ATE373013T1 - In vitro verfahren zur diagnose von neoplastischen erkrankungen durch analyse des methylierungsstatus des cdh4 gens, oligonukleotide und kits zur durchführung eines solchen verfahrens - Google Patents

In vitro verfahren zur diagnose von neoplastischen erkrankungen durch analyse des methylierungsstatus des cdh4 gens, oligonukleotide und kits zur durchführung eines solchen verfahrens

Info

Publication number: ATE373013T1
Authority: AT; Austria
Prior art keywords: cdh4; gene; methylation status; neoplastic diseases; oligonucleotides
Prior art date: 2004-04-09

Application number

AT05102717T

Other languages

English (en)

Inventor

Elena Miotto

Massimo Negrini

Silvia Sabbioni

Original Assignee

Univ Ferrara

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-09

Filing date

2005-04-07

Publication date

2007-09-15

2005-04-07 Application filed by Univ Ferrara filed Critical Univ Ferrara

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE373013T1 publication Critical patent/ATE373013T1/de

Links

238000000034 method Methods 0.000 title abstract 4
201000010099 disease Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
230000011987 methylation Effects 0.000 title abstract 2
238000007069 methylation reaction Methods 0.000 title abstract 2
230000001613 neoplastic effect Effects 0.000 title abstract 2
101100326581 Caenorhabditis elegans cdh-4 gene Proteins 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
238000000338 in vitro Methods 0.000 title 1
239000000523 sample Substances 0.000 abstract 2
101150005024 CDH4 gene Proteins 0.000 abstract 1
108091029523 CpG island Proteins 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
230000002489 hematologic effect Effects 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000013615 primer Substances 0.000 abstract 1
239000002987 primer (paints) Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pathology (AREA)
Analytical Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Physics & Mathematics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Biophysics (AREA)
Oncology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT05102717T 2004-04-09 2005-04-07 In vitro verfahren zur diagnose von neoplastischen erkrankungen durch analyse des methylierungsstatus des cdh4 gens, oligonukleotide und kits zur durchführung eines solchen verfahrens ATE373013T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000224A ITTO20040224A1 (it)	2004-04-09	2004-04-09	Procedimento in vitro per la diagnosi di malattie neoplastiche mediante analisi della metilazione del gene cdh4, oligonucleotidi e kit utili in tale procedimento

Publications (1)

Publication Number	Publication Date
ATE373013T1 true ATE373013T1 (de)	2007-09-15

Family

ID=34897828

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05102717T ATE373013T1 (de)	2004-04-09	2005-04-07	In vitro verfahren zur diagnose von neoplastischen erkrankungen durch analyse des methylierungsstatus des cdh4 gens, oligonukleotide und kits zur durchführung eines solchen verfahrens

Country Status (4)

Country	Link
EP (1)	EP1584629B1 (de)
AT (1)	ATE373013T1 (de)
DE (1)	DE602005002390T2 (de)
IT (1)	ITTO20040224A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2660218A1 (en)	2006-08-08	2008-02-14	Epigenomics Ag	A method for methylation analysis of nucleic acid
CN115651980A (zh) *	2022-05-31	2023-01-31	益善生物技术股份有限公司	人rnf180基因甲基化检测试剂盒和提取待检测dna的方法

2004
- 2004-04-09 IT IT000224A patent/ITTO20040224A1/it unknown
2005
- 2005-04-07 EP EP05102717A patent/EP1584629B1/de not_active Expired - Lifetime
- 2005-04-07 DE DE602005002390T patent/DE602005002390T2/de not_active Expired - Lifetime
- 2005-04-07 AT AT05102717T patent/ATE373013T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1584629B1 (de)	2007-09-12
EP1584629A1 (de)	2005-10-12
DE602005002390D1 (de)	2007-10-25
DE602005002390T2 (de)	2008-06-05
ITTO20040224A1 (it)	2004-07-09

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Legal Events

Date	Code	Title	Description
2008-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties