ATE367801T1 - Verfahren und gerät zur herstellung von trägerkomplexen - Google Patents

Verfahren und gerät zur herstellung von trägerkomplexen

Info

Publication number
ATE367801T1
ATE367801T1 AT05717901T AT05717901T ATE367801T1 AT E367801 T1 ATE367801 T1 AT E367801T1 AT 05717901 T AT05717901 T AT 05717901T AT 05717901 T AT05717901 T AT 05717901T AT E367801 T1 ATE367801 T1 AT E367801T1
Authority
AT
Austria
Prior art keywords
active ingredient
carrier
complexation
aqueous medium
producing
Prior art date
Application number
AT05717901T
Other languages
English (en)
Inventor
Mohammad Mozafari
Original Assignee
Univ Liverpool John Moores
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Liverpool John Moores filed Critical Univ Liverpool John Moores
Application granted granted Critical
Publication of ATE367801T1 publication Critical patent/ATE367801T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/402—Mixers using gas or liquid agitation, e.g. with air supply tubes comprising supplementary stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B01F35/531—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00822—Metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/00862—Dimensions of the reaction cavity itself
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00909—Separation using filters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Developing Agents For Electrophotography (AREA)
AT05717901T 2004-03-05 2005-03-03 Verfahren und gerät zur herstellung von trägerkomplexen ATE367801T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0404993.8A GB0404993D0 (en) 2004-03-05 2004-03-05 Method and apparatus for producing carrier complexes

Publications (1)

Publication Number Publication Date
ATE367801T1 true ATE367801T1 (de) 2007-08-15

Family

ID=32088781

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05717901T ATE367801T1 (de) 2004-03-05 2005-03-03 Verfahren und gerät zur herstellung von trägerkomplexen

Country Status (5)

Country Link
EP (1) EP1725215B1 (de)
AT (1) ATE367801T1 (de)
DE (1) DE602005001768D1 (de)
GB (1) GB0404993D0 (de)
WO (1) WO2005084641A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100239521A1 (en) * 2010-06-01 2010-09-23 Mohammad Reza Mozafari Method for the preparation of micro- and nano-sized carrier systems for the encapsulation of bioactive substances
FR3008908B1 (fr) 2013-07-25 2017-09-15 Eric Chapotat Recipient pour le nettoyage d'un objet immerge dans un fluide comprenant des composants ferromagnetiques
MX364310B (es) 2013-11-05 2019-04-22 Gustavo A Garcia Sanchez Método para preparar una formulación inmunosupresora.
GR20180100082A (el) * 2018-02-28 2019-09-25 ΝΙΚΟΛΑΟΣ Α. ΦΙΚΙΩΡΗΣ ΚΑΙ ΣΙΑ ΕΤΑΙΡΕΙΑ ΠΕΡΙΟΡΙΣΜΕΝΗΣ ΕΥΘΗΝΗΣ με δ.τ. IN TOUCH HEALTH Ε.Π.Ε Μεθοδος για την παραγωγη οχηματων μεταφορας λιπιδιων
EP3974048A4 (de) * 2019-05-20 2023-06-28 Kagoshima University Vorrichtung und verfahren zur blasenbildung
CN111974291A (zh) * 2020-09-29 2020-11-24 广州市爱百伊生物技术有限公司 一种酵母修复精华液制作的混合过滤一体化装置及方法
WO2025221335A1 (en) * 2024-04-16 2025-10-23 Purdue Research Foundation Engineered polymeric excipients for enhancing the stability of protein biologics
CN120437063A (zh) * 2025-05-13 2025-08-08 上海交通大学医学院附属第九人民医院 靶向肺巨噬细胞的脂质体及其在肺纤维化治疗中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79114A (en) * 1985-08-07 1990-09-17 Allergan Pharma Method and composition for making liposomes
JPS63119848A (ja) * 1986-11-07 1988-05-24 Shimadzu Corp リポソ−ム製造装置
US5538343A (en) * 1995-03-06 1996-07-23 E. I. Du Pond De Nemours And Company Apparatus and method for liquid mixing employing nip zones
JPH0924269A (ja) * 1995-07-10 1997-01-28 M Technic Kk リン脂質を使ったマイクロカプセルの製造方法
DE19924643B4 (de) * 1999-05-28 2017-02-23 Roche Diagnostics Gmbh Verfahren zur Herstellung von Protein-beladenen Mikropartikeln
DE10061656A1 (de) * 2000-12-11 2002-06-20 Nutricon Umweltschutztechnik G Multifunktionales wasserlösliches Copolymer-Hydrogel mit hohem Molekulargewicht, Verfahren zu seiner Herstellung und seine Verwendung

Also Published As

Publication number Publication date
EP1725215B1 (de) 2007-07-25
WO2005084641A1 (en) 2005-09-15
EP1725215A1 (de) 2006-11-29
DE602005001768D1 (de) 2007-09-06
GB0404993D0 (en) 2004-04-07

Similar Documents

Publication Publication Date Title
Hu et al. Organophotocatalytic Generation of N‐and O‐Centred Radicals Enables Aerobic Oxyamination and Dioxygenation of Alkenes
Wang et al. Catalytic asymmetric C− H functionalization under photoredox conditions by radical translocation and stereocontrolled alkene addition
Williamson et al. Cobalt-catalysed C–H carbonylative cyclisation of aliphatic amides
Zhao et al. Catalytic Ring Expansion of Cyclic Hemiaminals for the Synthesis of Medium‐Ring Lactams
Iqbal et al. Controlled trifluoromethylation reactions of alkynes through visible‐light photoredox catalysis
Awata et al. PyBidine/copper catalyst: asymmetric exo′‐selective [3+ 2] cycloaddition using imino ester and electrophilic indole
Fürstner et al. Total synthesis of roseophilin
Ling et al. Exploratory investigations probing a preparatively versatile, pyridinium salt photoelectrocyclization− solvolytic aziridine ring opening sequence
Bartberger et al. Theory, spectroscopy, and crystallographic analysis of S-nitrosothiols: conformational distribution dictates spectroscopic behavior
Zhang et al. Peptide Fragment Coupling Using a Continuous‐Flow Photochemical Rearrangement of Nitrones
Hsieh et al. Indole synthesis: palladium-catalyzed C–H bond amination via reduction of nitroalkenes with carbon monoxide
Raja et al. Experimental and Computational Study of the Catalytic Asymmetric 4π‐Electrocyclization of N‐Heterocycles
Wu et al. Copper‐Promoted Site‐Selective Acyloxylation of Unactivated C (sp3) H Bonds
Di Gioia et al. “One-pot” methylation of N-nosyl-α-amino acid methyl esters with diazomethane and their coupling to prepare N-methyl dipeptides
MXPA06000522A (es) Proceso catalizado con peroxido de hidrogeno para la preparacion de n-hidrocarbiloxiaminas estericamnte impedidas.
ATE427174T1 (de) Syntheseverfahren fur metallnanopartikel
Gupta et al. Copper-catalyzed N-arylation of sulfoximines with arylboronic acids under mild conditions
Zheng et al. Titanocene (III)‐Catalyzed Three‐Component Reaction of Secondary Amides, Aldehydes, and Electrophilic Alkenes
ATE367801T1 (de) Verfahren und gerät zur herstellung von trägerkomplexen
Hayashi et al. Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic Michael Reaction for the Formation of α, α‐Disubstituted α‐Amino Acid Derivatives
Bourboula et al. A Photochemical Protocol for the Synthesis of Weinreb and Morpholine Amides from Carboxylic Acids
Zhou et al. A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd (OAc) 2/HCOOH system
Huang et al. Iodine‐Mediated Oxidation of Ynamides: A Facile Access to N‐Monosubstituted α‐Ketoamides and α‐Ketoimides
Matsui et al. Enantioselective Morita–Baylis–Hillman (MBH) reaction promoted by a heterobimetallic complex with a Lewis base
ATE482188T1 (de) Verfahren zur synthese von 3-hydroxyglutaronitril

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties