ATE373667T1 - Verfahren zur herstellung von ceftiofur - Google Patents

Verfahren zur herstellung von ceftiofur

Info

Publication number: ATE373667T1
Authority: AT; Austria
Prior art keywords: ceftiofur; water; formula; impurities; salt
Prior art date: 2002-10-29

Application number

AT03809833T

Other languages

English (en)

Inventor

Om Dutt Tyagi

Santosh K Richhariya

Rajesh Kumar R Pawar

Yuvaraj Atmaram Chavan

Original Assignee

Lupin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-29

Filing date

2003-10-27

Publication date

2007-10-15

2003-10-27 Application filed by Lupin Ltd filed Critical Lupin Ltd

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE373667T1 publication Critical patent/ATE373667T1/de

Links

ZBHXIWJRIFEVQY-IHMPYVIRSA-N ceftiofur Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC(=O)C1=CC=CO1 ZBHXIWJRIFEVQY-IHMPYVIRSA-N 0.000 title abstract 7
229960005229 ceftiofur Drugs 0.000 title abstract 7
238000004519 manufacturing process Methods 0.000 title 1
239000012535 impurity Substances 0.000 abstract 3
239000003960 organic solvent Substances 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
239000008346 aqueous phase Substances 0.000 abstract 2
239000002585 base Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000012074 organic phase Substances 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
ZMPDMYFTSINIIZ-QHDYGNBISA-N (6r)-7-amino-3-(furan-2-carbonylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S([C@@H]1C(C(N1C=1C(O)=O)=O)N)CC=1CSC(=O)C1=CC=CO1 ZMPDMYFTSINIIZ-QHDYGNBISA-N 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
239000012296 anti-solvent Substances 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
230000008020 evaporation Effects 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
238000005192 partition Methods 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
238000000638 solvent extraction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)

AT03809833T 2002-10-29 2003-10-27 Verfahren zur herstellung von ceftiofur ATE373667T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IN937MU2002		2002-10-29

Publications (1)

Publication Number	Publication Date
ATE373667T1 true ATE373667T1 (de)	2007-10-15

Family

ID=32211318

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03809833T ATE373667T1 (de)	2002-10-29	2003-10-27	Verfahren zur herstellung von ceftiofur

Country Status (10)

Country	Link
US (2)	US7511135B2 (de)
EP (1)	EP1556388B1 (de)
JP (1)	JP2006507290A (de)
AT (1)	ATE373667T1 (de)
AU (1)	AU2003300691A1 (de)
CA (1)	CA2503885A1 (de)
DE (1)	DE60316459T2 (de)
ES (1)	ES2294367T3 (de)
NZ (1)	NZ540225A (de)
WO (1)	WO2004039811A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60316459T2 (de) *	2002-10-29	2008-06-19	Lupin Ltd., Mumbai	Verfahren zur herstellung von ceftiofur
US7335767B2 (en) *	2002-10-29	2008-02-26	Lupin Limited	Method for preparation of ceftiofur and salts thereof
US8470809B2 (en) *	2005-10-12	2013-06-25	Orchid Chemicals & Pharmaceuticals Limited	Crystalline sodium salt of cephalosporin antibiotic
EP1934231A4 (de) *	2005-10-12	2011-10-26	Orchid Chemicals & Pharm Ltd	Kristallines natriumsalz des antibiotikums cephalosporin
US8431562B2 (en) *	2008-08-22	2013-04-30	Orchid Chemicals & Pharmaceuticals Limited	Crystalline sodium salt of cephalosporin antibiotic
WO2012049576A1 (en) *	2010-10-13	2012-04-19	Orchid Chemicals And Pharmaceuticals Limited	Crystalline sodium salt of cephalosporin antibiotic
CN102584855B (zh) *	2012-02-16	2014-06-25	青岛科技大学	一种改进的头孢噻呋的制备方法
CN107056816B (zh) *	2017-04-26	2019-11-15	齐鲁动物保健品有限公司	一种头孢噻呋钠的结晶方法
CN116003439A (zh) *	2023-01-05	2023-04-25	山东久隆信和药业有限公司	一种盐酸头孢噻呋的精制方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1987001117A2 (en) *	1985-08-12	1987-02-26	The Upjohn Company	Conversion of cephalosporin hydrohalide salt to alkali metal salt
US6458949B1 (en) *	2000-08-14	2002-10-01	Aurobindo Pharma Limited	Ceftiofur, its intermediate and a process for the preparation of the same
DE60117620T2 (de) *	2000-11-22	2006-10-12	Sandoz Ag	Herstellung von cephalosporin
US6388070B1 (en) *	2001-01-05	2002-05-14	Orchid Chemicals & Pharmaceuticals Ltd.	Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
US6555680B1 (en) *	2001-12-10	2003-04-29	Orchid Chemicals & Pharmaceuticals Ltd.	Method for the preparation of ceftiofur sodium
US20030135041A1 (en) *	2002-01-04	2003-07-17	Orchid Chemicals & Pharmaceuticals Limited, India	Synthesis of ceftiofur intermediate
US7335767B2 (en) *	2002-10-29	2008-02-26	Lupin Limited	Method for preparation of ceftiofur and salts thereof
DE60316459T2 (de) *	2002-10-29	2008-06-19	Lupin Ltd., Mumbai	Verfahren zur herstellung von ceftiofur
WO2004058695A1 (en) *	2002-12-26	2004-07-15	Lupin Limited	Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates
WO2005019227A1 (en) *	2003-08-22	2005-03-03	Orchid Chemicals & Pharmaceuticals Ltd	Process for the preparation of cephalosporin antibiotic
US20060094872A1 (en) *	2003-08-22	2006-05-04	Orchid Chemicals & Pharmaceuticals Ltd.	Process for the preparation of cephalosporin antibiotic
US20050119244A1 (en) *	2003-12-02	2005-06-02	Acs Dobfar S.P.A.	Process for preparing cephalosporins with salified intermediate
EP1934231A4 (de) *	2005-10-12	2011-10-26	Orchid Chemicals & Pharm Ltd	Kristallines natriumsalz des antibiotikums cephalosporin

2003
- 2003-10-27 DE DE60316459T patent/DE60316459T2/de not_active Expired - Lifetime
- 2003-10-27 US US10/532,194 patent/US7511135B2/en not_active Expired - Fee Related
- 2003-10-27 NZ NZ540225A patent/NZ540225A/en unknown
- 2003-10-27 AT AT03809833T patent/ATE373667T1/de not_active IP Right Cessation
- 2003-10-27 EP EP03809833A patent/EP1556388B1/de not_active Expired - Lifetime
- 2003-10-27 AU AU2003300691A patent/AU2003300691A1/en not_active Abandoned
- 2003-10-27 ES ES03809833T patent/ES2294367T3/es not_active Expired - Lifetime
- 2003-10-27 CA CA002503885A patent/CA2503885A1/en not_active Abandoned
- 2003-10-27 WO PCT/IN2003/000345 patent/WO2004039811A2/en not_active Ceased
- 2003-10-27 JP JP2004547964A patent/JP2006507290A/ja active Pending
2008
- 2008-04-30 US US12/150,744 patent/US20080207912A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20060149054A1 (en)	2006-07-06
JP2006507290A (ja)	2006-03-02
WO2004039811A2 (en)	2004-05-13
AU2003300691A1 (en)	2004-05-25
CA2503885A1 (en)	2004-05-13
EP1556388B1 (de)	2007-09-19
US7511135B2 (en)	2009-03-31
DE60316459D1 (de)	2007-10-31
DE60316459T2 (de)	2008-06-19
EP1556388A2 (de)	2005-07-27
ES2294367T3 (es)	2008-04-01
US20080207912A1 (en)	2008-08-28
NZ540225A (en)	2007-06-29
WO2004039811A3 (en)	2004-08-12

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Legal Events

Date	Code	Title	Description
2008-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties