ATE374765T1 - Substituierte heterocyclische amide - Google Patents
Substituierte heterocyclische amideInfo
- Publication number
- ATE374765T1 ATE374765T1 AT01958825T AT01958825T ATE374765T1 AT E374765 T1 ATE374765 T1 AT E374765T1 AT 01958825 T AT01958825 T AT 01958825T AT 01958825 T AT01958825 T AT 01958825T AT E374765 T1 ATE374765 T1 AT E374765T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted heterocyclic
- heterocyclic amides
- amides
- inhibitor
- factor
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22109200P | 2000-07-27 | 2000-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE374765T1 true ATE374765T1 (de) | 2007-10-15 |
Family
ID=22826311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01958825T ATE374765T1 (de) | 2000-07-27 | 2001-07-18 | Substituierte heterocyclische amide |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7160878B2 (de) |
| EP (1) | EP1307444B1 (de) |
| AT (1) | ATE374765T1 (de) |
| AU (1) | AU2001280438A1 (de) |
| DE (1) | DE60130771T2 (de) |
| ES (1) | ES2292607T3 (de) |
| WO (1) | WO2002010154A2 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU776053B2 (en) * | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| AU2001282871A1 (en) | 2000-08-17 | 2002-02-25 | Eli Lilly And Company | Antithrombotic agents |
| RU2276137C2 (ru) * | 2000-11-22 | 2006-05-10 | Астеллас Фарма Инк. | Замещенные производные бензола или их соли, фармацевтическая композиция на их основе |
| US7163938B2 (en) | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
| ES2357808T3 (es) * | 2001-06-07 | 2011-04-29 | Christine Dr. Sang | Tratamiento del dolor neuropático con antagonistas del receptor de n-metil-d-aspartato (nmda). |
| US7449457B2 (en) | 2001-12-07 | 2008-11-11 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| ATE382607T1 (de) * | 2003-05-30 | 2008-01-15 | Lilly Co Eli | Antitrombotische aether |
| ES2386354T3 (es) | 2003-07-29 | 2012-08-17 | Xenon Pharmaceuticals Inc. | Derivados de piridilo y su uso como agentes terapéuticos |
| US7759348B2 (en) | 2003-07-30 | 2010-07-20 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| US7754711B2 (en) | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| AU2004261249B2 (en) * | 2003-07-30 | 2008-09-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| EP3042895A1 (de) * | 2003-07-30 | 2016-07-13 | Xenon Pharmaceuticals Inc. | Pyridazinderivate und deren verwendung als therapeutische wirkstoffe |
| RU2326118C2 (ru) * | 2003-07-30 | 2008-06-10 | Зинон Фармасьютиклз Инк. | Производные пиридазина и их применение в качестве терапевтических агентов |
| US7456180B2 (en) | 2003-07-30 | 2008-11-25 | Xenon Pharmaceuticals Inc. | Piperazine derivatives and their use as therapeutic agents |
| WO2005049604A2 (en) * | 2003-09-30 | 2005-06-02 | Eli Lilly And Company | Antithrombotic aromatic ethers |
| US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| SE0401342D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds |
| BRPI0418939A (pt) * | 2004-07-06 | 2008-04-08 | Xenon Pharmaceuticals Inc | derivados de nicotinamida e sua utilização como agentes terapêuticos |
| EP2289510A1 (de) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate zur Behandlung von durch Stearoyl-Coa-Desaturase-Enzyme verursachten Krankheiten |
| MX2007003332A (es) * | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| MX2007003327A (es) * | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| EP2269610A3 (de) * | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren |
| US20080167321A1 (en) * | 2004-09-20 | 2008-07-10 | Xenon Pharmaceuticals Inc. | Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase |
| JP4958786B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
| EP1799667B1 (de) * | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Heterozyklische derivate und ihre verwendung als therapeutische wirkstoffe |
| US7547698B2 (en) * | 2004-09-20 | 2009-06-16 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD) |
| MX2007003319A (es) * | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| DE602005019316D1 (en) | 2004-11-24 | 2010-03-25 | Lilly Co Eli | Aromatische etherderivate als thrombin-hemmer |
| ATE440833T1 (de) * | 2004-11-29 | 2009-09-15 | Lilly Co Eli | Antithrombotische diamide |
| US7264402B2 (en) * | 2005-03-10 | 2007-09-04 | Corning Cable Systems Llc | Multi-fiber optic receptacle and plug assembly |
| BRPI0611187A2 (pt) * | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| CA2697551C (en) | 2007-09-20 | 2013-03-12 | Irm Llc | Piperidine derivatives as modulators of gpr119 activity |
| WO2012059442A2 (en) * | 2010-11-01 | 2012-05-10 | Neurotune Ag | Neurotrypsin inhibitors |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2664238B2 (ja) * | 1989-03-01 | 1997-10-15 | 日清製粉株式会社 | ニコチン酸またはそのエステル誘導体 |
| US4994456A (en) * | 1989-03-01 | 1991-02-19 | Nisshin Flour Milling Co., Ltd. | Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same |
| GB9816837D0 (en) * | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| HUP9601331A3 (en) * | 1996-05-17 | 2000-06-28 | Egyt Gyogyszervegyeszeti Gyar | Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them |
| WO1998054164A1 (en) | 1997-05-30 | 1998-12-03 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
| IL133623A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| AU8270898A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
| EP1007037A4 (de) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | Antithrombose mittel |
| US6313151B1 (en) | 1997-06-26 | 2001-11-06 | Eli Lilly And Company | Antithrombotic agents |
| AU735144B2 (en) * | 1997-07-23 | 2001-07-05 | Yamanouchi Pharmaceutical Co., Ltd. | Novel hexahydro-1,4-diazepine derivatives or their salts |
| US6525042B1 (en) | 1997-09-30 | 2003-02-25 | Daiichi Pharmaceutical Co., Ltd. | Sulfonyl derivatives |
| WO1999032447A2 (en) | 1997-12-11 | 1999-07-01 | American Home Products Corporation | 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof |
| US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| NZ503809A (en) | 1997-12-19 | 2002-04-26 | Schering Ag | Ortho-anthranilamide derivatives as anti-coagulants |
| EP1057818A4 (de) * | 1998-01-30 | 2003-01-29 | Meiji Seika Kaisha | Phenylpiperazinderivate als integrin alpha v beta 3 antagonisten |
| CN1142912C (zh) * | 1998-08-04 | 2004-03-24 | 阿斯特拉曾尼卡有限公司 | 用作细胞因子产生的抑制剂的酰胺衍生物 |
| CA2358091A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | Antithrombotic amides |
| ES2196917T3 (es) | 1998-12-23 | 2003-12-16 | Lilly Co Eli | Amidas heteroaromaticas como inhibidores del factor xa`. |
| ATE272633T1 (de) | 1998-12-23 | 2004-08-15 | Lilly Co Eli | Aromatische amiden |
| ATE261941T1 (de) | 1998-12-24 | 2004-04-15 | Lilly Co Eli | Heterocyclische amide als inhibitoren von faktor xa |
| JP4390024B2 (ja) | 1999-04-23 | 2009-12-24 | アステラス製薬株式会社 | 新規なジアゼパン誘導体又はその塩 |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| JP2003509412A (ja) | 1999-09-17 | 2003-03-11 | シーオーアール セラピューティクス インコーポレイテッド | Ｘａ因子阻害剤 |
| DE60040676D1 (de) | 1999-09-17 | 2008-12-11 | Millennium Pharm Inc | BENZAMIDE UND ÄHNLICHE INHIBITOREN VON FAKTOR Xa |
| ES2254385T3 (es) * | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
-
2001
- 2001-07-18 EP EP01958825A patent/EP1307444B1/de not_active Expired - Lifetime
- 2001-07-18 AT AT01958825T patent/ATE374765T1/de not_active IP Right Cessation
- 2001-07-18 DE DE60130771T patent/DE60130771T2/de not_active Expired - Fee Related
- 2001-07-18 WO PCT/US2001/016528 patent/WO2002010154A2/en not_active Ceased
- 2001-07-18 ES ES01958825T patent/ES2292607T3/es not_active Expired - Lifetime
- 2001-07-18 US US10/332,120 patent/US7160878B2/en not_active Expired - Fee Related
- 2001-07-18 AU AU2001280438A patent/AU2001280438A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1307444A2 (de) | 2003-05-07 |
| AU2001280438A1 (en) | 2002-02-13 |
| DE60130771D1 (de) | 2007-11-15 |
| US7160878B2 (en) | 2007-01-09 |
| WO2002010154A3 (en) | 2002-06-27 |
| DE60130771T2 (de) | 2008-07-17 |
| WO2002010154A2 (en) | 2002-02-07 |
| EP1307444B1 (de) | 2007-10-03 |
| ES2292607T3 (es) | 2008-03-16 |
| US20040097491A1 (en) | 2004-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |