ATE366727T1 - Diaryl-1,2,4-triazolderivate als hochselektive cyclooxygenase-2-inhibitoren - Google Patents

Diaryl-1,2,4-triazolderivate als hochselektive cyclooxygenase-2-inhibitoren

Info

Publication number
ATE366727T1
ATE366727T1 AT02793527T AT02793527T ATE366727T1 AT E366727 T1 ATE366727 T1 AT E366727T1 AT 02793527 T AT02793527 T AT 02793527T AT 02793527 T AT02793527 T AT 02793527T AT E366727 T1 ATE366727 T1 AT E366727T1
Authority
AT
Austria
Prior art keywords
sub
diaryl
highly selective
inhibitors
selective cyclooxygenase
Prior art date
Application number
AT02793527T
Other languages
English (en)
Inventor
Il-Hwan Cho
Jee-Woong Lim
J Noh
J Kim
S Park
Hyung-Chul Ryu
Je-Hak Kim
So-Young Wang
Dal-Hyun Kim
C Lyu
Original Assignee
Cj Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Corp filed Critical Cj Corp
Application granted granted Critical
Publication of ATE366727T1 publication Critical patent/ATE366727T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Detergent Compositions (AREA)
AT02793527T 2001-12-28 2002-12-27 Diaryl-1,2,4-triazolderivate als hochselektive cyclooxygenase-2-inhibitoren ATE366727T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020010086698A KR100686537B1 (ko) 2001-12-28 2001-12-28 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체

Publications (1)

Publication Number Publication Date
ATE366727T1 true ATE366727T1 (de) 2007-08-15

Family

ID=19717755

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02793527T ATE366727T1 (de) 2001-12-28 2002-12-27 Diaryl-1,2,4-triazolderivate als hochselektive cyclooxygenase-2-inhibitoren

Country Status (10)

Country Link
US (2) US7169929B2 (de)
EP (1) EP1458706B1 (de)
JP (1) JP4242286B2 (de)
KR (1) KR100686537B1 (de)
CN (1) CN1290842C (de)
AT (1) ATE366727T1 (de)
AU (1) AU2002359985A1 (de)
DE (1) DE60221152T2 (de)
ES (1) ES2286321T3 (de)
WO (1) WO2003055875A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491317B1 (ko) * 2002-11-26 2005-05-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470076B1 (ko) * 2002-11-27 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100576343B1 (ko) * 2004-07-22 2006-05-03 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
WO2006124687A1 (en) * 2005-05-12 2006-11-23 University Of Medicine And Dentistry Of New Jersey Opioid receptor subtype-selective agents
CN102464652B (zh) 2010-11-02 2013-08-28 北京欧博方医药科技有限公司 咪唑衍生物、制备方法及用途
KR101893624B1 (ko) * 2010-11-26 2018-08-30 가부시키가이샤 한도오따이 에네루기 켄큐쇼 유기금속 착물, 발광 엘리먼트, 발광 디바이스, 전자 디바이스 및 조명 디바이스

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US125368A (en) * 1872-04-02 Improvement in railway rails
US75507A (en) * 1868-03-17 ingk adams
DE69633566T2 (de) * 1995-07-21 2005-12-08 Savvipharm Inc. Orotatsalze von 5-amino- oder substituierten amino-1,2,3-triazolen zur behandlung von neoplasmen
BR9713522A (pt) * 1996-11-19 2000-03-21 Searle & Co Método de uso de inibidores da cicloxigenase-2 como agentes antiangiogênicos.
EE200300169A (et) * 1997-04-18 2003-06-16 G.D. Searle & Co. Tsüklooksügenaas-2 inhibiitorite kasutamise meetod südame-veresoonkonna haiguste ärahoidmiseks
TW438784B (en) * 1997-08-29 2001-06-07 Ssp Co Ltd Triazole derivative or salt thereof and pharmaceutical composition for treating mycosis containing the same
DK1032575T3 (da) 1997-09-05 2003-10-20 Glaxo Group Ltd 2,3-diaryl-pyrazol(1,5-b)pyridazinderivater, deres fremstilling og anvendelse som cyclooxygenase 2 (COX-2) inhibitor
EP1099695A1 (de) * 1999-11-09 2001-05-16 Laboratoire Theramex S.A. 5-Aryl-1H-1,2,4-triazolverbindungen als Cyclooxygenase-2 Inhibitoren und diese enthaltende pharmazeutische Zusammensetzungen
OA12100A (en) * 1999-12-03 2006-05-04 Pfizer Prod Inc Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents.
EP1142889A1 (de) * 2000-04-03 2001-10-10 Pfizer Products Inc. Pyrazolderivate als entzündungs-/schmerzhemmende Mittel
DE60204633T2 (de) * 2001-07-05 2006-06-14 Pfizer Prod Inc Sulfonyl-Heteroaryl-Triazole als entzündungshemmende und analgetische Mittel
CA2390181A1 (en) * 2001-07-05 2003-01-05 Andrei Shavnya Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents
KR100467668B1 (ko) * 2002-08-07 2005-01-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물

Also Published As

Publication number Publication date
US7135572B2 (en) 2006-11-14
CN1290842C (zh) 2006-12-20
DE60221152D1 (en) 2007-08-23
JP4242286B2 (ja) 2009-03-25
DE60221152T2 (de) 2008-03-20
US7169929B2 (en) 2007-01-30
ES2286321T3 (es) 2007-12-01
WO2003055875A1 (en) 2003-07-10
KR100686537B1 (ko) 2007-02-27
EP1458706A4 (de) 2005-06-08
EP1458706A1 (de) 2004-09-22
AU2002359985A1 (en) 2003-07-15
US20050075373A1 (en) 2005-04-07
JP2005518396A (ja) 2005-06-23
EP1458706B1 (de) 2007-07-11
US20060009495A1 (en) 2006-01-12
CN1608060A (zh) 2005-04-20
KR20030056481A (ko) 2003-07-04

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