MA25515A1 - Nouveaux procedes pour la preparation de (r)- alpha-(2,3-dimethoxyphenyl)-1[2-(4-fluorophenyl) etryl]-4-piperidinemethanol - Google Patents

Nouveaux procedes pour la preparation de (r)- alpha-(2,3-dimethoxyphenyl)-1[2-(4-fluorophenyl) etryl]-4-piperidinemethanol

Info

Publication number: MA25515A1
Authority: MA; Morocco
Prior art keywords: etryl; piperidinemethanol; dimethoxyphenyl; fluorophenyl; alpha
Prior art date: 1998-03-13

Application number

MA25491A

Other languages

English (en)

Inventor

Alan G Bina

Jonathan C Evans

Hans-Wolfram Flemming

Gerard Guillamot

Thomas H E Hilpert

James E Hitt

Johannes N Koek

John R Lefler

Alexey L Margolin

Sharon K Minish

Lian G Rajewski

Paul F Skultety

Sandra K Stolz-Dunn

Ian A Tomlinson

Edward D Daugs

Robert A Hawthorne

Chi-Hsin R King

Frederick M Laskovics

Thomas T Ortyl

Marvin J Sack

Alonzo L Tigner

Marion Roussel Deutsch Hoechst

Original Assignee

Alonzo L Tigner

Hoechst Marion Roussel De Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-13

Filing date

1999-03-10

Publication date

2002-10-01

1999-03-10 Application filed by Alonzo L Tigner, Hoechst Marion Roussel De Gmbh filed Critical Alonzo L Tigner

2002-10-01 Publication of MA25515A1 publication Critical patent/MA25515A1/fr

Links

-1 2,3-DIMETHOXYPHENYL Chemical class 0.000 title 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Urology & Nephrology (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Pyridine Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

MA25491A 1998-03-13 1999-03-10 Nouveaux procedes pour la preparation de (r)- alpha-(2,3-dimethoxyphenyl)-1[2-(4-fluorophenyl) etryl]-4-piperidinemethanol MA25515A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4225198A	1998-03-13	1998-03-13
US25071899A	1999-02-16	1999-02-16

Publications (1)

Publication Number	Publication Date
MA25515A1 true MA25515A1 (fr)	2002-10-01

Family

ID=26719032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA25491A MA25515A1 (fr)	1998-03-13	1999-03-10	Nouveaux procedes pour la preparation de (r)- alpha-(2,3-dimethoxyphenyl)-1[2-(4-fluorophenyl) etryl]-4-piperidinemethanol

Country Status (25)

Country	Link
EP (3)	EP1734037A3 (fr)
JP (2)	JP4511723B2 (fr)
KR (7)	KR100586327B1 (fr)
CN (1)	CN100436415C (fr)
AR (1)	AR015540A1 (fr)
AT (1)	ATE373639T1 (fr)
AU (1)	AU755436B2 (fr)
BR (1)	BR9909260A (fr)
CA (1)	CA2322501C (fr)
CY (1)	CY1107104T1 (fr)
DE (1)	DE69937162T2 (fr)
DK (1)	DK1192134T3 (fr)
DZ (1)	DZ2742A1 (fr)
EG (1)	EG24052A (fr)
ES (1)	ES2294838T3 (fr)
HK (1)	HK1042484B (fr)
HU (1)	HUP0400889A3 (fr)
IL (3)	IL138307A0 (fr)
MA (1)	MA25515A1 (fr)
NO (1)	NO317981B1 (fr)
NZ (1)	NZ506807A (fr)
PT (1)	PT1192134E (fr)
TN (1)	TNSN99035A1 (fr)
TW (1)	TWI249526B (fr)
WO (1)	WO1999046245A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6713627B2 (en) *	1998-03-13	2004-03-30	Aventis Pharmaceuticals Inc.	Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
DE19934432A1 (de)	1999-07-22	2001-02-01	Merck Patent Gmbh	Indolderivate
EP1370244A1 (fr) *	2001-03-12	2003-12-17	Novo Nordisk A/S	Nouveaux comprimes et gelules et procede de preparation correspondant
DE102004010132A1 (de)	2004-02-27	2005-09-15	Merck Patent Gmbh	Piperidinderivate
CA2672134C (fr) *	2006-12-07	2015-02-10	Daiichi Sankyo Company, Limited	Preparation medicale sous forme solide contenant un mannitol ou un lactose
US8964338B2 (en)	2012-01-11	2015-02-24	Emerson Climate Technologies, Inc.	System and method for compressor motor protection
WO2014144446A1 (fr)	2013-03-15	2014-09-18	Emerson Electric Co.	Diagnostic et système de télésurveillance de chauffage, de ventilation et de climatisation
CN112358398A (zh) *	2020-11-19	2021-02-12	山东新华制药股份有限公司	D-(+)-二对甲苯甲酰酒石酸的回收制备方法
CN116082705B (zh) *	2022-12-05	2023-09-12	苏州易昇光学材料股份有限公司	一种抗黄变自修复凝胶

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4260623A (en) *	1979-11-26	1981-04-07	Warner-Lambert Company	Hexahydro-1-arylspiro(3H-oxazolo(3,4-A)pyridine-3,4'-piperidene) antidepressants, pharmaceutical compositions thereof and method of use thereof
ZA864772B (en) *	1985-07-02	1987-02-25	Merrell Dow Pharma	Novel chemical compounds
US5169096A (en) *	1985-07-02	1992-12-08	Merrell Dow Pharmaceuticals Inc.	N-aralkyl-piperidine-methanol derivatives
CA2083698C (fr) *	1990-06-01	1997-11-04	Albert A. Carr	(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
HU214587B (hu) *	1990-06-07	1998-04-28	Merrell Dow Pharmaceuticals Inc.	Eljárás 1-piperidinil-alkanoil-aril-szulfonamid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények előállítására
US5477029A (en) *	1994-01-28	1995-12-19	Skutt Ceramic Products, Inc.	Kiln with hinged control panel
US5618824A (en) *	1994-03-09	1997-04-08	Merrell Pharmaceuticals Inc.	Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
EP0796619A1 (fr) *	1996-03-21	1997-09-24	Merrell Pharmaceuticals Inc.	Utilisation de (+)-alpha-(2,3-diméthoxyphényle)-1-(2-(4-fluorophényle)éthyle)-4-pipéridineméthanol pour le traitement des troubles dépressifs et bipolaires

1999
- 1999-03-09 TW TW088103619A patent/TWI249526B/zh not_active IP Right Cessation
- 1999-03-10 DZ DZ990043A patent/DZ2742A1/fr active
- 1999-03-10 MA MA25491A patent/MA25515A1/fr unknown
- 1999-03-10 EG EG23399A patent/EG24052A/xx active
- 1999-03-11 EP EP06016486A patent/EP1734037A3/fr not_active Ceased
- 1999-03-11 HK HK02103493.4A patent/HK1042484B/en not_active IP Right Cessation
- 1999-03-11 KR KR1020057024569A patent/KR100586327B1/ko not_active Expired - Fee Related
- 1999-03-11 EP EP06016487A patent/EP1736469A3/fr not_active Withdrawn
- 1999-03-11 PT PT99911318T patent/PT1192134E/pt unknown
- 1999-03-11 ES ES99911318T patent/ES2294838T3/es not_active Expired - Lifetime
- 1999-03-11 CN CNB998060224A patent/CN100436415C/zh not_active Expired - Fee Related
- 1999-03-11 AR ARP990101039A patent/AR015540A1/es unknown
- 1999-03-11 KR KR1020007010103A patent/KR100591642B1/ko not_active Expired - Fee Related
- 1999-03-11 HU HU0400889A patent/HUP0400889A3/hu unknown
- 1999-03-11 IL IL13830799A patent/IL138307A0/xx active IP Right Grant
- 1999-03-11 NZ NZ506807A patent/NZ506807A/xx unknown
- 1999-03-11 KR KR1020057024568A patent/KR100591640B1/ko not_active Expired - Fee Related
- 1999-03-11 TN TNTNSN99035A patent/TNSN99035A1/fr unknown
- 1999-03-11 KR KR1020057024573A patent/KR100591641B1/ko not_active Expired - Fee Related
- 1999-03-11 CA CA002322501A patent/CA2322501C/fr not_active Expired - Fee Related
- 1999-03-11 DE DE69937162T patent/DE69937162T2/de not_active Expired - Lifetime
- 1999-03-11 DK DK99911318T patent/DK1192134T3/da active
- 1999-03-11 WO PCT/US1999/005332 patent/WO1999046245A2/fr not_active Ceased
- 1999-03-11 BR BR9909260-3A patent/BR9909260A/pt not_active Application Discontinuation
- 1999-03-11 EP EP99911318A patent/EP1192134B1/fr not_active Expired - Lifetime
- 1999-03-11 KR KR1020057024567A patent/KR100591643B1/ko not_active Expired - Fee Related
- 1999-03-11 JP JP2000535626A patent/JP4511723B2/ja not_active Expired - Fee Related
- 1999-03-11 AT AT99911318T patent/ATE373639T1/de not_active IP Right Cessation
- 1999-03-11 KR KR1020057024572A patent/KR100591997B1/ko not_active Expired - Fee Related
- 1999-03-11 KR KR1020057024570A patent/KR100586328B1/ko not_active Expired - Fee Related
- 1999-03-11 AU AU29988/99A patent/AU755436B2/en not_active Ceased
2000
- 2000-09-06 IL IL138307A patent/IL138307A/en not_active IP Right Cessation
- 2000-09-12 NO NO20004545A patent/NO317981B1/no not_active IP Right Cessation
2006
- 2006-05-29 IL IL175983A patent/IL175983A0/en unknown
2007
- 2007-12-19 CY CY20071101617T patent/CY1107104T1/el unknown
2009
- 2009-12-28 JP JP2009296809A patent/JP2010143925A/ja not_active Abandoned

Also Published As

Publication number	Publication date
DZ2742A1 (fr)	2003-09-08
JP2010143925A (ja)	2010-07-01
TNSN99035A1 (fr)	2005-11-10
KR100591641B1 (ko)	2006-06-20
KR100586328B1 (ko)	2006-06-08
EP1192134B1 (fr)	2007-09-19
HK1042484B (en)	2008-05-02
KR20060002036A (ko)	2006-01-06
DE69937162T2 (de)	2008-06-12
HUP0400889A2 (hu)	2004-08-30
IL138307A (en)	2006-09-05
NO20004545L (no)	2000-11-13
DE69937162D1 (de)	2007-10-31
KR100586327B1 (ko)	2006-06-08
KR20060002037A (ko)	2006-01-06
IL175983A0 (en)	2006-10-05
WO1999046245A3 (fr)	1999-10-21
EP1736469A3 (fr)	2010-06-09
EP1736469A2 (fr)	2006-12-27
WO1999046245A2 (fr)	1999-09-16
EP1192134A2 (fr)	2002-04-03
BR9909260A (pt)	2000-11-21
DK1192134T3 (da)	2007-11-26
KR20060002034A (ko)	2006-01-06
EG24052A (en)	2008-04-13
NO317981B1 (no)	2005-01-17
JP4511723B2 (ja)	2010-07-28
CN1300280A (zh)	2001-06-20
ATE373639T1 (de)	2007-10-15
NO20004545D0 (no)	2000-09-12
KR20010041819A (ko)	2001-05-25
KR100591640B1 (ko)	2006-06-20
TWI249526B (en)	2006-02-21
KR20060002039A (ko)	2006-01-06
ES2294838T3 (es)	2008-04-01
AR015540A1 (es)	2001-05-02
HUP0400889A3 (en)	2010-08-30
HK1042484A1 (en)	2002-08-16
AU755436B2 (en)	2002-12-12
KR20060002035A (ko)	2006-01-06
EP1734037A2 (fr)	2006-12-20
KR100591643B1 (ko)	2006-06-20
NZ506807A (en)	2003-03-28
JP2002506059A (ja)	2002-02-26
CN100436415C (zh)	2008-11-26
PT1192134E (pt)	2007-11-13
KR100591997B1 (ko)	2006-06-26
KR20060002038A (ko)	2006-01-06
CA2322501A1 (fr)	1999-09-16
IL138307A0 (en)	2001-10-31
EP1734037A3 (fr)	2010-06-16
KR100591642B1 (ko)	2006-06-20
AU2998899A (en)	1999-09-27
CY1107104T1 (el)	2012-01-25
CA2322501C (fr)	2006-05-09

Publication	Publication Date	Title
MA25984A1 (fr)	2003-12-31	Procede pour preparation de maleate d'amlodipine.
NO994077D0 (no)	1999-08-24	Fremgangsmåte for fremstilling av keramiske membraner
MA25223A1 (fr)	2001-07-02	Procede pour la preparation de 4-carboxy-amino-2-substitue-1,2,3,4 tetrahydroquinoleine
IT1315269B1 (it)	2003-02-03	Metodo per la preparazione di 5-cianoftalide
MA25515A1 (fr)	2002-10-01	Nouveaux procedes pour la preparation de (r)- alpha-(2,3-dimethoxyphenyl)-1[2-(4-fluorophenyl) etryl]-4-piperidinemethanol
PL344390A1 (en)	2001-06-18	Method of obtaining derivatives of 1,4-dihydropyridine
AU1987400A (en)	2000-07-03	Process for preparation of paroxetine maleate
PT963985E (pt)	2003-06-30	Derivados de di- ou triaza-espiro(4,5)decano
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