ATE370744T1 - Selbstemulgierende formulierung mit erhöhter bioverfügbarkeit und immunsupprimierender wirkung - Google Patents

Selbstemulgierende formulierung mit erhöhter bioverfügbarkeit und immunsupprimierender wirkung

Info

Publication number: ATE370744T1
Authority: AT; Austria
Prior art keywords: formulation; agent; immunosuppression; labrasol; preservative
Prior art date: 2000-09-18

Application number

AT00988993T

Other languages

English (en)

Inventor

Saibal Chakravorty

Prasad Bharti

Original Assignee

Rpg Life Sciences Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-18

Filing date

2000-09-18

Publication date

2007-09-15

2000-09-18 Application filed by Rpg Life Sciences Ltd filed Critical Rpg Life Sciences Ltd

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE370744T1 publication Critical patent/ATE370744T1/de

Links

238000009472 formulation Methods 0.000 title abstract 6
239000000203 mixture Substances 0.000 title abstract 6
230000001506 immunosuppresive effect Effects 0.000 title abstract 5
239000003795 chemical substances by application Substances 0.000 abstract 6
206010062016 Immunosuppression Diseases 0.000 abstract 4
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
239000004094 surface-active agent Substances 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 abstract 2
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 abstract 2
239000003755 preservative agent Substances 0.000 abstract 2
230000002335 preservative effect Effects 0.000 abstract 2
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 2
239000005632 Capric acid (CAS 334-48-5) Substances 0.000 abstract 1
239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 abstract 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
229940087168 alpha tocopherol Drugs 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
235000006708 antioxidants Nutrition 0.000 abstract 1
235000019445 benzyl alcohol Nutrition 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
229920000159 gelatin Polymers 0.000 abstract 1
239000008273 gelatin Substances 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
239000004530 micro-emulsion Substances 0.000 abstract 1
229960002446 octanoic acid Drugs 0.000 abstract 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
229920000053 polysorbate 80 Polymers 0.000 abstract 1
229940068968 polysorbate 80 Drugs 0.000 abstract 1
229960000984 tocofersolan Drugs 0.000 abstract 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
239000002076 α-tocopherol Substances 0.000 abstract 1
235000004835 α-tocopherol Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Dispersion Chemistry (AREA)
Transplantation (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT00988993T 2000-09-18 2000-09-18 Selbstemulgierende formulierung mit erhöhter bioverfügbarkeit und immunsupprimierender wirkung ATE370744T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IN2000/000091 WO2002022158A1 (en)	2000-09-18	2000-09-18	Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities

Publications (1)

Publication Number	Publication Date
ATE370744T1 true ATE370744T1 (de)	2007-09-15

Family

ID=11076272

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00988993T ATE370744T1 (de)	2000-09-18	2000-09-18	Selbstemulgierende formulierung mit erhöhter bioverfügbarkeit und immunsupprimierender wirkung

Country Status (12)

Country	Link
US (1)	US7056530B1 (de)
EP (1)	EP1333851B1 (de)
AT (1)	ATE370744T1 (de)
AU (2)	AU2545901A (de)
BR (1)	BR0013813A (de)
CA (1)	CA2422580C (de)
DE (1)	DE60036137T2 (de)
ES (1)	ES2292496T3 (de)
MX (1)	MXPA02004900A (de)
PT (1)	PT1333851E (de)
SI (1)	SI1333851T1 (de)
WO (1)	WO2002022158A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY28057A1 (es) *	2002-10-31	2003-12-31	Alza Corp	Formulacion y forma de dosificacion que provee mayor biodisponibilidad de los farmacos hidrófobos
GB0308734D0 (en)	2003-04-15	2003-05-21	Axcess Ltd	Uptake of macromolecules
GB0308732D0 (en)	2003-04-15	2003-05-21	Axcess Ltd	Absorption enhancers
GB0603252D0 (en)	2006-02-17	2006-03-29	Axcess Ltd	Dissolution aids for oral peptide delivery
US20130266615A1 (en) *	2012-04-10	2013-10-10	Bin Wu	Non-immunogenic delivery vehicle for beta-, gamma-, and delta-tocopherols and methods of using and making same
CN114010597B (zh) *	2021-11-25	2023-05-16	广州白云山汉方现代药业有限公司	一种特殊油脂比例的棓丙酯脂肪乳注射液及其制备方法
CN114246827B (zh) *	2022-01-04	2023-04-11	中山大学	一种鱼油微乳制剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2870062A (en)	1956-04-27	1959-01-20	Scherer Corp R P	Gelatin composition for capsules
DE2907460A1 (de) *	1978-03-07	1979-09-13	Sandoz Ag	Neue resorbierbare galenische kompositionen
GB2222770B (en) *	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
FR2705568B1 (fr) *	1993-05-27	1995-08-18	Carilene Laboratoires	Utilisation de lipides peroxydés pour la préparation d'une composition pharmaceutique destinées au traitement par application locale des télangiectasies.
ES2152281T3 (es) *	1993-09-28	2001-02-01	Scherer Gmbh R P	Fabricacion de capsulas de gelatina blanda.
PE52896A1 (es) *	1994-10-26	1996-12-12	Novartis Ag	Composicion farmaceutica
KR0167613B1 (ko)	1994-12-28	1999-01-15	한스 루돌프 하우스, 니콜 케르커	사이클로스포린-함유 연질캅셀제 조성물
US5858401A (en) *	1996-01-22	1999-01-12	Sidmak Laboratories, Inc.	Pharmaceutical composition for cyclosporines
DE69731072T2 (de)	1996-06-19	2005-10-06	Novartis Ag	Cyclosporin enthaltende weichkapselpräparate
KR100587551B1 (ko) *	1997-12-10	2006-06-08	싸이클로스포린 테라퓨틱스 리미티드	오메가-3 지방산 오일을 함유하는 약학 조성물
RU2178293C2 (ru) *	1998-08-18	2002-01-20	Панацея Биотек Лимитед	Фармацевтическая композиция, содержащая циклоспорин, способ получения мягких желатиновых капсул
US6267985B1 (en) *	1999-06-30	2001-07-31	Lipocine Inc.	Clear oil-containing pharmaceutical compositions

2000
- 2000-09-18 AT AT00988993T patent/ATE370744T1/de active
- 2000-09-18 AU AU2545901A patent/AU2545901A/xx active Pending
- 2000-09-18 ES ES00988993T patent/ES2292496T3/es not_active Expired - Lifetime
- 2000-09-18 SI SI200030971T patent/SI1333851T1/sl unknown
- 2000-09-18 WO PCT/IN2000/000091 patent/WO2002022158A1/en not_active Ceased
- 2000-09-18 US US10/380,598 patent/US7056530B1/en not_active Expired - Fee Related
- 2000-09-18 AU AU2001225459A patent/AU2001225459B2/en not_active Ceased
- 2000-09-18 MX MXPA02004900A patent/MXPA02004900A/es active IP Right Grant
- 2000-09-18 BR BR0013813-4A patent/BR0013813A/pt not_active Application Discontinuation
- 2000-09-18 PT PT00988993T patent/PT1333851E/pt unknown
- 2000-09-18 EP EP00988993A patent/EP1333851B1/de not_active Expired - Lifetime
- 2000-09-18 CA CA2422580A patent/CA2422580C/en not_active Expired - Fee Related
- 2000-09-18 DE DE60036137T patent/DE60036137T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SI1333851T1 (sl)	2008-02-29
AU2001225459B2 (en)	2005-12-22
EP1333851A1 (de)	2003-08-13
DE60036137D1 (de)	2007-10-04
US7056530B1 (en)	2006-06-06
PT1333851E (pt)	2007-11-26
MXPA02004900A (es)	2003-10-24
BR0013813A (pt)	2002-04-30
WO2002022158A1 (en)	2002-03-21
ES2292496T3 (es)	2008-03-16
DE60036137T2 (de)	2008-05-15
AU2001225459C1 (en)	2002-03-26
CA2422580A1 (en)	2002-03-21
CA2422580C (en)	2011-05-17
EP1333851B1 (de)	2007-08-22
AU2545901A (en)	2002-03-26

Legal Events

Date

Code

Title

Description

2008-02-15

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Publication of translation of european patent specification

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