ATE369427T1 - Glykosylierungsresistente cyanovirine und damit verbundene konjugate, zusammensetzungen, nukleinsäuren, vektoren, wirtszellen, herstellungsverfahren sowie verfahren zur verwendung nichtglykosylierter cyanovirine - Google Patents
Glykosylierungsresistente cyanovirine und damit verbundene konjugate, zusammensetzungen, nukleinsäuren, vektoren, wirtszellen, herstellungsverfahren sowie verfahren zur verwendung nichtglykosylierter cyanovirineInfo
- Publication number
- ATE369427T1 ATE369427T1 AT02723611T AT02723611T ATE369427T1 AT E369427 T1 ATE369427 T1 AT E369427T1 AT 02723611 T AT02723611 T AT 02723611T AT 02723611 T AT02723611 T AT 02723611T AT E369427 T1 ATE369427 T1 AT E369427T1
- Authority
- AT
- Austria
- Prior art keywords
- cyanovirins
- methods
- glycosylated
- glycosylation
- vectors
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 abstract 4
- 206010022005 Influenza viral infections Diseases 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/815,079 US6780847B2 (en) | 1995-04-27 | 2001-03-22 | Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE369427T1 true ATE369427T1 (de) | 2007-08-15 |
Family
ID=29550490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02723611T ATE369427T1 (de) | 2001-03-22 | 2002-03-22 | Glykosylierungsresistente cyanovirine und damit verbundene konjugate, zusammensetzungen, nukleinsäuren, vektoren, wirtszellen, herstellungsverfahren sowie verfahren zur verwendung nichtglykosylierter cyanovirine |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7339037B2 (de) |
| EP (1) | EP1456382B1 (de) |
| JP (1) | JP4307841B2 (de) |
| AT (1) | ATE369427T1 (de) |
| AU (1) | AU2002254382B2 (de) |
| CA (1) | CA2441287C (de) |
| DE (1) | DE60221705T2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE531385T1 (de) * | 2006-08-18 | 2011-11-15 | Us Gov Health & Human Serv | Anti-h5n1-influenza-aktivität des antiviralen proteins cyanovirin |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| MY184269A (en) * | 2015-11-27 | 2021-03-30 | Viramatix Sdn Bhd | Broad-spectrum anti-influenza virus therapeutic peptides |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2019108656A1 (en) | 2017-11-28 | 2019-06-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Microbicidal composition |
| CN111150724B (zh) * | 2020-01-16 | 2020-12-22 | 华中农业大学 | 缬氨酸在制备治疗或预防禽流感病毒感染的药物中的应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3470067A (en) | 1967-09-19 | 1969-09-30 | Pfizer & Co C | Concentration and purification of viruses from particulate magnetic iron oxide-virus complexes |
| US4795740A (en) | 1986-05-20 | 1989-01-03 | Cohen Eric A | Antiviral peptides and means for treating herpes infections |
| US5266478A (en) | 1987-05-29 | 1993-11-30 | Tanox Biosystems, Inc. | Antibodies which target a neutralization site within the second variable region of human immunodeficiency virus type 1 gp120 |
| DE3828842A1 (de) | 1988-03-29 | 1989-10-12 | Laube Hans Juergen | Verfahren zur behandlung von rna und/oder dna |
| US5445960A (en) | 1988-03-31 | 1995-08-29 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Monoclonal antibodies specific for HIV and hybridomas for their production |
| US5104854A (en) | 1989-02-01 | 1992-04-14 | Washington University | Antiviral peptides |
| WO1990012868A1 (en) | 1989-04-25 | 1990-11-01 | Tanox Biosystems, Inc. | Antibodies specific for cd4-binding domain of hiv |
| IE904161A1 (en) | 1989-11-20 | 1991-05-22 | Oncogen | Nonreplicating recombinant-made retroviral particles useful¹as anti-viral agents and as immunogens for prophylaxis and¹therapy against human retroviruses |
| AU7160691A (en) | 1989-12-21 | 1991-07-24 | Tanox Biosystems, Inc. | Monoclonal antibodies which neutralize hiv-1 infection and their anti-idiotypes |
| SE9000333D0 (sv) | 1990-01-31 | 1990-01-31 | Britta Wahren | Monoklonal antikropp |
| EP0651818B1 (de) | 1990-05-16 | 1999-01-07 | Dana Farber Cancer Institute | Immunogene peptide, antikörper sowie deren verwendungen im zusammenhang mit der cd4-rezeptorbindung |
| AP237A (en) | 1990-05-29 | 1993-04-29 | Cedars Sinai Medical Center | Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use. |
| JP2989862B2 (ja) | 1990-07-02 | 1999-12-13 | 財団法人化学及血清療法研究所 | モノクローナル抗体 |
| WO1992007878A1 (en) | 1990-10-26 | 1992-05-14 | The Public Health Research Institute Of The City Of New York, Inc. | Neutralizing human monoclonal antibodies specific for the v3 loop and cd-4 binding site of hiv-1 gp120 |
| AU8900691A (en) | 1990-11-19 | 1992-06-11 | Queen's University At Kingston | Hiv marker/aids vaccine |
| WO1992008491A1 (en) | 1990-11-20 | 1992-05-29 | Tanox Biosystems, Inc. | Conjugates of anti-idiotype antibodies and carriers and their use in epitope-directed immunization |
| WO1992015885A1 (en) | 1991-03-11 | 1992-09-17 | Idec Pharmaceuticals Corporation | Methods for selecting antibody reagents; anti-idiotype antibodies; and aids vaccine formulations |
| EP0503916A1 (de) | 1991-03-11 | 1992-09-16 | Idec Pharmaceuticals Corporation | Verfahren zur Auswahl Antikörperreagenzes; Anti-Idiotype-Antikörper; und Aidsimpfstoffabfassungen |
| JPH0570493A (ja) | 1991-05-31 | 1993-03-23 | Chemo Sero Therapeut Res Inst | ヒト免疫不全ウイルス（ｈｉｖ）関連免疫調製物 |
| WO1993004090A1 (en) | 1991-08-22 | 1993-03-04 | Nissin Shokuhin Kabushiki Kaisha | Hiv immunotherapeutics |
| US5665569A (en) | 1991-08-22 | 1997-09-09 | Nissin Shokuhin Kabushiki Kaisha | HIV immunotherapeutics |
| AU2752892A (en) | 1991-09-26 | 1993-04-27 | Oklahoma Medical Research Foundation | Fusion proteins targeted to lysosomes, for the treatment of aids |
| EP0618970A1 (de) | 1991-12-10 | 1994-10-12 | Dana Farber Cancer Institute | Reaktive neutralisierende humane anti-gp120 rekombinante antikörper, entsprechend kodierende dna und ihre verwendung |
| EP0581353A1 (de) | 1992-07-03 | 1994-02-02 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Monoklonale Antikörper gegen HIV-1 gp120, Zellinien die sie herstellen und entsprechende Epitope-Strukturen |
| US5652138A (en) | 1992-09-30 | 1997-07-29 | The Scripps Research Institute | Human neutralizing monoclonal antibodies to human immunodeficiency virus |
| FI951488L (fi) | 1992-09-30 | 1995-05-23 | Scripps Research Inst | Ihmisen immuunikatoviruksen vastaiset ihmisen neutraloivat monoklonaaliset vasta-aineet |
| JPH06141885A (ja) | 1992-11-05 | 1994-05-24 | Chemo Sero Therapeut Res Inst | モノクローナル抗体 |
| US5817767A (en) | 1993-02-24 | 1998-10-06 | Progenics Pharmaceuticals, Inc. | Synergistic composition of CD4-based protein and anti-HIV-1 antibody, and methods of using same |
| AU7203194A (en) | 1993-06-04 | 1995-01-03 | New York University | Bispecific human monoclonal antibodies specific for human immunodeficiency virus |
| ATE238420T1 (de) | 1993-08-24 | 2003-05-15 | Nissin Food Products Ltd | Rekombinanter humanisierter antikörper gegen menschlichen immunschwächevirus |
| NL9400384A (nl) | 1994-03-11 | 1995-10-02 | Smit Victor | Retrovirus-vaccins, vaccinatie en immunotherapie tegen retrovirale infecties. |
| CA2124545A1 (en) | 1994-05-27 | 1995-11-28 | Raoul E. Benveniste | Method of inducing cell-mediated protective immunity against hiv using low doses of immunogens |
| US5618922A (en) | 1994-07-25 | 1997-04-08 | Nissin Shokuhin Kabushiki Kaisha | NM03 antibody materials and methods |
| US5843882A (en) | 1995-04-27 | 1998-12-01 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides |
| US6780847B2 (en) * | 1995-04-27 | 2004-08-24 | The United States Of America As Represented By The Department Of Health And Human Services | Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins |
| US6987096B1 (en) * | 1995-04-27 | 2006-01-17 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides, DNA coding sequences therefor, and uses thereof |
| US5891444A (en) | 1995-06-07 | 1999-04-06 | Virus Research Institute, Inc. | HIV-1 prophylactic composition and method |
| US6555367B1 (en) | 1997-10-10 | 2003-04-29 | The United States Of America As Represented By The Department Of Health And Human Services | Complex of biotinylated viral vector and ligand for targeted gene delivery |
-
2002
- 2002-03-22 DE DE60221705T patent/DE60221705T2/de not_active Expired - Lifetime
- 2002-03-22 AT AT02723611T patent/ATE369427T1/de not_active IP Right Cessation
- 2002-03-22 JP JP2002576632A patent/JP4307841B2/ja not_active Expired - Fee Related
- 2002-03-22 AU AU2002254382A patent/AU2002254382B2/en not_active Ceased
- 2002-03-22 CA CA2441287A patent/CA2441287C/en not_active Expired - Fee Related
- 2002-03-22 EP EP02723611A patent/EP1456382B1/de not_active Expired - Lifetime
-
2004
- 2004-05-28 US US10/857,158 patent/US7339037B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1456382A2 (de) | 2004-09-15 |
| US20040220107A1 (en) | 2004-11-04 |
| DE60221705T2 (de) | 2008-06-05 |
| EP1456382A4 (de) | 2004-12-22 |
| DE60221705D1 (de) | 2007-09-20 |
| JP4307841B2 (ja) | 2009-08-05 |
| AU2002254382B2 (en) | 2007-02-15 |
| JP2004535784A (ja) | 2004-12-02 |
| CA2441287C (en) | 2014-06-10 |
| EP1456382B1 (de) | 2007-08-08 |
| US7339037B2 (en) | 2008-03-04 |
| CA2441287A1 (en) | 2002-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |