DK2049529T3 - Substituerede diazepan-orexin-receptor- antagonister - Google Patents

Substituerede diazepan-orexin-receptor- antagonister

Info

Publication number: DK2049529T3
Authority: DK; Denmark
Prior art keywords: receptor antagonists; orexin receptor; substituted diazepan; compounds; substituted
Prior art date: 2006-07-14

Application number

DK07796852.7T

Other languages

English (en)

Inventor

Christopher D Cox

Michael J Breslin

Paul J Coleman

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-14

Filing date

2007-07-13

Publication date

2010-11-29

2007-07-13 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2010-11-29 Application granted granted Critical

2010-11-29 Publication of DK2049529T3 publication Critical patent/DK2049529T3/da

Links

229940123730 Orexin receptor antagonist Drugs 0.000 title 1
108050000742 Orexin Receptor Proteins 0.000 abstract 3
102000008834 Orexin receptor Human genes 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
QPMLSUSACCOBDK-UHFFFAOYSA-N diazepane Chemical class C1CCNNCC1 QPMLSUSACCOBDK-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000020016 psychiatric disease Diseases 0.000 abstract 1

Classifications

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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Addiction (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Psychology (AREA)
Oncology (AREA)
Virology (AREA)
Child & Adolescent Psychology (AREA)
Otolaryngology (AREA)
AIDS & HIV (AREA)

DK07796852.7T 2006-07-14 2007-07-13 Substituerede diazepan-orexin-receptor- antagonister DK2049529T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US83098306P	2006-07-14	2006-07-14
PCT/US2007/016038 WO2008008518A1 (en)	2006-07-14	2007-07-13	Substituted diazepan orexin receptor antagonists

Publications (1)

Publication Number	Publication Date
DK2049529T3 true DK2049529T3 (da)	2010-11-29

Family

ID=38654759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK07796852.7T DK2049529T3 (da)	2006-07-14	2007-07-13	Substituerede diazepan-orexin-receptor- antagonister

Country Status (14)

Country	Link
US (1)	US20090192143A1 (da)
EP (1)	EP2049529B1 (da)
JP (1)	JP5479893B2 (da)
AT (1)	ATE477252T1 (da)
AU (1)	AU2007272855B2 (da)
CA (1)	CA2657552A1 (da)
CY (1)	CY1110882T1 (da)
DE (1)	DE602007008434D1 (da)
DK (1)	DK2049529T3 (da)
ES (1)	ES2348685T3 (da)
PL (1)	PL2049529T3 (da)
PT (1)	PT2049529E (da)
SI (1)	SI2049529T1 (da)
WO (1)	WO2008008518A1 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2049110B1 (en)	2006-07-14	2014-08-20	Merck Sharp & Dohme Corp.	Bridged diazepan orexin receptor antagonists
PE20081229A1 (es) *	2006-12-01	2008-08-28	Merck & Co Inc	Antagonistas de receptor de orexina de diazepam sustituido
JP2010527924A (ja)	2007-05-18	2010-08-19	メルク・シャープ・エンド・ドーム・コーポレイション	オキソ架橋ジアゼパンオレキシン受容体アンタゴニスト
WO2008147518A1 (en)	2007-05-23	2008-12-04	Merck & Co., Inc.	Pyridyl piperidine orexin receptor antagonists
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP2011502146A (ja)	2007-10-29	2011-01-20	メルク・シャープ・エンド・ドーム・コーポレイション	置換ジアゼパンオレキシン受容体アンタゴニスト
CA2739927A1 (en) *	2008-10-21	2010-04-29	Merck Sharp & Dohme Corp.	Disubstituted azepan orexin receptor antagonists
WO2010048514A1 (en)	2008-10-23	2010-04-29	Albany Molecular Research, Inc.	Synthesis of 2-aminobenzoxazole compounds
US8853202B2 (en)	2008-11-04	2014-10-07	Chemocentryx, Inc.	Modulators of CXCR7
CN102271681B (zh) *	2008-11-04	2014-11-12	凯莫森特里克斯股份有限公司	Cxcr7调节剂
EP2491034B1 (en)	2009-10-23	2013-12-18	Janssen Pharmaceutica, N.V.	Fused heterocyclic compounds as orexin receptor modulators
WO2011050202A1 (en) *	2009-10-23	2011-04-28	Janssen Pharmaceutica Nv	Fused heterocyclic compounds as orexin receptor modulators
ES2585806T3 (es) *	2009-10-23	2016-10-10	Janssen Pharmaceutica N.V.	Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina
TW201204732A (en)	2010-07-09	2012-02-01	Leo Pharma As	Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
WO2012145581A1 (en)	2011-04-20	2012-10-26	Janssen Pharmaceutica Nv	Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
AR088352A1 (es)	2011-10-19	2014-05-28	Merck Sharp & Dohme	Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
WO2013119639A1 (en)	2012-02-07	2013-08-15	Eolas Therapeutics, Inc.	Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en)	2012-02-07	2016-09-13	Eolas Therapeutics, Inc.	Substituted prolines/piperidines as orexin receptor antagonists
ES2681593T3 (es)	2012-11-29	2018-09-14	Chemocentryx, Inc.	Antagonistas de CXCR7
WO2015095111A1 (en)	2013-12-18	2015-06-25	Merck Sharp & Dohme Corp.	Diazepane orexin receptor antagonists
WO2016020404A1 (en) *	2014-08-04	2016-02-11	Sandoz Ag	Process for the resolution of (r,s)-diazepane and diazepanone derivatives
TW201613902A (en)	2014-08-13	2016-04-16	Eolas Therapeutics Inc	Difluoropyrrolidines as orexin receptor modulators
CN105461699B (zh) *	2014-09-25	2019-07-09	广东东阳光药业有限公司	取代的杂环化合物及其使用方法和用途
WO2016085784A1 (en) *	2014-11-26	2016-06-02	Merck Sharp & Dohme Corp.	Methyl diazepane orexin receptor antagonists
US10131653B2 (en)	2015-04-24	2018-11-20	Takeda Pharmaceutical Company Limited	Heterocyclic compound
WO2017012502A1 (en)	2015-07-17	2017-01-26	Sunshine Lake Pharma Co., Ltd.	Substituted quinazoline compounds and preparation and uses thereof
SG11201804223TA (en)	2015-11-23	2018-06-28	Sunshine Lake Pharma Co Ltd	OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF
CN107021964A (zh) *	2016-02-01	2017-08-08	广东东阳光药业有限公司	萘啶衍生物及其用途
LT3414241T (lt)	2016-02-12	2022-08-25	Astrazeneca Ab	Halogenu pakeisti piperidinai kaip oreksino receptoriaus moduliatoriai
HRP20220642T1 (hr)	2016-03-10	2022-06-24	Janssen Pharmaceutica Nv	Postupci za liječenje depresije uporabom antagonista receptora oreksina 2
WO2017194548A1 (en)	2016-05-10	2017-11-16	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
GB201702174D0 (en)	2017-02-09	2017-03-29	Benevolentai Bio Ltd	Orexin receptor antagonists
GB201707504D0 (en)	2017-05-10	2017-06-21	Benevolentai Bio Ltd	Orexin receptor antagonists
GB201707499D0 (en)	2017-05-10	2017-06-21	Benevolentai Bio Ltd	Orexin receptor antagonists
MA54465A (fr)	2018-12-12	2021-10-20	Chemocentryx Inc	Inhibiteurs de cxcr7 destinés au traitement du cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0747574B2 (ja) *	1989-03-03	1995-05-24	大日本製薬株式会社	ピリジン誘導体及びそれを有効成分とする向精神剤
DE69010232T2 (de) *	1989-03-03	1994-12-01	Dainippon Pharmaceutical Co	2-(1-Piperazinyl)-4-phenylcycloalkanpyridin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten.
GB0127145D0 (en) *	2001-11-10	2002-01-02	Smithkline Beecham	Compounds
PE20081229A1 (es) *	2006-12-01	2008-08-28	Merck & Co Inc	Antagonistas de receptor de orexina de diazepam sustituido
JP2011502146A (ja) *	2007-10-29	2011-01-20	メルク・シャープ・エンド・ドーム・コーポレイション	置換ジアゼパンオレキシン受容体アンタゴニスト

2007
- 2007-07-13 CA CA002657552A patent/CA2657552A1/en not_active Abandoned
- 2007-07-13 DK DK07796852.7T patent/DK2049529T3/da active
- 2007-07-13 JP JP2009519552A patent/JP5479893B2/ja not_active Expired - Fee Related
- 2007-07-13 AU AU2007272855A patent/AU2007272855B2/en not_active Ceased
- 2007-07-13 WO PCT/US2007/016038 patent/WO2008008518A1/en not_active Ceased
- 2007-07-13 ES ES07796852T patent/ES2348685T3/es active Active
- 2007-07-13 AT AT07796852T patent/ATE477252T1/de active
- 2007-07-13 SI SI200730378T patent/SI2049529T1/sl unknown
- 2007-07-13 DE DE602007008434T patent/DE602007008434D1/de active Active
- 2007-07-13 PT PT07796852T patent/PT2049529E/pt unknown
- 2007-07-13 EP EP07796852A patent/EP2049529B1/en active Active
- 2007-07-13 US US12/309,239 patent/US20090192143A1/en not_active Abandoned
- 2007-07-13 PL PL07796852T patent/PL2049529T3/pl unknown
2010
- 2010-11-10 CY CY20101101013T patent/CY1110882T1/el unknown

Also Published As

Publication number	Publication date
AU2007272855A1 (en)	2008-01-17
CA2657552A1 (en)	2008-01-17
AU2007272855B2 (en)	2013-08-01
JP5479893B2 (ja)	2014-04-23
US20090192143A1 (en)	2009-07-30
PT2049529E (pt)	2010-10-13
EP2049529A1 (en)	2009-04-22
SI2049529T1 (sl)	2010-11-30
JP2009543786A (ja)	2009-12-10
EP2049529B1 (en)	2010-08-11
ES2348685T3 (es)	2010-12-10
CY1110882T1 (el)	2015-06-10
PL2049529T3 (pl)	2011-01-31
DE602007008434D1 (de)	2010-09-23
ATE477252T1 (de)	2010-08-15
WO2008008518A1 (en)	2008-01-17

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UA100974C2 (ru)	2013-02-25	Соединения замещенных диазепанов как антагонисты орексиновых рецепторов
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