ATE368657T1 - Pyrrol-2,5-dion derivate und deren verwendung als gsk-3 inhibitoren - Google Patents
Pyrrol-2,5-dion derivate und deren verwendung als gsk-3 inhibitorenInfo
- Publication number
- ATE368657T1 ATE368657T1 AT03713551T AT03713551T ATE368657T1 AT E368657 T1 ATE368657 T1 AT E368657T1 AT 03713551 T AT03713551 T AT 03713551T AT 03713551 T AT03713551 T AT 03713551T AT E368657 T1 ATE368657 T1 AT E368657T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- gsk
- pyrrole
- dione derivatives
- dione
- Prior art date
Links
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 title 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 title 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical class O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36337502P | 2002-03-08 | 2002-03-08 | |
| US36943302P | 2002-04-02 | 2002-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE368657T1 true ATE368657T1 (de) | 2007-08-15 |
Family
ID=27807992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03713551T ATE368657T1 (de) | 2002-03-08 | 2003-03-05 | Pyrrol-2,5-dion derivate und deren verwendung als gsk-3 inhibitoren |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7405305B2 (de) |
| EP (1) | EP1487822B1 (de) |
| JP (1) | JP2005530707A (de) |
| KR (1) | KR20040091113A (de) |
| CN (1) | CN1639152A (de) |
| AT (1) | ATE368657T1 (de) |
| AU (1) | AU2003217596A1 (de) |
| CA (1) | CA2477984A1 (de) |
| DE (1) | DE60315270T2 (de) |
| ES (1) | ES2289274T3 (de) |
| IL (1) | IL163777A0 (de) |
| MX (1) | MXPA04008671A (de) |
| WO (1) | WO2003076398A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0303319D0 (en) | 2003-02-13 | 2003-03-19 | Novartis Ag | Organic compounds |
| JP2007502300A (ja) * | 2003-08-13 | 2007-02-08 | カイロン コーポレイション | Ｇｓｋ−３インヒビターおよびその使用 |
| US20080207594A1 (en) | 2005-05-04 | 2008-08-28 | Davelogen Aktiengesellschaft | Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders |
| PL1904482T3 (pl) * | 2005-07-11 | 2011-06-30 | Novartis Ag | Pochodne indolilomaleimidowe |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| EP1779851A1 (de) * | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Behandlung von Diabetes |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| MX2009006533A (es) | 2006-12-19 | 2009-06-26 | Novartis Ag | Derivados de indolil-maleimida como inhibidores de cinasa. |
| ES2446269T3 (es) | 2006-12-19 | 2014-03-06 | The Board Of Trustees Of The University Of Illinois | 3-Benzofuranil-4-indolil-maleimidas como potentes inhibidores de GSK-3 para trastornos neurodegenerativos |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| RU2402547C1 (ru) * | 2009-08-13 | 2010-10-27 | Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) | 1-ЗАМЕЩЕННЫЕ 3-(2-ХЛОР-1Н-ИНДОЛ-3-ИЛ)-4-ФЕНИЛ-1Н-ПИРРОЛ-2,5-ДИОНЫ И ИХ ПРИМЕНЕНИЕ ДЛЯ ФОТОХИМИЧЕСКОГО ГЕНЕРИРОВАНИЯ СТАБИЛЬНЫХ ФЛУОРЕСЦИРУЮЩИХ СОЕДИНЕНИЙ И 2,8-ЗАМЕЩЕННЫЕ БЕНЗО[а]ПИРРОЛО[3,4-с]КАРБАЗОЛ-1,3-(2Н,8Н)-ДИОНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ФЛУОРОФОРОВ |
| CN101812062A (zh) * | 2010-03-31 | 2010-08-25 | 北京京卫信康医药科技发展有限公司 | 一种新的米诺膦酸重要中间体的制备方法 |
| CN102443002A (zh) * | 2010-10-12 | 2012-05-09 | 四川滇虹医药开发有限公司 | 2-(咪唑并[1，2-α]吡啶-3-基)乙酸的制备方法 |
| US20140031547A1 (en) | 2010-12-14 | 2014-01-30 | Electrophoretics Limited | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES |
| PL2912019T3 (pl) | 2012-10-25 | 2021-11-02 | Tetra Discovery Partners Llc | Heteroarylowe inhibitory pde4 |
| US9993463B2 (en) * | 2012-12-10 | 2018-06-12 | Centogene Ag | Use of maleimide derivatives for preventing and treating cancer |
| ES2845298T3 (es) * | 2012-12-10 | 2021-07-26 | Centogene Gmbh | Uso de derivados de maleimida para prevenir y tratar la leucemia |
| US20170165230A1 (en) | 2014-04-09 | 2017-06-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| WO2016049595A1 (en) * | 2014-09-26 | 2016-03-31 | Tetra Discovery Partners, LLC | Heteroaryl inhibitors of pde4 |
| CN106674079A (zh) * | 2015-11-10 | 2017-05-17 | 南京卡文迪许生物工程技术有限公司 | 一种帕比司他的合成方法 |
| WO2018132636A1 (en) * | 2017-01-12 | 2018-07-19 | The Research Foundation For The State University Of New York | [18f]maleimide-based glycogen synthase kinase-3beta ligands for positron emission tomography imaging and radiosynthesis method |
| EP3920885A1 (de) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproinsäureverbindungen und wnt-agonisten zur behandlung von ohrerkrankungen |
| CN113801054A (zh) * | 2021-09-30 | 2021-12-17 | 西南大学 | 3-烷基-3-羟基吲哚-2-酮及其衍生物的制备方法及其产品 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK75289A3 (en) * | 1988-02-10 | 1998-05-06 | Hoffmann La Roche | Substituted pyrroles, their use for producing a drug, and the drug on their base |
| GB8904161D0 (en) * | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
| SE9603283D0 (sv) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
| WO1998016528A1 (en) | 1996-10-11 | 1998-04-23 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
| GB9828640D0 (en) * | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
| DE60010934T2 (de) | 1999-12-16 | 2005-05-19 | Eli Lilly And Co., Indianapolis | Medikamente geeignet zur Behandlung von proliferativen Erkrankungen |
| US6867198B2 (en) | 1999-12-16 | 2005-03-15 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
| IL153851A0 (en) | 2000-07-27 | 2003-07-31 | Hoffmann La Roche | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
| DE60112611T2 (de) | 2000-12-08 | 2006-06-14 | Ortho Mcneil Pharm Inc | Makroheterocyclische verbindungen als kinase inhibitoren |
| KR20040016828A (ko) | 2000-12-08 | 2004-02-25 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 키나제 저해제로서 인다졸릴-치환된 피롤린 화합물 |
| CA2477967C (en) * | 2002-03-05 | 2010-08-10 | Eli Lilly And Company | Purine derivatives as kinase inhibitors |
-
2003
- 2003-03-05 CA CA002477984A patent/CA2477984A1/en not_active Abandoned
- 2003-03-05 ES ES03713551T patent/ES2289274T3/es not_active Expired - Lifetime
- 2003-03-05 JP JP2003574619A patent/JP2005530707A/ja not_active Withdrawn
- 2003-03-05 WO PCT/US2003/005052 patent/WO2003076398A2/en not_active Ceased
- 2003-03-05 IL IL16377703A patent/IL163777A0/xx unknown
- 2003-03-05 CN CNA038054531A patent/CN1639152A/zh active Pending
- 2003-03-05 DE DE60315270T patent/DE60315270T2/de not_active Expired - Lifetime
- 2003-03-05 US US10/506,029 patent/US7405305B2/en not_active Expired - Fee Related
- 2003-03-05 EP EP03713551A patent/EP1487822B1/de not_active Expired - Lifetime
- 2003-03-05 MX MXPA04008671A patent/MXPA04008671A/es not_active Application Discontinuation
- 2003-03-05 AU AU2003217596A patent/AU2003217596A1/en not_active Abandoned
- 2003-03-05 AT AT03713551T patent/ATE368657T1/de not_active IP Right Cessation
- 2003-03-05 KR KR10-2004-7014028A patent/KR20040091113A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1487822A2 (de) | 2004-12-22 |
| EP1487822B1 (de) | 2007-08-01 |
| JP2005530707A (ja) | 2005-10-13 |
| US20050288321A1 (en) | 2005-12-29 |
| CN1639152A (zh) | 2005-07-13 |
| AU2003217596A1 (en) | 2003-09-22 |
| ES2289274T3 (es) | 2008-02-01 |
| DE60315270T2 (de) | 2008-04-17 |
| DE60315270D1 (de) | 2007-09-13 |
| US7405305B2 (en) | 2008-07-29 |
| KR20040091113A (ko) | 2004-10-27 |
| IL163777A0 (en) | 2005-12-18 |
| WO2003076398A3 (en) | 2004-02-26 |
| WO2003076398A2 (en) | 2003-09-18 |
| MXPA04008671A (es) | 2004-12-06 |
| CA2477984A1 (en) | 2003-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |