ATE370109T1 - Festphasenherstellung von 18f-markierten aminosäuren - Google Patents

Festphasenherstellung von 18f-markierten aminosäuren

Info

Publication number
ATE370109T1
ATE370109T1 AT03782656T AT03782656T ATE370109T1 AT E370109 T1 ATE370109 T1 AT E370109T1 AT 03782656 T AT03782656 T AT 03782656T AT 03782656 T AT03782656 T AT 03782656T AT E370109 T1 ATE370109 T1 AT E370109T1
Authority
AT
Austria
Prior art keywords
labled
amino acids
solid phase
phase preparation
sup
Prior art date
Application number
AT03782656T
Other languages
English (en)
Inventor
Alexander Gibson
Lynda Brown
Richard Brown
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE370109T1 publication Critical patent/ATE370109T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/68—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a carbon skeleton substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03782656T 2002-12-20 2003-12-19 Festphasenherstellung von 18f-markierten aminosäuren ATE370109T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0229695.2A GB0229695D0 (en) 2002-12-20 2002-12-20 Solid-phase preparation of 18F-labelled amino acids

Publications (1)

Publication Number Publication Date
ATE370109T1 true ATE370109T1 (de) 2007-09-15

Family

ID=9950069

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03782656T ATE370109T1 (de) 2002-12-20 2003-12-19 Festphasenherstellung von 18f-markierten aminosäuren

Country Status (9)

Country Link
US (1) US7264792B2 (de)
EP (1) EP1572601B1 (de)
JP (1) JP2006510706A (de)
AT (1) ATE370109T1 (de)
AU (1) AU2003290295A1 (de)
DE (1) DE60315709T2 (de)
ES (1) ES2290528T3 (de)
GB (1) GB0229695D0 (de)
WO (1) WO2004056725A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
CA2608919C (en) 2005-05-23 2012-11-20 Nihon Medi-Physics Co., Ltd. Novel organic compound and method for producing radioactive halogen-labeled organic compound using the same
AU2006262425C1 (en) * 2005-06-23 2012-06-21 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
WO2007001940A2 (en) 2005-06-23 2007-01-04 Emory University Imaging agents
WO2007063824A1 (ja) 2005-11-29 2007-06-07 Nihon Medi-Physics Co., Ltd. 放射性ハロゲン標識有機化合物の前駆体化合物
GB0524851D0 (en) * 2005-12-06 2006-01-11 Ge Healthcare Ltd Radiolabelling method using polymers
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
KR101317258B1 (ko) * 2006-05-11 2013-10-14 니혼 메디피직스 가부시키가이샤 방사성 불소 표식 유기 화합물의 제조 방법
WO2007148755A1 (ja) * 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
EP2080526A4 (de) * 2006-11-09 2012-11-07 Nihon Mediphysics Co Ltd Radioaktives diagnostisches abbildungsagens
JP5159636B2 (ja) * 2006-12-21 2013-03-06 日本メジフィジックス株式会社 放射性画像診断剤
WO2008078589A1 (ja) * 2006-12-27 2008-07-03 Nihon Medi-Physics Co., Ltd. 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法
JP5258583B2 (ja) * 2007-02-13 2013-08-07 日本メジフィジックス株式会社 放射性画像診断剤の製造方法
TW200918102A (en) * 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
KR20100089858A (ko) * 2007-10-30 2010-08-12 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
US20100216994A1 (en) * 2007-10-30 2010-08-26 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
KR101583544B1 (ko) 2007-12-19 2016-01-08 니혼 메디피직스 가부시키가이샤 방사성 불소 표식 유기 화합물의 제조방법
JP2011526267A (ja) * 2008-07-03 2011-10-06 バイエル ファーマ アクチエンゲゼルシャフト 化合物および放射性医薬品の製造方法
JP5590540B2 (ja) * 2009-05-13 2014-09-17 国立大学法人東北大学 ポジトロン標識タンパク質の合成方法
WO2011099480A1 (ja) * 2010-02-12 2011-08-18 国立大学法人東京工業大学 18f標識化合物の製造方法及びその方法に用いる高分子化合物
FR2957345B1 (fr) * 2010-03-09 2012-04-20 Polyintell Procede de preparation d'un radiotraceur
US20130217908A1 (en) * 2010-10-28 2013-08-22 Ge Healthcare Limited Stabilisation of radiopharmaceutical precursors
GB201021523D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
GB201021530D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
US9061977B2 (en) * 2010-12-20 2015-06-23 Ge Healthcare Limited Purification of precursor compound by crystallisation
EP2734494B1 (de) * 2011-07-21 2019-01-02 GE Healthcare Limited Vorläuferverbindungen und verfahren zu ihrer herstellung
CN103242152B (zh) * 2013-05-07 2015-12-02 兰州安杰利生物化学科技有限公司 化合物3-(苄氧基)-1-环丁酮的合成方法
FR3054445B1 (fr) * 2016-07-26 2019-07-05 Laboratoires Cyclopharma Synthese d'une composition d'agent radioactif
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
CN111848423B (zh) * 2019-04-30 2022-10-14 尚科生物医药（上海）有限公司 3-氧代环丁基氨基甲酸叔丁酯的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424525A1 (de) * 1984-07-04 1986-01-16 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch
JP2738224B2 (ja) * 1992-06-15 1998-04-08 日本鋼管株式会社 １８ｆ標識有機化合物の製造法
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
JP3133251B2 (ja) * 1996-03-29 2001-02-05 エヌケ−ケ−プラント建設株式会社 陽イオン交換樹脂カラム上で、溶媒除去と加水分解反応を同時に行うｆｄｇ合成装置
BE1010280A3 (fr) * 1996-05-02 1998-05-05 Coincidence S A Procede et dispositif de synthese de 2-[18f] fluoro-2-deoxy-d-glucose.
CA2422767A1 (en) * 1999-10-22 2001-04-22 Glaxo Group Limited In vivo imaging
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination

Also Published As

Publication number Publication date
US7264792B2 (en) 2007-09-04
ES2290528T3 (es) 2008-02-16
JP2006510706A (ja) 2006-03-30
WO2004056725A1 (en) 2004-07-08
GB0229695D0 (en) 2003-01-29
DE60315709T2 (de) 2008-06-05
AU2003290295A1 (en) 2004-07-14
EP1572601A1 (de) 2005-09-14
EP1572601B1 (de) 2007-08-15
US20060039855A1 (en) 2006-02-23
DE60315709D1 (de) 2007-09-27

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