ATE373662T1 - Tyrosinkinase-hemmer - Google Patents

Tyrosinkinase-hemmer

Info

Publication number: ATE373662T1
Authority: AT; Austria
Prior art keywords: compounds; tyrosine kinase; kinase inhibitors; present; receptor
Prior art date: 2002-04-12

Application number

AT03719886T

Other languages

English (en)

Inventor

B Trotter

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-12

Filing date

2003-04-08

Publication date

2007-10-15

2003-04-08 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE373662T1 publication Critical patent/ATE373662T1/de

Links

229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
QBDOBFNOPHZPCZ-UHFFFAOYSA-N 1-benzazocine Chemical group N1=CC=CC=CC2=CC=CC=C21 QBDOBFNOPHZPCZ-UHFFFAOYSA-N 0.000 abstract 1
102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000019491 signal transduction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT03719886T 2002-04-12 2003-04-08 Tyrosinkinase-hemmer ATE373662T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37223202P	2002-04-12	2002-04-12

Publications (1)

Publication Number	Publication Date
ATE373662T1 true ATE373662T1 (de)	2007-10-15

Family

ID=29250816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03719886T ATE373662T1 (de)	2002-04-12	2003-04-08	Tyrosinkinase-hemmer

Country Status (9)

Country	Link
US (1)	US7371754B2 (de)
EP (1)	EP1496907B1 (de)
JP (1)	JP4475389B2 (de)
AT (1)	ATE373662T1 (de)
AU (1)	AU2003223689B2 (de)
CA (1)	CA2480758A1 (de)
DE (1)	DE60316423T2 (de)
ES (1)	ES2292956T3 (de)
WO (1)	WO2003086315A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1496897A4 (de) *	2002-04-12	2006-05-10	Merck & Co Inc	Tyrosinkinase-hemmer
EP1496898B1 (de) *	2002-04-12	2008-05-28	Merck & Co., Inc.	Tyrosinkinase-hemmer
WO2007105590A1 (ja)	2006-03-09	2007-09-20	Nec Corporation	動画像符号化方法、およびこれを用いた装置とプログラム
WO2007137168A2 (en) *	2006-05-18	2007-11-29	Janssen Pharmaceutica N.V.	Bridged aryl piperazines derivatives useful for the treatment of cns, gi-urinary and reproductive disorders
US8642067B2 (en)	2007-04-02	2014-02-04	Allergen, Inc.	Methods and compositions for intraocular administration to treat ocular conditions
CN117257805B (zh) *	2023-11-10	2024-03-12	中山大学附属第八医院（深圳福田）	核苷类逆转录酶抑制剂在制备抗血管钙化药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4332810A (en)	1981-01-26	1982-06-01	Merck & Co., Inc.	N-(Substituted)-2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine centrally-acting analgesics
AU9042201A (en) *	2000-09-20	2002-04-02	Karolinska Innovations Ab	1-azabicyclo(2.2.2)octan-3-one derivatives and maleimide derivatives and their use for treating cancer tumors
GB0110797D0 (en) *	2001-05-02	2001-06-27	Celltech R&D Ltd	Chemical compounds
EP1496897A4 (de)	2002-04-12	2006-05-10	Merck & Co Inc	Tyrosinkinase-hemmer
EP1496898B1 (de)	2002-04-12	2008-05-28	Merck & Co., Inc.	Tyrosinkinase-hemmer

2003
- 2003-04-08 WO PCT/US2003/012457 patent/WO2003086315A2/en not_active Ceased
- 2003-04-08 AU AU2003223689A patent/AU2003223689B2/en not_active Ceased
- 2003-04-08 DE DE60316423T patent/DE60316423T2/de not_active Expired - Lifetime
- 2003-04-08 AT AT03719886T patent/ATE373662T1/de not_active IP Right Cessation
- 2003-04-08 JP JP2003583340A patent/JP4475389B2/ja not_active Expired - Lifetime
- 2003-04-08 EP EP03719886A patent/EP1496907B1/de not_active Expired - Lifetime
- 2003-04-08 US US10/510,610 patent/US7371754B2/en not_active Expired - Fee Related
- 2003-04-08 ES ES03719886T patent/ES2292956T3/es not_active Expired - Lifetime
- 2003-04-08 CA CA002480758A patent/CA2480758A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1496907A4 (de)	2006-05-10
DE60316423T2 (de)	2008-06-12
CA2480758A1 (en)	2003-10-23
AU2003223689B2 (en)	2009-08-20
AU2003223689A1 (en)	2003-10-27
EP1496907A2 (de)	2005-01-19
DE60316423D1 (de)	2007-10-31
ES2292956T3 (es)	2008-03-16
US7371754B2 (en)	2008-05-13
WO2003086315A3 (en)	2004-01-08
EP1496907B1 (de)	2007-09-19
JP4475389B2 (ja)	2010-06-09
US20050227988A1 (en)	2005-10-13
WO2003086315A2 (en)	2003-10-23
JP2005528387A (ja)	2005-09-22

Legal Events

Date	Code	Title	Description
2008-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60334386D1 (de)	2010-11-11	Tyrosinkinaseinhibitoren
WO2004014300A3 (en)	2004-04-22	Tyrosine kinase inhibitors
WO2003035615A3 (en)	2004-03-18	Tyrosine kinase inhibitors
DK1362047T3 (da)	2006-09-04	Indazolylsubstituerede pyrrolinforbindelser som kinaseinhibitorer
WO2004031401A3 (en)	2004-07-29	Novel tyrosine kinases inhibitors
WO2004096795A3 (en)	2005-03-10	C-fms kinase inhibitors
ID27535A (id)	2001-04-12	Turunan pirasola sebagai inhibitor p-38 map kinase
WO2003035616A3 (en)	2003-10-23	Tyrosine kinase inhibitors
SG132683A1 (en)	2007-06-28	Imidazopyrazine tyrosine kinase inhibitors
BRPI0412894A (pt)	2006-10-03	tienopiridina e furopiridina inibidores de quinases
ATE554087T1 (de)	2012-05-15	Neue kinaseinhibitoren
CA2400447A1 (en)	2001-08-23	Kinase inhibitors
MY139689A (en)	2009-10-30	Imidazotriazines as protein kinase inhibitors
WO2003035619A8 (en)	2003-07-03	Tyrosine kinase inhibitors
IL163781A0 (en)	2005-12-18	Purine derivatives as kinase inhibitors
WO2003035614A3 (en)	2004-03-18	Tyrosine kinase inhibitors
IL163777A0 (en)	2005-12-18	Kinase inhibitors
WO2006047479A3 (en)	2007-01-04	C-fms kinase inhibitors
WO2006047503A3 (en)	2006-09-28	Inhibitors of c-fms kinase
MXPA05009151A (es)	2005-10-20	Inhibidores de cinasa heterociclica.
ATE373662T1 (de)	2007-10-15	Tyrosinkinase-hemmer
TW200628153A (en)	2006-08-16	Novel compounds
ATE396727T1 (de)	2008-06-15	Tyrosinkinase-hemmer
WO2005009373A3 (en)	2005-09-09	Tyrosine kinase inhibitors
IL162820A (en)	2010-04-15	Composition against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors