ATE369363T1 - Antibiotika mit doppelwirkung - Google Patents

Antibiotika mit doppelwirkung

Info

Publication number
ATE369363T1
ATE369363T1 AT02796533T AT02796533T ATE369363T1 AT E369363 T1 ATE369363 T1 AT E369363T1 AT 02796533 T AT02796533 T AT 02796533T AT 02796533 T AT02796533 T AT 02796533T AT E369363 T1 ATE369363 T1 AT E369363T1
Authority
AT
Austria
Prior art keywords
antibiotics
dual effect
dual
effect
compounds
Prior art date
Application number
AT02796533T
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Luc Specklin
Original Assignee
Morphochem Ag Komb Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem Ag Komb Chemie filed Critical Morphochem Ag Komb Chemie
Application granted granted Critical
Publication of ATE369363T1 publication Critical patent/ATE369363T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT02796533T 2001-10-04 2002-10-04 Antibiotika mit doppelwirkung ATE369363T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32716201P 2001-10-04 2001-10-04

Publications (1)

Publication Number Publication Date
ATE369363T1 true ATE369363T1 (de) 2007-08-15

Family

ID=23275422

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02796533T ATE369363T1 (de) 2001-10-04 2002-10-04 Antibiotika mit doppelwirkung

Country Status (20)

Country Link
US (2) US7820823B2 (de)
EP (1) EP1432705B1 (de)
JP (2) JP4398245B2 (de)
KR (2) KR100927864B1 (de)
CN (2) CN1630655A (de)
AT (1) ATE369363T1 (de)
AU (1) AU2002361948B2 (de)
BR (1) BRPI0213063B8 (de)
CA (1) CA2460572C (de)
CY (1) CY1107503T1 (de)
DE (1) DE60221684T2 (de)
DK (1) DK1432705T3 (de)
ES (1) ES2287354T3 (de)
HU (1) HU229935B1 (de)
IL (2) IL160769A0 (de)
NZ (1) NZ531879A (de)
PL (1) PL210850B1 (de)
PT (1) PT1432705E (de)
WO (2) WO2003031443A1 (de)
ZA (1) ZA200401909B (de)

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SI1427711T1 (sl) 2001-09-11 2005-12-31 Astrazeneca Ab Oksazolidinonski in/ali izoksazolinski derivati kot antibakterijska sredstva
WO2003031443A1 (de) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
JP4805139B2 (ja) 2003-04-30 2011-11-02 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用
WO2004101552A1 (en) * 2003-05-14 2004-11-25 Orchid Chemicals & Pharmaceuticals Ltd Oxazolidinone derivatives as antibacterial agents
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
BRPI0417193B8 (pt) * 2003-12-18 2021-05-25 Morphochem Ag Fuer Komb Chemie antibióticos híbridos de oxazolidinona-quinolona, seus sais monossódicos, dissódicos ou trissódicos e seus pró-fármacos, composições farmacêuticas, e seu uso
EP1557416A1 (de) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinon-Chinolon Hybrid Antibiotika
WO2005111030A1 (en) * 2004-05-12 2005-11-24 Warner-Lambert Company Llc Quinolone antibacterial agents
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
BRPI0620736A2 (pt) 2005-12-30 2011-12-20 Novartis Ag compostos orgánicos
MX2008012488A (es) * 2006-03-28 2008-10-10 Procter & Gamble Un proceso de acoplamiento para preparar intermedios de quinolona.
KR20080110877A (ko) * 2006-03-31 2008-12-19 재단법인 이쯔우 연구소 헤테로환을 갖는 신규 화합물
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
HRP20120385T1 (hr) * 2006-11-10 2012-06-30 Actelion Pharmaceuticals Ltd. Derivati 5-hidroksimetil-oksazolidin-2-ona
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
SG182223A1 (en) 2007-06-25 2012-07-30 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
AU2008317353B2 (en) * 2007-10-24 2014-08-07 Merck Sharp & Dohme Llc Heterocycle phenyl amide T-type calcium channel antagonists
NZ589734A (en) * 2008-05-09 2012-11-30 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
BR112015021388A2 (pt) 2013-03-08 2017-07-18 Allergan Inc conjugados esteroides de ciclosporina a
RU2015138891A (ru) 2013-03-08 2017-04-11 Аллерган, Инк. Конъюгаты антибиотиков, напрямую связанные со стероидными препаратами
CN103145615B (zh) * 2013-03-20 2015-07-29 浙江医药股份有限公司 一种奈诺沙星螯合物的后处理方法
US9993469B2 (en) 2013-05-28 2018-06-12 Morphochem Aktiengesellschaft Für Kombinatorishe Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
MX371037B (es) 2013-05-28 2020-01-14 Morphochem Aktiengesellschaft Fuer Komb Chemie Antibacterianos híbridos de oxazolidinona-quinolona para el tratamiento parenteral o profilaxis de enfermedades bacterianas.
CN103421008B (zh) * 2013-09-07 2015-05-27 吉首大学 一类多靶点呋喃酮-喹啉酮型化合物及其制法和用途
CN107286182A (zh) * 2016-04-12 2017-10-24 李靖 新型噁唑烷酮‑氟喹诺酮衍生物及用途
CN107648181B (zh) * 2016-07-25 2021-05-04 广东赛法洛药业有限公司 一种利他唑酮磷脂复合物及其制备方法和应用
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
CN109942546B (zh) * 2019-04-16 2022-04-08 西南大学 喹诺酮嘧啶类化合物及其制备方法和应用
AR127435A1 (es) * 2021-10-26 2024-01-24 Hoffmann La Roche Compuestos piperazinilsulfonilarilo para el tratamiento de infecciones bacterianas

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WO2001009107A1 (en) 1999-07-28 2001-02-08 Pharmacia & Upjohn Company Oxazolidinones and their use as antiinfectives
US6518285B2 (en) 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
US6689769B2 (en) * 2000-12-21 2004-02-10 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
ES2186550B2 (es) 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
WO2003031443A1 (de) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
WO2003031441A1 (en) 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
US20040132764A1 (en) * 2002-10-23 2004-07-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Antibiotics for the treatment of infections in acidic environments
EP1594852A1 (de) 2003-02-07 2005-11-16 Ranbaxy Laboratories, Ltd. Oxazolidinonderivate als antimikrobielle mittel
JP4805139B2 (ja) 2003-04-30 2011-11-02 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
BRPI0417193B8 (pt) 2003-12-18 2021-05-25 Morphochem Ag Fuer Komb Chemie antibióticos híbridos de oxazolidinona-quinolona, seus sais monossódicos, dissódicos ou trissódicos e seus pró-fármacos, composições farmacêuticas, e seu uso
US8158797B2 (en) * 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
AR054608A1 (es) 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
KR200430712Y1 (ko) 2006-08-30 2006-11-13 명 식 신 천장등
US8124623B2 (en) * 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
HRP20120385T1 (hr) 2006-11-10 2012-06-30 Actelion Pharmaceuticals Ltd. Derivati 5-hidroksimetil-oksazolidin-2-ona
CL2007003332A1 (es) 2006-11-24 2008-06-20 Actelion Pharmaceuticals Ltd Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas.
NZ589734A (en) 2008-05-09 2012-11-30 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases

Also Published As

Publication number Publication date
ZA200401909B (en) 2005-05-25
PT1432705E (pt) 2007-08-27
EP1432705A2 (de) 2004-06-30
DE60221684T2 (de) 2008-04-30
HK1128469A1 (en) 2009-10-30
JP2010006814A (ja) 2010-01-14
KR20040055781A (ko) 2004-06-26
JP4398245B2 (ja) 2010-01-13
US20050096343A1 (en) 2005-05-05
BRPI0213063B1 (pt) 2018-02-14
HUP0402126A2 (hu) 2005-02-28
NZ531879A (en) 2005-10-28
IL160769A (en) 2009-12-24
CN101381365B (zh) 2011-07-06
EP1432705B1 (de) 2007-08-08
CA2460572C (en) 2011-11-08
HU229935B1 (en) 2015-01-28
BRPI0213063B8 (pt) 2021-05-25
KR100987696B1 (ko) 2010-10-13
CY1107503T1 (el) 2013-03-13
BR0213063A (pt) 2004-09-28
CN101381365A (zh) 2009-03-11
DK1432705T3 (da) 2007-09-17
US7820823B2 (en) 2010-10-26
US20110059946A1 (en) 2011-03-10
PL210850B1 (pl) 2012-03-30
US8329908B2 (en) 2012-12-11
DE60221684D1 (de) 2007-09-20
AU2002361948B2 (en) 2007-03-29
WO2003031443A1 (de) 2003-04-17
WO2003032962A3 (en) 2003-07-17
KR100927864B1 (ko) 2009-11-23
CN1630655A (zh) 2005-06-22
ES2287354T3 (es) 2007-12-16
JP2005529061A (ja) 2005-09-29
KR20090100426A (ko) 2009-09-23
IL160769A0 (en) 2004-08-31
HUP0402126A3 (en) 2012-10-29
PL367517A1 (en) 2005-02-21
WO2003032962A2 (en) 2003-04-24
CA2460572A1 (en) 2003-04-24

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