ATE371865T1 - Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse - Google Patents

Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse

Info

Publication number
ATE371865T1
ATE371865T1 AT03817382T AT03817382T ATE371865T1 AT E371865 T1 ATE371865 T1 AT E371865T1 AT 03817382 T AT03817382 T AT 03817382T AT 03817382 T AT03817382 T AT 03817382T AT E371865 T1 ATE371865 T1 AT E371865T1
Authority
AT
Austria
Prior art keywords
characterization
marker
classification
free method
cellular events
Prior art date
Application number
AT03817382T
Other languages
English (en)
Inventor
Vivian Liu
Chris Fuller
Simon Pitchford
Ed Verdonk
Original Assignee
Mds Inc Dba Mds Sciex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mds Inc Dba Mds Sciex filed Critical Mds Inc Dba Mds Sciex
Application granted granted Critical
Publication of ATE371865T1 publication Critical patent/ATE371865T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G01N33/4836—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Sorting Of Articles (AREA)
AT03817382T 2003-07-14 2003-07-14 Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse ATE371865T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA2003/001060 WO2005005979A1 (en) 2003-07-14 2003-07-14 Label-free method for classification and characterization of cellular events

Publications (1)

Publication Number Publication Date
ATE371865T1 true ATE371865T1 (de) 2007-09-15

Family

ID=33569429

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03817382T ATE371865T1 (de) 2003-07-14 2003-07-14 Markierungsfreies verfahren zur klassifizierung und charakterisierung zellulärer ereignisse

Country Status (7)

Country Link
EP (1) EP1664765B1 (de)
JP (1) JP4668786B2 (de)
AT (1) ATE371865T1 (de)
AU (1) AU2003250657A1 (de)
CA (1) CA2531342C (de)
DE (1) DE60316044T2 (de)
WO (1) WO2005005979A1 (de)

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US7468255B2 (en) 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US7470533B2 (en) 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
US7732127B2 (en) 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
CN100577811C (zh) 2002-07-20 2010-01-06 美国艾森生物科学公司 基于阻抗分析细胞和颗粒的装置和方法
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
JP4789469B2 (ja) 2002-12-27 2011-10-12 イメリーズ ピグメンツ インコーポレイテッド 紙コーティング顔料
CA2550274A1 (en) 2003-11-12 2005-05-26 Acea Biosciences, Inc. Real time electronic cell sensing systems and applications for cell-based assays
EP1773980B1 (de) 2004-08-04 2015-07-01 Acea Biosciences, Inc. Verfahren zur untersuchung auf natürliche killerzellen, cytotoxisches t-lymphozyt- und neutrophilvermitteltes töten von targetzellen unter verwendung von mikroelektronischer zellenabtasttechnologie in echtzeit
WO2007022043A2 (en) * 2005-08-15 2007-02-22 Janssen Pharmaceutica N.V. Method of measuring the biological activity of an urotensin ii receptor
US7459918B2 (en) * 2005-09-09 2008-12-02 David Jones Impedance measurement system with incorporated internal measurement drift compensation networks
KR100801694B1 (ko) * 2005-09-15 2008-02-11 삼성전자주식회사 원핵 세포를 이용한 독성물질 유해성의 전기적 분석방법 및분석장치
US8041515B2 (en) 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
WO2008036375A2 (en) * 2006-09-20 2008-03-27 Acea Biosciences Corporation Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
JP5168478B2 (ja) * 2007-06-04 2013-03-21 株式会社リコー 電子写真感光体、電子写真方法、電子写真装置、並びに電子写真装置用プロセスカートリッジ
US8703428B2 (en) 2007-10-06 2014-04-22 Corning Incorporated Single-cell label-free assay
US8426148B2 (en) 2007-10-06 2013-04-23 Corning Incorporated Label-free methods using a resonant waveguide grating biosensor to determine GPCR signaling pathways
US8846575B2 (en) 2008-03-05 2014-09-30 Corning Incorporated High-throughput high-information content label-free cell biology screening methods
US8759013B2 (en) 2008-03-05 2014-06-24 Corning Incorporated Dual-target biosensor cell assays
US8313898B2 (en) 2008-03-05 2012-11-20 Corning Incorporated Dual-target biosensor cell assays
JP2009244197A (ja) * 2008-03-31 2009-10-22 Hioki Ee Corp 薬剤感受性試験方法及び装置
CA2723223C (en) 2008-05-05 2017-06-06 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
WO2011146531A1 (en) 2010-05-18 2011-11-24 Acea Biosciences, Inc Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments
KR101527797B1 (ko) * 2014-06-03 2015-06-15 한국과학기술원 신호전달경로의 활성화 상태 분석방법 및 이를 이용한 개인 맞춤형 치료제의 선정방법
US12066428B2 (en) 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
EP3589299B1 (de) 2017-03-03 2025-04-09 Agilent Technologies, Inc. Verfahren und systeme zur funktionellen reifung von kardiomyozyten aus ipsc und esc
CN112730821B (zh) * 2019-10-14 2024-04-09 泰州医药城国科化物生物医药科技有限公司 一种受体拮抗剂长效性分析方法
US20210301245A1 (en) 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792668A (en) * 1993-08-06 1998-08-11 Solid State Farms, Inc. Radio frequency spectral analysis for in-vitro or in-vivo environments
US6048692A (en) * 1997-10-07 2000-04-11 Motorola, Inc. Sensors for electrically sensing binding events for supported molecular receptors
US6377057B1 (en) * 1999-02-18 2002-04-23 The Board Of Trustees Of The Leland Stanford Junior University Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
WO2003016555A1 (en) * 2001-08-09 2003-02-27 Matsushita Electric Industrial Co., Ltd. Cell diagnosing method, and device and apparatus used for it
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events

Also Published As

Publication number Publication date
AU2003250657A1 (en) 2005-01-28
JP2007504801A (ja) 2007-03-08
CA2531342A1 (en) 2005-01-20
WO2005005979A1 (en) 2005-01-20
DE60316044D1 (de) 2007-10-11
CA2531342C (en) 2011-07-05
EP1664765B1 (de) 2007-08-29
EP1664765A1 (de) 2006-06-07
DE60316044T2 (de) 2008-05-15
JP4668786B2 (ja) 2011-04-13

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