ATE372332T1 - Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga - Google Patents
Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analogaInfo
- Publication number
- ATE372332T1 ATE372332T1 AT02710021T AT02710021T ATE372332T1 AT E372332 T1 ATE372332 T1 AT E372332T1 AT 02710021 T AT02710021 T AT 02710021T AT 02710021 T AT02710021 T AT 02710021T AT E372332 T1 ATE372332 T1 AT E372332T1
- Authority
- AT
- Austria
- Prior art keywords
- discodermolid
- sub
- analogs
- production
- intermediate compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0101599.9A GB0101599D0 (en) | 2001-01-22 | 2001-01-22 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE372332T1 true ATE372332T1 (de) | 2007-09-15 |
Family
ID=9907244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02710021T ATE372332T1 (de) | 2001-01-22 | 2002-01-21 | Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6974875B2 (de) |
| EP (1) | EP1368334B1 (de) |
| JP (1) | JP4301810B2 (de) |
| CN (2) | CN1775774A (de) |
| AT (1) | ATE372332T1 (de) |
| AU (1) | AU2002228057A1 (de) |
| BR (1) | BR0206585A (de) |
| CA (1) | CA2435371A1 (de) |
| DE (1) | DE60222244T2 (de) |
| ES (1) | ES2292726T3 (de) |
| GB (1) | GB0101599D0 (de) |
| WO (1) | WO2002057251A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI251591B (en) * | 2000-08-07 | 2006-03-21 | Novartis Ag | Process for preparing discodermolide and analogues thereof |
| WO2004009574A1 (en) * | 2002-07-22 | 2004-01-29 | Novartis Ag | Synthesis of discodermolide |
| AU2003263090A1 (en) | 2002-09-06 | 2004-03-29 | University Of Pittsburgh | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof |
| US7321046B2 (en) | 2002-09-06 | 2008-01-22 | University Of Pittsburgh | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof |
| GB0226434D0 (en) * | 2002-11-13 | 2002-12-18 | Astrazeneca Ab | Combination product |
| US7348436B2 (en) * | 2004-03-02 | 2008-03-25 | Kosan Biosciences Incorporated | Compounds useful for the synthesis of (+)-discodermolide and methods thereof |
| US7214708B2 (en) * | 2004-11-18 | 2007-05-08 | Kosan Biosciences Incorporated | Synthetic discodermolide analogs |
| US7816405B2 (en) | 2005-04-19 | 2010-10-19 | Eisai R&D Management Co., Ltd. | Calcium bis [(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl ]-2-isopropoxypropionate] and intermediate thereof |
| JPWO2006115130A1 (ja) * | 2005-04-19 | 2008-12-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ビス［（２ｓ）−３−［３−［（２ｓ）−３−（４−クロロ−２−シアノフェノキシ）−２−フルオロプロポキシ］フェニル］−２−イソプロポキシプロピオン酸］カルシウム及びその中間体 |
| US7297807B1 (en) | 2006-05-31 | 2007-11-20 | The Research Foundation Of State University Of New York | Intermediates for the synthesis of polypropionate antibiotics |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9315802D0 (en) | 1993-07-30 | 1993-09-15 | Roussel Lab Ltd | Chemical compounds |
| US6096904A (en) | 1996-12-03 | 2000-08-01 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
| US5789605A (en) * | 1996-12-03 | 1998-08-04 | Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof |
| AU7267298A (en) * | 1997-04-30 | 1998-11-24 | Regents Of The University Of California, The | Synthesis of discodermolide and analogs |
-
2001
- 2001-01-22 GB GBGB0101599.9A patent/GB0101599D0/en not_active Ceased
-
2002
- 2002-01-21 CA CA002435371A patent/CA2435371A1/en not_active Abandoned
- 2002-01-21 BR BR0206585-1A patent/BR0206585A/pt not_active IP Right Cessation
- 2002-01-21 WO PCT/EP2002/000570 patent/WO2002057251A2/en not_active Ceased
- 2002-01-21 AT AT02710021T patent/ATE372332T1/de not_active IP Right Cessation
- 2002-01-21 ES ES02710021T patent/ES2292726T3/es not_active Expired - Lifetime
- 2002-01-21 US US10/466,728 patent/US6974875B2/en not_active Expired - Fee Related
- 2002-01-21 DE DE60222244T patent/DE60222244T2/de not_active Expired - Fee Related
- 2002-01-21 CN CNA2005101126328A patent/CN1775774A/zh active Pending
- 2002-01-21 AU AU2002228057A patent/AU2002228057A1/en not_active Abandoned
- 2002-01-21 EP EP02710021A patent/EP1368334B1/de not_active Expired - Lifetime
- 2002-01-21 CN CNB028039920A patent/CN1261428C/zh not_active Expired - Fee Related
- 2002-01-21 JP JP2002557932A patent/JP4301810B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1261428C (zh) | 2006-06-28 |
| US6974875B2 (en) | 2005-12-13 |
| WO2002057251A3 (en) | 2002-10-10 |
| BR0206585A (pt) | 2003-12-16 |
| HK1060882A1 (en) | 2004-08-27 |
| CN1487929A (zh) | 2004-04-07 |
| EP1368334B1 (de) | 2007-09-05 |
| JP2004517891A (ja) | 2004-06-17 |
| ES2292726T3 (es) | 2008-03-16 |
| DE60222244D1 (de) | 2007-10-18 |
| JP4301810B2 (ja) | 2009-07-22 |
| WO2002057251A2 (en) | 2002-07-25 |
| AU2002228057A1 (en) | 2002-07-30 |
| DE60222244T2 (de) | 2008-05-29 |
| GB0101599D0 (en) | 2001-03-07 |
| CN1775774A (zh) | 2006-05-24 |
| EP1368334A2 (de) | 2003-12-10 |
| US20040073049A1 (en) | 2004-04-15 |
| CA2435371A1 (en) | 2002-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |