ATE369140T1 - Stickstoffoxid zur behandlung therapieresistenter organismen - Google Patents

Stickstoffoxid zur behandlung therapieresistenter organismen

Info

Publication number
ATE369140T1
ATE369140T1 AT01965420T AT01965420T ATE369140T1 AT E369140 T1 ATE369140 T1 AT E369140T1 AT 01965420 T AT01965420 T AT 01965420T AT 01965420 T AT01965420 T AT 01965420T AT E369140 T1 ATE369140 T1 AT E369140T1
Authority
AT
Austria
Prior art keywords
therapy
treatment
nitrogen oxide
resistant organisms
resistant
Prior art date
Application number
AT01965420T
Other languages
English (en)
Inventor
Nigel Benjamin
Anthony Ormerod
Original Assignee
Univ Aberdeen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Aberdeen filed Critical Univ Aberdeen
Application granted granted Critical
Publication of ATE369140T1 publication Critical patent/ATE369140T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/191Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01965420T 2000-09-08 2001-09-10 Stickstoffoxid zur behandlung therapieresistenter organismen ATE369140T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0022084.8A GB0022084D0 (en) 2000-09-08 2000-09-08 Treatment of multiply antibiotic-resistant organisms

Publications (1)

Publication Number Publication Date
ATE369140T1 true ATE369140T1 (de) 2007-08-15

Family

ID=9899110

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01965420T ATE369140T1 (de) 2000-09-08 2001-09-10 Stickstoffoxid zur behandlung therapieresistenter organismen

Country Status (9)

Country Link
US (1) US20040037897A1 (de)
EP (1) EP1315509B1 (de)
JP (1) JP5634655B2 (de)
AT (1) ATE369140T1 (de)
AU (1) AU2001286064A1 (de)
DE (1) DE60129823T2 (de)
ES (1) ES2291345T3 (de)
GB (1) GB0022084D0 (de)
WO (1) WO2002020026A2 (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0125222D0 (en) * 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
US7846141B2 (en) 2002-09-03 2010-12-07 Bluesky Medical Group Incorporated Reduced pressure treatment system
GB0224986D0 (en) 2002-10-28 2002-12-04 Smith & Nephew Apparatus
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
TR201900345T4 (tr) * 2003-04-23 2019-02-21 Univ Akron Şelatlanmış reaktif malzemeler.
JP5564158B2 (ja) 2003-07-09 2014-07-30 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ 亜硝酸塩によって特定の心臓血管状態を処置する方法
US7909805B2 (en) 2004-04-05 2011-03-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US8062272B2 (en) 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US10058642B2 (en) 2004-04-05 2018-08-28 Bluesky Medical Group Incorporated Reduced pressure treatment system
GB0409446D0 (en) 2004-04-28 2004-06-02 Smith & Nephew Apparatus
US7362274B1 (en) * 2004-07-09 2008-04-22 Huan-Cheng Lien Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna
US7618594B2 (en) 2004-08-18 2009-11-17 Geno Llc Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
AU2005277397B2 (en) 2004-08-18 2011-08-25 VERO Biotech LLC. Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
EP1871433B1 (de) * 2005-03-24 2009-04-22 NOLabs AB Kosmetische behandlung mit stickoxid, vorrichtung zur durchführung dieser behandlung und herstellungsverfahren dafür
WO2006125123A2 (en) * 2005-05-19 2006-11-23 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
EP1888510A4 (de) 2005-05-27 2013-01-16 Univ North Carolina Stickoxidfreisetzende partikel für stickoxidtherapeutika und biomedizinische anwendungen
US7288622B1 (en) * 2006-09-19 2007-10-30 Issar Pharmaceuticals Pvt Ltd Composition for treatment of burns and wounds
GB0618711D0 (en) * 2006-09-22 2006-11-01 Univ Exeter Agricultural treatment
US20100178319A1 (en) * 2007-03-27 2010-07-15 Lars Lindgren Topical Dermal Delivery Device For Nitric Oxide Delivery
CN103977003A (zh) * 2007-04-02 2014-08-13 帕金森氏病研究院 用于降低治疗的副作用的方法和组合物
US9278157B2 (en) 2007-08-09 2016-03-08 Insense Limited Nitric oxide-generating skin dressings
GB0715556D0 (en) * 2007-08-09 2007-09-19 Insense Ltd Improvements relating to skin dressings
US8399005B2 (en) 2007-10-12 2013-03-19 University Of North Carolina At Chapel Hill Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents
WO2009055008A1 (en) * 2007-10-24 2009-04-30 Wharton Innovative Products, Llc Two part lotion for the delivery of nitrite ions to the skin
GB0722820D0 (en) 2007-11-21 2008-01-02 Smith & Nephew Vacuum assisted wound dressing
ES2776709T3 (es) 2007-11-21 2020-07-31 Smith & Nephew Apósito para heridas
ES2555204T3 (es) 2007-11-21 2015-12-29 T.J. Smith & Nephew Limited Dispositivo de succión y venda
US20130096518A1 (en) 2007-12-06 2013-04-18 Smith & Nephew Plc Wound filling apparatuses and methods
US11253399B2 (en) 2007-12-06 2022-02-22 Smith & Nephew Plc Wound filling apparatuses and methods
GB0723875D0 (en) 2007-12-06 2008-01-16 Smith & Nephew Wound management
EP2237788A4 (de) * 2007-12-27 2013-06-05 Aires Pharmaceuticals Inc Aerosolisierte nitrit- und stickoxidspendende verbindungen und ihre verwendung
CA2713049C (en) 2008-01-28 2017-02-28 Geno Llc Conversion of nitrogen dioxide (no2) to nitric oxide (no)
GB0803564D0 (en) 2008-02-27 2008-04-02 Smith & Nephew Fluid collection
US8607785B2 (en) 2008-08-21 2013-12-17 Geno Llc Systems and devices for generating nitric oxide
WO2010044875A2 (en) * 2008-10-16 2010-04-22 Novan, Inc. Nitric oxide releasing particles for oral care applications
CA2740135A1 (en) * 2008-10-30 2010-05-06 Chris Miller Wound dressings comprising a nitric oxide gas producing component and an oxygen releasing component
US8568793B2 (en) * 2009-02-11 2013-10-29 Hope Medical Enterprises, Inc. Sodium nitrite-containing pharmaceutical compositions
GB0902816D0 (en) 2009-02-19 2009-04-08 Smith & Nephew Fluid communication path
EP2445508B1 (de) 2009-06-22 2018-11-14 VERO Biotech LLC Stickoxidtherapien
WO2011022652A1 (en) 2009-08-21 2011-02-24 Novan, Inc. Topical gels
BR112012003804B1 (pt) 2009-08-21 2019-02-19 Novan, Inc. Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento
WO2011047013A1 (en) * 2009-10-13 2011-04-21 Novan, Inc. Nitric oxide-releasing coatings
US9061095B2 (en) 2010-04-27 2015-06-23 Smith & Nephew Plc Wound dressing and method of use
GB201011173D0 (en) 2010-07-02 2010-08-18 Smith & Nephew Provision of wound filler
GB201020005D0 (en) 2010-11-25 2011-01-12 Smith & Nephew Composition 1-1
JP6078472B2 (ja) 2010-11-25 2017-02-08 スミス アンド ネフュー ピーエルシーSmith & Nephew Public Limited Company 組成物i−iiおよび生成物ならびにそれらの使用
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
ES2695173T3 (es) 2011-02-28 2019-01-02 Novan Inc Partículas de sílice modificadas con S-nitrosotiol que liberan óxido nítrico y procedimientos de fabricación de las mismas
ES2804263T3 (es) 2011-07-05 2021-02-05 Novan Inc Composiciones tópicas
US20150159066A1 (en) 2011-11-25 2015-06-11 Smith & Nephew Plc Composition, apparatus, kit and method and uses thereof
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
US20160120706A1 (en) 2013-03-15 2016-05-05 Smith & Nephew Plc Wound dressing sealant and use thereof
EP2968647B1 (de) 2013-03-15 2022-06-29 Smith & Nephew plc Wundverbanddichtmasse und verwendung davon
US10517817B2 (en) 2013-05-09 2019-12-31 Syk Technologies, Llc Deep topical systemic nitric oxide therapy apparatus and method
US11813284B2 (en) 2013-08-08 2023-11-14 Novan, Inc. Topical compositions and methods of using the same
EP3166593B1 (de) 2014-07-11 2020-05-20 Novan, Inc. Topische antivirale zusammensetzungen und verfahren zur verwendung davon
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
US10925689B2 (en) 2014-07-14 2021-02-23 Novan, Inc. Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same
EP3177262A4 (de) 2014-08-08 2018-04-18 Novan Inc. Topische emulsionen
WO2017019614A1 (en) 2015-07-28 2017-02-02 Novan, Inc. Combinations and methods for the treatment and/or prevention of fungal infections
CA2997896C (en) 2015-09-09 2026-03-17 Beyond Air Ltd Nitric oxide inhalation therapy for infants with bronchiolitis
ES2968200T3 (es) 2016-01-27 2024-05-08 Syk Tech Llc Aparato y métodos de aplicación tópica de óxido nítrico
CN119185266A (zh) * 2016-02-25 2024-12-27 密歇根大学董事会 氧化氮产生制剂和试剂盒
US10912743B2 (en) 2016-03-02 2021-02-09 Novan, Inc. Compositions for treating inflammation and methods of treating the same
US11166980B2 (en) 2016-04-13 2021-11-09 Novan, Inc. Compositions, systems, kits, and methods for treating an infection
WO2019157295A1 (en) * 2018-02-09 2019-08-15 The Trustees Of Columbia University In The City Of New York Treating infections using inhibitor of cbb3-type oxidases
GB2579240B (en) * 2018-11-27 2020-12-16 Attgeno Ab New processes, compositions and medical uses
GB2599818B (en) * 2019-06-04 2024-01-31 Thirty Respiratory Ltd Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract
EP3980373A1 (de) * 2019-06-04 2022-04-13 Thirty Holdings Limited Verfahren und zusammensetzungen zur erzeugung von stickstoffmonoxid und verwendungen davon
BR112022021454A2 (pt) * 2020-04-23 2023-01-31 Thirty Respiratory Ltd Óxido nítrico ou composições liberadoras de óxido nítrico para uso no tratamento de sars-cov e sars-cov-2
JP2023526583A (ja) * 2020-04-23 2023-06-22 サーティー レスピラトリー リミテッド 結核を治療及び抑制するための方法及び組成物
GB202101543D0 (en) 2021-02-04 2021-03-24 Thirty Respiratory Ltd Vaping e-liquid composition and the use thereof
EP4452219A2 (de) 2021-12-22 2024-10-30 ConvaTec Limited Pulverzusammensetzung
WO2023118839A1 (en) 2021-12-22 2023-06-29 Thirty Holdings Limited Powder composition
GB202302117D0 (en) 2023-02-14 2023-03-29 Thirty Respiratory Ltd Compositions, kits and combinations
JP7617347B1 (ja) * 2023-06-26 2025-01-17 積水化学工業株式会社 樹脂組成物及び接続構造体の製造方法
GB2644374A (en) 2024-09-20 2026-04-08 Thirty Holdings Ltd Compositions and kits for generating nitric oxide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3164617B2 (ja) * 1991-11-07 2001-05-08 株式会社日立製作所 文字図形変形処理装置および方法
US5664086A (en) * 1993-04-16 1997-09-02 Adobe Systems Incorporated Method and apparatus for generating digital type font, and resulting fonts using generic font and descriptor file
DK0746327T3 (da) * 1994-02-21 2004-05-10 Univ Aberdeen Forsuret nitrit som antimikrobielt middel
US6426066B1 (en) * 2000-01-12 2002-07-30 California Pacific Labs, Inc. Use of physiologically balanced, ionized, acidic solution in wound healing
CA2402520A1 (en) * 2000-03-13 2001-09-20 Kenneth Beckman Biocidal methods and compositions

Also Published As

Publication number Publication date
WO2002020026A2 (en) 2002-03-14
JP5634655B2 (ja) 2014-12-03
US20040037897A1 (en) 2004-02-26
EP1315509A2 (de) 2003-06-04
GB0022084D0 (en) 2000-10-25
EP1315509B1 (de) 2007-08-08
AU2001286064A1 (en) 2002-03-22
DE60129823D1 (de) 2007-09-20
JP2004508337A (ja) 2004-03-18
ES2291345T3 (es) 2008-03-01
WO2002020026A3 (en) 2002-05-16
DE60129823T2 (de) 2008-04-24

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