ATE396727T1 - Tyrosinkinase-hemmer - Google Patents

Tyrosinkinase-hemmer

Info

Publication number: ATE396727T1
Authority: AT; Austria
Prior art keywords: compounds; tyrosine kinase; kinase inhibitors; present; receptor
Prior art date: 2002-04-12

Application number

AT03746762T

Other languages

English (en)

Inventor

Annette Kim

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-12

Filing date

2003-04-08

Publication date

2008-06-15

2003-04-08 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2008-06-15 Application granted granted Critical

2008-06-15 Publication of ATE396727T1 publication Critical patent/ATE396727T1/de

Links

229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
QBDOBFNOPHZPCZ-UHFFFAOYSA-N 1-benzazocine Chemical group N1=CC=CC=CC2=CC=CC=C21 QBDOBFNOPHZPCZ-UHFFFAOYSA-N 0.000 abstract 1
102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000019491 signal transduction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)

AT03746762T 2002-04-12 2003-04-08 Tyrosinkinase-hemmer ATE396727T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37235802P	2002-04-12	2002-04-12

Publications (1)

Publication Number	Publication Date
ATE396727T1 true ATE396727T1 (de)	2008-06-15

Family

ID=29250844

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03746762T ATE396727T1 (de)	2002-04-12	2003-04-08	Tyrosinkinase-hemmer

Country Status (8)

Country	Link
US (1)	US7348431B2 (de)
EP (1)	EP1496898B1 (de)
JP (1)	JP4516758B2 (de)
AT (1)	ATE396727T1 (de)
AU (1)	AU2003231747B2 (de)
CA (1)	CA2480754A1 (de)
DE (1)	DE60321330D1 (de)
WO (1)	WO2003086314A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003230835A1 (en) *	2002-04-12	2003-10-27	Merck & Co., Inc.	Tyrosine kinase inhibitors
US7371754B2 (en)	2002-04-12	2008-05-13	Merck & Co., Inc.	Tyrosine kinase inhibitors
US7569725B2 (en) *	2004-10-21	2009-08-04	Britsol-Myers Squibb Company	Anthranilic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US8642067B2 (en)	2007-04-02	2014-02-04	Allergen, Inc.	Methods and compositions for intraocular administration to treat ocular conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4332810A (en) *	1981-01-26	1982-06-01	Merck & Co., Inc.	N-(Substituted)-2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine centrally-acting analgesics
DE60136473D1 (de) *	2000-09-20	2008-12-18	Aprea Ab	Verwendung von 1-azabicyclo(2.2.2)octan-3-on-derivaten zur behandlung von krebstumoren
AU2003230835A1 (en)	2002-04-12	2003-10-27	Merck & Co., Inc.	Tyrosine kinase inhibitors
US7371754B2 (en)	2002-04-12	2008-05-13	Merck & Co., Inc.	Tyrosine kinase inhibitors

2003
- 2003-04-08 CA CA002480754A patent/CA2480754A1/en not_active Abandoned
- 2003-04-08 EP EP03746762A patent/EP1496898B1/de not_active Expired - Lifetime
- 2003-04-08 AU AU2003231747A patent/AU2003231747B2/en not_active Ceased
- 2003-04-08 JP JP2003583339A patent/JP4516758B2/ja not_active Expired - Fee Related
- 2003-04-08 DE DE60321330T patent/DE60321330D1/de not_active Expired - Lifetime
- 2003-04-08 AT AT03746762T patent/ATE396727T1/de not_active IP Right Cessation
- 2003-04-08 WO PCT/US2003/012456 patent/WO2003086314A2/en not_active Ceased
- 2003-04-08 US US10/510,609 patent/US7348431B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2003231747A1 (en)	2003-10-27
US7348431B2 (en)	2008-03-25
EP1496898A4 (de)	2006-05-10
WO2003086314A2 (en)	2003-10-23
US20060167036A1 (en)	2006-07-27
EP1496898A2 (de)	2005-01-19
CA2480754A1 (en)	2003-10-23
JP2005527580A (ja)	2005-09-15
WO2003086314A3 (en)	2004-04-08
AU2003231747B2 (en)	2008-09-18
JP4516758B2 (ja)	2010-08-04
DE60321330D1 (de)	2008-07-10
EP1496898B1 (de)	2008-05-28

Legal Events

Date	Code	Title	Description
2008-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60334386D1 (de)	2010-11-11	Tyrosinkinaseinhibitoren
WO2004014300A3 (en)	2004-04-22	Tyrosine kinase inhibitors
WO2003035615A3 (en)	2004-03-18	Tyrosine kinase inhibitors
DK1362047T3 (da)	2006-09-04	Indazolylsubstituerede pyrrolinforbindelser som kinaseinhibitorer
WO2004031401A3 (en)	2004-07-29	Novel tyrosine kinases inhibitors
AU2001241798A1 (en)	2001-09-12	3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
WO2004096795A3 (en)	2005-03-10	C-fms kinase inhibitors
ID27535A (id)	2001-04-12	Turunan pirasola sebagai inhibitor p-38 map kinase
WO2003035616A3 (en)	2003-10-23	Tyrosine kinase inhibitors
SG132683A1 (en)	2007-06-28	Imidazopyrazine tyrosine kinase inhibitors
ATE554087T1 (de)	2012-05-15	Neue kinaseinhibitoren
MY139689A (en)	2009-10-30	Imidazotriazines as protein kinase inhibitors
WO2003035619A8 (en)	2003-07-03	Tyrosine kinase inhibitors
IL163781A0 (en)	2005-12-18	Purine derivatives as kinase inhibitors
MXPA05013076A (es)	2006-03-09	Compuestos de isoindolina-1-ona como inhibidores de cinasa.
ATE419253T1 (de)	2009-01-15	Inhibitoren von thienopyridin- und furopyridinkinase
WO2003035614A3 (en)	2004-03-18	Tyrosine kinase inhibitors
IL163777A0 (en)	2005-12-18	Kinase inhibitors
WO2006047479A3 (en)	2007-01-04	C-fms kinase inhibitors
MXPA05009151A (es)	2005-10-20	Inhibidores de cinasa heterociclica.
WO2001056573A8 (en)	2001-11-01	Use of cox-2 inhibitors as gastroprokinetics
ATE373662T1 (de)	2007-10-15	Tyrosinkinase-hemmer
TW200628153A (en)	2006-08-16	Novel compounds
DE60321330D1 (de)	2008-07-10	Tyrosinkinase-hemmer
WO2005009373A3 (en)	2005-09-09	Tyrosine kinase inhibitors