DK1517899T3 - Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor - Google Patents

Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor

Info

Publication number: DK1517899T3
Authority: DK; Denmark
Prior art keywords: protease inhibitor; broad spectrum; hiv protease; substituted benzisoxazole; sulfonamide hiv
Prior art date: 2002-05-17

Application number

DK03735707T

Other languages

English (en)

Inventor

Dominique Louis Nest Surleraux

Bernhard Joanna Bern Vergouwen

Kock Herman Augustinus De

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-17

Filing date

2003-05-16

Publication date

2007-12-03

2003-05-16 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2007-12-03 Application granted granted Critical

2007-12-03 Publication of DK1517899T3 publication Critical patent/DK1517899T3/da

Links

OIFAKIJHBGJKLD-UHFFFAOYSA-N 1,2-benzoxazole-3-sulfonamide Chemical class C1=CC=C2C(S(=O)(=O)N)=NOC2=C1 OIFAKIJHBGJKLD-UHFFFAOYSA-N 0.000 title 1
229940122440 HIV protease inhibitor Drugs 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK03735707T 2002-05-17 2003-05-16 Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor DK1517899T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02076957		2002-05-17
PCT/EP2003/050173 WO2003097616A1 (en)	2002-05-17	2003-05-16	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number	Publication Date
DK1517899T3 true DK1517899T3 (da)	2007-12-03

Family

ID=29433159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03735707T DK1517899T3 (da)	2002-05-17	2003-05-16	Bredspektret substitueret benzisoxazolsulfonamid HIV-proteaseinhibitor

Country Status (28)

Country	Link
US (1)	US7462636B2 (da)
EP (1)	EP1517899B1 (da)
JP (2)	JP4674084B2 (da)
KR (2)	KR20100130234A (da)
CN (1)	CN100582097C (da)
AP (1)	AP2004003190A0 (da)
AR (1)	AR039887A1 (da)
AT (1)	ATE371652T1 (da)
AU (1)	AU2003238074B2 (da)
BR (1)	BR0310089A (da)
CA (1)	CA2485903C (da)
CY (1)	CY1107040T1 (da)
DE (1)	DE60315984T2 (da)
DK (1)	DK1517899T3 (da)
EA (1)	EA010908B1 (da)
ES (1)	ES2292976T3 (da)
HR (1)	HRP20050607B1 (da)
IL (1)	IL165043A0 (da)
MX (1)	MXPA04011466A (da)
MY (1)	MY135226A (da)
NO (1)	NO330184B1 (da)
NZ (1)	NZ536496A (da)
PL (1)	PL373425A1 (da)
PT (1)	PT1517899E (da)
SI (1)	SI1517899T1 (da)
TW (1)	TWI356700B (da)
WO (1)	WO2003097616A1 (da)
ZA (1)	ZA200410156B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2485903C (en) *	2002-05-17	2011-08-16	Tibotec Pharmaceuticals Ltd.	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
WO2005087728A1 (en) *	2004-03-11	2005-09-22	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
AU2005244121B2 (en) *	2004-05-07	2012-01-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
ES2331257T3 (es)	2005-02-25	2009-12-28	Tibotec Pharmaceuticals	Sintesis de precursores de inhibidores de proteasas.
WO2008118849A2 (en) *	2007-03-23	2008-10-02	University Of Massachusetts	Hiv-1 protease inhibitors
EP2170289B1 (en) *	2008-03-25	2012-02-15	Formac Pharmaceuticals N.v.	Preparation method for solid disupersions
WO2011061590A1 (en)	2009-11-17	2011-05-26	Hetero Research Foundation	Novel carboxamide derivatives as hiv inhibitors
DE102010004957A1 (de)	2010-01-14	2011-07-21	Universitätsklinikum Jena, 07743	Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
US20150284380A1 (en)	2012-10-31	2015-10-08	Bayer Cropscience Ag	Novel heterocyclic compounds as pest control agents
CN105025887B (zh) *	2013-03-07	2017-07-28	陶氏环球技术有限责任公司	新颖极低粘度酯化纤维素醚

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US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
DE122007000045I2 (de) *	1992-08-25	2011-07-21	Gd Searle Llc Gd Searle Llc	Darunavir oder pharmazeutisch vertragliche Salze, Hydroxyethylaminosulfonamide verwendbar als InhibiEster oder Prodrugs davon. toren retroviraler Proteasen.
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
ES2127938T3 (es)	1993-08-24	1999-05-01	Searle & Co	Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.
ES2166786T3 (es)	1993-10-01	2002-05-01	Astrazeneca Ab	Procedimiento i.
DE69637380T2 (de) *	1995-01-20	2009-09-17	G.D. Searle Llc, Chicago	Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen
US5756533A (en)	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
CN1149223C (zh) *	1995-03-10	2004-05-12	G·D·瑟尔公司	杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
US5705500A (en)	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) *	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5753660A (en) *	1995-11-15	1998-05-19	G. D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6509038B2 (en)	1996-05-20	2003-01-21	Janssen Pharmaceutica N.V.	Antifungal compositions with improved bioavailability
CZ295502B6 (cs)	1997-03-26	2005-08-17	Janssen Pharmaceutica N. V.	Antifungální peleta, způsob její přípravy a farmaceutická dávková forma s obsahem těchto pelet
AU2010299A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
AU2012199A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
EP1042280A2 (en)	1997-12-24	2000-10-11	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
AU4828199A (en)	1998-06-23	2000-01-10	Board Of Trustees Of The University Of Illinois, The	Multi-drug resistant retroviral protease inhibitors and associated methods
PT2336134T (pt) *	1998-06-23	2016-10-19	The Board Of Trustees Of The Univ Of Illionis	Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
CA2386850C (en)	1999-10-06	2010-03-30	Piet Tom Bert Paul Wigerinck	Hexahydrofuro[2,3-b]furan-3-yl-n-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor
EP1397367A2 (en) *	2001-04-09	2004-03-17	Tibotec Pharmaceuticals Ltd.	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
CA2485903C (en) *	2002-05-17	2011-08-16	Tibotec Pharmaceuticals Ltd.	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

2003
- 2003-05-16 CA CA2485903A patent/CA2485903C/en not_active Expired - Fee Related
- 2003-05-16 AR ARP030101725A patent/AR039887A1/es active IP Right Grant
- 2003-05-16 AP AP2004003190A patent/AP2004003190A0/xx unknown
- 2003-05-16 EA EA200401524A patent/EA010908B1/ru not_active IP Right Cessation
- 2003-05-16 IL IL16504303A patent/IL165043A0/xx not_active IP Right Cessation
- 2003-05-16 CN CN03816458A patent/CN100582097C/zh not_active Expired - Fee Related
- 2003-05-16 ES ES03735707T patent/ES2292976T3/es not_active Expired - Lifetime
- 2003-05-16 SI SI200331012T patent/SI1517899T1/sl unknown
- 2003-05-16 KR KR1020107025714A patent/KR20100130234A/ko not_active Withdrawn
- 2003-05-16 BR BR0310089-8A patent/BR0310089A/pt not_active IP Right Cessation
- 2003-05-16 DE DE60315984T patent/DE60315984T2/de not_active Expired - Lifetime
- 2003-05-16 PL PL03373425A patent/PL373425A1/xx unknown
- 2003-05-16 KR KR1020047018261A patent/KR101019648B1/ko not_active Expired - Fee Related
- 2003-05-16 TW TW092113367A patent/TWI356700B/zh not_active IP Right Cessation
- 2003-05-16 NZ NZ536496A patent/NZ536496A/en not_active IP Right Cessation
- 2003-05-16 EP EP03735707A patent/EP1517899B1/en not_active Expired - Lifetime
- 2003-05-16 WO PCT/EP2003/050173 patent/WO2003097616A1/en not_active Ceased
- 2003-05-16 AT AT03735707T patent/ATE371652T1/de active
- 2003-05-16 US US10/514,539 patent/US7462636B2/en not_active Expired - Fee Related
- 2003-05-16 AU AU2003238074A patent/AU2003238074B2/en not_active Ceased
- 2003-05-16 MX MXPA04011466A patent/MXPA04011466A/es active IP Right Grant
- 2003-05-16 DK DK03735707T patent/DK1517899T3/da active
- 2003-05-16 JP JP2004505349A patent/JP4674084B2/ja not_active Expired - Fee Related
- 2003-05-16 HR HRP20050607AA patent/HRP20050607B1/hr not_active IP Right Cessation
- 2003-05-16 PT PT03735707T patent/PT1517899E/pt unknown
- 2003-05-16 MY MYPI20031819A patent/MY135226A/en unknown
2004
- 2004-12-14 NO NO20045444A patent/NO330184B1/no not_active IP Right Cessation
- 2004-12-15 ZA ZA2004/10156A patent/ZA200410156B/en unknown
2007
- 2007-11-29 CY CY20071101524T patent/CY1107040T1/el unknown
2010
- 2010-10-25 JP JP2010238833A patent/JP2011051999A/ja active Pending

Also Published As

Publication number	Publication date
JP2011051999A (ja)	2011-03-17
EA200401524A1 (ru)	2005-06-30
ATE371652T1 (de)	2007-09-15
CA2485903A1 (en)	2003-11-27
KR101019648B1 (ko)	2011-03-07
NZ536496A (en)	2006-06-30
BR0310089A (pt)	2005-02-15
EP1517899A1 (en)	2005-03-30
CY1107040T1 (el)	2012-09-26
NO330184B1 (no)	2011-02-28
NO20045444L (no)	2005-02-16
EA010908B1 (ru)	2008-12-30
JP4674084B2 (ja)	2011-04-20
PL373425A1 (en)	2005-08-22
AU2003238074A1 (en)	2003-12-02
TWI356700B (en)	2012-01-21
KR20100130234A (ko)	2010-12-10
CN1668605A (zh)	2005-09-14
IL165043A0 (en)	2005-12-18
AU2003238074B2 (en)	2009-04-30
TW200404538A (en)	2004-04-01
HRP20050607B1 (hr)	2014-07-04
ES2292976T3 (es)	2008-03-16
SI1517899T1 (sl)	2008-02-29
CN100582097C (zh)	2010-01-20
DE60315984D1 (de)	2007-10-11
CA2485903C (en)	2011-08-16
MXPA04011466A (es)	2005-02-14
MY135226A (en)	2008-02-29
DE60315984T2 (de)	2008-05-29
WO2003097616A1 (en)	2003-11-27
JP2005527607A (ja)	2005-09-15
AP2004003190A0 (en)	2004-12-31
US20050171173A1 (en)	2005-08-04
AR039887A1 (es)	2005-03-09
ZA200410156B (en)	2005-11-30
EP1517899B1 (en)	2007-08-29
HK1076099A1 (en)	2006-01-06
PT1517899E (pt)	2007-11-16
HRP20050607A2 (en)	2006-02-28
US7462636B2 (en)	2008-12-09
KR20050013549A (ko)	2005-02-04

Publication	Publication Date	Title
NO20043004L (no)	2004-07-14	4-oksokinolin forbindelse og anvendelse derav som HIV-integraseinhibitor
EP1499336A4 (en)	2005-06-01	PROTEASE INHIBITORS
NO20034042D0 (no)	2003-09-12	Metallproteinase-inhibitorer
NO20033593D0 (no)	2003-08-13	Kinazoliner som MMP-13 inhibitorer
ATE308544T1 (de)	2005-11-15	N-substituiete heteroaryloxy-aryl-spiro- pyrimidine-2,4,6-trion metalloproteinase inhibitoren
DK1567529T4 (da)	2021-05-10	Pseudopolymorfe former af en hiv-proteaseinhibitor
ATE304015T1 (de)	2005-09-15	Triaryl-oxy-aryl-spiro-pyrimidin-2, 4, 6-trion metalloproteinase inhibitoren
DE60215623D1 (de)	2006-12-07	Breitspektrum 2-(substituierte-amino)-benzothiazol-sulfonamide hiv protease inhibitoren
NO20042916L (no)	2004-09-10	HIV integrase inhibitorer
DE60232067D1 (de)	2009-06-04	2-amino-benzoxazol-suphonamide als breitspektrum-hiv-protease-inhibitoren
DK1466970T3 (da)	2009-04-06	Alkalisk protease
AP1878A (en)	2008-08-13	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors.
NO20034505L (no)	2003-12-08	Bredspektret 2-(substituert-amino)-benzoxasolsulfonamid HIV proteasehemmere
IL165043A0 (en)	2005-12-18	broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
PL375307A1 (en)	2005-11-28	Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
NO20043114L (no)	2004-09-20	Bredspektrede heterocyklisk substituerte fenylinneholdende sulfonamid-HIV-proteaseinhibitorer
DE50311673D1 (de)	2009-08-13	Bohrhammer
DE60335939D1 (de)	2011-03-17	Substituierte benzimidazol-sulfonamid-derivate als breitspectrum hiv- protease- inhibitoren
NO20043610L (no)	2004-10-05	Fenylpyrimidinaminer som IgE inhibitorer
NO20032290L (no)	2003-05-21	Nye forbindelser for anvendelse som HIV-protease-inhibitorer
ZA200500926B (en)	2006-03-29	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors
DE602004014762D1 (de)	2008-08-14	Proteasehemmer
HK1079684A (en)	2006-04-13	Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
SE0300778D0 (sv)	2003-03-24	Novel alkaline protease