ATE368652T1 - Nitrosierte und nitrosylierte alpha- adrenorezeptoreantagonisten, zubereitungen und deren verwendungen - Google Patents
Nitrosierte und nitrosylierte alpha- adrenorezeptoreantagonisten, zubereitungen und deren verwendungenInfo
- Publication number
- ATE368652T1 ATE368652T1 AT97904887T AT97904887T ATE368652T1 AT E368652 T1 ATE368652 T1 AT E368652T1 AT 97904887 T AT97904887 T AT 97904887T AT 97904887 T AT97904887 T AT 97904887T AT E368652 T1 ATE368652 T1 AT E368652T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- nitrozed
- preparations
- nitrosylated
- adrenoreceptor antagonists
- Prior art date
Links
- 229940124308 alpha-adrenoreceptor antagonist Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 4
- KEJOCWOXCDWNID-UHFFFAOYSA-N Nitrilooxonium Chemical compound [O+]#N KEJOCWOXCDWNID-UHFFFAOYSA-N 0.000 abstract 3
- 239000000674 adrenergic antagonist Substances 0.000 abstract 2
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 abstract 2
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 abstract 2
- 201000001881 impotence Diseases 0.000 abstract 2
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D459/00—Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/595,732 US5932538A (en) | 1996-02-02 | 1996-02-02 | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
| US08/714,313 US5994294A (en) | 1996-02-02 | 1996-09-18 | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE368652T1 true ATE368652T1 (de) | 2007-08-15 |
Family
ID=24384444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97904887T ATE368652T1 (de) | 1996-02-02 | 1997-01-28 | Nitrosierte und nitrosylierte alpha- adrenorezeptoreantagonisten, zubereitungen und deren verwendungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5932538A (de) |
| EP (1) | EP1018879B1 (de) |
| JP (1) | JP2000505424A (de) |
| AT (1) | ATE368652T1 (de) |
| AU (1) | AU721247B2 (de) |
| CA (1) | CA2244879A1 (de) |
| DE (1) | DE69737980T2 (de) |
| WO (1) | WO1997027749A1 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
| US6469065B1 (en) | 1996-02-02 | 2002-10-22 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use |
| US6294517B1 (en) | 1996-02-02 | 2001-09-25 | Nitromed, Inc. | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use |
| US6323211B1 (en) | 1996-02-02 | 2001-11-27 | Nitromed, Inc. | Compositions and methods for treating sexual dysfunctions |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| USRE37234E1 (en) | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
| US20030040514A1 (en) * | 1999-11-12 | 2003-02-27 | Wyllie Michael G. | Combination effective for the treatment of impotence |
| FR2774593B1 (fr) * | 1998-02-12 | 2000-05-05 | Philippe Gorny | Obtention d'un medicament destine a combattre les dysfonctions sexuelles feminines |
| FR2774594A1 (fr) * | 1998-02-12 | 1999-08-13 | Philippe Gorny | Medicament destine notamment a prevenir ou traiter les dysfonctions erectiles |
| AU2004201585B2 (en) * | 1998-09-01 | 2007-01-18 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use |
| EP1126838A4 (de) * | 1998-10-30 | 2005-02-16 | Nitromed Inc | Nitrosierte und nitrosylierte nichtsteroidale antiphlogistishe verbindungen, zusammenstellungen und verwendungsmethoden |
| US6391869B1 (en) | 1998-12-14 | 2002-05-21 | Cellergy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
| US6395736B1 (en) * | 1998-12-14 | 2002-05-28 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
| US6627632B2 (en) | 1998-12-14 | 2003-09-30 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
| AU3724400A (en) * | 1999-03-08 | 2000-09-28 | Merck & Co., Inc. | Methods and compositions for treating erectile dysfunction |
| IT1312310B1 (it) * | 1999-05-07 | 2002-04-15 | Recordati Ind Chimica E Farma | Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale |
| AU6124401A (en) * | 2000-05-09 | 2001-11-20 | Nitromed Inc | Infrared thermography and methods of use |
| IT1318673B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Farmaci per le disfunzioni sessuali. |
| ATE437637T1 (de) | 2001-05-02 | 2009-08-15 | Nitromed Inc | Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren |
| US20030158184A1 (en) * | 2001-12-21 | 2003-08-21 | Garvey David S. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| EP1469862A2 (de) * | 2002-01-30 | 2004-10-27 | Pharmacia Corporation | Kombination von einem aldosterone rezeptor antagonisten und einem alpha-adrenergen modulierenden agens zur vorbeugung und behandlung von kardiovaskulären beschwerden |
| WO2003095623A2 (en) * | 2002-05-10 | 2003-11-20 | The Trustees Of Columbia University In The City Of New York | Genetically engineered cell lines and systems for propagating varicella zoster virus and methods of use thereof |
| CA2486564A1 (en) * | 2002-05-23 | 2003-12-04 | Abbott Laboratories | Acetamides and benzamides that are useful in treating sexual dysfunction |
| JP2007502831A (ja) * | 2003-08-20 | 2007-02-15 | ニトロメッド インコーポレーティッド | ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法 |
| AU2004270161A1 (en) * | 2003-08-28 | 2005-03-17 | Nicox S.A. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
| DK1691804T3 (da) * | 2003-12-02 | 2007-07-16 | Nicox Sa | Nitrooxydderivater af carvedilol og andre beta-blokkere som antihypertensive lægemidler |
| US20090131342A1 (en) * | 2004-01-22 | 2009-05-21 | Nitromed, Inc. | Nitrosated and/or nitrosylated compounds, compositions and methods of use |
| US20070167511A1 (en) * | 2004-03-05 | 2007-07-19 | Kissei Pharmaceutical Co,. Ltd. | Medicinal composition for prevention or treatment of overactive bladder accompanying nervous disorder |
| CA2577084A1 (en) | 2004-08-25 | 2006-03-02 | Olivier Bezencon | Bicyclononene derivatives as renin inhibitors |
| US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
| AU2006206249A1 (en) * | 2005-01-21 | 2006-07-27 | Nicox S.A. | Cardiovascular compounds comprising heterocyclic nitric oxide donor group compositions and methods of use |
| CA2597422A1 (en) * | 2005-02-16 | 2007-08-02 | Nitromed, Inc. | Organic nitric oxide donor salts of antimicrobial compounds, compositions and methods of use |
| WO2006093864A1 (en) * | 2005-02-28 | 2006-09-08 | Nitromed, Inc. | Cardiovascular compounds comprising nitric oxide enhancing groups, compositions and methods of use |
| US20090215838A1 (en) * | 2005-03-09 | 2009-08-27 | Nitromed, Inc. | Organic nitric oxide enhancing salts of angiotensin ii antagonists, compositions and methods of use |
| EP1883614A4 (de) * | 2005-05-23 | 2010-04-14 | Nicox Sa | Organische stickoxide verbessernde salze aus nichtsteroiden entzündungshemmenden verbindungen sowie zusammensetzungen und verwendungsverfahren dafür |
| EP2669269B1 (de) | 2005-05-27 | 2019-05-22 | The University of North Carolina At Chapel Hill | Stickoxidfreisetzende partikel für stickoxidtherapeutika und biomedizinische anwendungen |
| US20090018091A1 (en) * | 2005-08-02 | 2009-01-15 | Nitromed, Inc. | Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use |
| AU2006299383A1 (en) * | 2005-10-04 | 2007-04-12 | Nitromed, Inc. | Methods for treating respiratory disorders |
| WO2007059311A2 (en) * | 2005-11-16 | 2007-05-24 | Nitromed, Inc. | Furoxan compounds, compositions and methods of use |
| WO2007075541A2 (en) * | 2005-12-20 | 2007-07-05 | Nitromed, Inc. | Nitric oxide enhancing glutamic acid compounds, compositions and methods of use |
| WO2007075542A2 (en) * | 2005-12-22 | 2007-07-05 | Nitromed, Inc. | Nitric oxide enhancing pyruvate compounds, compositions and methods of use |
| WO2007104652A2 (en) * | 2006-03-16 | 2007-09-20 | Nicox S.A. | Non-peptidic renin inhibitors nitroderivatives |
| CA2647859C (en) | 2006-03-29 | 2016-01-05 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
| US7807716B2 (en) * | 2008-09-24 | 2010-10-05 | Oral Delivery Technology Ltd. | Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use |
| DK3266463T3 (da) | 2009-06-09 | 2024-01-08 | Prolong Pharmaceuticals Llc | Hæmoglobinsammensætninger |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| EP2467173B8 (de) | 2009-08-21 | 2019-06-19 | Novan, Inc. | Wundverbände, verfahren zu ihrer anwendung und verfahren zu ihrer herstellung |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118819A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
| CN118304300B (zh) * | 2024-04-12 | 2025-03-14 | 儋州市人民医院 | 一种具有麻醉作用的组合物及其在制备麻醉药物中的应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1445500A1 (de) * | 1963-06-07 | 1968-12-05 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung neuer Yohimban-Derivate und deren Salze |
| US3574212A (en) * | 1968-02-02 | 1971-04-06 | Pfizer | Quinazolinylureas |
| DE1913199C3 (de) * | 1969-03-15 | 1975-11-27 | Beiersdorf Ag, 2000 Hamburg | Mannichbasen aus alpha-Tetralon bzw. dessen Derivaten und Arylalkylaminen und deren Salze |
| FR2135087B1 (de) * | 1971-05-06 | 1974-08-23 | Serdex | |
| NL175059C (nl) * | 1974-02-23 | Boehringer Mannheim Gmbh | Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten. | |
| US4060615A (en) * | 1976-02-18 | 1977-11-29 | Mead Johnson & Company | 2-Piperazinyl-6,7-dimethoxyquinazolines |
| FI770485A7 (de) * | 1976-02-18 | 1977-08-19 | Bristol Myers Co | |
| SE435380B (sv) * | 1976-06-15 | 1984-09-24 | Pfizer | Forfarande for framstellning av kinazolinforeningar |
| US4959360A (en) * | 1988-06-01 | 1990-09-25 | Smithkline Beecham Corporation | α-adrenergic receptor antagonists |
| IT1221826B (it) * | 1988-06-08 | 1990-07-12 | Medico Harvey Srl Centro | Preparato per uso topico per il trattamento terapeutico dell impotentia coeundi |
| SE463851B (sv) * | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
| US5447912A (en) * | 1989-09-18 | 1995-09-05 | Senetek, Plc | Erection-inducing methods and compositions |
| US5236904A (en) * | 1989-09-18 | 1993-08-17 | Senetek, Plc | Erection-inducing methods and compositions |
| US5242391A (en) * | 1990-04-25 | 1993-09-07 | Alza Corporation | Urethral insert for treatment of erectile dysfunction |
| US5096916A (en) * | 1990-05-07 | 1992-03-17 | Aegis Technology, Inc. | Treatment of chronic obstructive pulmonary disease (copd) by inhalation of an imidazoline |
| US5399581A (en) * | 1990-12-26 | 1995-03-21 | Laragh; John H. | Method and compositions for treatment of sexual impotence |
| US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| DK0676964T3 (da) * | 1991-11-14 | 2001-02-05 | Brigham & Womens Hospital | Nitrosylering af enzym-SH-grupper som en terapeutisk modalitet |
| AU3237193A (en) * | 1991-12-11 | 1993-07-19 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| US5646181A (en) * | 1992-07-02 | 1997-07-08 | Research Foundation Of State University Of New York | Method and compositions for treating impotence |
| US5910316A (en) * | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
| US5508306A (en) * | 1992-11-13 | 1996-04-16 | Synaptic Pharmaceutical Corporation | Aromatic amine derivatives |
| US5403847A (en) * | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
| ES2146249T3 (es) * | 1993-02-10 | 2000-08-01 | Bmra Corp Bv | Composicion farmaceutica para tratar la impotencia que contiene un inhibidor alfa-1 y un inhibidor alfa-2. |
| US5565466A (en) * | 1993-08-13 | 1996-10-15 | Zonagen, Inc. | Methods for modulating the human sexual response |
| US5612314A (en) * | 1995-04-21 | 1997-03-18 | Brigham & Women's Hospital | Nitrosylated neuropeptides |
-
1996
- 1996-02-02 US US08/595,732 patent/US5932538A/en not_active Expired - Fee Related
-
1997
- 1997-01-28 DE DE69737980T patent/DE69737980T2/de not_active Expired - Fee Related
- 1997-01-28 AU AU17562/97A patent/AU721247B2/en not_active Ceased
- 1997-01-28 AT AT97904887T patent/ATE368652T1/de not_active IP Right Cessation
- 1997-01-28 EP EP97904887A patent/EP1018879B1/de not_active Expired - Lifetime
- 1997-01-28 CA CA002244879A patent/CA2244879A1/en not_active Abandoned
- 1997-01-28 WO PCT/US1997/001294 patent/WO1997027749A1/en not_active Ceased
- 1997-01-28 JP JP9527755A patent/JP2000505424A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU721247B2 (en) | 2000-06-29 |
| AU1756297A (en) | 1997-08-22 |
| WO1997027749A1 (en) | 1997-08-07 |
| DE69737980T2 (de) | 2007-12-06 |
| JP2000505424A (ja) | 2000-05-09 |
| EP1018879A4 (de) | 2002-07-24 |
| DE69737980D1 (de) | 2007-09-13 |
| EP1018879B1 (de) | 2007-08-01 |
| US5932538A (en) | 1999-08-03 |
| EP1018879A1 (de) | 2000-07-19 |
| CA2244879A1 (en) | 1997-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69737980D1 (de) | Nitrosierte und nitrosylierte alpha-adrenorezeptoreantagonisten, zubereitungen und deren verwendungen | |
| EP1852422A3 (de) | Nitrosierte und nitrosylierte alpha-andrenergische Rezeptor-Antagonisten-Verbindungen, Zusammensetzungen daraus und Verwendungen davon | |
| TR199900408T2 (xx) | �kameli 6,6-Heterobisiklik t�revler. | |
| ES2104797T3 (es) | Composiciones farmaceuticas con actividad antagonista de angiotensina-ii. | |
| TR200002345T2 (tr) | Glukokortikoit seçiçi antienflamatuar ajanlar | |
| BR0112160A (pt) | Agentes antiinflamatórios seletivos para glicocorticóides | |
| DK1129093T3 (da) | Pyrazolopyrimidinonderivater til behandling af impotens | |
| DK0948527T3 (da) | Cylosporinderivater, fremstilling af disse og farmaceutiske præparater indeholdende disse | |
| ES2124793T3 (es) | Derivados de rapamicina alquilados en o y su uso, particularmente como inmunosupresores. | |
| NO20004053L (no) | Glukokortikoid-selektive antiinflammatoriske midler | |
| DK1200418T3 (da) | Nematodicide trifluorbutener | |
| ATE296304T1 (de) | Immunsuppressive wirkstoffe und verfahren | |
| FR2757520B1 (fr) | Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent | |
| TR200102029T2 (tr) | 1-Heterosiklil ikameli diarilaminler. | |
| WO2002092004A3 (en) | Use of hmg fragment as anti-inflammatory agents | |
| TR199802282T2 (xx) | Karbolin t�revleri. | |
| TR199801179T2 (xx) | Yeni taksoitler, bunlar�n haz�rlanmalar� ve ila� bile�imleri. | |
| GEP20084539B (en) | 4-tetrazolyl-4phenylpiperidine derivatives for treating pain | |
| ATE231872T1 (de) | Thiazolopyrimidinderivate | |
| ATE246678T1 (de) | Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren | |
| BG40955A3 (en) | Acaricide means and method for protection from acars | |
| TR200003377T2 (tr) | Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol | |
| ATE413179T1 (de) | Therapeutische verwendungen von steroiden bei blutzellmangelzustaenden | |
| TR200000152T2 (tr) | Yeni bileşikler. | |
| BR0007864A (pt) | Composto, e, uso de um composto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |