ATE371652T1 - Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung - Google Patents

Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung

Info

Publication number: ATE371652T1
Authority: AT; Austria
Prior art keywords: broad; band; inhibiting effect; hiv protease; protease inhibiting
Prior art date: 2002-05-17

Application number

AT03735707T

Other languages

English (en)

Inventor

Dominique Surleraux

Bernhard Vergouwen

Kock Herman De

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-17

Filing date

2003-05-16

Publication date

2007-09-15

2003-05-16 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE371652T1 publication Critical patent/ATE371652T1/de

Links

OIFAKIJHBGJKLD-UHFFFAOYSA-N 1,2-benzoxazole-3-sulfonamide Chemical class C1=CC=C2C(S(=O)(=O)N)=NOC2=C1 OIFAKIJHBGJKLD-UHFFFAOYSA-N 0.000 title 1
108091005804 Peptidases Proteins 0.000 title 1
239000004365 Protease Substances 0.000 title 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03735707T 2002-05-17 2003-05-16 Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung ATE371652T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02076957		2002-05-17

Publications (1)

Publication Number	Publication Date
ATE371652T1 true ATE371652T1 (de)	2007-09-15

Family

ID=29433159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03735707T ATE371652T1 (de)	2002-05-17	2003-05-16	Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung

Country Status (28)

Country	Link
US (1)	US7462636B2 (de)
EP (1)	EP1517899B1 (de)
JP (2)	JP4674084B2 (de)
KR (2)	KR101019648B1 (de)
CN (1)	CN100582097C (de)
AP (1)	AP2004003190A0 (de)
AR (1)	AR039887A1 (de)
AT (1)	ATE371652T1 (de)
AU (1)	AU2003238074B2 (de)
BR (1)	BR0310089A (de)
CA (1)	CA2485903C (de)
CY (1)	CY1107040T1 (de)
DE (1)	DE60315984T2 (de)
DK (1)	DK1517899T3 (de)
EA (1)	EA010908B1 (de)
ES (1)	ES2292976T3 (de)
HR (1)	HRP20050607B1 (de)
IL (1)	IL165043A0 (de)
MX (1)	MXPA04011466A (de)
MY (1)	MY135226A (de)
NO (1)	NO330184B1 (de)
NZ (1)	NZ536496A (de)
PL (1)	PL373425A1 (de)
PT (1)	PT1517899E (de)
SI (1)	SI1517899T1 (de)
TW (1)	TWI356700B (de)
WO (1)	WO2003097616A1 (de)
ZA (1)	ZA200410156B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL165043A0 (en) *	2002-05-17	2005-12-18	Tibotec Pharm Ltd	broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
JP2007528423A (ja) *	2004-03-11	2007-10-11	セコイア、ファーマシューティカルズ、インコーポレイテッド	耐性防止レトロウイルスプロテアーゼ阻害薬
US7378441B2 (en) *	2004-05-07	2008-05-27	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
DK1856125T3 (da)	2005-02-25	2009-12-07	Tibotec Pharm Ltd	Syntese af proteasehæmmerforstadie
EP2139883A4 (de) *	2007-03-23	2011-06-22	Univ Massachusetts	Hiv-1-proteasehemmer
JP2011515444A (ja) *	2008-03-25	2011-05-19	フォーマックファーマシューティカルズナムローゼフェンノートシャップ	固体分散体の調製方法
WO2011061590A1 (en)	2009-11-17	2011-05-26	Hetero Research Foundation	Novel carboxamide derivatives as hiv inhibitors
DE102010004957A1 (de)	2010-01-14	2011-07-21	Universitätsklinikum Jena, 07743	Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
JP2016503395A (ja)	2012-10-31	2016-02-04	バイエル・クロップサイエンス・アクチェンゲゼルシャフト	病害生物防除剤としての複素環化合物
KR101661952B1 (ko) *	2013-03-07	2016-10-04	다우 글로벌 테크놀로지스 엘엘씨	극저점도의 신규한 에스테르화된 셀룰로스 에테르

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
ES2123065T3 (es) *	1992-08-25	1999-01-01	Searle & Co	Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas.
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
EP0715618B1 (de)	1993-08-24	1998-12-16	G.D. Searle & Co.	Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
PT721331E (pt)	1993-10-01	2002-05-31	Astrazeneca Ab	Processo i
CA2210889C (en) *	1995-01-20	2007-08-28	G.D. Searle & Co.	Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5756533A (en) *	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) *	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en)	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
BR9607625A (pt)	1995-03-10	1999-06-15	Searle & Co	Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila
US5753660A (en)	1995-11-15	1998-05-19	G. D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1997044014A1 (en)	1996-05-20	1997-11-27	Janssen Pharmaceutica N.V.	Antifungal compositions with improved bioavailability
SK284813B6 (sk)	1997-03-26	2005-12-01	Janssen Pharmaceutica N. V.	Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom
EA200000702A1 (ru)	1997-12-24	2000-12-25	Вертекс Фармасьютикалз Инкорпорейтед	Пролекарства ингибиторов аспартилпротеаз
AU2012199A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
WO1999033792A2 (en)	1997-12-24	1999-07-08	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
AU4828199A (en)	1998-06-23	2000-01-10	Board Of Trustees Of The University Of Illinois, The	Multi-drug resistant retroviral protease inhibitors and associated methods
CA2872424C (en) *	1998-06-23	2017-03-07	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Bisfuran derivatives useful in preventing the emergence of multidrug resistant hiv strains and treatment of hiv
PL204924B1 (pl)	1999-10-06	2010-02-26	Tibotec Pharm Ltd	Heksahydrofuro [2,3-b] furanylo-3-N-{3(1,3-benzodioksolilo-5-sulfonylo) (izobutylo) amino] -1-benzylo-2-hydroksypropylo} karbaminian oraz jego zastosowanie
OA12464A (en) *	2001-04-09	2006-05-24	Tibotec Pharm Ltd	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors.
IL165043A0 (en) *	2002-05-17	2005-12-18	Tibotec Pharm Ltd	broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

2003
- 2003-05-16 IL IL16504303A patent/IL165043A0/xx not_active IP Right Cessation
- 2003-05-16 DK DK03735707T patent/DK1517899T3/da active
- 2003-05-16 CA CA2485903A patent/CA2485903C/en not_active Expired - Fee Related
- 2003-05-16 ES ES03735707T patent/ES2292976T3/es not_active Expired - Lifetime
- 2003-05-16 PT PT03735707T patent/PT1517899E/pt unknown
- 2003-05-16 JP JP2004505349A patent/JP4674084B2/ja not_active Expired - Fee Related
- 2003-05-16 US US10/514,539 patent/US7462636B2/en not_active Expired - Fee Related
- 2003-05-16 BR BR0310089-8A patent/BR0310089A/pt not_active IP Right Cessation
- 2003-05-16 EP EP03735707A patent/EP1517899B1/de not_active Expired - Lifetime
- 2003-05-16 NZ NZ536496A patent/NZ536496A/en not_active IP Right Cessation
- 2003-05-16 SI SI200331012T patent/SI1517899T1/sl unknown
- 2003-05-16 DE DE60315984T patent/DE60315984T2/de not_active Expired - Lifetime
- 2003-05-16 MX MXPA04011466A patent/MXPA04011466A/es active IP Right Grant
- 2003-05-16 AP AP2004003190A patent/AP2004003190A0/xx unknown
- 2003-05-16 EA EA200401524A patent/EA010908B1/ru not_active IP Right Cessation
- 2003-05-16 KR KR1020047018261A patent/KR101019648B1/ko not_active Expired - Fee Related
- 2003-05-16 TW TW092113367A patent/TWI356700B/zh not_active IP Right Cessation
- 2003-05-16 HR HRP20050607AA patent/HRP20050607B1/hr not_active IP Right Cessation
- 2003-05-16 WO PCT/EP2003/050173 patent/WO2003097616A1/en not_active Ceased
- 2003-05-16 MY MYPI20031819A patent/MY135226A/en unknown
- 2003-05-16 KR KR1020107025714A patent/KR20100130234A/ko not_active Withdrawn
- 2003-05-16 AT AT03735707T patent/ATE371652T1/de active
- 2003-05-16 AU AU2003238074A patent/AU2003238074B2/en not_active Ceased
- 2003-05-16 PL PL03373425A patent/PL373425A1/xx unknown
- 2003-05-16 AR ARP030101725A patent/AR039887A1/es active IP Right Grant
- 2003-05-16 CN CN03816458A patent/CN100582097C/zh not_active Expired - Fee Related
2004
- 2004-12-14 NO NO20045444A patent/NO330184B1/no not_active IP Right Cessation
- 2004-12-15 ZA ZA2004/10156A patent/ZA200410156B/en unknown
2007
- 2007-11-29 CY CY20071101524T patent/CY1107040T1/el unknown
2010
- 2010-10-25 JP JP2010238833A patent/JP2011051999A/ja active Pending

Also Published As

Publication number	Publication date
US7462636B2 (en)	2008-12-09
JP4674084B2 (ja)	2011-04-20
CN100582097C (zh)	2010-01-20
NO330184B1 (no)	2011-02-28
CY1107040T1 (el)	2012-09-26
KR20100130234A (ko)	2010-12-10
BR0310089A (pt)	2005-02-15
AU2003238074B2 (en)	2009-04-30
ZA200410156B (en)	2005-11-30
CA2485903A1 (en)	2003-11-27
TW200404538A (en)	2004-04-01
EP1517899B1 (de)	2007-08-29
JP2011051999A (ja)	2011-03-17
JP2005527607A (ja)	2005-09-15
DE60315984T2 (de)	2008-05-29
EP1517899A1 (de)	2005-03-30
AR039887A1 (es)	2005-03-09
HRP20050607B1 (hr)	2014-07-04
AP2004003190A0 (en)	2004-12-31
DE60315984D1 (de)	2007-10-11
US20050171173A1 (en)	2005-08-04
EA200401524A1 (ru)	2005-06-30
MY135226A (en)	2008-02-29
NZ536496A (en)	2006-06-30
PL373425A1 (en)	2005-08-22
ES2292976T3 (es)	2008-03-16
CA2485903C (en)	2011-08-16
EA010908B1 (ru)	2008-12-30
PT1517899E (pt)	2007-11-16
DK1517899T3 (da)	2007-12-03
IL165043A0 (en)	2005-12-18
KR20050013549A (ko)	2005-02-04
AU2003238074A1 (en)	2003-12-02
TWI356700B (en)	2012-01-21
HK1076099A1 (en)	2006-01-06
SI1517899T1 (sl)	2008-02-29
MXPA04011466A (es)	2005-02-14
NO20045444L (no)	2005-02-16
WO2003097616A1 (en)	2003-11-27
CN1668605A (zh)	2005-09-14
KR101019648B1 (ko)	2011-03-07
HRP20050607A2 (en)	2006-02-28

Legal Events

Date

Code

Title

Description

2008-02-15

UEP

Publication of translation of european patent specification

Ref document number: 1517899

Country of ref document: EP

Publication	Publication Date	Title
EP1663113A4 (de)	2007-06-13	Substituierte sulfonamide
DE60322920D1 (de)	2008-09-25	Heterocyclische verbindungen mit hiv-integrase-hemmender wirkung
DK1414803T3 (da)	2013-03-25	Pyrazolylcarboxanilider som fungicider
DK1608624T3 (da)	2011-07-11	6-alkyl eller -alkenyl-4-aminopicolinater som herbicider
DK1442030T3 (da)	2006-12-27	Thiopen- og thiazolsulfonamider som antineoplastiske midler
NO20032613D0 (no)	2003-06-10	Farmasöytisk sammensetning som har en forbedret vannopplöselighet
DE60215623D1 (de)	2006-12-07	Breitspektrum 2-(substituierte-amino)-benzothiazol-sulfonamide hiv protease inhibitoren
NO20034949L (no)	2003-11-06	Sulfonamider
DE60235536D1 (de)	2010-04-15	Sulfonamidderivate
NO20034695D0 (no)	2003-10-20	Nye sammensetninger
NO20042916L (no)	2004-09-10	HIV integrase inhibitorer
NO20040860L (no)	2004-04-22	Farmasoytisk sammensetning som innbefatter lumiracoxib
DE60316954D1 (de)	2007-11-29	Shampoozusammensetzungen
ATE371652T1 (de)	2007-09-15	Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung
BR0300119B1 (pt)	2013-04-09	composiÇço aquosa.
NO20034988D0 (no)	2003-11-10	Bredspektret 2-(amino)-benzoxazolsulfonamid HIV proteasehemmere
DE60322421D1 (de)	2008-09-04	Verbesserter brillenbügel
EP1596222A4 (de)	2009-04-08	Laser-radar
DE602004027792D1 (de)	2010-08-05	Indazolamide mit analgetischer wirkung
NO20034505D0 (no)	2003-10-08	Bredspektret 2-(substituert-amino)-benzoxasolsulfonamid HIV proteasehemmere
NO20043114L (no)	2004-09-20	Bredspektrede heterocyklisk substituerte fenylinneholdende sulfonamid-HIV-proteaseinhibitorer
DK1651047T3 (da)	2008-05-05	Herbicidekombinationer med specielle sulfonamider
DK1485358T3 (da)	2011-05-09	Substitueret benzimidazol-sulfonamid som bred-sprektrum HIV-protease-inhibitorer
DE60323088D1 (de)	2008-10-02	Leberschützende wirkung der 10-o-p-hydroxybenzoylaucubin
DE602004010291D1 (de)	2008-01-03	Hcv-hemmende sulfonamide