP2002543043A (de)
KR (1)	KR100771712B1 (de)
CN (1)	CN1279053C (de)
AT (1)	ATE366259T1 (de)
AU (1)	AU781292B2 (de)
BR (1)	BR0008738A (de)
CA (1)	CA2362834C (de)
CY (1)	CY1106899T1 (de)
DE (1)	DE60035412T2 (de)
DK (1)	DK1161449T3 (de)
ES (1)	ES2290023T3 (de)
HK (1)	HK1040722B (de)
NZ (1)	NZ514414A (de)
PT (1)	PT1161449E (de)
RU (1)	RU2260599C2 (de)
WO (1)	WO2000052048A1 (de)
ZA (1)	ZA200107913B (de)

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US7060670B1 (en) *	1999-05-05	2006-06-13	Neurochem (International) Limited	Stereoselective antifibrillogenic peptides and peptidomimetics thereof
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US20020094335A1 (en) *	1999-11-29	2002-07-18	Robert Chalifour	Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
US20070135337A2 (en) *	1999-11-29	2007-06-14	Neurochem (International) Limited	Vaccine for the Prevention and Treatment of Alzheimer's and Amyloid Related Diseases
CA2398567A1 (en) *	2000-02-11	2001-08-16	Praecis Pharmaceuticals Incorporated	Methods for enhancing the bioavailability of a drug
AUPR215700A0 (en) *	2000-12-19	2001-01-25	Fujisawa Pharmaceutical Co., Ltd.	Carboxylic acid compound having cyclopropane ring
DE10117281A1 (de) *	2001-04-06	2002-10-24	Inst Molekulare Biotechnologie	Peptid zur Diagnose und Therapie der Alzheimer-Demenz
US7416730B2 (en)	2002-04-18	2008-08-26	Yeda Research And Development Co. Ltd.	Derivatives of the IL-2 receptor gamma chain, their production and use
NZ541282A (en) *	2002-12-24	2009-02-28	Bellus Health International Ltd	Therapeutic formulations for the treatment of beta-amyloid related diseases
CN100340599C (zh) *	2003-06-09	2007-10-03	湖南大学	多聚赖氨酸淀粉纳米颗粒与制备方法及作为基因载体的应用
EP1664793B9 (de) *	2003-08-12	2008-07-16	The Institute for Ethnomedicine	Neurotoxische aminosäure oder neurotoxisches derivat davon im zusammenhang mit neurologischen störungen
GB0503434D0 (en) *	2005-02-18	2005-03-30	Senexis Ltd	Amyloid-binding peptides, analogues and uses thereof
NZ568241A (en) *	2005-12-12	2011-08-26	Hoffmann La Roche	Antibodies against amyloid beta 4 with glycosylation in the variable region
AU2008215948A1 (en)	2007-02-12	2008-08-21	Merck & Co., Inc.	Piperazine derivatives for treatment of AD and related conditions
RU2372355C1 (ru) *	2008-06-27	2009-11-10	Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН	Пептид, обладающий защитным действием против болезни альцгеймера
DE102008037564A1 (de) *	2008-11-19	2010-05-20	Forschungszentrum Jülich GmbH	Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden
EP3660510A3 (de) *	2009-12-07	2020-07-08	Pieris Pharmaceuticals GmbH	Muteine von humanem lipocalin 2 (lcn2, hngal) mit affinität für ein bestimmtes zielmolekül
JP2014529630A (ja)	2011-09-07	2014-11-13	ザウラー−ブロシュ、ローラント	哺乳類の消化管における一つあるいは複数の物質の放出制御製剤
US10653631B2 (en)	2011-09-07	2020-05-19	Roland SAUR-BROSCH	Optimal colon targeting technology
KR101437354B1 (ko) *	2012-07-27	2014-09-05	한국과학기술연구원	고수율 및 고순도의 아밀로이드-베타 펩타이드의 제조방법
KR20230128606A (ko) *	2022-02-28	2023-09-05	경상국립대학교산학협력단	티로신을 유효성분으로 함유하는 알츠하이머병의 예방, 개선 또는 치료용 조성물
EP4534546A1 (de) *	2022-05-27	2025-04-09	Zincure Corp.	Neuartiges peptid und verwendung davon
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US6303567B1 (en) *	1995-03-14	2001-10-16	Praecis Pharmaceuticals, Inc .	Modulators of β-amyloid peptide aggregation comprising D-amino acids
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US5985242A (en)	1995-10-27	1999-11-16	Praecis Pharmaceuticals, Inc.	Modulators of β-amyloid peptide aggregation comprising D-amino acids
US6277826B1 (en) *	1996-08-27	2001-08-21	Praecis Pharmaceuticals, Inc.	Modulators of β-amyloid peptide aggregation comprising D-amino acids
EP0866805A1 (de) *	1995-12-12	1998-09-30	Karolinska Innovations AB	Peptide, das die KLVFF Sequenz von beta-Amyloid bindet
DE69733655T2 (de) *	1996-08-27	2006-04-27	Praecis Pharmaceuticals, Inc., Cambridge	beta-AMYLOID PEPTIDAGGREGATION REGULIERENDE PEPTIDE MIT D-AMINOSÄUREN
NZ514414A (en)	1999-03-04	2004-02-27	Praecis Pharm Inc	Modulators of beta-amyloid peptide aggregation comprising D-amino acids

2000
- 2000-03-03 NZ NZ514414A patent/NZ514414A/xx unknown
- 2000-03-03 US US09/519,019 patent/US6610658B1/en not_active Expired - Fee Related
- 2000-03-03 ES ES00916028T patent/ES2290023T3/es not_active Expired - Lifetime
- 2000-03-03 EP EP00916028A patent/EP1161449B1/de not_active Expired - Lifetime
- 2000-03-03 AU AU37196/00A patent/AU781292B2/en not_active Ceased
- 2000-03-03 AT AT00916028T patent/ATE366259T1/de not_active IP Right Cessation
- 2000-03-03 WO PCT/US2000/005574 patent/WO2000052048A1/en not_active Ceased
- 2000-03-03 CN CNB008071926A patent/CN1279053C/zh not_active Expired - Fee Related
- 2000-03-03 JP JP2000602272A patent/JP2002543043A/ja active Pending
- 2000-03-03 CA CA002362834A patent/CA2362834C/en not_active Expired - Fee Related
- 2000-03-03 DE DE60035412T patent/DE60035412T2/de not_active Expired - Lifetime
- 2000-03-03 DK DK00916028T patent/DK1161449T3/da active
- 2000-03-03 PT PT00916028T patent/PT1161449E/pt unknown
- 2000-03-03 HK HK02102235.9A patent/HK1040722B/en not_active IP Right Cessation
- 2000-03-03 RU RU2001127246/04A patent/RU2260599C2/ru active
- 2000-03-03 KR KR1020017011038A patent/KR100771712B1/ko not_active Expired - Fee Related
- 2000-03-03 BR BR0008738-6A patent/BR0008738A/pt not_active Application Discontinuation
2001
- 2001-09-26 ZA ZA200107913A patent/ZA200107913B/xx unknown
2003
- 2003-03-24 US US10/395,290 patent/US6831066B2/en not_active Expired - Fee Related
2004
- 2004-11-15 US US10/989,763 patent/US7803774B2/en not_active Expired - Fee Related
2007
- 2007-10-02 CY CY20071101254T patent/CY1106899T1/el unknown
2010
- 2010-12-24 JP JP2010287097A patent/JP2011121952A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
BR0008738A (pt)	2001-12-26
ZA200107913B (en)	2002-11-27
HK1040722A1 (en)	2002-06-21
HK1040722B (en)	2008-02-22
AU781292B2 (en)	2005-05-12
NZ514414A (en)	2004-02-27
US7803774B2 (en)	2010-09-28
DE60035412D1 (de)	2007-08-16
CN1362967A (zh)	2002-08-07
KR100771712B1 (ko)	2007-10-30
US20050137128A1 (en)	2005-06-23
CN1279053C (zh)	2006-10-11
CA2362834C (en)	2005-12-06
EP1161449A1 (de)	2001-12-12
WO2000052048A1 (en)	2000-09-08
CY1106899T1 (el)	2012-09-26
PT1161449E (pt)	2007-10-12
US6610658B1 (en)	2003-08-26
ES2290023T3 (es)	2008-02-16
KR20020007316A (ko)	2002-01-26
DE60035412T2 (de)	2008-02-14
CA2362834A1 (en)	2000-09-08
WO2000052048A9 (en)	2002-04-11
US20030236197A1 (en)	2003-12-25
EP1161449B1 (de)	2007-07-04
RU2260599C2 (ru)	2005-09-20
JP2002543043A (ja)	2002-12-17
AU3719600A (en)	2000-09-21
US6831066B2 (en)	2004-12-14
DK1161449T3 (da)	2007-11-05
JP2011121952A (ja)	2011-06-23

Legal Events

Date	Code	Title	Description
2010-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE366259T1 (de)	2007-07-15	Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren
ATE298765T1 (de)	2005-07-15	Beta-amyloid peptidaggregation regulierende peptide mit d-aminosäuren
DK1521774T3 (da)	2008-10-27	Trunkerede Tau-proteiner
DE69713112D1 (de)	2002-07-11	Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidin-analogen
EP2036924A3 (de)	2010-02-24	Gen-regulierende Peptide
AU2672900A (en)	2000-11-10	Neuronal exocytosis inhibiting peptides and cosmetic and pharmaceutical compositions containing said peptides
DE60041119D1 (de)	2009-01-29	Verfahren zur präsentation von (poly)peptiden/proteinen auf bakteriophagenpartikeln via disulfidbindungen
WO2005060683A3 (en)	2007-04-12	Small peptides for the treatment of alzheimer’s disease and other beta-amyloid protein fibrillogenesis disorders
NO920671D0 (no)	1992-02-20	Fremgangsmaate for aktivering av rekombinante proteiner
PT896615E (pt)	2003-01-31	Peptido proveniente de uma forma soluvel de acetilcolinesterase activo como modulador dos canais de calcio
ATE245433T1 (de)	2003-08-15	Verwendung von lipopeptiden oder lipoproteinen zur wundbehandlung
DE60039049D1 (de)	2008-07-10	Erhöhte expression von proteinen mittels gfp
EP1499349A4 (de)	2005-11-16	Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens
DE69413637D1 (de)	1998-11-05	Verwendung von verzweigtkettigen Aminosäuren zur Herstellung eines Arzneimittels zur Behandlung von tardiver Dyskinesia
EP1870419A3 (de)	2008-01-02	Modulatoren der Beta-Amyloid-Peptid-Aggregation mit D-Aminosäuren
ATE346091T1 (de)	2006-12-15	Neues diagnostisches reagens und kit zur erkennung von rickettsiose
AR026068A1 (es)	2002-12-26	Peptidos modificados y peptidomimeticos para el uso en inmunoterapia.
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