ATE296304T1 - Immunsuppressive wirkstoffe und verfahren - Google Patents

Immunsuppressive wirkstoffe und verfahren

Info

Publication number: ATE296304T1
Authority: AT; Austria
Prior art keywords: methods; immunosupressive; ingredients; compounds; immunosuppressive
Prior art date: 1996-03-01

Application number

AT97908794T

Other languages

English (en)

Inventor

You Mao Qi

John H Musser

John M Fidler

Original Assignee

Pharmagenesis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-01

Filing date

1997-02-28

Publication date

2005-06-15

1997-02-28 Application filed by Pharmagenesis Inc filed Critical Pharmagenesis Inc

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE296304T1 publication Critical patent/ATE296304T1/de

Links

230000001506 immunosuppresive effect Effects 0.000 title abstract 2
239000004615 ingredient Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical class O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)

AT97908794T 1996-03-01 1997-02-28 Immunsuppressive wirkstoffe und verfahren ATE296304T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/609,277 US5663335A (en)	1996-03-01	1996-03-01	Immunosuppressive compounds and methods
PCT/US1997/003202 WO1997031921A1 (en)	1996-03-01	1997-02-28	Immunosuppressive compounds and methods

Publications (1)

Publication Number	Publication Date
ATE296304T1 true ATE296304T1 (de)	2005-06-15

Family

ID=24440096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97908794T ATE296304T1 (de)	1996-03-01	1997-02-28	Immunsuppressive wirkstoffe und verfahren

Country Status (12)

Country	Link
US (1)	US5663335A (de)
EP (1)	EP0907652B1 (de)
JP (1)	JP4267697B2 (de)
CN (1)	CN1133637C (de)
AT (1)	ATE296304T1 (de)
AU (2)	AU2125897A (de)
CA (1)	CA2248266C (de)
DE (1)	DE69733353T2 (de)
DK (1)	DK0907652T3 (de)
ES (1)	ES2242214T3 (de)
PT (1)	PT907652E (de)
WO (2)	WO1997031920A1 (de)

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US5880116A (en) *	1996-12-13	1999-03-09	Neurocal International	Use of celastrol to treat alzheimer's disease
CN1257507A (zh) *	1997-05-23	2000-06-21	赫斯特·马里昂·罗素公司	适合用于自身免疫性疾病治疗的新的雷公藤内酯衍生物
US5972998A (en) *	1997-05-23	1999-10-26	Hoechst Marion Roussel, Inc.	Triptolide derivatives useful in the treatment of autoimmune diseases
US6004999A (en) *	1997-05-23	1999-12-21	Hoechst Marion Roussel, Inc.	Triptolide derivatives useful in the treatment of autoimmune diseases
IL133089A0 (en) *	1997-05-23	2001-03-19	Hoechst Marion Roussel Inc	Novel triptolide derivatives useful in the treatment of autoimmune diseases
DE69932649T2 (de) *	1998-09-02	2007-08-09	Pharmagenesis, Inc., Palo Alto	Triptolid-Prodrugs mit hoher Wasserlöslichkeit
EP1375488B1 (de) *	1998-09-02	2006-08-02	Pharmagenesis, Inc.	Triptolid-Prodrugs mit hoher Wasserlöslichkeit
US6548537B1 (en)	1998-09-02	2003-04-15	Pharmagenesis, Inc.	Triptolide prodrugs having high aqueous solubility
CA2361561A1 (en) *	1999-02-02	2000-08-10	K.U. Leuven Research & Development	Immunosurpressive effects of pteridine derivatives
US6329148B1 (en)	1999-02-16	2001-12-11	The Board Of Trustees Of The Leland Stanford University	Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
AU5368699A (en) *	1999-04-16	2000-11-02	Chengdu Diao Pharmaceutical Group Company Limited	Derivatives of triptolide, and preparation and uses thereof
US7323471B1 (en) *	1999-08-13	2008-01-29	Dor Biopharma, Inc.	Topical azathioprine for the treatment of oral autoimmune diseases
US6294546B1 (en) *	1999-08-30	2001-09-25	The Broad Of Trustees Of The Leland Stanford Junior University	Uses of diterpenoid triepoxides as an anti-proliferative agent
US6620843B2 (en) *	2001-01-19	2003-09-16	Pharmagenesis	Anticancer treatment using triptolide prodrugs
US6569893B2 (en) *	2001-03-15	2003-05-27	Pharmagenesis, Inc.	Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
JP4680589B2 (ja) *	2002-05-31	2011-05-11	ファーマジェネシス，インコーポレイテッド	アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体
CN100398544C (zh) *	2002-09-18	2008-07-02	成都达远药物有限公司	高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
WO2004058246A1 (en) *	2002-12-17	2004-07-15	Pharmagenesis, Inc.	Triptolide derivatives as immunomodulator and anticancer agents
CN1223595C (zh) *	2002-12-27	2005-10-19	中国科学院上海药物研究所	雷公藤内酯醇衍生物及其应用
US6943259B2 (en) *	2003-02-25	2005-09-13	Pharmagenesis, Inc.	Halogenated triptolide derivatives as immunomodulators and anticancer agents
CN100408583C (zh) *	2003-02-25	2008-08-06	美国泛华医药公司	用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物
US7820834B2 (en) *	2003-12-24	2010-10-26	Pharmagenesis, Inc.	Triptolide 5,6-derivatives as immunomodulators and anticancer agents
CN1917893A (zh) *	2004-02-09	2007-02-21	美国泛华医药公司	从雷公藤多苷中分离雷公藤内酯醇化合物的方法
DK1732536T3 (da) *	2004-03-02	2012-06-25	Pharmagenesis Inc	Tripolidlactonringderivater som immunomodulatorer og anticancermidler
WO2006012204A2 (en) *	2004-06-25	2006-02-02	Pharmagenesis, Inc.	Method for treatment of inflammatory disorders using triptolide compounds
US8617906B2 (en)	2004-10-13	2013-12-31	Pharmagenesis, Inc.	Identification and screening of triptolide target molecules
US8022103B2 (en) *	2005-07-13	2011-09-20	Salvia Sciences, Inc.	Ester prodrugs of prostratin and related phorbol compounds
US10144736B2 (en)	2006-07-20	2018-12-04	Gilead Sciences, Inc.	Substituted pteridines useful for the treatment and prevention of viral infections
WO2008009078A2 (en)	2006-07-20	2008-01-24	Gilead Sciences, Inc.	4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US8067632B2 (en)	2007-07-26	2011-11-29	The Board Of Trustees Of The Leland Stanford Junior University	Process to produce prostratin and structural or functional analogs thereof
CN101235041B (zh) *	2007-10-26	2013-05-29	北京美迪克斯生物技术有限公司	四种雷公藤甲素衍生物及其制剂的制备方法
CN104387406A (zh) *	2009-02-05	2015-03-04	药物起源公司	作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物
US9150600B2 (en)	2009-05-07	2015-10-06	Regents Of The University Of Minnesota	Triptolide prodrugs
EP2427467B1 (de)	2009-05-07	2015-08-05	Regents of the University of Minnesota	Triptolid-prodrugs
CN102286065B (zh) *	2010-06-18	2012-11-14	中国科学院上海药物研究所	松香烷型二萜衍生物、其制备方法和应用
RS58781B1 (sr) *	2012-08-23	2019-06-28	Senestech Inc	Kompozicije i postupci za redukciju reproduktivnog kapaciteta ženki pacova
DK3097102T3 (en)	2015-03-04	2018-01-22	Gilead Sciences Inc	TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO [3,2-D] PYRIMIDINE COMPOUNDS
WO2016205539A1 (en) *	2015-06-16	2016-12-22	Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno	Non-hormonal male contraceptive agents and methods using same
EP3248981B1 (de) *	2015-10-29	2022-03-09	Hangzhou Weben Pharmaceuticals Inc.	C14-hydroxylveresterte aminosäurederivate von triptolid sowie herstellungsverfahren und verwendung davon
MA46093A (fr)	2016-09-02	2021-05-19	Gilead Sciences Inc	Composés modulateurs du recepteur de type toll
WO2018045150A1 (en)	2016-09-02	2018-03-08	Gilead Sciences, Inc.	4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
CN106890187A (zh) *	2017-02-22	2017-06-27	中山大学附属第三医院	雷公藤甲素及其修饰物在抑制b细胞产生抗体中的应用
CN109021061B (zh) *	2018-09-29	2019-07-12	郭可点	雷公藤甲素靶向前药及其制备方法和应用
TW202212339A (zh)	2019-04-17	2022-04-01	美商基利科學股份有限公司	類鐸受體調節劑之固體形式
TW202210480A (zh)	2019-04-17	2022-03-16	美商基利科學股份有限公司	類鐸受體調節劑之固體形式
TWI879779B (zh)	2019-06-28	2025-04-11	美商基利科學股份有限公司	類鐸受體調節劑化合物的製備方法
CN111440185B (zh) *	2020-03-31	2021-05-14	中国农业科学院蜜蜂研究所	一种半抗原及其在检测雷公藤乙素和雷公藤甲素方面的应用
CN115466269A (zh) *	2021-06-11	2022-12-13	复旦大学	一种胆碱碳酸酯类前药及其制备方法和应用
CN114478684B (zh) *	2022-01-21	2023-10-31	南京中医药大学	一类雷公藤甲素前药、其制备方法及其医药用途

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CA1310009C (en) *	1984-03-28	1992-11-10	John Mark Braughler	Ester prodrugs of steroids
CN1027371C (zh) *	1989-09-08	1995-01-11	中国医学科学院皮肤病研究所	二萜内酯化合物的合成方法
CN1052860A (zh) *	1989-12-22	1991-07-10	中国医学科学院皮肤病研究所	雷藤氯内酯醇的制备方法及抗生育用途
CN1052861A (zh) *	1989-12-22	1991-07-10	中国医学科学院皮肤病研究所	雷醇内酯的制备方法及抗生育用途
CN1052859A (zh) *	1989-12-22	1991-07-10	中国医学科学院皮肤病研究所	17-羟基雷藤内酯醇及类似物的结构与制备方法
US5430054A (en) *	1989-12-22	1995-07-04	Jiangsu Family Planning Institute	Preparation methods of diterpene lactone compounds and application of the same to antifertility
AU7570191A (en) *	1990-03-14	1991-10-10	Board Of Regents, The University Of Texas System	Tripterygium wilfordii hook f extracts and components thereof for immunosuppression

1996
- 1996-03-01 US US08/609,277 patent/US5663335A/en not_active Expired - Lifetime
1997
- 1997-02-18 WO PCT/US1997/002331 patent/WO1997031920A1/en not_active Ceased
- 1997-02-18 AU AU21258/97A patent/AU2125897A/en not_active Abandoned
- 1997-02-28 DK DK97908794T patent/DK0907652T3/da active
- 1997-02-28 JP JP53117297A patent/JP4267697B2/ja not_active Expired - Fee Related
- 1997-02-28 DE DE69733353T patent/DE69733353T2/de not_active Expired - Lifetime
- 1997-02-28 EP EP97908794A patent/EP0907652B1/de not_active Expired - Lifetime
- 1997-02-28 ES ES97908794T patent/ES2242214T3/es not_active Expired - Lifetime
- 1997-02-28 CA CA002248266A patent/CA2248266C/en not_active Expired - Fee Related
- 1997-02-28 AU AU20613/97A patent/AU712241B2/en not_active Ceased
- 1997-02-28 AT AT97908794T patent/ATE296304T1/de not_active IP Right Cessation
- 1997-02-28 WO PCT/US1997/003202 patent/WO1997031921A1/en not_active Ceased
- 1997-02-28 CN CNB971942471A patent/CN1133637C/zh not_active Expired - Fee Related
- 1997-02-28 PT PT97908794T patent/PT907652E/pt unknown

Also Published As

Publication number	Publication date
PT907652E (pt)	2005-08-31
EP0907652A1 (de)	1999-04-14
CA2248266C (en)	2007-10-23
CN1246121A (zh)	2000-03-01
EP0907652B1 (de)	2005-05-25
WO1997031920A1 (en)	1997-09-04
AU2061397A (en)	1997-09-16
JP4267697B2 (ja)	2009-05-27
AU2125897A (en)	1997-09-16
CN1133637C (zh)	2004-01-07
WO1997031921A1 (en)	1997-09-04
DE69733353T2 (de)	2006-02-02
ES2242214T3 (es)	2005-11-01
AU712241B2 (en)	1999-11-04
CA2248266A1 (en)	1997-09-04
JP2001504437A (ja)	2001-04-03
DE69733353D1 (de)	2005-06-30
US5663335A (en)	1997-09-02
DK0907652T3 (da)	2005-08-08
HK1019444A1 (en)	2000-02-11

Legal Events

Date

Code

Title

Description

2006-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0907652

Country of ref document: EP

2009-11-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69733353D1 (de)	2005-06-30	Immunsuppressive wirkstoffe und verfahren
ATE245145T1 (de)	2003-08-15	Gut wasserlösliche triptolid-prodrugs
LV12358A (lv)	1999-10-20	7-(Aizvietoti)-9-(aizvietoti glicil)-amido-6-demetil-6-deoksitetraciklini
DK0946507T3 (da)	2004-01-26	Substituerede pyrrolylforbindelser til behandling af inflammation
DK0960107T3 (da)	2003-02-10	6-Thiosubstituerede paclitaxeler
ES2194106T3 (es)	2003-11-16	.ompuestos de imidazol
AR010062A1 (es)	2000-05-17	Nuevos benzamidaldehidos y su utilizacion
ES2186783T3 (es)	2003-05-16	Derivados de la dolastatina, su preparacion y uso.
ES2151921T3 (es)	2001-01-16	Analogo de dolastatina.
ITMI942626A0 (it)	1994-12-23	Composti diastereomericamente puri derivati da 3-oxo e 3-tioxo-4-azaandrostani e loro uso come antiandrogeni
BG103310A (en)	2000-05-31	Benzonaphthyridins as bronchial therapeutical means
DE69729302T2 (de)	2005-04-21	Illudin analoge verwendet als antitumormittel
DE69720757D1 (de)	2003-05-15	Pde-iv hemmende 2-cyanoiminoimidazol-derivate
ES2150705T3 (es)	2000-12-01	Derivados de ester de nitrito esteroideos utiles como farmacos antiinflamatorios.
TR199902257T2 (xx)	1999-12-21	Tetrahidropirido bile�ikleri
ATE222910T1 (de)	2002-09-15	Triptolid-derivate nützlich zur behandlung von autoimmunkrankheiten
PT983272E (pt)	2004-03-31	Nova classe de compostos fotoactivos derivados de benzoporfirina
NO981818D0 (no)	1998-04-23	FremgangsmÕte for Õ mobilisere hematopoetiske stamceller
ATE261434T1 (de)	2004-03-15	Triptolid-derivate geeignet zur behandlung von autoimmunkrankheiten
ES2184761T3 (es)	2003-04-16	Derivados de taxanos c10 y composiciones farmaceuticas.
DE3873278D1 (de)	1992-09-03	Aryl-substituierte thiophen-3-ole, ihre derivate und analoge als lipoxygenase-inhibitoren.
DK0827505T3 (da)	2003-02-17	Udvalgte opløselige estere af hydroxylholdige indolocarbazoler
MY116769A (en)	2004-03-31	Immunosuppressive compounds and methods
ES2101531T3 (es)	1997-07-01	Derivados de benzo(f)quinoxalinadiona, su preparacion y su utilizacion en medicamentos.
ES2165020T3 (es)	2002-03-01	Monohidrato de famciclovir.