PL1904482T3 - Pochodne indolilomaleimidowe - Google Patents

Pochodne indolilomaleimidowe

Info

Publication number: PL1904482T3
Authority: PL; Poland
Prior art keywords: indolylmaleimide derivatives; indolylmaleimide; derivatives; ring; transplantation
Prior art date: 2005-07-11

Application number

PL06754708T

Other languages

English (en)

Inventor

Jürgen Wagner

Eis Maurice Van

Matt Peter Von

Jean-Pierre Evenou

Walter Schuler

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-11

Filing date

2006-07-10

Publication date

2011-06-30

2005-07-11 Priority claimed from GB0514205A external-priority patent/GB0514205D0/en

2005-07-11 Priority claimed from GB0514204A external-priority patent/GB0514204D0/en

2006-07-10 Application filed by Novartis Ag filed Critical Novartis Ag

2011-06-30 Publication of PL1904482T3 publication Critical patent/PL1904482T3/pl

Links

WIQRSJOCVVPMPS-UHFFFAOYSA-N 3-(1h-indol-2-yl)pyrrole-2,5-dione Chemical class O=C1NC(=O)C(C=2NC3=CC=CC=C3C=2)=C1 WIQRSJOCVVPMPS-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Virology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Gynecology & Obstetrics (AREA)
Tropical Medicine & Parasitology (AREA)

PL06754708T 2005-07-11 2006-07-10 Pochodne indolilomaleimidowe PL1904482T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0514205A GB0514205D0 (en)	2005-07-11	2005-07-11	Organic compounds
GB0514204A GB0514204D0 (en)	2005-07-11	2005-07-11	Organic compounds
PCT/EP2006/006732 WO2007006533A2 (en)	2005-07-11	2006-07-10	Indolylmaleimide derivatives
EP06754708A EP1904482B1 (en)	2005-07-11	2006-07-10	Indolylmaleimide derivatives

Publications (1)

Publication Number	Publication Date
PL1904482T3 true PL1904482T3 (pl)	2011-06-30

Family

ID=37202261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06754708T PL1904482T3 (pl)	2005-07-11	2006-07-10	Pochodne indolilomaleimidowe

Country Status (15)

Country	Link
US (2)	US7781438B2 (pl)
EP (2)	EP2246346B1 (pl)
JP (2)	JP2009501172A (pl)
KR (1)	KR20080023732A (pl)
AT (1)	ATE496044T1 (pl)
AU (1)	AU2006268908A1 (pl)
BR (1)	BRPI0613064A2 (pl)
CA (1)	CA2611607A1 (pl)
DE (1)	DE602006019732D1 (pl)
ES (1)	ES2396671T3 (pl)
MX (1)	MX2008000463A (pl)
PL (1)	PL1904482T3 (pl)
PT (1)	PT1904482E (pl)
RU (1)	RU2008104510A (pl)
WO (1)	WO2007006533A2 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20090100363A (ko)	2006-12-19	2009-09-23	노파르티스 아게	키나제 억제제로서의 인돌릴말레이미드 유도체
FR2927075A1 (fr) *	2008-02-04	2009-08-07	Centre Nat Rech Scient	Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
JP5641664B2 (ja)	2009-10-30	2014-12-17	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎＰｈａｒｍａｃｅｕｔｉｃａＮａａｍｌｏｚｅＶｅｎｎｏｏｔｓｃｈａｐ	イミダゾ［１，２−ｂ］ピリダジン誘導体およびＰＤＥ１０阻害剤としてのそれらの使用
AR080754A1 (es)	2010-03-09	2012-05-09	Janssen Pharmaceutica Nv	Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
BR112012024585A2 (pt) *	2010-03-30	2016-05-31	Novartis Ag	inibidores de pkc para o tratamento de linfomade células b tendo sinalização do receptor de células b ativas crônicas
BR112013033375B1 (pt)	2011-06-27	2022-05-10	Janssen Pharmaceutica N.V	Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
GB201111427D0 (en) *	2011-07-05	2011-08-17	Amakem Nv	Novel bisindolylmaleimides, pan-pkc inhibitors
AU2013283426B2 (en)	2012-06-26	2018-02-22	Janssen Pharmaceutica Nv	Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological or metabolic disorders
WO2014009305A1 (en)	2012-07-09	2014-01-16	Janssen Pharmaceutica Nv	Inhibitors of phosphodiesterase 10 enzyme
PL2925366T3 (pl)	2012-11-29	2018-08-31	Novartis Ag	Kombinacje farmaceutyczne
WO2014174478A1 (en)	2013-04-26	2014-10-30	Novartis Ag	Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor
JO3589B1 (ar)	2014-08-06	2020-07-05	Novartis Ag	مثبطات كيناز البروتين c وطرق استخداماتها
WO2018175340A1 (en)	2017-03-20	2018-09-27	Sienna Biopharmaceuticals, Inc.	Reduced exposure conjugates modulating therapeutic targets
WO2018175302A1 (en)	2017-03-20	2018-09-27	Sienna Biopharmaceuticals, Inc.	Polymer conjugates targeting c-src with reduced exposure

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US36736A (en) *		1862-10-21		Improvement in curry-combs
SK75289A3 (en) *	1988-02-10	1998-05-06	Hoffmann La Roche	Substituted pyrroles, their use for producing a drug, and the drug on their base
MC2096A1 (fr) *	1989-02-23	1991-02-15	Hoffmann La Roche	Pyrroles substitues
GB9123396D0 (en)	1991-11-04	1991-12-18	Hoffmann La Roche	A process for the manufacture of substituted maleimides
ATE456367T1 (de) *	1993-12-23	2010-02-15	Lilly Co Eli	Proteinkinase c inhibitoren
ES2332770T3 (es) *	2000-11-07	2010-02-12	Novartis Ag	Derivados de indolilmaleimida como inhibidores de la proteina quinasa c.
US6645970B2 (en) *	2000-11-07	2003-11-11	Novartis Ag	Indolylmaleimide derivatives
BE1014306A6 (fr)	2001-07-19	2003-08-05	Project 21C	Dispositif de stationnement d'un cycle avec antivol.
IL163777A0 (en) *	2002-03-08	2005-12-18	Lilly Co Eli	Kinase inhibitors
PE20040079A1 (es) *	2002-04-03	2004-04-19	Novartis Ag	Derivados de indolilmaleimida
EP1513520B1 (en) *	2002-06-05	2008-09-24	Janssen Pharmaceutica N.V.	Substituted pyrrolines as kinase inhibitors
JP2005531609A (ja) *	2002-06-05	2005-10-20	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	キナーゼ阻害剤としてのシスインドリル−マレイミド誘導体
GB0303319D0 (en) *	2003-02-13	2003-03-19	Novartis Ag	Organic compounds
EP1745037B1 (en) *	2004-01-19	2013-01-02	Novartis AG	Indolylmaleimide derivatives as inhibitors for the treatment of graft rejection or autoimmune diseases

2006
- 2006-07-10 EP EP10006826A patent/EP2246346B1/en not_active Not-in-force
- 2006-07-10 US US11/995,450 patent/US7781438B2/en not_active Expired - Fee Related
- 2006-07-10 CA CA002611607A patent/CA2611607A1/en not_active Abandoned
- 2006-07-10 PT PT06754708T patent/PT1904482E/pt unknown
- 2006-07-10 JP JP2008520772A patent/JP2009501172A/ja active Pending
- 2006-07-10 EP EP06754708A patent/EP1904482B1/en not_active Not-in-force
- 2006-07-10 ES ES10006826T patent/ES2396671T3/es active Active
- 2006-07-10 KR KR1020087000790A patent/KR20080023732A/ko not_active Withdrawn
- 2006-07-10 BR BRPI0613064-0A patent/BRPI0613064A2/pt not_active IP Right Cessation
- 2006-07-10 DE DE602006019732T patent/DE602006019732D1/de active Active
- 2006-07-10 AU AU2006268908A patent/AU2006268908A1/en not_active Abandoned
- 2006-07-10 PL PL06754708T patent/PL1904482T3/pl unknown
- 2006-07-10 WO PCT/EP2006/006732 patent/WO2007006533A2/en not_active Ceased
- 2006-07-10 MX MX2008000463A patent/MX2008000463A/es not_active Application Discontinuation
- 2006-07-10 AT AT06754708T patent/ATE496044T1/de active
- 2006-07-10 RU RU2008104510/04A patent/RU2008104510A/ru not_active Application Discontinuation
2010
- 2010-07-09 US US12/833,462 patent/US8426440B2/en not_active Expired - Fee Related
2012
- 2012-02-02 JP JP2012021182A patent/JP2012121901A/ja active Pending

Also Published As

Publication number	Publication date
EP1904482B1 (en)	2011-01-19
US8426440B2 (en)	2013-04-23
RU2008104510A (ru)	2009-08-20
US20100273774A1 (en)	2010-10-28
ES2396671T3 (es)	2013-02-25
MX2008000463A (es)	2008-03-11
JP2012121901A (ja)	2012-06-28
US7781438B2 (en)	2010-08-24
US20080318975A1 (en)	2008-12-25
AU2006268908A1 (en)	2007-01-18
BRPI0613064A2 (pt)	2010-12-21
ATE496044T1 (de)	2011-02-15
CA2611607A1 (en)	2007-01-18
WO2007006533A3 (en)	2007-05-24
JP2009501172A (ja)	2009-01-15
EP1904482A2 (en)	2008-04-02
KR20080023732A (ko)	2008-03-14
EP2246346B1 (en)	2012-10-24
WO2007006533A2 (en)	2007-01-18
EP2246346A1 (en)	2010-11-03
PT1904482E (pt)	2011-04-01
DE602006019732D1 (de)	2011-03-03

Publication	Publication Date	Title
IL192253A0 (en)	2008-12-29	Substituted cyclohexylmethyl derivatives
WO2007061923A3 (en)	2007-11-01	Glucokinase activators
MX2007005933A (es)	2007-06-20	Compuestos de acetamida como fungicidas.
MX2009009774A (es)	2009-09-23	Derivados de quinolina como fungicidas.
MY156319A (en)	2016-02-15	Spiroheterocyclic n-oxypiperidines as pesticides
DE602004024213D1 (en)	2009-12-31	Aminopropanolderivate
WO2008116107A3 (en)	2009-03-19	Piperazine derivatives as glucokinase activators
TN2010000064A1 (en)	2011-09-26	Novel herbicides
MX2010001364A (es)	2010-03-01	Derivados de ciclopentandiona puenteados triciclicos como herbicidas.
TW200732335A (en)	2007-09-01	Organic compounds
MX2009006533A (es)	2009-06-26	Derivados de indolil-maleimida como inhibidores de cinasa.
GB0411929D0 (en)	2004-06-30	Organic compounds
PL1904482T3 (pl)	2011-06-30	Pochodne indolilomaleimidowe
WO2006100082A3 (de)	2006-12-07	Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung
JO2734B1 (en)	2013-09-15	Organic compounds
TW200732337A (en)	2007-09-01	Organic compounds
MX2009008221A (es)	2009-08-12	Antagonista de receptor de cromeno s1p1.
TN2010000094A1 (en)	2011-09-26	Novel herbicides
MY150497A (en)	2014-01-30	New camptothecin analogue compounds, a process for their preparation and pharmaceutical compositions containing them
IL205083A0 (en)	2010-11-30	Process for the preparation of tetranorlabdane derivatives
GEP20084502B (en)	2008-10-10	Piperazine compounds, a process for their preparation and pharmaceutical compositions containing them
WO2007048843A3 (de)	2007-08-16	Imidazo-pyridin-haltige beta-agonisten, verfahren zu deren herstellung und deren verwendung als arzneimittel
WO2007026041A3 (es)	2007-05-03	Compuestos 1,4 antraquinonicos, su procedimiento de obtencion y su aplicacion como antiumorales.
UA94235C2 (en)	2011-04-26	Novel benzothiazolone derivatives
UA105372C2 (en)	2014-05-12	Normal;heading 1;heading 2;heading 3;SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES