ATE36645T1 - METHOD OF FREEZE DRYING OF LIQUIDS AND ITS APPLICATION. - Google Patents
METHOD OF FREEZE DRYING OF LIQUIDS AND ITS APPLICATION.Info
- Publication number
- ATE36645T1 ATE36645T1 AT82400943T AT82400943T ATE36645T1 AT E36645 T1 ATE36645 T1 AT E36645T1 AT 82400943 T AT82400943 T AT 82400943T AT 82400943 T AT82400943 T AT 82400943T AT E36645 T1 ATE36645 T1 AT E36645T1
- Authority
- AT
- Austria
- Prior art keywords
- liquid
- container
- neck
- wall
- utilization
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title abstract 10
- 238000004108 freeze drying Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000003750 conditioning effect Effects 0.000 abstract 3
- 230000001143 conditioned effect Effects 0.000 abstract 1
- 238000007599 discharging Methods 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 230000008022 sublimation Effects 0.000 abstract 1
- 238000000859 sublimation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Drying Of Solid Materials (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Abstract
1. Method of conditioning and utilization of a liquid involving its lyophilization, wherein : - in order to contain the liquid in the conditioning stage and in the utilization stage, there is employed one and the same container constructed in the form of a flexible bag having a first and a second wall (1) bonded along their external contour (82) so as to form an envelope and a rigid neck (6) which extends through said envelope in leak-tight manner, thus forming an opening of the bag ; - in the conditioning stage : the liquid container is partially filled with liquid, the container is placed in a substantially horizontal position on a support of the lyophilization device in such a manner as to ensure that a first wall and the neck are in contact with said support, the two walls being maintained in relatively spaced relation solely by the neck in the vicinity of this latter, said second wall is lifted in its remaining non-spaced portion so as to ensure that the liquid which rests substantially on said first wall has a free surface which is not in contact with the second wall, the liquid is cooled to freezing point, it is reheated in a vacuum while discharging through the neck the steam extracted by sublimation of the frozen product, the opening of the neck is hermetically sealed-off, said container is stored until direct utilization of the conditioned liquid ; - and in the utilization stage : the liquid is reconstituted by injecting water into the container without impairing leak-tightness, the reconstituted liquid is withdrawn from said container.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8110069A FR2506264A1 (en) | 1981-05-20 | 1981-05-20 | FLEXIBLE POUCH CONTAINER FOR LYOPHILIZING LIQUID AND METHOD OF USE |
| EP82400943A EP0065469B1 (en) | 1981-05-20 | 1982-05-19 | Method for preparation of a liquid to be lyophilized and use of said liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE36645T1 true ATE36645T1 (en) | 1988-09-15 |
Family
ID=9258695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82400943T ATE36645T1 (en) | 1981-05-20 | 1982-05-19 | METHOD OF FREEZE DRYING OF LIQUIDS AND ITS APPLICATION. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0065469B1 (en) |
| AT (1) | ATE36645T1 (en) |
| DE (1) | DE3278928D1 (en) |
| FR (1) | FR2506264A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973327A (en) * | 1989-11-01 | 1990-11-27 | Cryopharm | Blood bag for lyophilization |
| DE4405965C2 (en) * | 1994-02-24 | 1997-08-07 | Bernd Hansen | Infusion container with two connections |
| US5871110A (en) * | 1996-09-13 | 1999-02-16 | Grimard; Jean-Pierre | Transfer assembly for a medicament container having a splashless valve |
| US5925029A (en) * | 1997-09-25 | 1999-07-20 | Becton, Dickinson And Company | Method and apparatus for fixing a connector assembly onto a vial with a crimp cap |
| US6090093A (en) * | 1997-09-25 | 2000-07-18 | Becton Dickinson And Company | Connector assembly for a vial having a flexible collar |
| US6213994B1 (en) | 1997-09-25 | 2001-04-10 | Becton Dickinson France, S.A. | Method and apparatus for fixing a connector assembly onto a vial |
| US6681946B1 (en) | 1998-02-26 | 2004-01-27 | Becton, Dickinson And Company | Resealable medical transfer set |
| US6382442B1 (en) | 1998-04-20 | 2002-05-07 | Becton Dickinson And Company | Plastic closure for vials and other medical containers |
| US6003566A (en) * | 1998-02-26 | 1999-12-21 | Becton Dickinson And Company | Vial transferset and method |
| US6957745B2 (en) | 1998-04-20 | 2005-10-25 | Becton, Dickinson And Company | Transfer set |
| US6378714B1 (en) | 1998-04-20 | 2002-04-30 | Becton Dickinson And Company | Transferset for vials and other medical containers |
| GB2361709A (en) * | 2000-04-26 | 2001-10-31 | Moorlodge Biotech Ventures Ltd | Vessel for transporting micro organisms |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2642866A (en) * | 1951-02-03 | 1953-06-23 | Arthur F Smith | Blood container and method of making the same |
| CH323689A (en) * | 1953-07-31 | 1957-08-15 | Antoine Rieutord Louis Marie | Process for controlling the desiccation of a vacuum body and device for implementing this process |
| GB730148A (en) * | 1953-08-04 | 1955-05-18 | Armour & Co | Improvements in or relating to closures for lyophilization containers |
| GB1428373A (en) * | 1972-06-12 | 1976-03-17 | Smith & Nephew Res | Containers |
| DE2437788A1 (en) * | 1974-08-06 | 1976-03-04 | Behringwerke Ag | METHOD OF MANUFACTURING A STERILE SEALED CONTAINER WITH FREEZE-DRIED MATERIAL |
| FR2284842A1 (en) * | 1974-09-11 | 1976-04-09 | Nestle Sa | IMPROVEMENT PROVIDES LYOPHILIZATION OF SOLID, LIQUID OR PASTE PRODUCTS |
| JPS5841964Y2 (en) * | 1979-05-18 | 1983-09-22 | テルモ株式会社 | plastic pharmaceutical liquid containers |
-
1981
- 1981-05-20 FR FR8110069A patent/FR2506264A1/en active Granted
-
1982
- 1982-05-19 DE DE8282400943T patent/DE3278928D1/en not_active Expired
- 1982-05-19 AT AT82400943T patent/ATE36645T1/en not_active IP Right Cessation
- 1982-05-19 EP EP82400943A patent/EP0065469B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0065469A3 (en) | 1983-06-22 |
| FR2506264A1 (en) | 1982-11-26 |
| EP0065469A2 (en) | 1982-11-24 |
| EP0065469B1 (en) | 1988-08-24 |
| DE3278928D1 (en) | 1988-09-29 |
| FR2506264B1 (en) | 1985-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |