ATE373639T1 - Verfahren zur herstellung von (r)-g(a)-(2,3- dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4- piperidinmethanol - Google Patents

Verfahren zur herstellung von (r)-g(a)-(2,3- dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4- piperidinmethanol

Info

Publication number: ATE373639T1
Authority: AT; Austria
Prior art keywords: dimethoxyphenyl; fluorophenyl; ethyl; producing; piperidine methanol
Prior art date: 1998-03-13

Application number

AT99911318T

Other languages

English (en)

Inventor

Alan G Bina

Edward D Daugs

Jonathan C Evans

Hans-Wolfram Flemming

Gerard Guillamot

Robert A Hawtorne

Thomas H E Hilpert

James E Hitt

Chi-Hsin R King

Johannes N Koek

Frederick M Laskovics

John M Lefler

Alexey L Margolin

Sharon K Minish

Thomas T Ortyl

Lian G Rajewski

Marvin J Sack

Paul F Skultety

Sandra K Stoltz-Dunn

Alonzo L Tigner

Ian A Tomlinson

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-13

Filing date

1999-03-11

Publication date

2007-10-15

1999-03-11 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE373639T1 publication Critical patent/ATE373639T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Nutrition Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Medicinal Preparation (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT99911318T 1998-03-13 1999-03-11 Verfahren zur herstellung von (r)-g(a)-(2,3- dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4- piperidinmethanol ATE373639T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4225198A	1998-03-13	1998-03-13
US25071899A	1999-02-16	1999-02-16

Publications (1)

Publication Number	Publication Date
ATE373639T1 true ATE373639T1 (de)	2007-10-15

Family

ID=26719032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99911318T ATE373639T1 (de)	1998-03-13	1999-03-11	Verfahren zur herstellung von (r)-g(a)-(2,3- dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4- piperidinmethanol

Country Status (25)

Country	Link
EP (3)	EP1736469A3 (de)
JP (2)	JP4511723B2 (de)
KR (7)	KR100586328B1 (de)
CN (1)	CN100436415C (de)
AR (1)	AR015540A1 (de)
AT (1)	ATE373639T1 (de)
AU (1)	AU755436B2 (de)
BR (1)	BR9909260A (de)
CA (1)	CA2322501C (de)
CY (1)	CY1107104T1 (de)
DE (1)	DE69937162T2 (de)
DK (1)	DK1192134T3 (de)
DZ (1)	DZ2742A1 (de)
EG (1)	EG24052A (de)
ES (1)	ES2294838T3 (de)
HK (1)	HK1042484B (de)
HU (1)	HUP0400889A3 (de)
IL (3)	IL138307A0 (de)
MA (1)	MA25515A1 (de)
NO (1)	NO317981B1 (de)
NZ (1)	NZ506807A (de)
PT (1)	PT1192134E (de)
TN (1)	TNSN99035A1 (de)
TW (1)	TWI249526B (de)
WO (1)	WO1999046245A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6713627B2 (en) *	1998-03-13	2004-03-30	Aventis Pharmaceuticals Inc.	Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
DE19934432A1 (de)	1999-07-22	2001-02-01	Merck Patent Gmbh	Indolderivate
WO2002072069A1 (en) *	2001-03-12	2002-09-19	Novo Nordisk A/S	Novel tablets and capsules and a process for its preparation
DE102004010132A1 (de)	2004-02-27	2005-09-15	Merck Patent Gmbh	Piperidinderivate
CA2672134C (en) *	2006-12-07	2015-02-10	Daiichi Sankyo Company, Limited	Solid medicinal preparation containing mannitol or lactose
US8964338B2 (en)	2012-01-11	2015-02-24	Emerson Climate Technologies, Inc.	System and method for compressor motor protection
EP2971989A4 (de)	2013-03-15	2016-11-30	Emerson Electric Co	Fernüberwachung und -diagnose für ein hvac-system
CN112358398A (zh) *	2020-11-19	2021-02-12	山东新华制药股份有限公司	D-(+)-二对甲苯甲酰酒石酸的回收制备方法
CN116082705B (zh) *	2022-12-05	2023-09-12	苏州易昇光学材料股份有限公司	一种抗黄变自修复凝胶

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4260623A (en) *	1979-11-26	1981-04-07	Warner-Lambert Company	Hexahydro-1-arylspiro(3H-oxazolo(3,4-A)pyridine-3,4'-piperidene) antidepressants, pharmaceutical compositions thereof and method of use thereof
CA1280421C (en) *	1985-07-02	1991-02-19	Albert A. Carr	1,4-disubstituted piperidinyl derivatives
US5169096A (en) *	1985-07-02	1992-12-08	Merrell Dow Pharmaceuticals Inc.	N-aralkyl-piperidine-methanol derivatives
WO1991018602A1 (en) *	1990-06-01	1991-12-12	Merrell Dow Pharmaceuticals Inc.	(+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL
ATE144899T1 (de) *	1990-06-07	1996-11-15	Merrell Pharma Inc	Derivate des 1-piperidinyl- alkanoylarylsulfonamids
US5477029A (en) *	1994-01-28	1995-12-19	Skutt Ceramic Products, Inc.	Kiln with hinged control panel
US5618824A (en) *	1994-03-09	1997-04-08	Merrell Pharmaceuticals Inc.	Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
EP0796619A1 (de) *	1996-03-21	1997-09-24	Merrell Pharmaceuticals Inc.	Verwendung von (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-Fluorophenyl)ethyl)-4-Piperidinmethanol zur Behandlung von Depressionen und bipolaren Erkrankungen

1999
- 1999-03-09 TW TW088103619A patent/TWI249526B/zh not_active IP Right Cessation
- 1999-03-10 EG EG23399A patent/EG24052A/xx active
- 1999-03-10 DZ DZ990043A patent/DZ2742A1/xx active
- 1999-03-10 MA MA25491A patent/MA25515A1/fr unknown
- 1999-03-11 HU HU0400889A patent/HUP0400889A3/hu unknown
- 1999-03-11 KR KR1020057024570A patent/KR100586328B1/ko not_active Expired - Fee Related
- 1999-03-11 AU AU29988/99A patent/AU755436B2/en not_active Ceased
- 1999-03-11 AR ARP990101039A patent/AR015540A1/es unknown
- 1999-03-11 EP EP06016487A patent/EP1736469A3/de not_active Withdrawn
- 1999-03-11 EP EP06016486A patent/EP1734037A3/de not_active Ceased
- 1999-03-11 EP EP99911318A patent/EP1192134B1/de not_active Expired - Lifetime
- 1999-03-11 IL IL13830799A patent/IL138307A0/xx active IP Right Grant
- 1999-03-11 PT PT99911318T patent/PT1192134E/pt unknown
- 1999-03-11 KR KR1020057024567A patent/KR100591643B1/ko not_active Expired - Fee Related
- 1999-03-11 DE DE69937162T patent/DE69937162T2/de not_active Expired - Lifetime
- 1999-03-11 KR KR1020057024569A patent/KR100586327B1/ko not_active Expired - Fee Related
- 1999-03-11 WO PCT/US1999/005332 patent/WO1999046245A2/en not_active Ceased
- 1999-03-11 ES ES99911318T patent/ES2294838T3/es not_active Expired - Lifetime
- 1999-03-11 BR BR9909260-3A patent/BR9909260A/pt not_active Application Discontinuation
- 1999-03-11 AT AT99911318T patent/ATE373639T1/de not_active IP Right Cessation
- 1999-03-11 KR KR1020057024568A patent/KR100591640B1/ko not_active Expired - Fee Related
- 1999-03-11 CA CA002322501A patent/CA2322501C/en not_active Expired - Fee Related
- 1999-03-11 CN CNB998060224A patent/CN100436415C/zh not_active Expired - Fee Related
- 1999-03-11 DK DK99911318T patent/DK1192134T3/da active
- 1999-03-11 KR KR1020057024572A patent/KR100591997B1/ko not_active Expired - Fee Related
- 1999-03-11 HK HK02103493.4A patent/HK1042484B/en not_active IP Right Cessation
- 1999-03-11 KR KR1020007010103A patent/KR100591642B1/ko not_active Expired - Fee Related
- 1999-03-11 JP JP2000535626A patent/JP4511723B2/ja not_active Expired - Fee Related
- 1999-03-11 TN TNTNSN99035A patent/TNSN99035A1/fr unknown
- 1999-03-11 NZ NZ506807A patent/NZ506807A/xx unknown
- 1999-03-11 KR KR1020057024573A patent/KR100591641B1/ko not_active Expired - Fee Related
2000
- 2000-09-06 IL IL138307A patent/IL138307A/en not_active IP Right Cessation
- 2000-09-12 NO NO20004545A patent/NO317981B1/no not_active IP Right Cessation
2006
- 2006-05-29 IL IL175983A patent/IL175983A0/en unknown
2007
- 2007-12-19 CY CY20071101617T patent/CY1107104T1/el unknown
2009
- 2009-12-28 JP JP2009296809A patent/JP2010143925A/ja not_active Abandoned

Also Published As

Publication number	Publication date
AR015540A1 (es)	2001-05-02
TNSN99035A1 (fr)	2005-11-10
NO317981B1 (no)	2005-01-17
WO1999046245A2 (en)	1999-09-16
JP2002506059A (ja)	2002-02-26
NO20004545L (no)	2000-11-13
KR100586328B1 (ko)	2006-06-08
NZ506807A (en)	2003-03-28
CA2322501C (en)	2006-05-09
DE69937162D1 (de)	2007-10-31
MA25515A1 (fr)	2002-10-01
EP1734037A3 (de)	2010-06-16
KR20060002037A (ko)	2006-01-06
DZ2742A1 (fr)	2003-09-08
PT1192134E (pt)	2007-11-13
ES2294838T3 (es)	2008-04-01
CA2322501A1 (en)	1999-09-16
HUP0400889A2 (hu)	2004-08-30
HK1042484A1 (en)	2002-08-16
IL138307A0 (en)	2001-10-31
KR20060002036A (ko)	2006-01-06
BR9909260A (pt)	2000-11-21
IL138307A (en)	2006-09-05
KR20060002035A (ko)	2006-01-06
KR100591641B1 (ko)	2006-06-20
AU755436B2 (en)	2002-12-12
KR100591997B1 (ko)	2006-06-26
EP1192134A2 (de)	2002-04-03
KR20060002034A (ko)	2006-01-06
EP1192134B1 (de)	2007-09-19
KR20060002039A (ko)	2006-01-06
KR100591640B1 (ko)	2006-06-20
CN100436415C (zh)	2008-11-26
EP1734037A2 (de)	2006-12-20
HUP0400889A3 (en)	2010-08-30
IL175983A0 (en)	2006-10-05
JP2010143925A (ja)	2010-07-01
EP1736469A3 (de)	2010-06-09
KR100591642B1 (ko)	2006-06-20
TWI249526B (en)	2006-02-21
DK1192134T3 (da)	2007-11-26
EP1736469A2 (de)	2006-12-27
KR100586327B1 (ko)	2006-06-08
EG24052A (en)	2008-04-13
DE69937162T2 (de)	2008-06-12
NO20004545D0 (no)	2000-09-12
HK1042484B (en)	2008-05-02
WO1999046245A3 (en)	1999-10-21
CN1300280A (zh)	2001-06-20
KR100591643B1 (ko)	2006-06-20
KR20060002038A (ko)	2006-01-06
CY1107104T1 (el)	2012-01-25
AU2998899A (en)	1999-09-27
KR20010041819A (ko)	2001-05-25
JP4511723B2 (ja)	2010-07-28

Legal Events

Date

Code

Title

Description

2008-01-15

UEP

Publication of translation of european patent specification

Ref document number: 1192134

Country of ref document: EP

2009-08-15

EEFA

Change of the company name

2010-12-15

REN

Ceased due to non-payment of the annual fee

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