ATE368735T1 - Neue aggrecanase - Google Patents

Neue aggrecanase

Info

Publication number
ATE368735T1
ATE368735T1 AT01271116T AT01271116T ATE368735T1 AT E368735 T1 ATE368735 T1 AT E368735T1 AT 01271116 T AT01271116 T AT 01271116T AT 01271116 T AT01271116 T AT 01271116T AT E368735 T1 ATE368735 T1 AT E368735T1
Authority
AT
Austria
Prior art keywords
polypeptide
aggrecanase
joint diseases
new
expression vector
Prior art date
Application number
AT01271116T
Other languages
English (en)
Inventor
Noboru Yamaji
Kouichi Nishimura
Kunitake Abe
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of ATE368735T1 publication Critical patent/ATE368735T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
AT01271116T 2000-12-18 2001-12-17 Neue aggrecanase ATE368735T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000384300 2000-12-18

Publications (1)

Publication Number Publication Date
ATE368735T1 true ATE368735T1 (de) 2007-08-15

Family

ID=18851794

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01271116T ATE368735T1 (de) 2000-12-18 2001-12-17 Neue aggrecanase

Country Status (8)

Country Link
US (2) US7094590B2 (de)
EP (1) EP1344821B9 (de)
JP (1) JP3800175B2 (de)
AT (1) ATE368735T1 (de)
AU (1) AU2002222658A1 (de)
DE (1) DE60129736T2 (de)
ES (1) ES2288909T3 (de)
WO (1) WO2002050258A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448388B1 (en) * 2000-08-16 2002-09-10 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
ATE368735T1 (de) * 2000-12-18 2007-08-15 Astellas Pharma Inc Neue aggrecanase
JP2005506833A (ja) * 2001-06-04 2005-03-10 キュラジェン コーポレイション 抗原性ポリペプチドに結合する新規抗体、抗原をコード化する核酸、および使用方法
AU2002329847B2 (en) * 2001-08-22 2007-08-09 Lexicon Pharmaceuticals, Inc. Novel human proteases and polynucleotides encoding the same
JP2003180384A (ja) * 2001-09-24 2003-07-02 Daiichi Fine Chemical Co Ltd Ａｄａｍｔｓ−１５，−１６，−１７，−１８及び−１９
WO2004055158A2 (en) * 2001-10-05 2004-07-01 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
CA2474908A1 (en) * 2002-01-31 2003-08-07 Wyeth Aggrecanase molecules
WO2003089644A1 (fr) * 2002-04-19 2003-10-30 Riken Nouvelles proteines et adn codant pour elles
EP2295570A1 (de) * 2005-07-27 2011-03-16 Oncotherapy Science, Inc. Verfahren zur Diagnose von kleinzelligem Lungenkrebs
ATE496133T1 (de) * 2006-02-08 2011-02-15 Usv Ltd Affinitätspolypeptid zur reinigung von rekombinanten proteinen
KR20110084254A (ko) * 2008-10-16 2011-07-21 사이토닉스 코포레이션 척추 및 관절 통증을 탐지하고 치료하는 생체표식 및 방법
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0998572A2 (de) 1997-07-25 2000-05-10 Du Pont Pharmaceuticals Company Aggrecan abbauende metalloproteasen
US6927056B2 (en) * 2001-09-06 2005-08-09 Incyte Corporation Proteases
ATE368735T1 (de) 2000-12-18 2007-08-15 Astellas Pharma Inc Neue aggrecanase
US20040018555A1 (en) * 2001-06-04 2004-01-29 Anderson David W. Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
JP2003180384A (ja) 2001-09-24 2003-07-02 Daiichi Fine Chemical Co Ltd Ａｄａｍｔｓ−１５，−１６，−１７，−１８及び−１９
JP2003144154A (ja) 2001-11-14 2003-05-20 Mitsubishi Pharma Corp 新規なａｄａｍｔｓファミリーポリペプチドおよびそれをコードする遺伝子

Also Published As

Publication number Publication date
JP3800175B2 (ja) 2006-07-26
DE60129736T2 (de) 2008-04-17
US7094590B2 (en) 2006-08-22
EP1344821B9 (de) 2008-02-27
JPWO2002050258A1 (ja) 2004-04-22
ES2288909T3 (es) 2008-02-01
AU2002222658A1 (en) 2002-07-01
US7193073B2 (en) 2007-03-20
DE60129736D1 (de) 2007-09-13
WO2002050258A1 (en) 2002-06-27
EP1344821A4 (de) 2004-06-09
EP1344821B1 (de) 2007-08-01
US20030185828A1 (en) 2003-10-02
US20060078957A1 (en) 2006-04-13
EP1344821A1 (de) 2003-09-17

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