ES2097368T3 - Nuevas proteinas inhibidoras de trombina a partir de sanguijuelas terrestres. - Google Patents

Nuevas proteinas inhibidoras de trombina a partir de sanguijuelas terrestres.

Info

Publication number
ES2097368T3
ES2097368T3 ES92924598T ES92924598T ES2097368T3 ES 2097368 T3 ES2097368 T3 ES 2097368T3 ES 92924598 T ES92924598 T ES 92924598T ES 92924598 T ES92924598 T ES 92924598T ES 2097368 T3 ES2097368 T3 ES 2097368T3
Authority
ES
Spain
Prior art keywords
glu
gly
cys
asp
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92924598T
Other languages
English (en)
Inventor
Karl-Hermann Strube
Siegfried Bialojan
Burkhard Kroeger
Thomas Friedrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2097368T3 publication Critical patent/ES2097368T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBEN NUEVAS PROTEINAS INHIBIDORAS DE TROMBINA OBTENIDAS A PARTIR DE SANGUIJUELAS TERRESTRES DE LA ESPECIE HAEMADIPSA Y CON LA SECUENCIA DE AMINOACIDOS ILE VAL PHE ENTO TERMINAL C DE LA SECUENCIA INDICADA POR MEDIO DE 1 HASTA 12 AMINOACIDOS. LAS PROTEINAS SON ADECUADAS PARA SU UTILIZACION CONTRA ENFERMEDADES. SE DESCRIBE TAMBIEN LA CODIFICACION DE ACIDOS NUCLEICOS PARA ESTAS PROTEINAS.
ES92924598T 1991-11-26 1992-11-19 Nuevas proteinas inhibidoras de trombina a partir de sanguijuelas terrestres. Expired - Lifetime ES2097368T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4138698 1991-11-26
DE4209110A DE4209110A1 (de) 1991-11-26 1992-03-20 Neue thrombininhibitorische proteine aus landblutegeln

Publications (1)

Publication Number Publication Date
ES2097368T3 true ES2097368T3 (es) 1997-04-01

Family

ID=25909466

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92924598T Expired - Lifetime ES2097368T3 (es) 1991-11-26 1992-11-19 Nuevas proteinas inhibidoras de trombina a partir de sanguijuelas terrestres.

Country Status (10)

Country Link
US (1) US5455181A (es)
EP (1) EP0616642B1 (es)
JP (1) JP3290661B2 (es)
AT (1) ATE148744T1 (es)
CA (1) CA2121601A1 (es)
DE (2) DE4209110A1 (es)
DK (1) DK0616642T3 (es)
ES (1) ES2097368T3 (es)
MX (1) MX9206732A (es)
WO (1) WO1993011239A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4234921A1 (de) * 1992-10-16 1994-04-21 Basf Ag Neues, die Gerinnungszeit des Blutes verlängerndes Protein aus dem Landblutegel Haemadipsa sylestris
ATE480561T1 (de) 2004-10-19 2010-09-15 Lonza Ag Verfahren zur festphasen-peptidsynthese
JP2009510105A (ja) * 2005-09-28 2009-03-12 バイオバスキュラー インコーポレーティッド 血小板および細胞の接着、細胞移動、および炎症を阻止するための方法および組成物
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US8784896B2 (en) 2012-09-17 2014-07-22 Biopep Solutions, Inc Antioxidant therapy with a whole, leech saliva extract
CN105732789A (zh) * 2016-03-03 2016-07-06 中国科学院昆明动物研究所 森林山蛭镇痛肽mh2620及其基因和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3583361D1 (de) * 1984-06-14 1991-08-08 Ucp Gen Pharma Ag Verfahren zur herstellung von thrombin-inhibitoren.

Also Published As

Publication number Publication date
EP0616642A1 (de) 1994-09-28
JP3290661B2 (ja) 2002-06-10
CA2121601A1 (en) 1993-06-10
DE59208025D1 (de) 1997-03-20
MX9206732A (es) 1993-05-01
DE4209110A1 (de) 1993-05-27
DK0616642T3 (da) 1997-07-07
JPH07501529A (ja) 1995-02-16
WO1993011239A1 (de) 1993-06-10
EP0616642B1 (de) 1997-02-05
US5455181A (en) 1995-10-03
ATE148744T1 (de) 1997-02-15

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