ATE368687T1 - Thrombopoietinproteine mit verbesserten eigenschaften - Google Patents

Thrombopoietinproteine mit verbesserten eigenschaften

Info

Publication number
ATE368687T1
ATE368687T1 AT04740298T AT04740298T ATE368687T1 AT E368687 T1 ATE368687 T1 AT E368687T1 AT 04740298 T AT04740298 T AT 04740298T AT 04740298 T AT04740298 T AT 04740298T AT E368687 T1 ATE368687 T1 AT E368687T1
Authority
AT
Austria
Prior art keywords
tpo
improved
thrombopoietin
proteins
improved properties
Prior art date
Application number
AT04740298T
Other languages
English (en)
Inventor
Matthew Baker
John Watkins
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE368687T1 publication Critical patent/ATE368687T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04740298T 2003-06-26 2004-06-25 Thrombopoietinproteine mit verbesserten eigenschaften ATE368687T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03014331 2003-06-26

Publications (1)

Publication Number Publication Date
ATE368687T1 true ATE368687T1 (de) 2007-08-15

Family

ID=33547598

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04740298T ATE368687T1 (de) 2003-06-26 2004-06-25 Thrombopoietinproteine mit verbesserten eigenschaften

Country Status (9)

Country Link
US (1) US7541439B2 (de)
EP (1) EP1636261B1 (de)
AT (1) ATE368687T1 (de)
DE (1) DE602004007924T2 (de)
DK (1) DK1636261T3 (de)
ES (1) ES2289528T3 (de)
PL (1) PL1636261T3 (de)
PT (1) PT1636261E (de)
WO (1) WO2005000891A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
GB0710529D0 (en) 2007-06-01 2007-07-11 Circassia Ltd Vaccine
AU2008279550B2 (en) * 2007-06-21 2012-08-09 Angelica Therapeutics, Inc. Modified toxins
NZ583362A (en) 2007-08-15 2012-06-29 Circassia Ltd Peptide with reduced dimer formation
WO2009110944A1 (en) * 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Modified toxins
EP2390261A4 (de) * 2009-01-20 2012-11-14 Hanall Biopharma Co Ltd Modifiziertes menschliches thrombopoietin-polypeptid-fragment und verfahren zu seiner herstellung
CA2863224A1 (en) 2012-01-09 2013-07-18 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
EP2943512A4 (de) 2013-01-11 2016-06-01 California Inst Biomedical Res Bovine fusionsantikörper
EP2968450A4 (de) 2013-03-15 2016-10-26 Angelica Therapeutics Inc Modifizierte toxine
CN106661128A (zh) * 2014-06-06 2017-05-10 加州生物医学研究所 构建氨基末端免疫球蛋白融合蛋白的方法及其组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284471B1 (en) * 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US6238890B1 (en) * 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US6458563B1 (en) * 1996-06-26 2002-10-01 Emory University Modified factor VIII
BR0207542A (pt) * 2001-02-26 2004-03-09 Merck Patent Gmbh Trombopoietina modificada com imunogenicidade reduzida
DK1454138T3 (da) * 2001-12-04 2012-02-13 Merck Patent Gmbh Immunocytokiner med moduleret selektivitet
DK1578772T3 (da) * 2002-05-01 2010-08-16 Danisco Us Inc Cytokiner og cytokinreceptorer med reduceret immunogenicitet

Also Published As

Publication number Publication date
DE602004007924T2 (de) 2008-04-10
ES2289528T3 (es) 2008-02-01
WO2005000891A3 (en) 2005-04-21
EP1636261B1 (de) 2007-08-01
US20060160995A1 (en) 2006-07-20
WO2005000891A2 (en) 2005-01-06
EP1636261A2 (de) 2006-03-22
PL1636261T3 (pl) 2007-12-31
DE602004007924D1 (de) 2007-09-13
DK1636261T3 (da) 2007-11-12
PT1636261E (pt) 2007-11-08
US7541439B2 (en) 2009-06-02

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