ATE370109T1 - Festphasenherstellung von 18f-markierten aminosäuren - Google Patents

Festphasenherstellung von 18f-markierten aminosäuren

Info

Publication number
ATE370109T1
ATE370109T1 AT03782656T AT03782656T ATE370109T1 AT E370109 T1 ATE370109 T1 AT E370109T1 AT 03782656 T AT03782656 T AT 03782656T AT 03782656 T AT03782656 T AT 03782656T AT E370109 T1 ATE370109 T1 AT E370109T1
Authority
AT
Austria
Prior art keywords
labled
amino acids
solid phase
phase preparation
sup
Prior art date
Application number
AT03782656T
Other languages
English (en)
Inventor
Alexander Gibson
Lynda Brown
Richard Brown
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE370109T1 publication Critical patent/ATE370109T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/68—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a carbon skeleton substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03782656T 2002-12-20 2003-12-19 Festphasenherstellung von 18f-markierten aminosäuren ATE370109T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0229695.2A GB0229695D0 (en) 2002-12-20 2002-12-20 Solid-phase preparation of 18F-labelled amino acids

Publications (1)

Publication Number Publication Date
ATE370109T1 true ATE370109T1 (de) 2007-09-15

Family

ID=9950069

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03782656T ATE370109T1 (de) 2002-12-20 2003-12-19 Festphasenherstellung von 18f-markierten aminosäuren

Country Status (9)

Country Link
US (1) US7264792B2 (de)
EP (1) EP1572601B1 (de)
JP (1) JP2006510706A (de)
AT (1) ATE370109T1 (de)
AU (1) AU2003290295A1 (de)
DE (1) DE60315709T2 (de)
ES (1) ES2290528T3 (de)
GB (1) GB0229695D0 (de)
WO (1) WO2004056725A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
WO2006126410A1 (ja) 2005-05-23 2006-11-30 Nihon Medi-Physics Co., Ltd. 新規有機化合物及び該化合物を利用した放射性ハロゲン標識有機化合物の製造方法
JP2009505947A (ja) 2005-06-23 2009-02-12 エモリー・ユニバーシティ 画像化剤
AU2006262425C1 (en) * 2005-06-23 2012-06-21 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
WO2007063824A1 (ja) * 2005-11-29 2007-06-07 Nihon Medi-Physics Co., Ltd. 放射性ハロゲン標識有機化合物の前駆体化合物
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
AU2007251015B2 (en) * 2006-05-11 2011-09-01 Nihon Medi-Physics Co., Ltd. Process for production of radioactive fluorine-labeled organic compound
AU2007261985B2 (en) * 2006-06-21 2012-04-19 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
US20100056826A1 (en) * 2006-11-09 2010-03-04 Nihon Medi-Physicis Co., Ltd. Radioactive diagnostic imaging agent
AU2007335633A1 (en) * 2006-12-21 2008-06-26 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
CA2672914C (en) 2006-12-27 2014-02-04 Nihon Medi-Physics Co., Ltd. Process for production of precursor compound for radioactive halogen-labeled organic compound
EP2119458B9 (de) * 2007-02-13 2013-08-21 Nihon Medi-Physics Co., Ltd. Verfahren zur herstellung eines abbildungsmittels zur strahlendiagnose
EP2213672A4 (de) * 2007-10-24 2012-05-02 Nihon Mediphysics Co Ltd Neue verbindung mit affinität zu amyloid
EP2216052A4 (de) * 2007-10-30 2012-11-21 Nihon Mediphysics Co Ltd Verwendung einer neuen verbindung mit affinität für amyloid und verfahren zu ihrer herstellung
KR20100089858A (ko) * 2007-10-30 2010-08-12 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
RU2476423C2 (ru) 2007-12-19 2013-02-27 Нихон Меди-Физикс Ко., Лтд. Способ получения радиоактивного, меченного фтором органического соединения
CA2729635A1 (en) * 2008-07-03 2010-01-07 Ananth Srinivasan Compounds and processes for production of radiopharmaceuticals
JP5590540B2 (ja) * 2009-05-13 2014-09-17 国立大学法人東北大学 ポジトロン標識タンパク質の合成方法
US9073802B2 (en) 2010-02-12 2015-07-07 Tokyo Institute Of Technology Method for producing 18F-labeled compound and high molecular compound to be used in the method
FR2957345B1 (fr) * 2010-03-09 2012-04-20 Polyintell Procede de preparation d'un radiotraceur
US20130217908A1 (en) * 2010-10-28 2013-08-22 Ge Healthcare Limited Stabilisation of radiopharmaceutical precursors
US9061977B2 (en) * 2010-12-20 2015-06-23 Ge Healthcare Limited Purification of precursor compound by crystallisation
GB201021530D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
GB201021523D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
JP6118318B2 (ja) * 2011-07-21 2017-04-19 ジーイー・ヘルスケア・リミテッド 前駆体化合物及びその製造方法
CN103242152B (zh) * 2013-05-07 2015-12-02 兰州安杰利生物化学科技有限公司 化合物3-(苄氧基)-1-环丁酮的合成方法
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
FR3054445B1 (fr) * 2016-07-26 2019-07-05 Laboratoires Cyclopharma Synthese d'une composition d'agent radioactif
CN111848423B (zh) * 2019-04-30 2022-10-14 尚科生物医药（上海）有限公司 3-氧代环丁基氨基甲酸叔丁酯的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424525A1 (de) * 1984-07-04 1986-01-16 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch
JP2738224B2 (ja) * 1992-06-15 1998-04-08 日本鋼管株式会社 １８ｆ標識有機化合物の製造法
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
JP3133251B2 (ja) * 1996-03-29 2001-02-05 エヌケ−ケ−プラント建設株式会社 陽イオン交換樹脂カラム上で、溶媒除去と加水分解反応を同時に行うｆｄｇ合成装置
BE1010280A3 (fr) * 1996-05-02 1998-05-05 Coincidence S A Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose.
WO2002102250A1 (en) * 1999-10-22 2002-12-27 Glaxo Group Limited $g(in vivo) imaging
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination

Also Published As

Publication number Publication date
AU2003290295A1 (en) 2004-07-14
GB0229695D0 (en) 2003-01-29
JP2006510706A (ja) 2006-03-30
DE60315709D1 (de) 2007-09-27
EP1572601B1 (de) 2007-08-15
WO2004056725A1 (en) 2004-07-08
DE60315709T2 (de) 2008-06-05
ES2290528T3 (es) 2008-02-16
EP1572601A1 (de) 2005-09-14
US7264792B2 (en) 2007-09-04
US20060039855A1 (en) 2006-02-23

Similar Documents

Publication Publication Date Title
DE60315709D1 (de) Festphasenherstellung von 18f-markierten aminosäuren
EA200600348A1 (ru) Новые соединения
EA200400368A1 (ru) Новые дигидроптеридиноны, способы их получения и их применение в качестве лекарственных средств
CY1109832T1 (el) Επεξεργασια τρυγικης φορμοτερολης και πολυμορφο
EA200201057A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
EP1392293A4 (de) Verfahren zur behandlung von tumoren mit nordihydroguaiaretinsäurederivaten
SE9903291D0 (sv) New process
BR0301667A (pt) Processo para a preparação de polìmeros em emulsão com pureza elevada
NO20040388L (no) Fremgangsmåte for fremstilling av beraprost og salter derav, samt forbindelser som er mellomprodukter i fremgangsmåten
BR0308345A (pt) Processo para derivados de ácido trans-4-amino-1-cicloexanocarboxìlico
DK1127886T3 (da) Syntese af 3,6-dialkyl-5,6-dihydro-4-hydroxy-2H-pyran-2-on
BR0212772A (pt) Processo para a preparação de repaglinida
DK1129087T3 (da) Fremgangsmåde til racemisering
PL362392A1 (pl) Sposób wytwarzania pochodnych taksanu
DE60012508D1 (de) Aminosäuren mit polycyclischer struktur als pharmaka
DE69920708D1 (de) Verfahren zur herstellung von 1,4-bis[[2-(dimethylamino)ethyl amino]-5,8-dihydroxyanthracene-9,10-dion
IS2084B (is) Aðferð við að framleiða útskipt imídasópýridínefnasamband
NO20014885L (no) Fremgangsmåte til fremstilling av en amidforbindelse
EA200501527A1 (ru) Способ получения полиморфа малеата розиглитазона
EP1571144A4 (de) Hydroxyalkylierte cyclischediaminverbindung
BR0210512A (pt) Processo de decomposição papa o ácido (r)-(-)-2-hidroxi-2-(2-clorofenil) acético
BR0008586A (pt) Processo de preparação de aminoácidos quirais e processo de preparação de compostos a partir destes
SE0101323D0 (sv) New process
HUP0400825A2 (hu) Eljárás amorf cilastatin nátrium előállítására
AR033305A1 (es) Procedimiento para preparar un aminoacido biciclico

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties