ATE368741T1 - Das nk1 fragment des hepatocytwachstumfaktors/dispersionsfaktors (hgf/sf), varianten davon und deren verwendung - Google Patents

Das nk1 fragment des hepatocytwachstumfaktors/dispersionsfaktors (hgf/sf), varianten davon und deren verwendung

Info

Publication number: ATE368741T1
Authority: AT; Austria
Prior art keywords: variants; hgf; fragment; factor; hepatocyt
Prior art date: 2001-04-27

Application number

AT02720271T

Other languages

English (en)

Inventor

Ermanno Gherardi

Daniel Lietha

Thomas Leon Blundell

Dimitry Yurievich Chirgadze

Original Assignee

Medical Res Council

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-27

Filing date

2002-04-29

Publication date

2007-08-15

2002-04-29 Application filed by Medical Res Council filed Critical Medical Res Council

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE368741T1 publication Critical patent/ATE368741T1/de

Links

239000012634 fragment Substances 0.000 title abstract 2
239000003102 growth factor Substances 0.000 title abstract 2
239000006185 dispersion Substances 0.000 title 1
210000003494 hepatocyte Anatomy 0.000 title 1
239000000556 agonist Substances 0.000 abstract 2
238000006467 substitution reaction Methods 0.000 abstract 2
208000007788 Acute Liver Failure Diseases 0.000 abstract 1
206010000804 Acute hepatic failure Diseases 0.000 abstract 1
230000006820 DNA synthesis Effects 0.000 abstract 1
102000003745 Hepatocyte Growth Factor Human genes 0.000 abstract 1
108090000100 Hepatocyte Growth Factor Proteins 0.000 abstract 1
206010067125 Liver injury Diseases 0.000 abstract 1
231100000836 acute liver failure Toxicity 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
231100000234 hepatic damage Toxicity 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000008818 liver damage Effects 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Obesity (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)

AT02720271T 2001-04-27 2002-04-29 Das nk1 fragment des hepatocytwachstumfaktors/dispersionsfaktors (hgf/sf), varianten davon und deren verwendung ATE368741T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0110430.6A GB0110430D0 (en)	2001-04-27	2001-04-27	Protein variants and uses thereof

Publications (1)

Publication Number	Publication Date
ATE368741T1 true ATE368741T1 (de)	2007-08-15

Family

ID=9913640

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02720271T ATE368741T1 (de)	2001-04-27	2002-04-29	Das nk1 fragment des hepatocytwachstumfaktors/dispersionsfaktors (hgf/sf), varianten davon und deren verwendung

Country Status (11)

Country	Link
US (3)	US7179786B2 (de)
EP (1)	EP1381681B1 (de)
JP (2)	JP4637452B2 (de)
AT (1)	ATE368741T1 (de)
AU (1)	AU2002251337B2 (de)
CA (1)	CA2440775C (de)
DE (1)	DE60221510T2 (de)
DK (1)	DK1381681T3 (de)
ES (1)	ES2291460T3 (de)
GB (1)	GB0110430D0 (de)
WO (1)	WO2002088354A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0110430D0 (en) *	2001-04-27	2001-06-20	Medical Res Council	Protein variants and uses thereof
US20050107296A1 (en) *	2001-10-31	2005-05-19	Institut Des Vaisseaux Et Du Sang	Isolated peptide of the hepatocyte growth factor and its variants, preparation method and therapeutic use as anti-angiogenic agents
AT412785B (de) *	2003-12-04	2005-07-25	Kungl Andreas J Dr	Gag-bindungsproteine
US7563570B2 (en)	2004-10-29	2009-07-21	Pangaea Biotech	Method of determining a chemotherapeutic regimen for non small cell lung cancer based on BRCA1 expression
US20090215686A1 (en) *	2007-03-05	2009-08-27	Huaqiang Eric Xu	Nk1-based polypeptides and related methods
AU2008323719B2 (en) *	2007-11-09	2013-04-04	New York Medical College	Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor
CN103037892A (zh) *	2010-02-22	2013-04-10	布里格姆妇女医院	诱导血管生成的组合物和方法
US9556248B2 (en) *	2010-03-19	2017-01-31	The Board Of Trustees Of The Leland Stanford Junior University	Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists
CA2817197C (en)	2010-11-08	2020-08-04	The Board Of Trustees Of The Leland Stanford Junior University	Fusion proteins comprising an engineered knottin peptide and uses thereof
WO2013037520A1 (en)	2011-09-16	2013-03-21	Glaxo Group Limited	Modified hgf-1k1 polypeptide
WO2013037521A1 (en)	2011-09-16	2013-03-21	Medical Research Council	Modified hgf-1k1 polypeptide
EP3247719B1 (de) *	2015-01-21	2019-09-25	Université de Lille	Met-rezeptoragonistenproteine
US10111966B2 (en)	2016-06-17	2018-10-30	Magenta Therapeutics, Inc.	Methods for the depletion of CD117+ cells
GB201611123D0 (en)	2016-06-27	2016-08-10	Euremab Srl	Anti met antibodiesand uses thereof
SG11201906319XA (en)	2017-01-20	2019-08-27	Magenta Therapeutics Inc	Compositions and methods for the depletion of cd137+ cells
IT201800000535A1 (it)	2018-01-03	2019-07-03		Procedimenti per la cura del cancro.
JP2022513178A (ja)	2018-10-09	2022-02-07	ザボードオブトラスティーズオブザレランドスタンフォードジュニアユニバーシティー	受容体アンタゴニストとしての操作された線維芽細胞増殖因子多様体
CN109535243B (zh) *	2019-01-07	2019-09-24	北京诺思兰德生物技术股份有限公司	人肝细胞生长因子突变体及其应用
CN119613527B (zh) *	2024-12-30	2026-02-06	江苏三仪生物工程有限公司	鸡肝细胞生长因子的截短突变体及其在防治肝脏相关疾病方面的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5594115A (en) *	1990-04-09	1997-01-14	Pharmacia & Upjohn Company	Process of purifying recombinant proteins and compounds useful in such process
US6566098B1 (en) *	1990-09-14	2003-05-20	The United States Of America As Represented By The Department Of Health And Human Services	DNA encoding truncated hepatocyte growth factor variants
DK0642580T3 (da)	1992-05-18	2002-12-23	Genentech Inc	Hepactocytvækstfaktorvarianter
JP4006058B2 (ja) *	1997-03-11	2007-11-14	第一三共株式会社	多臓器不全予防及び／又は治療剤
GB0110430D0 (en) *	2001-04-27	2001-06-20	Medical Res Council	Protein variants and uses thereof

2001
- 2001-04-27 GB GBGB0110430.6A patent/GB0110430D0/en not_active Ceased
2002
- 2002-04-29 ES ES02720271T patent/ES2291460T3/es not_active Expired - Lifetime
- 2002-04-29 DK DK02720271T patent/DK1381681T3/da active
- 2002-04-29 JP JP2002585635A patent/JP4637452B2/ja not_active Expired - Fee Related
- 2002-04-29 US US10/475,616 patent/US7179786B2/en not_active Expired - Fee Related
- 2002-04-29 WO PCT/GB2002/001941 patent/WO2002088354A1/en not_active Ceased
- 2002-04-29 DE DE60221510T patent/DE60221510T2/de not_active Expired - Lifetime
- 2002-04-29 CA CA2440775A patent/CA2440775C/en not_active Expired - Fee Related
- 2002-04-29 AT AT02720271T patent/ATE368741T1/de not_active IP Right Cessation
- 2002-04-29 AU AU2002251337A patent/AU2002251337B2/en not_active Ceased
- 2002-04-29 EP EP02720271A patent/EP1381681B1/de not_active Expired - Lifetime
2007
- 2007-01-26 US US11/627,761 patent/US7795214B2/en not_active Expired - Fee Related
2010
- 2010-08-17 US US12/858,189 patent/US8232258B2/en not_active Expired - Fee Related
- 2010-09-17 JP JP2010208693A patent/JP2011045370A/ja active Pending

Also Published As

Publication number	Publication date
US20110021612A1 (en)	2011-01-27
AU2002251337B2 (en)	2007-08-02
US20040236073A1 (en)	2004-11-25
ES2291460T3 (es)	2008-03-01
JP2004532032A (ja)	2004-10-21
EP1381681B1 (de)	2007-08-01
GB0110430D0 (en)	2001-06-20
JP2011045370A (ja)	2011-03-10
CA2440775C (en)	2013-02-26
WO2002088354A1 (en)	2002-11-07
DE60221510D1 (de)	2007-09-13
US8232258B2 (en)	2012-07-31
DK1381681T3 (da)	2007-10-29
US7795214B2 (en)	2010-09-14
US7179786B2 (en)	2007-02-20
DE60221510T2 (de)	2008-04-17
CA2440775A1 (en)	2002-11-07
JP4637452B2 (ja)	2011-02-23
EP1381681A1 (de)	2004-01-21
US20080167224A1 (en)	2008-07-10

Legal Events

Date	Code	Title	Description
2008-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60221510D1 (de)	2007-09-13	Das nk1 fragment des hepatocytwachstumfaktors/dispersionsfaktors (hgf/sf), varianten davon und deren verwendung
TR200100267T2 (tr)	2001-09-21	İkameli anilid bileşimleri ve yöntemler.
DK1091975T3 (da)	2006-04-18	Ny cyclosporin med forbedret aktivitetsprofil
DE69916591T2 (de)	2005-04-21	Hochzähe, hochfeste amorphe zirkoniumlegierung
EE200300307A (et)	2003-10-15	1,5-bensotiasepiinid ja nende kasutamine antilipideemiliste vahenditena
DE60039515D1 (de)	2008-08-28	Zusammensetzung für ersatz für knochentransplantat
EE9700363A (et)	1998-06-15	Uus anesteseeriva toimega farmatseutiline segu
PL375874A1 (pl)	2005-12-12	Wodne kompozycje farmaceutyczne 2,6-diizopropylofenolu
TR200103233T2 (tr)	2002-04-22	Antikolinerjik etkili bileşik ve ß-mimetikler bazında yeni ilaç bileşimleri.
TR200101772T2 (tr)	2002-04-22	IL-8 Reseptörü antagonistleri olarak hidroksi difenil üre sülfonamidler
BR0213207A (pt)	2006-10-31	remodelagem e glicoconjugação de peptìdeos
DK1077941T3 (da)	2009-12-07	Forbindelser med væksthormonfrigörende egenskaber
DE69916828D1 (de)	2004-06-03	Pyrazoline, ihre herstellung und verwendung als medikamente
FI991485L (fi)	2000-12-31	Uusi farmaseuttinen koostumus
DE60038922D1 (de)	2008-07-03	Zusammensetzungen für den wiederaufbau von knochengewebe
MA25527A1 (fr)	2002-10-01	Composition d'encollage.
PT1321135E (pt)	2006-09-29	Composicao para o tigimento de oxidacao das fibras ceratinicas
DE60041418D1 (de)	2009-03-05	Zusammensetzung für hydrogele, hydrogel und dessen verwendung
ATE305517T1 (de)	2005-10-15	Neurotrypsin
SE9904404L (sv)	2000-12-23	Ny komposition
DK1100824T3 (da)	2011-06-20	Forbindelser med væksthormonfrigivende egenskaber
DE60015187D1 (de)	2004-11-25	Urotensin-ii rezeptorantagonisten
NO20060420L (no)	2006-01-25	2-aminobenzoylderivater
BR9811694A (pt)	2000-09-26	Forno de cúpula.
EP1096927A4 (de)	2002-09-04	Zusammensetzung für stressbehandlung